# CRELD1 > Mediated Wiki article. Canonical URL: https://mediated.wiki/source/CRELD1 > Markdown URL: https://mediated.wiki/source/CRELD1.md > Source: https://en.wikipedia.org/wiki/CRELD1 > Source revision: 1301006847 > License: Creative Commons Attribution-ShareAlike 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/) {{Short description|Protein-coding gene in humans}} {{Infobox_gene}} '''Cysteine-rich with EGF-like domain protein 1''' is a [protein](/source/protein) that in humans is encoded by the ''CRELD1'' [gene](/source/gene).{{cite journal | vauthors = Green EK, Priestley MD, Waters J, Maliszewska C, Latif F, Maher ER | title = Detailed mapping of a congenital heart disease gene in chromosome 3p25 | journal = J Med Genet | volume = 37 | issue = 8 | pages = 581–7 |date=Sep 2000 | pmid = 10922384 | pmc = 1734659 | doi =10.1136/jmg.37.8.581 }}{{cite journal | vauthors = Rupp PA, Fouad GT, Egelston CA, Reifsteck CA, Olson SB, Knosp WM, Glanville RW, Thornburg KL, Robinson SW, Maslen CL | title = Identification, genomic organization and mRNA expression of CRELD1, the founding member of a unique family of matricellular proteins | journal = Gene | volume = 293 | issue = 1–2 | pages = 47–57 |date=Jul 2002 | pmid = 12137942 | doi =10.1016/S0378-1119(02)00696-0 | title-link = matricellular protein }} == Function == [Epidermal growth factor](/source/Epidermal_growth_factor) (EGF)-like repeats are a class of [cysteine](/source/cysteine)-rich domains that mediate interactions between proteins of diverse function. [EGF domain](/source/EGF_domain)s are found in proteins that are either completely secreted or have transmembrane regions that tether the protein to the cell surface. CRELD1 is the founding member of a family of [matricellular protein](/source/matricellular_protein)s.{{cite web | title = Entrez Gene: CRELD1 cysteine-rich with EGF-like domains 1| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=78987}} ==References== {{reflist}} ==Further reading== {{refbegin | 2}} *{{cite journal | vauthors=Hartley JL, Temple GF, Brasch MA |title=DNA Cloning Using In Vitro Site-Specific Recombination |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=10.1101/gr.143000 | pmc=310948 }} *{{cite journal | vauthors=Wiemann S, Weil B, Wellenreuther R |title=Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.GR1547R | pmc=311072 |display-authors=etal}} *{{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }} *{{cite journal | vauthors=Robinson SW, Morris CD, Goldmuntz E |title=Missense Mutations in CRELD1 Are Associated with Cardiac Atrioventricular Septal Defects |journal=Am. J. Hum. Genet. |volume=72 |issue= 4 |pages= 1047–52 |year= 2003 |pmid= 12632326 |doi=10.1086/374319 | pmc=1180336 |display-authors=etal}} *{{cite journal | vauthors=Clark HF, Gurney AL, Abaya E |title=The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 | pmc=403697 |display-authors=etal}} *{{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}} *{{cite journal | vauthors=Wiemann S, Arlt D, Huber W |title=From ORFeome to Biology: A Functional Genomics Pipeline |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136–44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 | pmc=528930 |display-authors=etal}} *{{cite journal | vauthors=Zatyka M, Priestley M, Ladusans EJ |title=Analysis of CRELD1 as a candidate 3p25 atrioventicular septal defect locus (AVSD2) |journal=Clin. Genet. |volume=67 |issue= 6 |pages= 526–8 |year= 2005 |pmid= 15857420 |doi= 10.1111/j.1399-0004.2005.00435.x |s2cid=31199574 |display-authors=etal}} *{{cite journal | vauthors=Stelzl U, Worm U, Lalowski M |title=A human protein-protein interaction network: a resource for annotating the proteome |journal=Cell |volume=122 |issue= 6 |pages= 957–68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029 |display-authors=etal|hdl=11858/00-001M-0000-0010-8592-0 |s2cid=8235923 |hdl-access=free }} *{{cite journal | vauthors=Kimura K, Wakamatsu A, Suzuki Y |title=Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 |display-authors=etal}} *{{cite journal | vauthors=Mehrle A, Rosenfelder H, Schupp I |title=The LIFEdb database in 2006 |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415–8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 | pmc=1347501 |display-authors=etal}} {{refend}} ==External links== * {{UCSC gene info|CRELD1}} {{gene-3-stub}} --- Adapted from the Wikipedia article [CRELD1](https://en.wikipedia.org/wiki/CRELD1) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/CRELD1?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.