# CP-154,526

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CP-154,526 Names Preferred IUPAC name N-Butyl-N-ethyl-2,5-dimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo[3,2-e]pyrimidin-4-amine Identifiers CAS Number 157286-86-7 Y 3D model (JSmol) Interactive image ChEMBL ChEMBL9946 N ChemSpider 4470592 N IUPHAR/BPS 3495 PubChem CID 5311055 UNII 9A549FB00R Y CompTox Dashboard (EPA) DTXSID201027582 InChI InChI=1S/C23H32N4/c1-8-10-11-26(9-2)22-20-18(6)14-27(23(20)25-19(7)24-22)21-16(4)12-15(3)13-17(21)5/h12-14H,8-11H2,1-7H3 N Key: FHQYJZCJRZHINA-UHFFFAOYSA-N N InChI=1/C23H32N4/c1-8-10-11-26(9-2)22-20-18(6)14-27(23(20)25-19(7)24-22)21-16(4)12-15(3)13-17(21)5/h12-14H,8-11H2,1-7H3 Key: FHQYJZCJRZHINA-UHFFFAOYAW SMILES CCCCN(CC)C1=NC(=NC2=C1C(=CN2C3=C(C=C(C=C3C)C)C)C)C Properties Chemical formula C23H32N4 Molar mass 364.52698 Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N verify (what is YN ?) Infobox references

Chemical compound

**CP-154,526** is a potent and selective [antagonist](/source/Receptor_antagonist) of the [corticotropin releasing hormone receptor 1](/source/Corticotropin_releasing_hormone_receptor_1) developed by [Pfizer](/source/Pfizer).[1]

CP-154,526 is under investigation for the potential treatment of [alcoholism](/source/Alcoholism).[2][3]

## See also

- [Antalarmin](/source/Antalarmin)

- [Pexacerfont](/source/Pexacerfont)

- [Corticotropin releasing hormone antagonist](/source/Corticotropin_releasing_hormone_antagonist)

## References

1. **[^](#cite_ref-pmid8816826_1-0)** Schulz DW, Mansbach RS, Sprouse J, Braselton JP, Collins J, Corman M, Dunaiskis A, Faraci S, Schmidt AW, Seeger T, Seymour P, Tingley FD, Winston EN, Chen YL, Heym J (September 1996). ["CP-154,526: a potent and selective nonpeptide antagonist of corticotropin releasing factor receptors"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC38410). *Proceedings of the National Academy of Sciences of the United States of America*. **93** (19): 10477–82. [Bibcode](/source/Bibcode_(identifier)):[1996PNAS...9310477S](https://ui.adsabs.harvard.edu/abs/1996PNAS...9310477S). [doi](/source/Doi_(identifier)):[10.1073/pnas.93.19.10477](https://doi.org/10.1073%2Fpnas.93.19.10477). [PMC](/source/PMC_(identifier)) [38410](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC38410). [PMID](/source/PMID_(identifier)) [8816826](https://pubmed.ncbi.nlm.nih.gov/8816826).

1. **[^](#cite_ref-urlDrug_Has_Potential_To_Prevent_Alcoholics_From_Relapsing_2-0)** ["Drug Has Potential To Prevent Alcoholics From Relapsing"](https://www.sciencedaily.com/releases/2008/07/080730175518.htm). *Science News*. ScienceDaily. 2008-08-02. Retrieved 2008-08-09.

1. **[^](#cite_ref-pmid18591672_3-0)** Pastor R, McKinnon CS, Scibelli AC, Burkhart-Kasch S, Reed C, Ryabinin AE, Coste SC, Stenzel-Poore MP, Phillips TJ (July 2008). ["Corticotropin-releasing factor-1 receptor involvement in behavioral neuroadaptation to ethanol: a urocortin1-independent mechanism"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2449366). *Proceedings of the National Academy of Sciences of the United States of America*. **105** (26): 9070–5. [Bibcode](/source/Bibcode_(identifier)):[2008PNAS..105.9070P](https://ui.adsabs.harvard.edu/abs/2008PNAS..105.9070P). [doi](/source/Doi_(identifier)):[10.1073/pnas.0710181105](https://doi.org/10.1073%2Fpnas.0710181105). [PMC](/source/PMC_(identifier)) [2449366](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2449366). [PMID](/source/PMID_(identifier)) [18591672](https://pubmed.ncbi.nlm.nih.gov/18591672).

## Further reading

- Seymour PA, Schmidt AW, Schulz DW (2006). ["The pharmacology of CP-154,526, a non-peptide antagonist of the CRH1 receptor: a review"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6741649). *CNS Drug Reviews*. **9** (1): 57–96. [doi](/source/Doi_(identifier)):[10.1111/j.1527-3458.2003.tb00244.x](https://doi.org/10.1111%2Fj.1527-3458.2003.tb00244.x). [PMC](/source/PMC_(identifier)) [6741649](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6741649). [PMID](/source/PMID_(identifier)) [12595912](https://pubmed.ncbi.nlm.nih.gov/12595912).

- Navarro-Zaragoza J, Núñez C, Laorden ML, Milanés MV (May 2010). "Effects of corticotropin-releasing factor receptor-1 antagonists on the brain stress system responses to morphine withdrawal". *Molecular Pharmacology*. **77** (5): 864–73. [doi](/source/Doi_(identifier)):[10.1124/mol.109.062463](https://doi.org/10.1124%2Fmol.109.062463). [PMID](/source/PMID_(identifier)) [20159948](https://pubmed.ncbi.nlm.nih.gov/20159948). [S2CID](/source/S2CID_(identifier)) [18588298](https://api.semanticscholar.org/CorpusID:18588298).

- Kobayashi T, Kiyokawa Y, Takeuchi Y, Mori Y (September 2011). ["Pretreatment with CP-154526 blocks the modifying effects of alarm pheromone on components of sexual behavior in male, but not in female, rats"](https://doi.org/10.1093%2Fchemse%2Fbjr017). *Chemical Senses*. **36** (7): 623–32. [doi](/source/Doi_(identifier)):[10.1093/chemse/bjr017](https://doi.org/10.1093%2Fchemse%2Fbjr017). [PMID](/source/PMID_(identifier)) [21502338](https://pubmed.ncbi.nlm.nih.gov/21502338).

## External links

- [CP+154526](https://meshb.nlm.nih.gov/record/ui?name=CP+154526) at the U.S. National Library of Medicine [Medical Subject Headings](/source/Medical_Subject_Headings) (MeSH)

v t e Antidepressants (N06A) Specific reuptake inhibitors or receptor modulators SSRIsTooltip Selective serotonin reuptake inhibitors Citalopram# Escitalopram# Fluoxetine# Fluvoxamine# Indalpine‡ Paroxetine# Sertraline# Zimelidine‡ SNRIsTooltip Serotonin–norepinephrine reuptake inhibitors Desvenlafaxine Duloxetine Levomilnacipran Milnacipran Tofenacin Venlafaxine NRIsTooltip Norepinephrine reuptake inhibitors Atomoxetine Reboxetine Viloxazine NDRIsTooltip Norepinephrine–dopamine reuptake inhibitors Amineptine‡ Bupropion Nomifensine‡ NaSSAsTooltip Noradrenergic and specific serotonergic antidepressants Mianserin Mirtazapine Setiptiline SARIsTooltip Serotonin antagonist and reuptake inhibitors Etoperidone Nefazodone Trazodone SMSTooltip Serotonin modulator and stimulators Vilazodone Vortioxetine Others Agomelatine Amisulpride Dextromethorphan/bupropion Esketamine Etryptamine‡ Gepirone Indeloxazine Flupentixol Ketamine§ Medifoxamine‡ Metryptamine‡ Oxaflozane‡ Pivagabine‡ Tandospirone Teniloxazine Tianeptine Tricyclic and tetracyclic antidepressants TCAsTooltip Tricyclic antidepressants Amineptine‡ Amitriptyline# Amitriptylinoxide Amoxapine Butriptyline‡ Clomipramine# Demexiptiline‡ Desipramine Dibenzepin Dimetacrine‡ Dosulepin Doxepin Imipramine Imipraminoxide‡ Iprindole‡ Lofepramine Melitracen Metapramine‡ Nitroxazepine Nortriptyline Noxiptiline Opipramol Pipofezine Propizepine‡ Protriptyline Quinupramine‡ Tianeptine Trimipramine TeCAsTooltip Tetracyclic antidepressants Maprotiline Mianserin Mirtazapine Setiptiline Others Tiazesim Monoamine oxidase inhibitors Non-selective Irreversible: Benmoxin‡ Iproclozide‡ Iproniazid‡ Isocarboxazid Isoniazid# Linezolid# Mebanazine‡ Nialamide‡ Octamoxin‡ Phenelzine Pheniprazine‡ Phenoxypropazine‡ Pivhydrazine‡ Safrazine‡ Tedizolid Tranylcypromine Reversible: Caroxazone‡ Mixed: Bifemelane MAOATooltip Monoamine oxidase A-selective Reversible: Eprobemide Metralindole Minaprine‡ Moclobemide Pirlindole Tetrindole Toloxatone MAOBTooltip Monoamine oxidase B-selective Irreversible: Selegiline Adjunctive therapies Atypical antipsychotics (aripiprazole, brexpiprazole, lurasidone, olanzapine, quetiapine, risperidone) Buspirone Lithium (lithium carbonate, lithium citrate) Thyroid hormones (triiodothyronine (T3), levothyroxine (T4)) Miscellaneous Ademetionine (SAMe) GABAkine neurosteroids (brexanolone, zuranolone) Hypericum perforatum (St. John's Wort) Oxitriptan (5-HTP) Rubidium chloride (RbCl) Tryptophan #WHO-EM ‡Withdrawn from market Clinical trials: †Phase III §Never to phase III

v t e Anxiolytics (N05B) 5-HT1ARTooltip 5-HT1A receptor agonists Buspirone Gepirone Tandospirone GABAARTooltip GABAA receptor PAMsTooltip positive allosteric modulators Benzodiazepines: Adinazolam Alprazolam Bromazepam Camazepam Chlordiazepoxide Clobazam Clonazepam Clorazepate Clotiazepam Cloxazolam Diazepam# Ethyl loflazepate Etizolam Fludiazepam Halazepam Ketazolam Lorazepam# Medazepam Nordazepam Oxazepam Pinazepam Prazepam; Others: Alpidem‡ Barbiturates (e.g., phenobarbital) Carbamates (e.g., meprobamate) Carisoprodol Chlormezanone‡ Ethanol (alcohol) Etifoxine Gabapentinoids (α2δ VDCC blockers) Gabapentin Gabapentin enacarbil Phenibut Baclofen Pregabalin Antidepressants SSRIsTooltip Selective serotonin reuptake inhibitors (e.g., escitalopram) SNRIsTooltip Serotonin-norepinephrine reuptake inhibitors (e.g., duloxetine) SARIsTooltip Serotonin antagonist and reuptake inhibitors (e.g., trazodone) TCAsTooltip Tricyclic antidepressants (e.g., clomipramine#) TeCAsTooltip Tetracyclic antidepressants (e.g., mirtazapine) MAOIsTooltip Monoamine oxidase inhibitors (e.g., phenelzine); Others: Agomelatine Bupropion Tianeptine Vilazodone Vortioxetine Sympatholytics (Antiadrenergics) Alpha-1 blockers (e.g., prazosin) Alpha-2 agonists (e.g., clonidine, dexmedetomidine, guanfacine) Beta blockers (e.g., propranolol, atenolol, betaxolol, nadolol, oxprenolol, pindolol) Others Benzoctamine Cycloserine Fabomotizole Hydroxyzine Lorpiprazole Mebicar Mepiprazole Nicotine (tobacco) Opipramol Oxaflozane‡ Phenaglycodol Phenibut Picamilon Selank Tiagabine Tofisopam Validolum #WHO-EM ‡Withdrawn from market Clinical trials: †Phase III §Never to phase III

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Adapted from the Wikipedia article [CP-154,526](https://en.wikipedia.org/wiki/CP-154%2C526) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/CP-154%2C526?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.