# CLCF1
> Mediated Wiki article. Canonical URL: https://mediated.wiki/source/CLCF1
> Markdown URL: https://mediated.wiki/source/CLCF1.md
> Source: https://en.wikipedia.org/wiki/CLCF1
> Source revision: 1324694281
> License: Creative Commons Attribution-ShareAlike 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/)
{{Short description|Protein-coding gene in humans}}
{{Infobox_gene}}
'''Cardiotrophin-like cytokine factor 1''' ('''CLCF1'''), also known as '''Novel Neurotrophin-1''' ('''NNT-1''') or '''B cell-stimulating factor-3''' ('''BSF-3'''), is a [protein](/source/protein) that in humans is encoded by the ''CLCF1'' [gene](/source/gene).[{{cite web | title = Entrez Gene: CLCF1 cardiotrophin-like cytokine factor 1| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=23529}}]
== Function ==
CLCF1 is a [cytokine](/source/cytokine). It induces [tyrosine phosphorylation](/source/tyrosine_phosphorylation) of the [IL-6 receptor](/source/Interleukin-6_receptor) common subunit [glycoprotein 130](/source/glycoprotein_130) (gp130), [leukemia inhibitory factor receptor](/source/leukemia_inhibitory_factor_receptor) beta, and the transcription factor [STAT3](/source/Stat3). It has been implicated in the induction of [IL-1](/source/interleukin-1) (via induction of [corticosterone](/source/corticosterone) and [IL-6](/source/Interleukin_6)) and [serum amyloid A](/source/serum_amyloid_A), and in [B cell](/source/B_cell) [hyperplasia](/source/hyperplasia). CLCF1 is capable of [B cell](/source/B_cell) activation via gp130 receptor stimulation.[{{cite journal | vauthors = Senaldi G, Varnum BC, Sarmiento U, Starnes C, Lile J, Scully S, Guo J, Elliott G, McNinch J, Shaklee CL, Freeman D, Manu F, Simonet WS, Boone T, Chang MS | title = Novel neurotrophin-1/B cell-stimulating factor-3: a cytokine of the IL-6 family | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 96 | issue = 20 | pages = 11458–63 |date=September 1999 | pmid = 10500198 | pmc = 18055 | doi = 10.1073/pnas.96.20.11458| bibcode = 1999PNAS...9611458S | doi-access = free }}]
== Structure ==
CLCF1 is a cytokine belonging to the [interleukin-6](/source/interleukin-6) (IL6) family. It is a [secreted protein](/source/secreted_protein), found predominantly in [lymph node](/source/lymph_node)s and [spleen](/source/spleen), and contains 225 amino acids with a molecular mass of 22 [kDa](/source/kDa) in its mature form. IL6 family members share similarity in gene structure and have a [4-helix bundle](/source/4-helix_bundle) in their protein structure. CLCF1 is closely related to other proteins called [cardiotrophin-1](/source/cardiotrophin-1) and [ciliary neurotrophic factor](/source/ciliary_neurotrophic_factor).
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
*{{cite journal | vauthors=Shi Y, Wang W, Yourey PA |title=Computational EST database analysis identifies a novel member of the neuropoietic cytokine family. |journal=Biochem. Biophys. Res. Commun. |volume=262 |issue= 1 |pages= 132–8 |year= 1999 |pmid= 10448081 |doi= 10.1006/bbrc.1999.1181 |display-authors=etal}}
*{{cite journal | vauthors=Senaldi G, Varnum BC, Sarmiento U |title=Novel neurotrophin-1/B cell-stimulating factor-3: a cytokine of the IL-6 family. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 20 |pages= 11458–63 |year= 1999 |pmid= 10500198 |doi=10.1073/pnas.96.20.11458 | pmc=18055 |bibcode=1999PNAS...9611458S |display-authors=etal|doi-access=free }}
*{{cite journal | vauthors=Elson GC, Lelièvre E, Guillet C |title=CLF associates with CLC to form a functional heteromeric ligand for the CNTF receptor complex. |journal=Nat. Neurosci. |volume=3 |issue= 9 |pages= 867–72 |year= 2000 |pmid= 10966616 |doi= 10.1038/78765 |s2cid=25766998 |display-authors=etal}}
*{{cite journal | vauthors=Plun-Favreau H, Elson G, Chabbert M |title=The ciliary neurotrophic factor receptor alpha component induces the secretion of and is required for functional responses to cardiotrophin-like cytokine. |journal=EMBO J. |volume=20 |issue= 7 |pages= 1692–703 |year= 2001 |pmid= 11285233 |doi= 10.1093/emboj/20.7.1692 | pmc=145510 |display-authors=etal}}
*{{cite journal | vauthors=Lelièvre E, Plun-Favreau H, Chevalier S |title=Signaling pathways recruited by the cardiotrophin-like cytokine/cytokine-like factor-1 composite cytokine: specific requirement of the membrane-bound form of ciliary neurotrophic factor receptor alpha component. |journal=J. Biol. Chem. |volume=276 |issue= 25 |pages= 22476–84 |year= 2001 |pmid= 11294841 |doi= 10.1074/jbc.M101681200 |display-authors=etal|doi-access=free }}
*{{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
*{{cite journal | vauthors=Auernhammer CJ, Isele NB, Kopp FB |title=Novel neurotrophin-1/B cell-stimulating factor-3 (cardiotrophin-like cytokine) stimulates corticotroph function via a signal transducer and activator of transcription-dependent mechanism negatively regulated by suppressor of cytokine signaling-3. |journal=Endocrinology |volume=144 |issue= 4 |pages= 1202–10 |year= 2003 |pmid= 12639901 |doi=10.1210/en.2002-220933 |display-authors=etal|doi-access=free }}
*{{cite journal | vauthors=Burger R, Bakker F, Guenther A |title=Functional significance of novel neurotrophin-1/B cell-stimulating factor-3 (cardiotrophin-like cytokine) for human myeloma cell growth and survival. |journal=Br. J. Haematol. |volume=123 |issue= 5 |pages= 869–78 |year= 2004 |pmid= 14632778 |doi=10.1046/j.1365-2141.2003.04686.x |s2cid=28659799 |display-authors=etal|doi-access=free }}
*{{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal | vauthors=Rousseau F, Gauchat JF, McLeod JG |title=Inactivation of cardiotrophin-like cytokine, a second ligand for ciliary neurotrophic factor receptor, leads to cold-induced sweating syndrome in a patient. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 26 |pages= 10068–73 |year= 2006 |pmid= 16782820 |doi= 10.1073/pnas.0509598103 | pmc=1502507 |bibcode=2006PNAS..10310068R |display-authors=etal|doi-access=free }}
*{{cite journal | vauthors=Dagoneau N, Bellais S, Blanchet P |title=Mutations in cytokine receptor-like factor 1 (CRLF1) account for both Crisponi and cold-induced sweating syndromes. |journal=Am. J. Hum. Genet. |volume=80 |issue= 5 |pages= 966–70 |year= 2007 |pmid= 17436251 |doi= 10.1086/513608 | pmc=1852726 |display-authors=etal}}
{{refend}}
==External links==
* [https://www.ncbi.nlm.nih.gov/books/NBK52917/ GeneReviews/NCBI/NIH/UW entry on Cold-Induced Sweating Syndrome including Crisponi Syndrome]
* [https://www.omim.org/search?index=entry&start=1&limit=10&search=601559+193700+601680+272430+601378+604237+607672+610313+272430+601378+604237+607672+610313&sort=score+desc&field=number OMIM enries on Cold-Induced Sweating Syndrome including Crisponi Syndrome]
* {{UCSC gene info|CLC}}
* {{UCSC gene info|CLCF1}}
{{gene-11-stub}}
---
Adapted from the Wikipedia article [CLCF1](https://en.wikipedia.org/wiki/CLCF1) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/CLCF1?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.