# COG3

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Protein-coding gene in the species Homo sapiens

COG3 Identifiers Aliases COG3, SEC34, component of oligomeric golgi complex 3 External IDs OMIM: 606975; MGI: 2450151; HomoloGene: 5854; GeneCards: COG3; OMA:COG3 - orthologs Gene location (Human) Chr. Chromosome 13 (human)[1] Band 13q14.13 Start 45,464,898 bp[1] End 45,536,701 bp[1] Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 D3 Start 75,939,790 bp[2] End 75,991,998 bp[2] RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas right lobe of liver Achilles tendon rectum olfactory zone of nasal mucosa monocyte mucosa of ileum granulocyte pancreatic ductal cell left adrenal cortex Top expressed in otolith organ utricle Paneth cell cumulus cell seminal vesicula hand ciliary body medullary collecting duct lacrimal gland iris More reference expression data BioGPS More reference expression data Gene ontology Molecular function protein binding Cellular component Golgi membrane cis-Golgi network membrane Golgi apparatus Golgi cisterna membrane Golgi transport complex trans-Golgi network membrane cytosol plasma membrane Biological process protein glycosylation intracellular protein transport protein stabilization intra-Golgi vesicle-mediated transport endoplasmic reticulum to Golgi vesicle-mediated transport protein transport Golgi organization protein localization to organelle retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum Sources:Amigo / QuickGO Orthologs Species Human Mouse Entrez 83548 338337 Ensembl ENSG00000136152 ENSMUSG00000034893 UniProt Q96JB2 Q8CI04 RefSeq (mRNA) NM_001204476 NM_031431 NM_177381 RefSeq (protein) NP_113619 n/a Location (UCSC) Chr 13: 45.46 – 45.54 Mb Chr 14: 75.94 – 75.99 Mb PubMed search [3] [4] Wikidata View/Edit Human View/Edit Mouse

**Conserved oligomeric Golgi complex subunit 3** is a [protein](/source/Protein) that in humans is encoded by the *COG3* [gene](/source/Gene).[5][6]

The protein encoded by this gene has similarity to a yeast protein. It seems to be part of a peripheral membrane protein complex localized on cis/medial Golgi cisternae where it may participate in tethering intra-Golgi transport vesicles.[6]

## Interactions

COG3 has been shown to [interact](/source/Protein-protein_interaction) with [COG2](/source/COG2)[7] and [COG1](/source/COG1).[7]

## References

1. ^ [***a***](#cite_ref-refGRCh38Ensembl_1-0) [***b***](#cite_ref-refGRCh38Ensembl_1-1) [***c***](#cite_ref-refGRCh38Ensembl_1-2) [GRCh38: Ensembl release 89: ENSG00000136152](http://May2017.archive.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000136152) – [Ensembl](/source/Ensembl_genome_database_project), May 2017

1. ^ [***a***](#cite_ref-refGRCm38Ensembl_2-0) [***b***](#cite_ref-refGRCm38Ensembl_2-1) [***c***](#cite_ref-refGRCm38Ensembl_2-2) [GRCm38: Ensembl release 89: ENSMUSG00000034893](http://May2017.archive.ensembl.org/Mus_musculus/Gene/Summary?db=core;g=ENSMUSG00000034893) – [Ensembl](/source/Ensembl_genome_database_project), May 2017

1. **[^](#cite_ref-3)** ["Human PubMed Reference:"](https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=83548). *National Center for Biotechnology Information, U.S. National Library of Medicine*.

1. **[^](#cite_ref-4)** ["Mouse PubMed Reference:"](https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=338337). *National Center for Biotechnology Information, U.S. National Library of Medicine*.

1. **[^](#cite_ref-pmid11980916_5-0)** Ungar D, Oka T, Brittle EE, Vasile E, Lupashin VV, Chatterton JE, Heuser JE, Krieger M, Waters MG (April 2002). ["Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173297). *The Journal of Cell Biology*. **157** (3): 405–15. [doi](/source/Doi_(identifier)):[10.1083/jcb.200202016](https://doi.org/10.1083%2Fjcb.200202016). [PMC](/source/PMC_(identifier)) [2173297](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173297). [PMID](/source/PMID_(identifier)) [11980916](https://pubmed.ncbi.nlm.nih.gov/11980916).

1. ^ [***a***](#cite_ref-entrez_6-0) [***b***](#cite_ref-entrez_6-1) ["Entrez Gene: COG3 component of oligomeric golgi complex 3"](https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=83548).

1. ^ [***a***](#cite_ref-pmid11929878_7-0) [***b***](#cite_ref-pmid11929878_7-1) Loh E, Hong W (June 2002). ["Sec34 is implicated in traffic from the endoplasmic reticulum to the Golgi and exists in a complex with GTC-90 and ldlBp"](https://doi.org/10.1074%2Fjbc.M202326200). *The Journal of Biological Chemistry*. **277** (24): 21955–61. [doi](/source/Doi_(identifier)):[10.1074/jbc.M202326200](https://doi.org/10.1074%2Fjbc.M202326200). [PMID](/source/PMID_(identifier)) [11929878](https://pubmed.ncbi.nlm.nih.gov/11929878).

## External links

- Human [*COG3*](https://genome.ucsc.edu/cgi-bin/hgTracks?db=hg38&singleSearch=knownCanonical&position=COG3) genome location and [*COG3*](https://genome.ucsc.edu/cgi-bin/hgGene?db=hg38&hgg_type=knownGene&hgg_gene=COG3) gene details page in the [UCSC Genome Browser](/source/UCSC_Genome_Browser).

## Further reading

- Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". *Gene*. **138** (1–2): 171–4. [doi](/source/Doi_(identifier)):[10.1016/0378-1119(94)90802-8](https://doi.org/10.1016%2F0378-1119%2894%2990802-8). [PMID](/source/PMID_(identifier)) [8125298](https://pubmed.ncbi.nlm.nih.gov/8125298).

- Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (April 1996). "A "double adaptor" method for improved shotgun library construction". *Analytical Biochemistry*. **236** (1): 107–13. [doi](/source/Doi_(identifier)):[10.1006/abio.1996.0138](https://doi.org/10.1006%2Fabio.1996.0138). [PMID](/source/PMID_(identifier)) [8619474](https://pubmed.ncbi.nlm.nih.gov/8619474).

- Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (April 1997). ["Large-scale concatenation cDNA sequencing"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139146). *Genome Research*. **7** (4): 353–8. [doi](/source/Doi_(identifier)):[10.1101/gr.7.4.353](https://doi.org/10.1101%2Fgr.7.4.353). [PMC](/source/PMC_(identifier)) [139146](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139146). [PMID](/source/PMID_(identifier)) [9110174](https://pubmed.ncbi.nlm.nih.gov/9110174).

- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". *Gene*. **200** (1–2): 149–56. [doi](/source/Doi_(identifier)):[10.1016/S0378-1119(97)00411-3](https://doi.org/10.1016%2FS0378-1119%2897%2900411-3). [PMID](/source/PMID_(identifier)) [9373149](https://pubmed.ncbi.nlm.nih.gov/9373149).

- Kim DW, Sacher M, Scarpa A, Quinn AM, Ferro-Novick S (October 1999). ["High-copy suppressor analysis reveals a physical interaction between Sec34p and Sec35p, a protein implicated in vesicle docking"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC25597). *Molecular Biology of the Cell*. **10** (10): 3317–29. [doi](/source/Doi_(identifier)):[10.1091/mbc.10.10.3317](https://doi.org/10.1091%2Fmbc.10.10.3317). [PMC](/source/PMC_(identifier)) [25597](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC25597). [PMID](/source/PMID_(identifier)) [10512869](https://pubmed.ncbi.nlm.nih.gov/10512869).

- VanRheenen SM, Cao X, Sapperstein SK, Chiang EC, Lupashin VV, Barlowe C, Waters MG (November 1999). ["Sec34p, a protein required for vesicle tethering to the yeast Golgi apparatus, is in a complex with Sec35p"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2156162). *The Journal of Cell Biology*. **147** (4): 729–42. [doi](/source/Doi_(identifier)):[10.1083/jcb.147.4.729](https://doi.org/10.1083%2Fjcb.147.4.729). [PMC](/source/PMC_(identifier)) [2156162](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2156162). [PMID](/source/PMID_(identifier)) [10562277](https://pubmed.ncbi.nlm.nih.gov/10562277).

- Suvorova ES, Kurten RC, Lupashin VV (June 2001). ["Identification of a human orthologue of Sec34p as a component of the cis-Golgi vesicle tethering machinery"](https://doi.org/10.1074%2Fjbc.M011624200). *The Journal of Biological Chemistry*. **276** (25): 22810–8. [doi](/source/Doi_(identifier)):[10.1074/jbc.M011624200](https://doi.org/10.1074%2Fjbc.M011624200). [PMID](/source/PMID_(identifier)) [11292827](https://pubmed.ncbi.nlm.nih.gov/11292827).

- Loh E, Hong W (June 2002). ["Sec34 is implicated in traffic from the endoplasmic reticulum to the Golgi and exists in a complex with GTC-90 and ldlBp"](https://doi.org/10.1074%2Fjbc.M202326200). *The Journal of Biological Chemistry*. **277** (24): 21955–61. [doi](/source/Doi_(identifier)):[10.1074/jbc.M202326200](https://doi.org/10.1074%2Fjbc.M202326200). [PMID](/source/PMID_(identifier)) [11929878](https://pubmed.ncbi.nlm.nih.gov/11929878).

- Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J (May 2003). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". *Nature Biotechnology*. **21** (5): 566–9. [doi](/source/Doi_(identifier)):[10.1038/nbt810](https://doi.org/10.1038%2Fnbt810). [PMID](/source/PMID_(identifier)) [12665801](https://pubmed.ncbi.nlm.nih.gov/12665801). [S2CID](/source/S2CID_(identifier)) [23783563](https://api.semanticscholar.org/CorpusID:23783563).

- Loh E, Hong W (June 2004). ["The binary interacting network of the conserved oligomeric Golgi tethering complex"](https://doi.org/10.1074%2Fjbc.M400662200). *The Journal of Biological Chemistry*. **279** (23): 24640–8. [doi](/source/Doi_(identifier)):[10.1074/jbc.M400662200](https://doi.org/10.1074%2Fjbc.M400662200). [PMID](/source/PMID_(identifier)) [15047703](https://pubmed.ncbi.nlm.nih.gov/15047703).

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Adapted from the Wikipedia article [COG3](https://en.wikipedia.org/wiki/COG3) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/COG3?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.