# CFAP47

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{{Short description|Protein-coding gene in humans}}'''''CFAP47''''', or '''cilia and flagella associated protein 47''', is a human gene encoded on the X chromosome.<ref name=":0">{{Cite web|url=https://www.ncbi.nlm.nih.gov/protein/AAI01699.1|title=Chromosome X open reading frame 59|last=|first=|date=|website=NCBI|access-date=}}</ref> in humans. CXorf59 is located  on chromosome X at locus Xp21.1 of the human genome.

== Protein ==
CXorf59 is most commonly known as Cilia- and flagella- associated protein 47 (CFAP47) in other species.

== Gene ==
CFAP47 is a 3187 amino acid protein that has seven splice variants and contains 64 exons.<ref name=":0" /> Genecard listed aliases for CXorf59 as Cilia and Flagella Associated Protein 47 (CFAP47), [Calponin](/source/Calponin) Homology Domain-Containing Protein 2 (CHDC2), FLJ3660, CXorf22, and CXorf30<ref>{{Cite web|url=https://www.genecards.org/cgi-bin/carddisp.pl?gene=CFAP47&keywords=cxorf59|title=CFAP47 Gene|last=|first=|date=|website=genecards.org/|access-date=}}</ref>

== Orthologs and paralogs ==
[Orthologs](/source/Orthologs) have been found in mammalia, aves, reptilia, amphibia, osteichthyes; sarcopterygii and actinopterygii, ascidiacea, gastropoda, cephalopoda, insecta, and demospongiae. There are no paralogs within the human genome.

== Expression  ==
thumb|Hypothetical protein structure of CFAP47 produced by I-Tasser.
CXorf59 is a protein coding gene that is confirmed to be expressed in 27 different tissues. The liver, testis, thyroid, brain, and endometrium were higher in reads per kilobase of transcript (RPKM).<ref name=":0" /> While this gene is associated with cilia and flagella, there is no current functional information available on this protein.<ref name=":0" /> CXorf59 is also related to Calponin, a calcium binding protein. In the 324 to 403 base pair region, there is a Calponin homology domain.<ref>{{Cite journal|title=Calponin homology domains at a glance|journal=Journal of Cell Science|year=2002|doi=10.1242/jcs.00003|last1=Korenbaum|first1=E.|last2=Rivero|first2=F.|volume=115|issue=18|pages=3543–3545|pmid=12186940|doi-access=free|citeseerx=10.1.1.608.8653}}</ref> Calponin homology domains are found in [cytoskeletal](/source/Cytoskeleton) and [signal transduction](/source/signal_transduction) proteins. They are composed of four alpha helices and are actin-binding.

== References ==
{{reflist}}

Category:Genes on human chromosome X
Category:Human proteins

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Adapted from the Wikipedia article [CFAP47](https://en.wikipedia.org/wiki/CFAP47) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/CFAP47?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.