# CRLF2

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{{Short description|Protein-coding gene in humans}}
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'''Cytokine receptor-like factor 2''' (also known as TSLP receptor, TSLP-R) is a [protein](/source/protein) that in humans is encoded by the ''CRLF2'' [gene](/source/gene). It forms a ternary signaling complex with [TSLP](/source/TSLP) and [interleukin-7 receptor-α](/source/interleukin-7_receptor-%CE%B1), capable of stimulating [cell proliferation](/source/cell_proliferation) through activation of STAT3, STAT5 and JAK2 pathways and is implicated in the development of the [hematopoietic system](/source/hematopoietic_system). Rearrangement of this gene with [immunoglobulin](/source/immunoglobulin) heavy chain gene (IGH) (chromosome 14), or with P2Y purinoceptor 8 gene (P2RY8) (chromosome X or Y) is associated with B-progenitor- and [Down syndrome](/source/Down_syndrome)- acute [lymphoblastic leukemia](/source/lymphoblastic_leukemia) (ALL).<ref name="Zhang_2001">{{cite journal | vauthors = Zhang W, Wang J, Wang Q, Chen G, Zhang J, Chen T, Wan T, Zhang Y, Cao X | title = Identification of a novel type I cytokine receptor CRL2 preferentially expressed by human dendritic cells and activated monocytes | journal = Biochemical and Biophysical Research Communications | volume = 281 | issue = 4 | pages = 878–883 | date = March 2001 | pmid = 11237741 | doi = 10.1006/bbrc.2001.4432 | bibcode = 2001BBRC..281..878Z }}</ref><ref name="Tonozuka_2001">{{cite journal | vauthors = Tonozuka Y, Fujio K, Sugiyama T, Nosaka T, Hirai M, Kitamura T | title = Molecular cloning of a human novel type I cytokine receptor related to delta1/TSLPR | journal = Cytogenetics and Cell Genetics | volume = 93 | issue = 1–2 | pages = 23–25 | date = Jul 2001 | pmid = 11474172 | doi = 10.1159/000056941 | s2cid = 83630087 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CRLF2 cytokine receptor-like factor 2 | url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=64109 }}</ref>

[Cytokine](/source/Cytokine) signals are mediated through specific [receptor](/source/sensory_receptor) complexes, the components of which are mostly members of the type I cytokine receptor family. Type I cytokine receptors share conserved structural features in their [extracellular domain](/source/extracellular_domain). Receptor complexes are typically heterodimeric, consisting of [alpha chain](/source/alpha_chain)s, which provide ligand specificity, and beta (or gamma) chains, which are required for the formation of high-affinity binding sites and [signal transduction](/source/signal_transduction).<ref name="entrez" />

== References ==
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== Further reading ==
{{refbegin | 2}}
* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–174 | date = January 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–156 | date = October 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
* {{cite journal | vauthors = Hiroyama T, Iwama A, Morita Y, Nakamura Y, Shibuya A, Nakauchi H | title = Molecular cloning and characterization of CRLM-2, a novel type I cytokine receptor preferentially expressed in hematopoietic cells | journal = Biochemical and Biophysical Research Communications | volume = 272 | issue = 1 | pages = 224–229 | date = May 2000 | pmid = 10872831 | doi = 10.1006/bbrc.2000.2764 | hdl-access = free | s2cid = 38299268 | bibcode = 2000BBRC..272..224H | hdl = 2241/1571 }}
* {{cite journal | vauthors = Reche PA, Soumelis V, Gorman DM, Clifford T, Travis M, Zurawski SM, Johnston J, Liu YJ, Spits H, de Waal Malefyt R, Kastelein RA, Bazan JF | title = Human thymic stromal lymphopoietin preferentially stimulates myeloid cells | journal = Journal of Immunology | volume = 167 | issue = 1 | pages = 336–343 | date = July 2001 | pmid = 11418668 | doi = 10.4049/jimmunol.167.1.336 | doi-access = free }}
* {{cite journal | vauthors = Blagoev B, Nielsen MM, Angrist M, Chakravarti A, Pandey A | title = Cloning of rat thymic stromal lymphopoietin receptor (TSLPR) and characterization of genomic structure of murine Tslpr gene | journal = Gene | volume = 284 | issue = 1–2 | pages = 161–168 | date = February 2002 | pmid = 11891057 | doi = 10.1016/S0378-1119(02)00380-3 }}
* {{cite journal | vauthors = Rochman I, Watanabe N, Arima K, Liu YJ, Leonard WJ | title = Cutting edge: direct action of thymic stromal lymphopoietin on activated human CD4+ T cells | journal = Journal of Immunology | volume = 178 | issue = 11 | pages = 6720–6724 | date = June 2007 | pmid = 17513717 | doi = 10.4049/jimmunol.178.11.6720 | doi-access = free }}
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== External links ==
* {{UCSC gene info|CRLF2}}

{{Cytokine receptor modulators}}

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Adapted from the Wikipedia article [CRLF2](https://en.wikipedia.org/wiki/CRLF2) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/CRLF2?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.