# CLDN3

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{{Short description|Protein-coding gene in humans}}
{{Infobox_gene}}
'''Claudin 3''', also known as '''CLDN3''', is a [protein](/source/protein) which in humans is encoded by the ''CLDN3'' [gene](/source/gene).<ref name="entrez">{{cite web | title = Entrez Gene: CLDN3 claudin 3| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=1365}}</ref> It is a member of the [claudin](/source/claudin) protein family.

[Tight junction](/source/Tight_junction)s represent one mode of cell-to-cell [adhesion](/source/cell_adhesion) in [epithelial](/source/epithelium) or [endothelial](/source/endothelium) cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the [paracellular](/source/paracellular_transport) space. These junctions are composed of sets of continuous networking strands in the outwardly facing [cytoplasm](/source/cytoplasm)ic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this [intron](/source/intron)-less gene, a member of the [claudin](/source/claudin) family, is an [integral membrane protein](/source/integral_membrane_protein) and a component of [tight junction](/source/tight_junction) strands. It is also a low-affinity receptor for [Clostridium perfringens enterotoxin](/source/Clostridium_perfringens_enterotoxin), and shares [amino acid sequence](/source/peptide_sequence) similarity with a putative apoptosis-related protein found in rat.<ref name="entrez" />

== Interactions ==

CLDN3 has been shown to [interact](/source/Protein-protein_interaction) with [CLDN1](/source/CLDN1)<ref name=pmid12909588>{{cite journal | vauthors = Coyne CB, Gambling TM, Boucher RC, Carson JL, Johnson LG | title = Role of claudin interactions in airway tight junctional permeability | journal = Am. J. Physiol. Lung Cell Mol. Physiol. | volume = 285 | issue = 5 | pages = L1166-78  | date = Nov 2003 | pmid = 12909588 | doi = 10.1152/ajplung.00182.2003 }}</ref> and [CLDN5](/source/CLDN5).<ref name=pmid12909588/>

== References ==
{{reflist}}

==External links==
* {{UCSC gene info|CLDN3}}
* {{PDBe-KB2|Q9Z0G9|Mouse Claudin-3}}

== Further reading ==
{{refbegin | 2}}
* {{cite journal | vauthors = Kniesel U, Wolburg H | title = Tight junctions of the blood-brain barrier | journal = Cell. Mol. Neurobiol. | volume = 20 | issue = 1 | pages = 57–76 | year = 2000 | pmid = 10690502 | doi = 10.1023/A:1006995910836 | s2cid = 26473781 | pmc = 11537529 }}
* {{cite journal | vauthors = Heiskala M, Peterson PA, Yang Y | title = The roles of claudin superfamily proteins in paracellular transport | journal = Traffic | volume = 2 | issue = 2 | pages = 93–8 | year = 2001 | pmid = 11247307 | doi = 10.1034/j.1600-0854.2001.020203.x | doi-access = free }}
* {{cite journal | vauthors = Tsukita S, Furuse M, Itoh M | title = Multifunctional strands in tight junctions | journal = Nat. Rev. Mol. Cell Biol. | volume = 2 | issue = 4 | pages = 285–93 | year = 2001 | pmid = 11283726 | doi = 10.1038/35067088 | s2cid = 36524601 }}
* {{cite journal | vauthors = Tsukita S, Furuse M | title = Claudin-based barrier in simple and stratified cellular sheets | journal = Curr. Opin. Cell Biol. | volume = 14 | issue = 5 | pages = 531–6 | year = 2002 | pmid = 12231346 | doi = 10.1016/S0955-0674(02)00362-9 }}
* {{cite journal | vauthors = González-Mariscal L, Betanzos A, Nava P, Jaramillo BE | title = Tight junction proteins | journal = Prog. Biophys. Mol. Biol. | volume = 81 | issue = 1 | pages = 1–44 | year = 2003 | pmid = 12475568 | doi = 10.1016/S0079-6107(02)00037-8 | doi-access = free }}
* {{cite journal | vauthors = Katahira J, Sugiyama H, Inoue N, Horiguchi Y, Matsuda M, Sugimoto N | title = Clostridium perfringens enterotoxin utilizes two structurally related membrane proteins as functional receptors in vivo | journal = J. Biol. Chem. | volume = 272 | issue = 42 | pages = 26652–8 | year = 1997 | pmid = 9334247 | doi = 10.1074/jbc.272.42.26652 | doi-access = free }}
* {{cite journal | vauthors = Peacock RE, Keen TJ, Inglehearn CF | title = Analysis of a human gene homologous to rat ventral prostate.1 protein | journal = Genomics | volume = 46 | issue = 3 | pages = 443–9 | year = 1997 | pmid = 9441748 | doi = 10.1006/geno.1997.5033 }}
* {{cite journal | vauthors = Morita K, Furuse M, Fujimoto K, Tsukita S | title = Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 96 | issue = 2 | pages = 511–6 | year = 1999 | pmid = 9892664 | pmc = 15167 | doi = 10.1073/pnas.96.2.511 | bibcode = 1999PNAS...96..511M | doi-access = free }}
* {{cite journal | vauthors = Furuse M, Sasaki H, Tsukita S | title = Manner of interaction of heterogeneous claudin species within and between tight junction strands | journal = J. Cell Biol. | volume = 147 | issue = 4 | pages = 891–903 | year = 1999 | pmid = 10562289 | pmc = 2156154 | doi = 10.1083/jcb.147.4.891 }}
* {{cite journal | vauthors = Itoh M, Furuse M, Morita K, Kubota K, Saitou M, Tsukita S | title = Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins | journal = J. Cell Biol. | volume = 147 | issue = 6 | pages = 1351–63 | year = 1999 | pmid = 10601346 | pmc = 2168087 | doi = 10.1083/jcb.147.6.1351 }}
* {{cite journal | vauthors = Miyamori H, Takino T, Kobayashi Y, Tokai H, Itoh Y, Seiki M, Sato H | title = Claudin promotes activation of pro-matrix metalloproteinase-2 mediated by membrane-type matrix metalloproteinases | journal = J. Biol. Chem. | volume = 276 | issue = 30 | pages = 28204–11 | year = 2001 | pmid = 11382769 | doi = 10.1074/jbc.M103083200 | doi-access = free | hdl = 2297/15688 | hdl-access = free }}
* {{cite journal | vauthors = Long H, Crean CD, Lee WH, Cummings OW, Gabig TG | title = Expression of Clostridium perfringens enterotoxin receptors claudin-3 and claudin-4 in prostate cancer epithelium | journal = Cancer Res. | volume = 61 | issue = 21 | pages = 7878–81 | year = 2001 | pmid = 11691807 }}
* {{cite journal | vauthors = Katoh M, Katoh M | title = CLDN23 gene, frequently down-regulated in intestinal-type gastric cancer, is a novel member of CLAUDIN gene family | journal = Int. J. Mol. Med. | volume = 11 | issue = 6 | pages = 683–9 | year = 2003 | pmid = 12736707 | doi = 10.3892/ijmm.11.6.683 }}
* {{cite journal | vauthors = Liu F, Koval M, Ranganathan S, Fanayan S, Hancock WS, Lundberg EK, Beavis RC, Lane L, Duek P, McQuade L, Kelleher NL, Baker MS | title = A systems proteomics view of the endogenous human claudin protein family | journal = J Proteome Res | volume = 15 | issue = 2 | pages = 339–359 | date= 2015 | pmid = 26680015 | doi = 10.1021/acs.jproteome.5b00769 | url = https://archive-ouverte.unige.ch/unige:79118/ATTACHMENT01 | pmc = 4777318 }}
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Adapted from the Wikipedia article [CLDN3](https://en.wikipedia.org/wiki/CLDN3) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/CLDN3?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.