# CLIP1

> Mediated Wiki article. Canonical URL: https://mediated.wiki/source/CLIP1
> Markdown URL: https://mediated.wiki/source/CLIP1.md
> Source: https://en.wikipedia.org/wiki/CLIP1
> Source revision: 1301005881
> License: Creative Commons Attribution-ShareAlike 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/)

Protein-coding gene in humans

CLIP1 Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2CP5, 2CP6, 2E3H, 2E3I, 2E4H, 2HQH, 2QK0, 3E2U, 3RDV Identifiers Aliases CLIP1, CLIP, CLIP-170, CLIP170, CYLN1, RSN, CAP-Gly domain containing linker protein 1 External IDs OMIM: 179838; MGI: 1928401; HomoloGene: 74455; GeneCards: CLIP1; OMA:CLIP1 - orthologs Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q24.31 Start 122,271,432 bp[1] End 122,422,669 bp[1] Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 F Start 123,577,795 bp[2] End 123,684,618 bp[2] RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in biceps brachii buccal mucosa cell Skeletal muscle tissue of rectus abdominis Skeletal muscle tissue of biceps brachii gastrocnemius muscle muscle of thigh tendon of biceps brachii tail of epididymis gingival epithelium amniotic fluid Top expressed in vastus lateralis muscle muscle of thigh triceps brachii muscle temporal muscle medial head of gastrocnemius muscle sternocleidomastoid muscle digastric muscle tibialis anterior muscle soleus muscle lobe of cerebellum More reference expression data BioGPS More reference expression data Gene ontology Molecular function protein homodimerization activity microtubule binding microtubule plus-end binding metal ion binding tubulin binding protein binding zinc ion binding identical protein binding Cellular component cytosol endosome centrosome cell projection membrane microtubule cytoskeleton ruffle microtubule plus-end macropinosome cytoplasmic microtubule microtubule cytoskeleton intermediate filament cytoplasmic vesicle membrane cytoplasmic vesicle kinetochore nuclear envelope cytoplasm Biological process microtubule bundle formation positive regulation of microtubule polymerization protein transport into plasma membrane raft mitotic cell cycle Sources:Amigo / QuickGO Orthologs Species Human Mouse Entrez 6249 56430 Ensembl ENSG00000130779 ENSMUSG00000049550 UniProt P30622 Q922J3 RefSeq (mRNA) NM_001247997 NM_002956 NM_198240 NM_001389291 NM_001291229 NM_019765 NM_001347468 NM_001359220 NM_001359221 NM_001359222 NM_001359223 NM_001359224 RefSeq (protein) NP_001234926 NP_002947 NP_937883 NP_001278158 NP_001334397 NP_062739 NP_001346149 NP_001346150 NP_001346151 NP_001346152 NP_001346153 Location (UCSC) Chr 12: 122.27 – 122.42 Mb Chr 5: 123.58 – 123.68 Mb PubMed search [3] [4] Wikidata View/Edit Human View/Edit Mouse

**CAP-Gly domain containing linker protein 1**, also known as **CLIP1**, is a [protein](/source/Protein) which in humans is encoded by the *CLIP1* [gene](/source/Gene).[5]

## Interactions

CLIP1 has been shown to [interact](/source/Protein-protein_interaction) with [IQGAP1](/source/IQGAP1),[6] [Mammalian target of rapamycin](/source/Mammalian_target_of_rapamycin)[7] and [PAFAH1B1](/source/PAFAH1B1).[8]

## References

1. ^ [***a***](#cite_ref-refGRCh38Ensembl_1-0) [***b***](#cite_ref-refGRCh38Ensembl_1-1) [***c***](#cite_ref-refGRCh38Ensembl_1-2) [GRCh38: Ensembl release 89: ENSG00000130779](http://May2017.archive.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000130779) – [Ensembl](/source/Ensembl_genome_database_project), May 2017

1. ^ [***a***](#cite_ref-refGRCm38Ensembl_2-0) [***b***](#cite_ref-refGRCm38Ensembl_2-1) [***c***](#cite_ref-refGRCm38Ensembl_2-2) [GRCm38: Ensembl release 89: ENSMUSG00000049550](http://May2017.archive.ensembl.org/Mus_musculus/Gene/Summary?db=core;g=ENSMUSG00000049550) – [Ensembl](/source/Ensembl_genome_database_project), May 2017

1. **[^](#cite_ref-3)** ["Human PubMed Reference:"](https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=6249). *National Center for Biotechnology Information, U.S. National Library of Medicine*.

1. **[^](#cite_ref-4)** ["Mouse PubMed Reference:"](https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=56430). *National Center for Biotechnology Information, U.S. National Library of Medicine*.

1. **[^](#cite_ref-entrez_5-0)** ["Entrez Gene: CLIP1 CAP-GLY domain containing linker protein 1"](https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=6249).

1. **[^](#cite_ref-pmid12110184_6-0)** Fukata M, Watanabe T, Noritake J, Nakagawa M, Yamaga M, Kuroda S, Matsuura Y, Iwamatsu A, Perez F, Kaibuchi K (Jun 2002). ["Rac1 and Cdc42 capture microtubules through IQGAP1 and CLIP-170"](https://doi.org/10.1016%2FS0092-8674%2802%2900800-0). *Cell*. **109** (7): 873–85. [doi](/source/Doi_(identifier)):[10.1016/S0092-8674(02)00800-0](https://doi.org/10.1016%2FS0092-8674%2802%2900800-0). [PMID](/source/PMID_(identifier)) [12110184](https://pubmed.ncbi.nlm.nih.gov/12110184). [S2CID](/source/S2CID_(identifier)) [15158637](https://api.semanticscholar.org/CorpusID:15158637).

1. **[^](#cite_ref-pmid12231510_7-0)** Choi JH, Bertram PG, Drenan R, Carvalho J, Zhou HH, Zheng XF (Oct 2002). ["The FKBP12-rapamycin-associated protein (FRAP) is a CLIP-170 kinase"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1307618). *EMBO Reports*. **3** (10): 988–94. [doi](/source/Doi_(identifier)):[10.1093/embo-reports/kvf197](https://doi.org/10.1093%2Fembo-reports%2Fkvf197). [PMC](/source/PMC_(identifier)) [1307618](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1307618). [PMID](/source/PMID_(identifier)) [12231510](https://pubmed.ncbi.nlm.nih.gov/12231510).

1. **[^](#cite_ref-pmid11940666_8-0)** Coquelle FM, Caspi M, Cordelières FP, Dompierre JP, Dujardin DL, Koifman C, Martin P, [Hoogenraad CC](/source/Casper_Hoogenraad), Akhmanova A, Galjart N, De Mey JR, Reiner O (May 2002). ["LIS1, CLIP-170's key to the dynein/dynactin pathway"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC133759). *Molecular and Cellular Biology*. **22** (9): 3089–102. [doi](/source/Doi_(identifier)):[10.1128/MCB.22.9.3089-3102.2002](https://doi.org/10.1128%2FMCB.22.9.3089-3102.2002). [PMC](/source/PMC_(identifier)) [133759](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC133759). [PMID](/source/PMID_(identifier)) [11940666](https://pubmed.ncbi.nlm.nih.gov/11940666).

## External links

- Human [*CLIP1*](https://genome.ucsc.edu/cgi-bin/hgTracks?db=hg38&singleSearch=knownCanonical&position=CLIP1) genome location and [*CLIP1*](https://genome.ucsc.edu/cgi-bin/hgGene?db=hg38&hgg_type=knownGene&hgg_gene=CLIP1) gene details page in the [UCSC Genome Browser](/source/UCSC_Genome_Browser).

## Further reading

- Galjart N (Jun 2005). "CLIPs and CLASPs and cellular dynamics". *Nature Reviews Molecular Cell Biology*. **6** (6): 487–98. [doi](/source/Doi_(identifier)):[10.1038/nrm1664](https://doi.org/10.1038%2Fnrm1664). [PMID](/source/PMID_(identifier)) [15928712](https://pubmed.ncbi.nlm.nih.gov/15928712). [S2CID](/source/S2CID_(identifier)) [23216754](https://api.semanticscholar.org/CorpusID:23216754).

- Pierre P, Scheel J, Rickard JE, Kreis TE (Sep 1992). "CLIP-170 links endocytic vesicles to microtubules". *Cell*. **70** (6): 887–900. [doi](/source/Doi_(identifier)):[10.1016/0092-8674(92)90240-D](https://doi.org/10.1016%2F0092-8674%2892%2990240-D). [PMID](/source/PMID_(identifier)) [1356075](https://pubmed.ncbi.nlm.nih.gov/1356075). [S2CID](/source/S2CID_(identifier)) [41119165](https://api.semanticscholar.org/CorpusID:41119165).

- Bilbe G, Delabie J, Brüggen J, Richener H, Asselbergs FA, Cerletti N, Sorg C, Odink K, Tarcsay L, Wiesendanger W (Jun 1992). ["Restin: a novel intermediate filament-associated protein highly expressed in the Reed-Sternberg cells of Hodgkin's disease"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC556677). *The EMBO Journal*. **11** (6): 2103–13. [doi](/source/Doi_(identifier)):[10.1002/j.1460-2075.1992.tb05269.x](https://doi.org/10.1002%2Fj.1460-2075.1992.tb05269.x). [PMC](/source/PMC_(identifier)) [556677](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC556677). [PMID](/source/PMID_(identifier)) [1600942](https://pubmed.ncbi.nlm.nih.gov/1600942).

- Pierre P, Pepperkok R, Kreis TE (Jul 1994). "Molecular characterization of two functional domains of CLIP-170 in vivo". *Journal of Cell Science*. **107** (7): 1909–20. [doi](/source/Doi_(identifier)):[10.1242/jcs.107.7.1909](https://doi.org/10.1242%2Fjcs.107.7.1909). [PMID](/source/PMID_(identifier)) [7983157](https://pubmed.ncbi.nlm.nih.gov/7983157).

- Hilliker C, Delabie J, Speleman F, Bilbe G, Bruggen J, Van Leuven F, Van den Berghe H (1993). "Localization of the gene (RSN) coding for restin, a marker for Reed-Sternberg cells in Hodgkin's disease, to human chromosome band 12q24.3 and YAC cloning of the locus". *Cytogenetics and Cell Genetics*. **65** (3): 172–6. [doi](/source/Doi_(identifier)):[10.1159/000133625](https://doi.org/10.1159%2F000133625). [PMID](/source/PMID_(identifier)) [8222754](https://pubmed.ncbi.nlm.nih.gov/8222754).

- Griparic L, Keller TC (Oct 1998). ["Identification and expression of two novel CLIP-170/Restin isoforms expressed predominantly in muscle"](https://doi.org/10.1016%2FS0167-4889%2898%2900096-2). *Biochimica et Biophysica Acta (BBA) - Molecular Cell Research*. **1405** (1–3): 35–46. [doi](/source/Doi_(identifier)):[10.1016/S0167-4889(98)00096-2](https://doi.org/10.1016%2FS0167-4889%2898%2900096-2). [PMID](/source/PMID_(identifier)) [9784600](https://pubmed.ncbi.nlm.nih.gov/9784600).

- Perez F, Diamantopoulos GS, Stalder R, Kreis TE (Feb 1999). ["CLIP-170 highlights growing microtubule ends in vivo"](https://doi.org/10.1016%2FS0092-8674%2800%2980656-X). *Cell*. **96** (4): 517–27. [doi](/source/Doi_(identifier)):[10.1016/S0092-8674(00)80656-X](https://doi.org/10.1016%2FS0092-8674%2800%2980656-X). [PMID](/source/PMID_(identifier)) [10052454](https://pubmed.ncbi.nlm.nih.gov/10052454). [S2CID](/source/S2CID_(identifier)) [18082011](https://api.semanticscholar.org/CorpusID:18082011).

- Akhmanova A, Hoogenraad CC, Drabek K, Stepanova T, Dortland B, Verkerk T, Vermeulen W, Burgering BM, De Zeeuw CI, Grosveld F, Galjart N (Mar 2001). ["Clasps are CLIP-115 and -170 associating proteins involved in the regional regulation of microtubule dynamics in motile fibroblasts"](https://doi.org/10.1016%2FS0092-8674%2801%2900288-4). *Cell*. **104** (6): 923–35. [doi](/source/Doi_(identifier)):[10.1016/S0092-8674(01)00288-4](https://doi.org/10.1016%2FS0092-8674%2801%2900288-4). [PMID](/source/PMID_(identifier)) [11290329](https://pubmed.ncbi.nlm.nih.gov/11290329). [S2CID](/source/S2CID_(identifier)) [14443149](https://api.semanticscholar.org/CorpusID:14443149).

- Coquelle FM, Caspi M, Cordelières FP, Dompierre JP, Dujardin DL, Koifman C, Martin P, Hoogenraad CC, Akhmanova A, Galjart N, De Mey JR, Reiner O (May 2002). ["LIS1, CLIP-170's key to the dynein/dynactin pathway"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC133759). *Molecular and Cellular Biology*. **22** (9): 3089–102. [doi](/source/Doi_(identifier)):[10.1128/MCB.22.9.3089-3102.2002](https://doi.org/10.1128%2FMCB.22.9.3089-3102.2002). [PMC](/source/PMC_(identifier)) [133759](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC133759). [PMID](/source/PMID_(identifier)) [11940666](https://pubmed.ncbi.nlm.nih.gov/11940666).

- Griffith KJ, Ryan JP, Senécal JL, Fritzler MJ (Mar 2002). ["The cytoplasmic linker protein CLIP-170 is a human autoantigen"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1906301). *Clinical and Experimental Immunology*. **127** (3): 533–8. [doi](/source/Doi_(identifier)):[10.1046/j.1365-2249.2002.01756.x](https://doi.org/10.1046%2Fj.1365-2249.2002.01756.x). [PMC](/source/PMC_(identifier)) [1906301](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1906301). [PMID](/source/PMID_(identifier)) [11966772](https://pubmed.ncbi.nlm.nih.gov/11966772).

- Fukata M, Watanabe T, Noritake J, Nakagawa M, Yamaga M, Kuroda S, Matsuura Y, Iwamatsu A, Perez F, Kaibuchi K (Jun 2002). ["Rac1 and Cdc42 capture microtubules through IQGAP1 and CLIP-170"](https://doi.org/10.1016%2FS0092-8674%2802%2900800-0). *Cell*. **109** (7): 873–85. [doi](/source/Doi_(identifier)):[10.1016/S0092-8674(02)00800-0](https://doi.org/10.1016%2FS0092-8674%2802%2900800-0). [PMID](/source/PMID_(identifier)) [12110184](https://pubmed.ncbi.nlm.nih.gov/12110184). [S2CID](/source/S2CID_(identifier)) [15158637](https://api.semanticscholar.org/CorpusID:15158637).

- Choi JH, Bertram PG, Drenan R, Carvalho J, Zhou HH, Zheng XF (Oct 2002). ["The FKBP12-rapamycin-associated protein (FRAP) is a CLIP-170 kinase"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1307618). *EMBO Reports*. **3** (10): 988–94. [doi](/source/Doi_(identifier)):[10.1093/embo-reports/kvf197](https://doi.org/10.1093%2Fembo-reports%2Fkvf197). [PMC](/source/PMC_(identifier)) [1307618](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1307618). [PMID](/source/PMID_(identifier)) [12231510](https://pubmed.ncbi.nlm.nih.gov/12231510).

- Sahin U, Neumann F, Tureci O, Schmits R, Perez F, Pfreundschuh M (Dec 2002). ["Hodgkin and Reed-Sternberg cell-associated autoantigen CLIP-170/restin is a marker for dendritic cells and is involved in the trafficking of macropinosomes to the cytoskeleton, supporting a function-based concept of Hodgkin and Reed-Sternberg cells"](https://doi.org/10.1182%2Fblood.V100.12.4139). *Blood*. **100** (12): 4139–45. [doi](/source/Doi_(identifier)):[10.1182/blood.V100.12.4139](https://doi.org/10.1182%2Fblood.V100.12.4139). [PMID](/source/PMID_(identifier)) [12433698](https://pubmed.ncbi.nlm.nih.gov/12433698).

- Goodson HV, Skube SB, Stalder R, Valetti C, Kreis TE, Morrison EE, Schroer TA (Jul 2003). "CLIP-170 interacts with dynactin complex and the APC-binding protein EB1 by different mechanisms". *Cell Motility and the Cytoskeleton*. **55** (3): 156–73. [doi](/source/Doi_(identifier)):[10.1002/cm.10114](https://doi.org/10.1002%2Fcm.10114). [PMID](/source/PMID_(identifier)) [12789661](https://pubmed.ncbi.nlm.nih.gov/12789661).

- Ho SM, Lau KM, Mok SC, Syed V (Jul 2003). ["Profiling follicle stimulating hormone-induced gene expression changes in normal and malignant human ovarian surface epithelial cells"](https://doi.org/10.1038%2Fsj.onc.1206437). *Oncogene*. **22** (27): 4243–56. [doi](/source/Doi_(identifier)):[10.1038/sj.onc.1206437](https://doi.org/10.1038%2Fsj.onc.1206437). [PMID](/source/PMID_(identifier)) [12833147](https://pubmed.ncbi.nlm.nih.gov/12833147).

- Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (Aug 2004). ["Large-scale characterization of HeLa cell nuclear phosphoproteins"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC514446). *Proceedings of the National Academy of Sciences of the United States of America*. **101** (33): 12130–5. [Bibcode](/source/Bibcode_(identifier)):[2004PNAS..10112130B](https://ui.adsabs.harvard.edu/abs/2004PNAS..10112130B). [doi](/source/Doi_(identifier)):[10.1073/pnas.0404720101](https://doi.org/10.1073%2Fpnas.0404720101). [PMC](/source/PMC_(identifier)) [514446](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC514446). [PMID](/source/PMID_(identifier)) [15302935](https://pubmed.ncbi.nlm.nih.gov/15302935).

- Ballif BA, Villén J, Beausoleil SA, Schwartz D, Gygi SP (Nov 2004). ["Phosphoproteomic analysis of the developing mouse brain"](https://doi.org/10.1074%2Fmcp.M400085-MCP200). *Molecular & Cellular Proteomics*. **3** (11): 1093–101. [doi](/source/Doi_(identifier)):[10.1074/mcp.M400085-MCP200](https://doi.org/10.1074%2Fmcp.M400085-MCP200). [PMID](/source/PMID_(identifier)) [15345747](https://pubmed.ncbi.nlm.nih.gov/15345747).

- Watanabe T, Wang S, Noritake J, Sato K, Fukata M, Takefuji M, Nakagawa M, Izumi N, Akiyama T, Kaibuchi K (Dec 2004). ["Interaction with IQGAP1 links APC to Rac1, Cdc42, and actin filaments during cell polarization and migration"](https://doi.org/10.1016%2Fj.devcel.2004.10.017). *Developmental Cell*. **7** (6): 871–83. [doi](/source/Doi_(identifier)):[10.1016/j.devcel.2004.10.017](https://doi.org/10.1016%2Fj.devcel.2004.10.017). [PMID](/source/PMID_(identifier)) [15572129](https://pubmed.ncbi.nlm.nih.gov/15572129).

v t e PDB gallery 2cp5: Solution structure of the 1st CAP-Gly domain in human CLIP-170/restin 2cp6: Solution structure of the 2nd CAP-Gly domain in human CLIP-170/restin 2cp7: Solution structure of the 1st CAP-Gly domain in mouse CLIP-170/restin

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by adding missing information.

- [v](https://en.wikipedia.org/wiki/Template:Gene-12-stub)
- [t](/source/Template_talk%3AGene-12-stub)
- [e](https://en.wikipedia.org/wiki/Special:EditPage/Template:Gene-12-stub)

---
Adapted from the Wikipedia article [CLIP1](https://en.wikipedia.org/wiki/CLIP1) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/CLIP1?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.