# CST11

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> Source: https://en.wikipedia.org/wiki/CST11
> Source revision: 1301006999
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{{Short description|Protein-coding gene in humans}}
{{Infobox_gene}}
'''Cystatin-11''' is a [protein](/source/protein) that in humans is encoded by the ''CST11'' [gene](/source/gene).<ref name="entrez">{{cite web | title = Entrez Gene: CST11 cystatin 11| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=140880}}</ref>

The [cystatin](/source/cystatin) superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active [cysteine protease inhibitors](/source/Cysteine_protease), while others have lost or perhaps never acquired this inhibitory activity. 

There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the [kininogens](/source/Kininogen). The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. 

The cystatin locus on [chromosome 20](/source/chromosome_20) contains the majority of the type 2 cystatin genes and [pseudogenes](/source/pseudogenes). This gene is located in the cystatin locus and encodes an [epididymal](/source/Epididymal_cyst)-specific protein whose specific function has not been determined. Alternative splicing yields two variants encoding distinct [isoforms](/source/isoforms).<ref name="entrez" />

==References==
{{reflist}}

==External links==
* {{UCSC gene info|CST11}}

==Further reading==
{{refbegin | 2}}
*{{cite journal  | vauthors=Brown WM, Dziegielewska KM |title=Friends and relations of the cystatin superfamily--new members and their evolution |journal=Protein Sci. |volume=6 |issue= 1 |pages= 5–12 |year= 1997 |pmid= 9007972 |doi=10.1002/pro.5560060102  | pmc=2143511  }}
*{{cite journal  | vauthors=Saitoh E, Isemura S, Sanada K |title=Cystatin superfamily. Evidence that family II cystatin genes are evolutionarily related to family III cystatin genes |journal=Biol. Chem. Hoppe-Seyler |volume=369 Suppl |pages= 191–7 |year= 1989 |pmid= 3202964 |display-authors=etal}}
*{{cite journal  | vauthors=Dickinson DP, Thiesse M, Dempsey LD, Millar SJ |title=Genomic cloning, physical mapping, and expression of human type 2 cystatin genes |journal=Crit. Rev. Oral Biol. Med. |volume=4 |issue= 3–4 |pages= 573–80 |year= 1993 |pmid= 7690606 |doi=  10.1177/10454411930040034401}}
*{{cite journal  | vauthors=Dickinson DP, Zhao Y, Thiesse M, Siciliano MJ |title=Direct mapping of seven genes encoding human type 2 cystatins to a single site located at 20p11.2 |journal=Genomics |volume=24 |issue= 1 |pages= 172–5 |year= 1995 |pmid= 7896273 |doi= 10.1006/geno.1994.1595 }}
*{{cite journal  | vauthors=Thiesse M, Millar SJ, Dickinson DP |title=The human type 2 cystatin gene family consists of eight to nine members, with at least seven genes clustered at a single locus on human chromosome 20 |journal=DNA Cell Biol. |volume=13 |issue= 2 |pages= 97–116 |year= 1994 |pmid= 8179826 |doi=10.1089/dna.1994.13.97  }}
*{{cite journal  | vauthors=Deloukas P, Matthews LH, Ashurst J |title=The DNA sequence and comparative analysis of human chromosome 20 |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a |bibcode=2001Natur.414..865D |display-authors=etal|doi-access=free }}
*{{cite journal  | vauthors=Hamil KG, Liu Q, Sivashanmugam P |title=Cystatin 11: a new member of the cystatin type 2 family |journal=Endocrinology |volume=143 |issue= 7 |pages= 2787–96 |year= 2002 |pmid= 12072414 |doi=10.1210/endo.143.7.8925  |display-authors=etal|doi-access=free }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 |display-authors=etal}}
{{refend}}

{{gene-20-stub}}

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Adapted from the Wikipedia article [CST11](https://en.wikipedia.org/wiki/CST11) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/CST11?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.