# CLDN5

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{{Short description|Protein-coding gene in humans}}
{{Infobox_gene}}
'''Claudin-5''' is a [protein](/source/protein) that in humans is encoded by the ''CLDN5'' [gene](/source/gene).<ref name="pmid9441748">{{cite journal | vauthors = Peacock RE, Keen TJ, Inglehearn CF | title = Analysis of a human gene homologous to rat ventral prostate.1 protein | journal = Genomics | volume = 46 | issue = 3 | pages = 443–9 | date = December 1997 | pmid = 9441748 | doi = 10.1006/geno.1997.5033 }}</ref><ref name="pmid9192844">{{cite journal | vauthors = Sirotkin H, Morrow B, Saint-Jore B, Puech A, Das Gupta R, Patanjali SR, Skoultchi A, Weissman SM, Kucherlapati R | title = Identification, characterization, and precise mapping of a human gene encoding a novel membrane-spanning protein from the 22q11 region deleted in velo-cardio-facial syndrome | journal = Genomics | volume = 42 | issue = 2 | pages = 245–51  | date = Sep 1997 | pmid = 9192844 | doi = 10.1006/geno.1997.4734 | doi-access = free }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CLDN5 claudin 5 (transmembrane protein deleted in velocardiofacial syndrome)| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=7122}}</ref> It belongs to the group of [claudin](/source/claudin)s.

== Function ==

This gene encodes a member of the claudin family. [Claudins](/source/Claudin) are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Mutations in this gene have been found in patients with [velocardiofacial syndrome](/source/DiGeorge_syndrome).<ref name="entrez" />

== Interactions ==

CLDN5 has been shown to [interact](/source/Protein-protein_interaction) with [CLDN1](/source/CLDN1)<ref name=pmid12909588>{{cite journal | vauthors = Coyne CB, Gambling TM, Boucher RC, Carson JL, Johnson LG | title = Role of claudin interactions in airway tight junctional permeability | journal = Am. J. Physiol. Lung Cell Mol. Physiol. | volume = 285 | issue = 5 | pages = L1166-78  | date = Nov 2003 | pmid = 12909588 | doi = 10.1152/ajplung.00182.2003 }}</ref> and [CLDN3](/source/CLDN3).<ref name=pmid12909588/>

== References ==
{{reflist}}

==External links==
* {{UCSC gene info|CLDN5}}

== Further reading ==
{{refbegin | 2}}
* {{cite journal | vauthors = Kniesel U, Wolburg H | title = Tight junctions of the blood-brain barrier | journal = Cell. Mol. Neurobiol. | volume = 20 | issue = 1 | pages = 57–76 | year = 2000 | pmid = 10690502 | doi = 10.1023/A:1006995910836 | s2cid = 26473781 | pmc = 11537529 }}
* {{cite journal | vauthors = Heiskala M, Peterson PA, Yang Y | title = The roles of claudin superfamily proteins in paracellular transport | journal = Traffic | volume = 2 | issue = 2 | pages = 93–8 | year = 2001 | pmid = 11247307 | doi = 10.1034/j.1600-0854.2001.020203.x | s2cid = 12132159 | doi-access =  }}
* {{cite journal | vauthors = Tsukita S, Furuse M, Itoh M | title = Multifunctional strands in tight junctions | journal = Nat. Rev. Mol. Cell Biol. | volume = 2 | issue = 4 | pages = 285–93 | year = 2001 | pmid = 11283726 | doi = 10.1038/35067088 | s2cid = 36524601 }}
* {{cite journal | vauthors = Tsukita S, Furuse M | title = Claudin-based barrier in simple and stratified cellular sheets | journal = Curr. Opin. Cell Biol. | volume = 14 | issue = 5 | pages = 531–6 | year = 2002 | pmid = 12231346 | doi = 10.1016/S0955-0674(02)00362-9 }}
* {{cite journal | vauthors = González-Mariscal L, Betanzos A, Nava P, Jaramillo BE | title = Tight junction proteins | journal = Prog. Biophys. Mol. Biol. | volume = 81 | issue = 1 | pages = 1–44 | year = 2003 | pmid = 12475568 | doi = 10.1016/S0079-6107(02)00037-8 | doi-access =  }}
* {{cite journal | vauthors = King JE, Eugenin EA, Buckner CM, Berman JW | title = HIV tat and neurotoxicity | journal = Microbes Infect. | volume = 8 | issue = 5 | pages = 1347–57 | year = 2006 | pmid = 16697675 | doi = 10.1016/j.micinf.2005.11.014 | doi-access = free }}
* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–4 | year = 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–56 | year = 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
* {{cite journal | vauthors = Morita K, Furuse M, Fujimoto K, Tsukita S | title = Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 96 | issue = 2 | pages = 511–6 | year = 1999 | pmid = 9892664 | pmc = 15167 | doi = 10.1073/pnas.96.2.511 | bibcode = 1999PNAS...96..511M | doi-access = free }}
* {{cite journal | vauthors = Itoh M, Furuse M, Morita K, Kubota K, Saitou M, Tsukita S | title = Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins | journal = J. Cell Biol. | volume = 147 | issue = 6 | pages = 1351–63 | year = 1999 | pmid = 10601346 | pmc = 2168087 | doi = 10.1083/jcb.147.6.1351 }}
* {{cite journal | vauthors = Kojima S, Rahner C, Peng S, Rizzolo LJ | title = Claudin 5 is transiently expressed during the development of the retinal pigment epithelium | journal = J. Membr. Biol. | volume = 186 | issue = 2 | pages = 81–8 | year = 2002 | pmid = 11944085 | doi = 10.1007/s00232-001-0137-7 | s2cid = 13468318 }}
* {{cite journal | vauthors = Poliak S, Matlis S, Ullmer C, Scherer SS, Peles E | title = Distinct claudins and associated PDZ proteins form different autotypic tight junctions in myelinating Schwann cells | journal = J. Cell Biol. | volume = 159 | issue = 2 | pages = 361–72 | year = 2002 | pmid = 12403818 | pmc = 2173042 | doi = 10.1083/jcb.200207050 }}
* {{cite journal | vauthors = Helms HC, Waagepetersen HS, Nielsen CU, Brodin B | title = Paracellular tightness and claudin-5 expression is increased in the BCEC/astrocyte blood-brain barrier model by increasing media buffer capacity during growth | journal = AAPS J | volume = 12 | issue = 4 | pages = 759–70 | year = 2010 | pmid = 20967520 | pmc = 2976989 | doi = 10.1208/s12248-010-9237-6 }}
* {{cite journal | vauthors = Liu F, Koval M, Ranganathan S, Fanayan S, Hancock WS, Lundberg EK, Beavis RC, Lane L, Duek P, McQuade L, Kelleher NL, Baker MS | title = A systems proteomics view of the endogenous human claudin protein family | journal = J Proteome Res | date= 2015 | volume = 15 | issue = 2 | pages = 339–359 | pmid = 26680015 | doi = 10.1021/acs.jproteome.5b00769 | url = https://archive-ouverte.unige.ch/unige:79118/ATTACHMENT01 | pmc = 4777318 }}
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Adapted from the Wikipedia article [CLDN5](https://en.wikipedia.org/wiki/CLDN5) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/CLDN5?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.