# CGK733 fraud

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2006 South Korean scientific misconduct

**CGK733** was a [synthetic](/source/Chemical_synthesis) chemical substance which was reported in 2006 to have remarkable properties in reversing cell [senescence](/source/Senescence) (aging).[1] However, the entire work behind the discovery of this compound has since been found to be falsified and the authors of the original reports have retracted all their claims.[2][3]

CGK733 was claimed to be an inhibitor of [ATM](/source/Ataxia_telangiectasia_mutated)/[ATR](/source/Ataxia_telangiectasia_and_Rad3_related) kinases,[4][5] which are involved in [DNA](/source/DNA) damage repair. CGK was claimed to extend the lifetime of cultured cells by approximately 20 divisions, or roughly 25%, specifically in [mammalian](/source/Mammal) cells.

The original report garnered scientific attention,[6] but was retracted in 2008.[7] The retraction states that the screen to identify CGK733 as an anti-senescence agent was not carried out; experiments exploring the cellular effects of CGK733 were misrepresented; the identification of ATM as the target of CGK733 was fabricated; a compound which was essential for ATM target validation had not been synthesized; and the chemical structure of CGK733 was misrepresented.[7]

The [principal investigator](/source/Principal_investigator), Tae Kook Kim, and several associates were consequently suspended from their positions at the [Korea Advanced Institute of Science & Technology](/source/Korea_Advanced_Institute_of_Science_%26_Technology).[2]

## References

1. **[^](#cite_ref-pmid16767085_1-0)** Won J, Kim M, Kim N, Ahn JH, Lee WG, Kim SS, Chang KY, Yi YW, Kim TK (July 2006). "Small molecule-based reversible reprogramming of cellular lifespan". *Nat. Chem. Biol*. **2** (7): 369–74. [doi](/source/Doi_(identifier)):[10.1038/nchembio800](https://doi.org/10.1038%2Fnchembio800). [PMID](/source/PMID_(identifier)) [16767085](https://pubmed.ncbi.nlm.nih.gov/16767085). [S2CID](/source/S2CID_(identifier)) [85372472](https://api.semanticscholar.org/CorpusID:85372472). (Retracted, see [doi](/source/Doi_(identifier)):[10.1038/nchembio0708-431](https://doi.org/10.1038%2Fnchembio0708-431), [PMID](/source/PMID_(identifier)) [18560433](https://pubmed.ncbi.nlm.nih.gov/18560433))

1. ^ [***a***](#cite_ref-Science_2-0) [***b***](#cite_ref-Science_2-1) Dennis Normile; Jennifer Couzin (March 5, 2008). ["South Korean researcher suspended over charges of scientific misconduct"](https://web.archive.org/web/20080309144425/http://sciencenow.sciencemag.org/cgi/content/full/2008/305/1). *Science Now*. Archived from [the original](http://sciencenow.sciencemag.org/cgi/content/full/2008/305/1) on 2008-03-09. Retrieved 2008-03-17.

1. **[^](#cite_ref-C&EN2_3-0)** Kenneth J. Moore (2008). ["Data Duping"](http://pubs.acs.org/isubscribe/journals/cen/86/i12/html/8612notw3.html). *Chemical & Engineering News*. Retrieved 2008-04-01.

1. **[^](#cite_ref-pmid19136059_4-0)** Bhattacharya S, Ray RM, Johnson LR (December 2008). "Role of polyamines in p53-dependent apoptosis of intestinal epithelial cells". *Cell. Signal*. **21** (4): 509–22. [doi](/source/Doi_(identifier)):[10.1016/j.cellsig.2008.12.003](https://doi.org/10.1016%2Fj.cellsig.2008.12.003). [PMID](/source/PMID_(identifier)) [19136059](https://pubmed.ncbi.nlm.nih.gov/19136059).

1. **[^](#cite_ref-pmid18347191_5-0)** Crescenzi E, Palumbo G, de Boer J, Brady HJ (March 2008). ["Ataxia telangiectasia mutated and p21CIP1 modulate cell survival of drug-induced senescent tumor cells: implications for chemotherapy"](https://doi.org/10.1158%2F1078-0432.CCR-07-4298). *Clin. Cancer Res*. **14** (6): 1877–87. [doi](/source/Doi_(identifier)):[10.1158/1078-0432.CCR-07-4298](https://doi.org/10.1158%2F1078-0432.CCR-07-4298). [PMID](/source/PMID_(identifier)) [18347191](https://pubmed.ncbi.nlm.nih.gov/18347191).

1. **[^](#cite_ref-C&EN_6-0)** Sarah Everts (2006). ["Aging Cells Get New Lease On Life - Small molecule is found to extend lifetime of mammalian cells"](http://pubs.acs.org/cen/news/84/i25/8425notw4.html). *Chemical & Engineering News*. Retrieved 2007-03-09.

1. ^ [***a***](#cite_ref-pmid18560433_7-0) [***b***](#cite_ref-pmid18560433_7-1) Won J, Kim M, Kim N, et al. (July 2008). ["Retraction: small molecule-based reversible reprogramming of cellular lifespan"](https://doi.org/10.1038%2Fnchembio0708-431). *Nat. Chem. Biol*. **4** (7): 431. [doi](/source/Doi_(identifier)):[10.1038/nchembio0708-431](https://doi.org/10.1038%2Fnchembio0708-431). [PMID](/source/PMID_(identifier)) [18560433](https://pubmed.ncbi.nlm.nih.gov/18560433).

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Adapted from the Wikipedia article [CGK733 fraud](https://en.wikipedia.org/wiki/CGK733_fraud) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/CGK733_fraud?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.