# CRIPT

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Protein-coding gene in the species Homo sapiens

For the muon detector known as the *CRIPT Detector*, see [Muon tomography](/source/Muon_tomography).

CRIPT Identifiers Aliases CRIPT, SSMDF, HSPC139, CXXC repeat containing interactor of PDZ3 domain External IDs OMIM: 604594; MGI: 1929655; HomoloGene: 8572; GeneCards: CRIPT; OMA:CRIPT - orthologs Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p21 Start 46,616,416 bp[1] End 46,630,176 bp[1] Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 E4 Start 87,332,978 bp[2] End 87,343,238 bp[2] RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell corpus epididymis caput epididymis tail of epididymis cerebellar vermis internal globus pallidus superficial temporal artery visceral pleura buccal mucosa cell trabecular bone Top expressed in zygote spermatocyte spermatid medial ganglionic eminence endocardial cushion Epithelium of choroid plexus seminal vesicula blood facial motor nucleus anterior horn of spinal cord More reference expression data BioGPS More reference expression data Gene ontology Molecular function microtubule binding scaffold protein binding PDZ domain binding protein binding protein-containing complex binding Cellular component cytoplasm dendritic shaft cell junction soma dendritic spine dendrite cell projection synapse nucleolus postsynaptic density nucleus fibrillar center Biological process regulation of postsynaptic density protein 95 clustering protein localization to microtubule cytoplasmic microtubule organization establishment of protein localization Sources:Amigo / QuickGO Orthologs Species Human Mouse Entrez 9419 56724 Ensembl ENSG00000119878 ENSMUSG00000024146 UniProt Q9P021 O70333 RefSeq (mRNA) NM_014171 NM_019936 RefSeq (protein) NP_054890 NP_064320 Location (UCSC) Chr 2: 46.62 – 46.63 Mb Chr 17: 87.33 – 87.34 Mb PubMed search [3] [4] Wikidata View/Edit Human View/Edit Mouse

**Cysteine-rich PDZ-binding protein** is a [protein](/source/Protein) that in humans is encoded by the *CRIPT* [gene](/source/Gene).[5][6][7][8][9]

## Interactions

CRIPT has been shown to [interact](/source/Protein-protein_interaction) with [DLG3](/source/DLG3).[10]

## References

1. ^ [***a***](#cite_ref-refGRCh38Ensembl_1-0) [***b***](#cite_ref-refGRCh38Ensembl_1-1) [***c***](#cite_ref-refGRCh38Ensembl_1-2) [GRCh38: Ensembl release 89: ENSG00000119878](http://May2017.archive.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000119878) – [Ensembl](/source/Ensembl_genome_database_project), May 2017

1. ^ [***a***](#cite_ref-refGRCm38Ensembl_2-0) [***b***](#cite_ref-refGRCm38Ensembl_2-1) [***c***](#cite_ref-refGRCm38Ensembl_2-2) [GRCm38: Ensembl release 89: ENSMUSG00000024146](http://May2017.archive.ensembl.org/Mus_musculus/Gene/Summary?db=core;g=ENSMUSG00000024146) – [Ensembl](/source/Ensembl_genome_database_project), May 2017

1. **[^](#cite_ref-3)** ["Human PubMed Reference:"](https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=9419). *National Center for Biotechnology Information, U.S. National Library of Medicine*.

1. **[^](#cite_ref-4)** ["Mouse PubMed Reference:"](https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=56724). *National Center for Biotechnology Information, U.S. National Library of Medicine*.

1. **[^](#cite_ref-pmid16091592_5-0)** Fukunaga Y, Matsubara M, Nagai R, Miyazawa A (Aug 2005). ["The interaction between PSD-95 and Ca2+/calmodulin is enhanced by PDZ-binding proteins"](https://doi.org/10.1093%2Fjb%2Fmvi107). *J Biochem*. **138** (2): 177–82. [doi](/source/Doi_(identifier)):[10.1093/jb/mvi107](https://doi.org/10.1093%2Fjb%2Fmvi107). [PMID](/source/PMID_(identifier)) [16091592](https://pubmed.ncbi.nlm.nih.gov/16091592).

1. **[^](#cite_ref-pmid11744724_6-0)** Piserchio A, Pellegrini M, Mehta S, Blackman SM, Garcia EP, Marshall J, Mierke DF (Feb 2002). ["The PDZ1 domain of SAP90. Characterization of structure and binding"](https://doi.org/10.1074%2Fjbc.M109453200). *J Biol Chem*. **277** (9): 6967–73. [doi](/source/Doi_(identifier)):[10.1074/jbc.M109453200](https://doi.org/10.1074%2Fjbc.M109453200). [PMID](/source/PMID_(identifier)) [11744724](https://pubmed.ncbi.nlm.nih.gov/11744724).

1. **[^](#cite_ref-pmid10570482_7-0)** Passafaro M, Sala C, Niethammer M, Sheng M (Jan 2000). "Microtubule binding by CRIPT and its potential role in the synaptic clustering of PSD-95". *Nat Neurosci*. **2** (12): 1063–9. [doi](/source/Doi_(identifier)):[10.1038/15990](https://doi.org/10.1038%2F15990). [PMID](/source/PMID_(identifier)) [10570482](https://pubmed.ncbi.nlm.nih.gov/10570482). [S2CID](/source/S2CID_(identifier)) [8145832](https://api.semanticscholar.org/CorpusID:8145832).

1. **[^](#cite_ref-pmid9581762_8-0)** Niethammer M, Valtschanoff JG, Kapoor TM, Allison DW, Weinberg RJ, Craig AM, Sheng M (Jun 1998). ["CRIPT, a novel postsynaptic protein that binds to the third PDZ domain of PSD-95/SAP90"](https://doi.org/10.1016%2FS0896-6273%2800%2981009-0). *Neuron*. **20** (4): 693–707. [doi](/source/Doi_(identifier)):[10.1016/S0896-6273(00)81009-0](https://doi.org/10.1016%2FS0896-6273%2800%2981009-0). [PMID](/source/PMID_(identifier)) [9581762](https://pubmed.ncbi.nlm.nih.gov/9581762). [S2CID](/source/S2CID_(identifier)) [16068361](https://api.semanticscholar.org/CorpusID:16068361).

1. **[^](#cite_ref-entrez_9-0)** ["Entrez Gene: CRIPT cysteine-rich PDZ-binding protein"](https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=9419).

1. **[^](#cite_ref-pmid11937501_10-0)** Lim, Indra Adi; Hall Duane D; Hell Johannes W (Jun 2002). ["Selectivity and promiscuity of the first and second PDZ domains of PSD-95 and synapse-associated protein 102"](https://doi.org/10.1074%2Fjbc.M112339200). *J. Biol. Chem*. **277** (24). United States: 21697–711. [doi](/source/Doi_(identifier)):[10.1074/jbc.M112339200](https://doi.org/10.1074%2Fjbc.M112339200). [ISSN](/source/ISSN_(identifier)) [0021-9258](https://search.worldcat.org/issn/0021-9258). [PMID](/source/PMID_(identifier)) [11937501](https://pubmed.ncbi.nlm.nih.gov/11937501).

## Further reading

- Zhang QH, Ye M, Wu XY, et al. (2001). ["Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC310934). *Genome Res*. **10** (10): 1546–60. [doi](/source/Doi_(identifier)):[10.1101/gr.140200](https://doi.org/10.1101%2Fgr.140200). [PMC](/source/PMC_(identifier)) [310934](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC310934). [PMID](/source/PMID_(identifier)) [11042152](https://pubmed.ncbi.nlm.nih.gov/11042152).

- Lim IA, Hall DD, Hell JW (2002). ["Selectivity and promiscuity of the first and second PDZ domains of PSD-95 and synapse-associated protein 102"](https://doi.org/10.1074%2Fjbc.M112339200). *J. Biol. Chem*. **277** (24): 21697–711. [doi](/source/Doi_(identifier)):[10.1074/jbc.M112339200](https://doi.org/10.1074%2Fjbc.M112339200). [PMID](/source/PMID_(identifier)) [11937501](https://pubmed.ncbi.nlm.nih.gov/11937501).

- Cai C, Coleman SK, Niemi K, Keinänen K (2002). ["Selective binding of synapse-associated protein 97 to GluR-A alpha-amino-5-hydroxy-3-methyl-4-isoxazole propionate receptor subunit is determined by a novel sequence motif"](https://doi.org/10.1074%2Fjbc.M204354200). *J. Biol. Chem*. **277** (35): 31484–90. [doi](/source/Doi_(identifier)):[10.1074/jbc.M204354200](https://doi.org/10.1074%2Fjbc.M204354200). [PMID](/source/PMID_(identifier)) [12070168](https://pubmed.ncbi.nlm.nih.gov/12070168).

- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). ["Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241). *Proc. Natl. Acad. Sci. U.S.A*. **99** (26): 16899–903. [Bibcode](/source/Bibcode_(identifier)):[2002PNAS...9916899M](https://ui.adsabs.harvard.edu/abs/2002PNAS...9916899M). [doi](/source/Doi_(identifier)):[10.1073/pnas.242603899](https://doi.org/10.1073%2Fpnas.242603899). [PMC](/source/PMC_(identifier)) [139241](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241). [PMID](/source/PMID_(identifier)) [12477932](https://pubmed.ncbi.nlm.nih.gov/12477932).

- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". *Nature*. **437** (7062): 1173–8. [Bibcode](/source/Bibcode_(identifier)):[2005Natur.437.1173R](https://ui.adsabs.harvard.edu/abs/2005Natur.437.1173R). [doi](/source/Doi_(identifier)):[10.1038/nature04209](https://doi.org/10.1038%2Fnature04209). [PMID](/source/PMID_(identifier)) [16189514](https://pubmed.ncbi.nlm.nih.gov/16189514). [S2CID](/source/S2CID_(identifier)) [4427026](https://api.semanticscholar.org/CorpusID:4427026).

- Stiffler MA, Grantcharova VP, Sevecka M, MacBeath G (2007). ["Uncovering quantitative protein interaction networks for mouse PDZ domains using protein microarrays"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2533859). *J. Am. Chem. Soc*. **128** (17): 5913–22. [doi](/source/Doi_(identifier)):[10.1021/ja060943h](https://doi.org/10.1021%2Fja060943h). [PMC](/source/PMC_(identifier)) [2533859](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2533859). [PMID](/source/PMID_(identifier)) [16637659](https://pubmed.ncbi.nlm.nih.gov/16637659).

- Lim J, Hao T, Shaw C, et al. (2006). ["A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration"](https://doi.org/10.1016%2Fj.cell.2006.03.032). *Cell*. **125** (4): 801–14. [doi](/source/Doi_(identifier)):[10.1016/j.cell.2006.03.032](https://doi.org/10.1016%2Fj.cell.2006.03.032). [PMID](/source/PMID_(identifier)) [16713569](https://pubmed.ncbi.nlm.nih.gov/16713569). [S2CID](/source/S2CID_(identifier)) [13709685](https://api.semanticscholar.org/CorpusID:13709685).

## External links

- Human [*CRIPT*](https://genome.ucsc.edu/cgi-bin/hgTracks?db=hg38&singleSearch=knownCanonical&position=CRIPT) genome location and [*CRIPT*](https://genome.ucsc.edu/cgi-bin/hgGene?db=hg38&hgg_type=knownGene&hgg_gene=CRIPT) gene details page in the [UCSC Genome Browser](/source/UCSC_Genome_Browser).

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by adding missing information.

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Adapted from the Wikipedia article [CRIPT](https://en.wikipedia.org/wiki/CRIPT) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/CRIPT?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.