# CENTG2

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> Source: https://en.wikipedia.org/wiki/CENTG2
> Source revision: 1301004913
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{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
'''Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1''' is an [enzyme](/source/enzyme) that in humans is encoded by the ''AGAP1'' [gene](/source/gene).<ref name="entrez">{{cite web | title = Entrez Gene: CENTG2 centaurin, gamma 2| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=116987| access-date = }}</ref>

== Function ==

CENTG2 belongs to an ADP-ribosylation factor GTPase-activating (ARF-GAP) protein family involved in membrane traffic and actin cytoskeleton dynamics (Nie et al., 2002).[supplied by OMIM]<ref name="entrez" />

== HACNS1 ==

HACNS1 is located in an intron of the gene CENTG2 (also known as [Human Accelerated Region](/source/Human_accelerated_regions) 2).  HACNS1 is hypothesized to be a [gene enhancer](/source/gene_enhancer) "that may have contributed to the evolution of the uniquely opposable [human](/source/human) [thumb](/source/thumb), and possibly also modifications in the [ankle](/source/ankle) or [foot](/source/foot) that allow humans to [walk](/source/walk) on two legs". Evidence to date shows that of the 110,000 gene enhancer sequences identified in the human [genome](/source/genome), HACNS1 has undergone the most change during the [evolution](/source/evolution) of humans following the split with the ancestors of [chimpanzee](/source/Pan_(genus))s.<ref>[http://www.sciencecodex.com/gene_enhancer_in_evolution_of_human_opposable_thumb HACNS1: Gene enhancer in evolution of human opposable thumb]</ref>

== References ==
{{reflist|33em}}

==External links==
* {{UCSC gene info|AGAP1}}

== Further reading ==
{{refbegin|33em}}
* {{cite journal | vauthors = Kikuno R, Nagase T, Ishikawa K, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Research | volume = 6 | issue = 3 | pages = 197–205 | date = Jun 1999 | pmid = 10470851 | doi = 10.1093/dnares/6.3.197 | doi-access = free }}
* {{cite journal | vauthors = Nie Z, Stanley KT, Stauffer S, Jacques KM, Hirsch DS, Takei J, Randazzo PA | title = AGAP1, an endosome-associated, phosphoinositide-dependent ADP-ribosylation factor GTPase-activating protein that affects actin cytoskeleton | journal = The Journal of Biological Chemistry | volume = 277 | issue = 50 | pages = 48965–75 | date = Dec 2002 | pmid = 12388557 | doi = 10.1074/jbc.M202969200 | doi-access = free }}
* {{cite journal | vauthors = Xia C, Ma W, Stafford LJ, Liu C, Gong L, Martin JF, Liu M | title = GGAPs, a new family of bifunctional GTP-binding and GTPase-activating proteins | journal = Molecular and Cellular Biology | volume = 23 | issue = 7 | pages = 2476–88 | date = Apr 2003 | pmid = 12640130 | pmc = 150724 | doi = 10.1128/MCB.23.7.2476-2488.2003 }}
* {{cite journal | vauthors = Nie Z, Boehm M, Boja ES, Vass WC, Bonifacino JS, Fales HM, Randazzo PA | title = Specific regulation of the adaptor protein complex AP-3 by the Arf GAP AGAP1 | journal = Developmental Cell | volume = 5 | issue = 3 | pages = 513–21 | date = Sep 2003 | pmid = 12967569 | doi = 10.1016/S1534-5807(03)00234-X | doi-access = free }}
* {{cite journal | vauthors = Meurer S, Pioch S, Wagner K, Müller-Esterl W, Gross S | title = AGAP1, a novel binding partner of nitric oxide-sensitive guanylyl cyclase | journal = The Journal of Biological Chemistry | volume = 279 | issue = 47 | pages = 49346–54 | date = Nov 2004 | pmid = 15381706 | doi = 10.1074/jbc.M410565200 | doi-access = free }}
* {{cite journal | vauthors = Wassink TH, Piven J, Vieland VJ, Jenkins L, Frantz R, Bartlett CW, Goedken R, Childress D, Spence MA, Smith M, Sheffield VC | title = Evaluation of the chromosome 2q37.3 gene CENTG2 as an autism susceptibility gene | journal = American Journal of Medical Genetics Part B | volume = 136B | issue = 1 | pages = 36–44 | date = Jul 2005 | pmid = 15892143 | doi = 10.1002/ajmg.b.30180 | s2cid = 3858998 | url = http://www.escholarship.org/uc/item/9m33n261 }}
* {{cite journal | vauthors = Nie Z, Fei J, Premont RT, Randazzo PA | title = The Arf GAPs AGAP1 and AGAP2 distinguish between the adaptor protein complexes AP-1 and AP-3 | journal = Journal of Cell Science | volume = 118 | issue = Pt 15 | pages = 3555–66 | date = Aug 2005 | pmid = 16079295 | doi = 10.1242/jcs.02486 | doi-access = free }}
* {{cite journal | vauthors = Oh JH, Yang JO, Hahn Y, Kim MR, Byun SS, Jeon YJ, Kim JM, Song KS, Noh SM, Kim S, Yoo HS, Kim YS, Kim NS | title = Transcriptome analysis of human gastric cancer | journal = Mammalian Genome | volume = 16 | issue = 12 | pages = 942–54 | date = Dec 2005 | pmid = 16341674 | doi = 10.1007/s00335-005-0075-2 | s2cid = 69278 }}
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Adapted from the Wikipedia article [CENTG2](https://en.wikipedia.org/wiki/CENTG2) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/CENTG2?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.