# CEP192

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Protein-coding gene in the species Homo sapiens

CEP192 Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 4N7Z Identifiers Aliases CEP192, PPP1R62, centrosomal protein 192 External IDs OMIM: 616426; MGI: 1918049; HomoloGene: 73526; GeneCards: CEP192; OMA:CEP192 - orthologs Gene location (Human) Chr. Chromosome 18 (human)[1] Band 18p11.21 Start 12,991,362 bp[1] End 13,125,052 bp[1] Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 E1- E2 Start 67,933,177 bp[2] End 68,018,241 bp[2] RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone gonad granulocyte Achilles tendon testicle right testis left testis secondary oocyte mucosa of transverse colon sperm Top expressed in genital tubercle tail of embryo hand spermatocyte secondary oocyte superior cervical ganglion epiblast zygote ventricular zone maxillary prominence More reference expression data BioGPS n/a Gene ontology Molecular function phosphatase binding protein binding Cellular component centriole centrosome pericentriolar material cytoskeleton cytoplasm cytosol Biological process negative regulation of phosphatase activity G2/M transition of mitotic cell cycle ciliary basal body-plasma membrane docking regulation of G2/M transition of mitotic cell cycle protein localization to centrosome centrosome-templated microtubule nucleation mitotic spindle assembly response to bacterium centrosome duplication spindle assembly Sources:Amigo / QuickGO Orthologs Species Human Mouse Entrez 55125 70799 Ensembl ENSG00000101639 ENSMUSG00000024542 UniProt Q8TEP8 n/a RefSeq (mRNA) NM_018069 NM_032142 NM_027556 RefSeq (protein) NP_115518 n/a Location (UCSC) Chr 18: 12.99 – 13.13 Mb Chr 18: 67.93 – 68.02 Mb PubMed search [3] [4] Wikidata View/Edit Human View/Edit Mouse

**Centrosomal protein of 192 kDa**, also known as **Cep192**, is a [protein](/source/Protein) that in humans is encoded by the *CEP192* [gene](/source/Gene).[5][6] It is the homolog of the [C. elegans](/source/Caenorhabditis_elegans) and [D. melanogaster](/source/Drosophila_melanogaster) gene SPD-2.[7]

Cep192 is a major regulator of [pericentriolar material](/source/Pericentriolar_material) recruitment, [centrosome](/source/Centrosome) maturation, and [centriole](/source/Centriole) duplication in [mammalian](/source/Mammal) cells.[7] It stimulates the formation of the scaffolding upon which [gamma tubulin](/source/Gamma_tubulin) ring complexes and other proteins involved in [microtubule nucleation](/source/Microtubule_nucleation) and [spindle assembly](/source/Spindle_apparatus) become functional during [mitosis](/source/Mitosis).[8]

## References

1. ^ [***a***](#cite_ref-refGRCh38Ensembl_1-0) [***b***](#cite_ref-refGRCh38Ensembl_1-1) [***c***](#cite_ref-refGRCh38Ensembl_1-2) [GRCh38: Ensembl release 89: ENSG00000101639](http://May2017.archive.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000101639) – [Ensembl](/source/Ensembl_genome_database_project), May 2017

1. ^ [***a***](#cite_ref-refGRCm38Ensembl_2-0) [***b***](#cite_ref-refGRCm38Ensembl_2-1) [***c***](#cite_ref-refGRCm38Ensembl_2-2) [GRCm38: Ensembl release 89: ENSMUSG00000024542](http://May2017.archive.ensembl.org/Mus_musculus/Gene/Summary?db=core;g=ENSMUSG00000024542) – [Ensembl](/source/Ensembl_genome_database_project), May 2017

1. **[^](#cite_ref-3)** ["Human PubMed Reference:"](https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=55125). *National Center for Biotechnology Information, U.S. National Library of Medicine*.

1. **[^](#cite_ref-4)** ["Mouse PubMed Reference:"](https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=70799). *National Center for Biotechnology Information, U.S. National Library of Medicine*.

1. **[^](#cite_ref-entrez_5-0)** ["Entrez Gene: centrosomal protein 192kDa"](https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=55125).

1. **[^](#cite_ref-pmid14654843_6-0)** Andersen JS, Wilkinson CJ, Mayor T, Mortensen P, Nigg EA, Mann M (December 2003). "Proteomic characterization of the human centrosome by protein correlation profiling". *Nature*. **426** (6966): 570–4. [Bibcode](/source/Bibcode_(identifier)):[2003Natur.426..570A](https://ui.adsabs.harvard.edu/abs/2003Natur.426..570A). [doi](/source/Doi_(identifier)):[10.1038/nature02166](https://doi.org/10.1038%2Fnature02166). [PMID](/source/PMID_(identifier)) [14654843](https://pubmed.ncbi.nlm.nih.gov/14654843). [S2CID](/source/S2CID_(identifier)) [4427303](https://api.semanticscholar.org/CorpusID:4427303).

1. ^ [***a***](#cite_ref-zhu2008_7-0) [***b***](#cite_ref-zhu2008_7-1) Zhu F, Lawo S, Bird A, Pinchev D, Ralph A, Richter C, Müller-Reichert T, Kittler R, Hyman A, Pelletier L (2008). ["The mammalian SPD-2 ortholog Cep192 regulates centrosome biogenesis"](https://doi.org/10.1016%2Fj.cub.2007.12.055). *Current Biology*. **18** (2): 136–141. [Bibcode](/source/Bibcode_(identifier)):[2008CBio...18..136Z](https://ui.adsabs.harvard.edu/abs/2008CBio...18..136Z). [doi](/source/Doi_(identifier)):[10.1016/j.cub.2007.12.055](https://doi.org/10.1016%2Fj.cub.2007.12.055). [PMID](/source/PMID_(identifier)) [18207742](https://pubmed.ncbi.nlm.nih.gov/18207742). [S2CID](/source/S2CID_(identifier)) [16159409](https://api.semanticscholar.org/CorpusID:16159409).

1. **[^](#cite_ref-8)** Gomez-Ferreria M, Rath U, Buster D, Chanda S, Caldwell J, Rines D, Sharp D (2007). ["Human Cep192 is required for mitotic centrosome and spindle assembly"](https://doi.org/10.1016%2Fj.cub.2007.10.019). *Current Biology*. **17** (22): 1960–1966. [Bibcode](/source/Bibcode_(identifier)):[2007CBio...17.1960G](https://ui.adsabs.harvard.edu/abs/2007CBio...17.1960G). [doi](/source/Doi_(identifier)):[10.1016/j.cub.2007.10.019](https://doi.org/10.1016%2Fj.cub.2007.10.019). [PMID](/source/PMID_(identifier)) [17980596](https://pubmed.ncbi.nlm.nih.gov/17980596). [S2CID](/source/S2CID_(identifier)) [10245690](https://api.semanticscholar.org/CorpusID:10245690).

## External links

- Human [*CEP192*](https://genome.ucsc.edu/cgi-bin/hgTracks?db=hg38&singleSearch=knownCanonical&position=CEP192) genome location and [*CEP192*](https://genome.ucsc.edu/cgi-bin/hgGene?db=hg38&hgg_type=knownGene&hgg_gene=CEP192) gene details page in the [UCSC Genome Browser](/source/UCSC_Genome_Browser).

- Overview of all the structural information available in the [PDB](/source/Protein_Data_Bank) for [UniProt](/source/UniProt): *[Q8TEP8](https://www.ebi.ac.uk/pdbe/pdbe-kb/proteins/Q8TEP8)* (Centrosomal protein of 192 kDa) at the [PDBe-KB](/source/PDBe-KB).

## Further reading

- Nagase T, Kikuno R, Nakayama M, et al. (2000). ["Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro"](https://doi.org/10.1093%2Fdnares%2F7.4.271). *DNA Res*. **7** (4): 273–81. [doi](/source/Doi_(identifier)):[10.1093/dnares/7.4.271](https://doi.org/10.1093%2Fdnares%2F7.4.271). [PMID](/source/PMID_(identifier)) [10997877](https://pubmed.ncbi.nlm.nih.gov/10997877).

- Golsteyn RM, Mundt KE, Fry AM, Nigg EA (1995). ["Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2291169). *J. Cell Biol*. **129** (6): 1617–28. [doi](/source/Doi_(identifier)):[10.1083/jcb.129.6.1617](https://doi.org/10.1083%2Fjcb.129.6.1617). [PMC](/source/PMC_(identifier)) [2291169](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2291169). [PMID](/source/PMID_(identifier)) [7790358](https://pubmed.ncbi.nlm.nih.gov/7790358).

- Zhu F, Lawo S, Bird A, et al. (2008). ["The mammalian SPD-2 ortholog Cep192 regulates centrosome biogenesis"](https://doi.org/10.1016%2Fj.cub.2007.12.055). *Curr. Biol*. **18** (2): 136–41. [Bibcode](/source/Bibcode_(identifier)):[2008CBio...18..136Z](https://ui.adsabs.harvard.edu/abs/2008CBio...18..136Z). [doi](/source/Doi_(identifier)):[10.1016/j.cub.2007.12.055](https://doi.org/10.1016%2Fj.cub.2007.12.055). [PMID](/source/PMID_(identifier)) [18207742](https://pubmed.ncbi.nlm.nih.gov/18207742). [S2CID](/source/S2CID_(identifier)) [16159409](https://api.semanticscholar.org/CorpusID:16159409).

- Gomez-Ferreria MA, Rath U, Buster DW, et al. (2007). ["Human Cep192 is required for mitotic centrosome and spindle assembly"](https://doi.org/10.1016%2Fj.cub.2007.10.019). *Curr. Biol*. **17** (22): 1960–6. [Bibcode](/source/Bibcode_(identifier)):[2007CBio...17.1960G](https://ui.adsabs.harvard.edu/abs/2007CBio...17.1960G). [doi](/source/Doi_(identifier)):[10.1016/j.cub.2007.10.019](https://doi.org/10.1016%2Fj.cub.2007.10.019). [PMID](/source/PMID_(identifier)) [17980596](https://pubmed.ncbi.nlm.nih.gov/17980596). [S2CID](/source/S2CID_(identifier)) [10245690](https://api.semanticscholar.org/CorpusID:10245690).

- Mayor T, Stierhof YD, Tanaka K, et al. (2000). ["The Centrosomal Protein C-Nap1 Is Required for Cell Cycle–Regulated Centrosome Cohesion"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2169446). *J. Cell Biol*. **151** (4): 837–46. [doi](/source/Doi_(identifier)):[10.1083/jcb.151.4.837](https://doi.org/10.1083%2Fjcb.151.4.837). [PMC](/source/PMC_(identifier)) [2169446](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2169446). [PMID](/source/PMID_(identifier)) [11076968](https://pubmed.ncbi.nlm.nih.gov/11076968).

- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). ["Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1356129). *Genome Res*. **16** (1): 55–65. [doi](/source/Doi_(identifier)):[10.1101/gr.4039406](https://doi.org/10.1101%2Fgr.4039406). [PMC](/source/PMC_(identifier)) [1356129](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1356129). [PMID](/source/PMID_(identifier)) [16344560](https://pubmed.ncbi.nlm.nih.gov/16344560).

- Wiemann S, Weil B, Wellenreuther R, et al. (2001). ["Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC311072). *Genome Res*. **11** (3): 422–35. [doi](/source/Doi_(identifier)):[10.1101/gr.GR1547R](https://doi.org/10.1101%2Fgr.GR1547R). [PMC](/source/PMC_(identifier)) [311072](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC311072). [PMID](/source/PMID_(identifier)) [11230166](https://pubmed.ncbi.nlm.nih.gov/11230166).

- Sowa ME, Bennett EJ, Gygi SP, Harper JW (2009). ["Defining the Human Deubiquitinating Enzyme Interaction Landscape"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2716422). *Cell*. **138** (2): 389–403. [doi](/source/Doi_(identifier)):[10.1016/j.cell.2009.04.042](https://doi.org/10.1016%2Fj.cell.2009.04.042). [PMC](/source/PMC_(identifier)) [2716422](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2716422). [PMID](/source/PMID_(identifier)) [19615732](https://pubmed.ncbi.nlm.nih.gov/19615732).

- Takahashi M, Yamagiwa A, Nishimura T, et al. (2002). ["Centrosomal Proteins CG-NAP and Kendrin Provide Microtubule Nucleation Sites by Anchoring γ-Tubulin Ring Complex"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC124155). *Mol. Biol. Cell*. **13** (9): 3235–45. [doi](/source/Doi_(identifier)):[10.1091/mbc.E02-02-0112](https://doi.org/10.1091%2Fmbc.E02-02-0112). [PMC](/source/PMC_(identifier)) [124155](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC124155). [PMID](/source/PMID_(identifier)) [12221128](https://pubmed.ncbi.nlm.nih.gov/12221128).

- Casenghi M, Meraldi P, Weinhart U, et al. (2003). ["Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation"](https://doi.org/10.1016%2FS1534-5807%2803%2900193-X). *Dev. Cell*. **5** (1): 113–25. [doi](/source/Doi_(identifier)):[10.1016/S1534-5807(03)00193-X](https://doi.org/10.1016%2FS1534-5807%2803%2900193-X). [PMID](/source/PMID_(identifier)) [12852856](https://pubmed.ncbi.nlm.nih.gov/12852856).

- Ota T, Suzuki Y, Nishikawa T, et al. (2004). ["Complete sequencing and characterization of 21,243 full-length human cDNAs"](https://doi.org/10.1038%2Fng1285). *Nat. Genet*. **36** (1): 40–5. [doi](/source/Doi_(identifier)):[10.1038/ng1285](https://doi.org/10.1038%2Fng1285). [PMID](/source/PMID_(identifier)) [14702039](https://pubmed.ncbi.nlm.nih.gov/14702039).

- Petretti C, Savoian M, Montembault E, et al. (2006). ["The PITSLRE/CDK11p58 protein kinase promotes centrosome maturation and bipolar spindle formation"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1456919). *EMBO Rep*. **7** (4): 418–24. [doi](/source/Doi_(identifier)):[10.1038/sj.embor.7400639](https://doi.org/10.1038%2Fsj.embor.7400639). [PMC](/source/PMC_(identifier)) [1456919](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1456919). [PMID](/source/PMID_(identifier)) [16462731](https://pubmed.ncbi.nlm.nih.gov/16462731).

- Strausberg RL, Feingold EA, Grouse LH, et al. (2002). ["Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241). *Proc. Natl. Acad. Sci. U.S.A*. **99** (26): 16899–903. [Bibcode](/source/Bibcode_(identifier)):[2002PNAS...9916899M](https://ui.adsabs.harvard.edu/abs/2002PNAS...9916899M). [doi](/source/Doi_(identifier)):[10.1073/pnas.242603899](https://doi.org/10.1073%2Fpnas.242603899). [PMC](/source/PMC_(identifier)) [139241](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241). [PMID](/source/PMID_(identifier)) [12477932](https://pubmed.ncbi.nlm.nih.gov/12477932).

- Pope SN, Lee IR (2005). "Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin". *J. Steroid Biochem. Mol. Biol*. **94** (1–3): 203–8. [doi](/source/Doi_(identifier)):[10.1016/j.jsbmb.2005.01.007](https://doi.org/10.1016%2Fj.jsbmb.2005.01.007). [PMID](/source/PMID_(identifier)) [15862967](https://pubmed.ncbi.nlm.nih.gov/15862967). [S2CID](/source/S2CID_(identifier)) [9746088](https://api.semanticscholar.org/CorpusID:9746088).

v t e The centrosome and its components Centrioles SASS6 CENPJ CNTROB CEP104 Centrins (CETN1, CETN2 and CETN3) SFI1 Pericentriolar material BBS4 LCK PCM1 PCNT TNKS TNKS2 TUBE1 other proteins CCP110 CEP55 CEP57 CEP63 CEP68 CEP70 CEP72 CEP76 CEP78 CEP90 CEP97 CEP120 CEP135 CEP152 CEP164 CEP170 CEP192 CEP215 CEP250 CEP350 CNTRL NIN NINL

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Adapted from the Wikipedia article [CEP192](https://en.wikipedia.org/wiki/CEP192) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/CEP192?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.