# CEP250

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Protein-coding gene in the species Homo sapiens

CEP250 Identifiers Aliases CEP250, C-NAP1, CEP2, CNAP1, centrosomal protein 250, CRDHL2 External IDs OMIM: 609689; MGI: 108084; HomoloGene: 38286; GeneCards: CEP250; OMA:CEP250 - orthologs Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q11.22 Start 35,455,164 bp[1] End 35,519,280 bp[1] Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 H1 Start 155,798,378 bp[2] End 155,840,820 bp[2] RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve ventricular zone granulocyte ganglionic eminence stromal cell of endometrium cerebellar hemisphere right hemisphere of cerebellum Achilles tendon lymph node epithelium of colon Top expressed in neural layer of retina granulocyte tail of embryo ventricular zone genital tubercle yolk sac thymus Jacobson's organ zygote secondary oocyte More reference expression data BioGPS More reference expression data Gene ontology Molecular function protein domain specific binding protein C-terminus binding protein binding protein kinase binding Cellular component cytoplasm cytosol centrosome cell projection cilium microtubule organizing center perinuclear region of cytoplasm centriole extracellular exosome cytoskeleton protein-containing complex Biological process protein localization to organelle protein localization regulation of centriole-centriole cohesion centriole-centriole cohesion G2/M transition of mitotic cell cycle cell cycle mitotic cell cycle ciliary basal body-plasma membrane docking positive regulation of protein localization to centrosome non-motile cilium assembly regulation of G2/M transition of mitotic cell cycle Sources:Amigo / QuickGO Orthologs Species Human Mouse Entrez 11190 16328 Ensembl ENSG00000126001 ENSMUSG00000038241 UniProt Q9BV73 Q60952 RefSeq (mRNA) NM_001035518 NM_007186 NM_001318219 NM_001129999 NM_001130000 NM_008383 NM_177217 RefSeq (protein) NP_001305148 NP_009117 NP_001123471 NP_001123472 NP_032409 NP_796191 Location (UCSC) Chr 20: 35.46 – 35.52 Mb Chr 2: 155.8 – 155.84 Mb PubMed search [3] [4] Wikidata View/Edit Human View/Edit Mouse

**Centrosome-associated protein CEP250** is a [protein](/source/Protein) that in humans is encoded by the *CEP250* [gene](/source/Gene).[5][6][7] This gene encodes a core [centrosomal](/source/Centrosome) protein required for [centriole](/source/Centriole)-centriole cohesion during [interphase](/source/Interphase) of the [cell cycle](/source/Cell_cycle). The encoded protein dissociates from the centrosomes when parental centrioles separate at the beginning of [mitosis](/source/Mitosis). The protein associates with and is [phosphorylated](/source/Phosphorylation) by [NIMA-related kinase 2](/source/NEK2), which is also associated with the centrosome.[7] Furthermore, [CEP135](/source/CEP135) is also required for the centriolar localization of CEP250.[8]

## References

1. ^ [***a***](#cite_ref-refGRCh38Ensembl_1-0) [***b***](#cite_ref-refGRCh38Ensembl_1-1) [***c***](#cite_ref-refGRCh38Ensembl_1-2) [GRCh38: Ensembl release 89: ENSG00000126001](http://May2017.archive.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000126001) – [Ensembl](/source/Ensembl_genome_database_project), May 2017

1. ^ [***a***](#cite_ref-refGRCm38Ensembl_2-0) [***b***](#cite_ref-refGRCm38Ensembl_2-1) [***c***](#cite_ref-refGRCm38Ensembl_2-2) [GRCm38: Ensembl release 89: ENSMUSG00000038241](http://May2017.archive.ensembl.org/Mus_musculus/Gene/Summary?db=core;g=ENSMUSG00000038241) – [Ensembl](/source/Ensembl_genome_database_project), May 2017

1. **[^](#cite_ref-3)** ["Human PubMed Reference:"](https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=11190). *National Center for Biotechnology Information, U.S. National Library of Medicine*.

1. **[^](#cite_ref-4)** ["Mouse PubMed Reference:"](https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=16328). *National Center for Biotechnology Information, U.S. National Library of Medicine*.

1. **[^](#cite_ref-pmid9506584_5-0)** Mack GJ, Rees J, Sandblom O, Balczon R, Fritzler MJ, Rattner JB (Apr 1998). ["Autoantibodies to a group of centrosomal proteins in human autoimmune sera reactive with the centrosome"](https://doi.org/10.1002%2F1529-0131%28199803%2941%3A3%3C551%3A%3AAID-ART22%3E3.0.CO%3B2-X). *Arthritis Rheum*. **41** (3): 551–8. [doi](/source/Doi_(identifier)):[10.1002/1529-0131(199803)41:3<551::AID-ART22>3.0.CO;2-X](https://doi.org/10.1002%2F1529-0131%28199803%2941%3A3%3C551%3A%3AAID-ART22%3E3.0.CO%3B2-X). [PMID](/source/PMID_(identifier)) [9506584](https://pubmed.ncbi.nlm.nih.gov/9506584).

1. **[^](#cite_ref-pmid9647649_6-0)** Fry AM, Mayor T, Meraldi P, Stierhof YD, Tanaka K, Nigg EA (Aug 1998). ["C-Nap1, a Novel Centrosomal Coiled-Coil Protein and Candidate Substrate of the Cell Cycle–regulated Protein Kinase Nek2"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2133000). *J Cell Biol*. **141** (7): 1563–74. [doi](/source/Doi_(identifier)):[10.1083/jcb.141.7.1563](https://doi.org/10.1083%2Fjcb.141.7.1563). [PMC](/source/PMC_(identifier)) [2133000](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2133000). [PMID](/source/PMID_(identifier)) [9647649](https://pubmed.ncbi.nlm.nih.gov/9647649).

1. ^ [***a***](#cite_ref-entrez_7-0) [***b***](#cite_ref-entrez_7-1) ["Entrez Gene: CEP250 centrosomal protein 250kDa"](https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=11190).

1. **[^](#cite_ref-pmid18851962_8-0)** Kim K, Lee S, Chang J, Rhee K (December 2008). "A novel function of CEP135 as a platform protein of C-NAP1 for its centriolar localization". *Exp. Cell Res*. **314** (20): 3692–700. [doi](/source/Doi_(identifier)):[10.1016/j.yexcr.2008.09.016](https://doi.org/10.1016%2Fj.yexcr.2008.09.016). [PMID](/source/PMID_(identifier)) [18851962](https://pubmed.ncbi.nlm.nih.gov/18851962).

## External links

- Human [*CEP250*](https://genome.ucsc.edu/cgi-bin/hgTracks?db=hg38&singleSearch=knownCanonical&position=CEP250) genome location and [*CEP250*](https://genome.ucsc.edu/cgi-bin/hgGene?db=hg38&hgg_type=knownGene&hgg_gene=CEP250) gene details page in the [UCSC Genome Browser](/source/UCSC_Genome_Browser).

## Further reading

- Gerhard DS, Wagner L, Feingold EA, et al. (2004). ["The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928). *Genome Res*. **14** (10B): 2121–7. [doi](/source/Doi_(identifier)):[10.1101/gr.2596504](https://doi.org/10.1101%2Fgr.2596504). [PMC](/source/PMC_(identifier)) [528928](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928). [PMID](/source/PMID_(identifier)) [15489334](https://pubmed.ncbi.nlm.nih.gov/15489334).

- Jin J, Smith FD, Stark C, et al. (2004). ["Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization"](https://doi.org/10.1016%2Fj.cub.2004.07.051). *Curr. Biol*. **14** (16): 1436–50. [Bibcode](/source/Bibcode_(identifier)):[2004CBio...14.1436J](https://ui.adsabs.harvard.edu/abs/2004CBio...14.1436J). [doi](/source/Doi_(identifier)):[10.1016/j.cub.2004.07.051](https://doi.org/10.1016%2Fj.cub.2004.07.051). [PMID](/source/PMID_(identifier)) [15324660](https://pubmed.ncbi.nlm.nih.gov/15324660). [S2CID](/source/S2CID_(identifier)) [2371325](https://api.semanticscholar.org/CorpusID:2371325).

- Colland F, Jacq X, Trouplin V, et al. (2004). ["Functional Proteomics Mapping of a Human Signaling Pathway"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC442148). *Genome Res*. **14** (7): 1324–32. [doi](/source/Doi_(identifier)):[10.1101/gr.2334104](https://doi.org/10.1101%2Fgr.2334104). [PMC](/source/PMC_(identifier)) [442148](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC442148). [PMID](/source/PMID_(identifier)) [15231748](https://pubmed.ncbi.nlm.nih.gov/15231748).

- Faragher AJ, Fry AM (2004). ["Nek2A kinase stimulates centrosome disjunction and is required for formation of bipolar mitotic spindles"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC165683). *Mol. Biol. Cell*. **14** (7): 2876–89. [doi](/source/Doi_(identifier)):[10.1091/mbc.E03-02-0108](https://doi.org/10.1091%2Fmbc.E03-02-0108). [PMC](/source/PMC_(identifier)) [165683](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC165683). [PMID](/source/PMID_(identifier)) [12857871](https://pubmed.ncbi.nlm.nih.gov/12857871).

- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). ["Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241). *Proc. Natl. Acad. Sci. U.S.A*. **99** (26): 16899–903. [Bibcode](/source/Bibcode_(identifier)):[2002PNAS...9916899M](https://ui.adsabs.harvard.edu/abs/2002PNAS...9916899M). [doi](/source/Doi_(identifier)):[10.1073/pnas.242603899](https://doi.org/10.1073%2Fpnas.242603899). [PMC](/source/PMC_(identifier)) [139241](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241). [PMID](/source/PMID_(identifier)) [12477932](https://pubmed.ncbi.nlm.nih.gov/12477932).

- Mayor T, Hacker U, Stierhof YD, Nigg EA (2003). ["The mechanism regulating the dissociation of the centrosomal protein C-Nap1 from mitotic spindle poles"](https://resolver.caltech.edu/CaltechAUTHORS:20111031-142910138). *J. Cell Sci*. **115** (Pt 16): 3275–84. [doi](/source/Doi_(identifier)):[10.1242/jcs.115.16.3275](https://doi.org/10.1242%2Fjcs.115.16.3275). [PMID](/source/PMID_(identifier)) [12140259](https://pubmed.ncbi.nlm.nih.gov/12140259).

- Deloukas P, Matthews LH, Ashurst J, et al. (2002). ["The DNA sequence and comparative analysis of human chromosome 20"](https://doi.org/10.1038%2F414865a). *Nature*. **414** (6866): 865–71. [Bibcode](/source/Bibcode_(identifier)):[2001Natur.414..865D](https://ui.adsabs.harvard.edu/abs/2001Natur.414..865D). [doi](/source/Doi_(identifier)):[10.1038/414865a](https://doi.org/10.1038%2F414865a). [PMID](/source/PMID_(identifier)) [11780052](https://pubmed.ncbi.nlm.nih.gov/11780052).

- Mayor T, Stierhof YD, Tanaka K, et al. (2000). ["The Centrosomal Protein C-Nap1 Is Required for Cell Cycle–Regulated Centrosome Cohesion"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2169446). *J. Cell Biol*. **151** (4): 837–46. [doi](/source/Doi_(identifier)):[10.1083/jcb.151.4.837](https://doi.org/10.1083%2Fjcb.151.4.837). [PMC](/source/PMC_(identifier)) [2169446](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2169446). [PMID](/source/PMID_(identifier)) [11076968](https://pubmed.ncbi.nlm.nih.gov/11076968).

- Hirsch DS, Pirone DM, Burbelo PD (2001). ["A new family of Cdc42 effector proteins, CEPs, function in fibroblast and epithelial cell shape changes"](https://doi.org/10.1074%2Fjbc.M007039200). *J. Biol. Chem*. **276** (2): 875–83. [doi](/source/Doi_(identifier)):[10.1074/jbc.M007039200](https://doi.org/10.1074%2Fjbc.M007039200). [PMID](/source/PMID_(identifier)) [11035016](https://pubmed.ncbi.nlm.nih.gov/11035016).

- Helps NR, Luo X, Barker HM, Cohen PT (2001). ["NIMA-related kinase 2 (Nek2), a cell-cycle-regulated protein kinase localized to centrosomes, is complexed to protein phosphatase 1"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1221174). *Biochem. J*. **349** (Pt 2): 509–18. [doi](/source/Doi_(identifier)):[10.1042/0264-6021:3490509](https://doi.org/10.1042%2F0264-6021%3A3490509). [PMC](/source/PMC_(identifier)) [1221174](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1221174). [PMID](/source/PMID_(identifier)) [10880350](https://pubmed.ncbi.nlm.nih.gov/10880350).

v t e The centrosome and its components Centrioles SASS6 CENPJ CNTROB CEP104 Centrins (CETN1, CETN2 and CETN3) SFI1 Pericentriolar material BBS4 LCK PCM1 PCNT TNKS TNKS2 TUBE1 other proteins CCP110 CEP55 CEP57 CEP63 CEP68 CEP70 CEP72 CEP76 CEP78 CEP90 CEP97 CEP120 CEP135 CEP152 CEP164 CEP170 CEP192 CEP215 CEP250 CEP350 CNTRL NIN NINL

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Adapted from the Wikipedia article [CEP250](https://en.wikipedia.org/wiki/CEP250) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/CEP250?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.