# CDC27

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Protein-coding gene in humans

CDC27 Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3T1N, 4RG6, 4RG7, 4RG9, 4UI9, 5A31, 5G04, 5G05 Identifiers Aliases CDC27, ANAPC3, APC3, CDC27Hs, D0S1430E, D17S978E, H-NUC, HNUC, NUC2, cell division cycle 27 External IDs OMIM: 116946; MGI: 102685; HomoloGene: 960; GeneCards: CDC27; OMA:CDC27 - orthologs Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.32 Start 47,117,703 bp[1] End 47,189,422 bp[1] Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 E1|11 67.79 cM Start 104,502,745 bp[2] End 104,550,620 bp[2] RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte buccal mucosa cell tibia Achilles tendon epithelium of colon Brodmann area 23 tendon of biceps brachii internal globus pallidus stromal cell of endometrium germinal epithelium Top expressed in genital tubercle tail of embryo zygote cumulus cell secondary oocyte mandibular prominence maxillary prominence renal corpuscle pineal gland human fetus More reference expression data BioGPS n/a Gene ontology Molecular function protein phosphatase binding protein binding Cellular component cytoplasm cytosol centrosome spindle spindle microtubule anaphase-promoting complex nucleus nucleoplasm Biological process metaphase anaphase-promoting complex-dependent catabolic process cell population proliferation protein ubiquitination protein K11-linked ubiquitination regulation of mitotic cell cycle phase transition ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO Orthologs Species Human Mouse Entrez 996 217232 Ensembl ENSG00000004897 ENSMUSG00000020687 UniProt P30260 A2A6Q5 RefSeq (mRNA) NM_001114091 NM_001256 NM_001293089 NM_001293091 NM_001353035 NM_001353047 NM_001353049 NM_001353050 NM_001353051 NM_001285988 NM_001285989 NM_001285990 NM_145436 RefSeq (protein) NP_001107563 NP_001247 NP_001280018 NP_001280020 NP_001339964 NP_001339976 NP_001339978 NP_001339979 NP_001339980 NP_001272917 NP_001272918 NP_001272919 NP_663411 Location (UCSC) Chr 17: 47.12 – 47.19 Mb Chr 11: 104.5 – 104.55 Mb PubMed search [3] [4] Wikidata View/Edit Human View/Edit Mouse

**Cell division cycle protein 27 homolog** is a [protein](/source/Protein) that in humans is encoded by the *CDC27* [gene](/source/Gene).[5][6]

## Function

The protein encoded by this gene shares strong similarity with *[Saccharomyces cerevisiae](/source/Saccharomyces_cerevisiae)* protein Cdc27, and the gene product of *[Schizosaccharomyces pombe](/source/Schizosaccharomyces_pombe)* nuc 2. This protein is a component of [anaphase-promoting complex](/source/Anaphase-promoting_complex) (APC), which is composed of eight protein subunits and highly conserved in eucaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the [ubiquitin](/source/Ubiquitin)-mediated [proteolysis](/source/Proteolysis) of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR ([tetratricopeptide](/source/Tetratricopeptide) repeat), a protein domain important for [protein-protein interaction](/source/Protein-protein_interaction). This protein was shown to interact with mitotic checkpoint proteins including [Mad2](/source/Mad2), p55CDC and BUBR1, and thus may be involved in controlling the timing of [mitosis](/source/Mitosis).[6]

## Interactions

CDC27 has been shown to [interact](/source/Protein-protein_interaction) with:

- [ANAPC10](/source/ANAPC10),[7][8]

- [ANAPC11](/source/ANAPC11),[7][8]

- [ANAPC1](/source/ANAPC1),[7][9]

- [ANAPC4](/source/ANAPC4),[7][8]

- [ANAPC5](/source/ANAPC5),[7][8][10]

- [ANAPC7](/source/ANAPC7),[7][8]

- [CDC16](/source/CDC16),[7][8][11][12]

- [CDC20](/source/CDC20),[7][11][13][14][15][16][17]

- [CDC23](/source/CDC23),[7][8]

- [CDH1](/source/CDH1_(gene)),[7]

- [FZR1](/source/FZR1),[13][18]

- [MAD2L1](/source/MAD2L1)[11][16] and

- [PIN1](/source/PIN1).[19][20]

## References

1. ^ [***a***](#cite_ref-refGRCh38Ensembl_1-0) [***b***](#cite_ref-refGRCh38Ensembl_1-1) [***c***](#cite_ref-refGRCh38Ensembl_1-2) [GRCh38: Ensembl release 89: ENSG00000004897](http://May2017.archive.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000004897) – [Ensembl](/source/Ensembl_genome_database_project), May 2017

1. ^ [***a***](#cite_ref-refGRCm38Ensembl_2-0) [***b***](#cite_ref-refGRCm38Ensembl_2-1) [***c***](#cite_ref-refGRCm38Ensembl_2-2) [GRCm38: Ensembl release 89: ENSMUSG00000020687](http://May2017.archive.ensembl.org/Mus_musculus/Gene/Summary?db=core;g=ENSMUSG00000020687) – [Ensembl](/source/Ensembl_genome_database_project), May 2017

1. **[^](#cite_ref-3)** ["Human PubMed Reference:"](https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=996). *National Center for Biotechnology Information, U.S. National Library of Medicine*.

1. **[^](#cite_ref-4)** ["Mouse PubMed Reference:"](https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=217232). *National Center for Biotechnology Information, U.S. National Library of Medicine*.

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1. **[^](#cite_ref-pmid15082755_10-0)** Koloteva-Levine N, Pinchasi D, Pereman I, Zur A, Brandeis M, Elroy-Stein O (May 2004). ["The Apc5 subunit of the anaphase-promoting complex/cyclosome interacts with poly(A) binding protein and represses internal ribosome entry site-mediated translation"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC387753). *Molecular and Cellular Biology*. **24** (9): 3577–87. [doi](/source/Doi_(identifier)):[10.1128/mcb.24.9.3577-3587.2004](https://doi.org/10.1128%2Fmcb.24.9.3577-3587.2004). [PMC](/source/PMC_(identifier)) [387753](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC387753). [PMID](/source/PMID_(identifier)) [15082755](https://pubmed.ncbi.nlm.nih.gov/15082755).

1. ^ [***a***](#cite_ref-pmid9628895_11-0) [***b***](#cite_ref-pmid9628895_11-1) [***c***](#cite_ref-pmid9628895_11-2) Kallio M, Weinstein J, Daum JR, Burke DJ, Gorbsky GJ (Jun 1998). ["Mammalian p55CDC mediates association of the spindle checkpoint protein Mad2 with the cyclosome/anaphase-promoting complex, and is involved in regulating anaphase onset and late mitotic events"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2132789). *The Journal of Cell Biology*. **141** (6): 1393–406. [doi](/source/Doi_(identifier)):[10.1083/jcb.141.6.1393](https://doi.org/10.1083%2Fjcb.141.6.1393). [PMC](/source/PMC_(identifier)) [2132789](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2132789). [PMID](/source/PMID_(identifier)) [9628895](https://pubmed.ncbi.nlm.nih.gov/9628895).

1. **[^](#cite_ref-pmid9405394_12-0)** Ollendorff V, Donoghue DJ (Dec 1997). ["The serine/threonine phosphatase PP5 interacts with CDC16 and CDC27, two tetratricopeptide repeat-containing subunits of the anaphase-promoting complex"](https://doi.org/10.1074%2Fjbc.272.51.32011). *The Journal of Biological Chemistry*. **272** (51): 32011–8. [doi](/source/Doi_(identifier)):[10.1074/jbc.272.51.32011](https://doi.org/10.1074%2Fjbc.272.51.32011). [PMID](/source/PMID_(identifier)) [9405394](https://pubmed.ncbi.nlm.nih.gov/9405394).

1. ^ [***a***](#cite_ref-pmid9811605_13-0) [***b***](#cite_ref-pmid9811605_13-1) Kramer ER, Gieffers C, Hölzl G, Hengstschläger M, Peters JM (Nov 1998). ["Activation of the human anaphase-promoting complex by proteins of the CDC20/Fizzy family"](https://doi.org/10.1016%2Fs0960-9822%2807%2900510-6). *Current Biology*. **8** (22): 1207–10. [Bibcode](/source/Bibcode_(identifier)):[1998CBio....8.1207K](https://ui.adsabs.harvard.edu/abs/1998CBio....8.1207K). [doi](/source/Doi_(identifier)):[10.1016/s0960-9822(07)00510-6](https://doi.org/10.1016%2Fs0960-9822%2807%2900510-6). [PMID](/source/PMID_(identifier)) [9811605](https://pubmed.ncbi.nlm.nih.gov/9811605). [S2CID](/source/S2CID_(identifier)) [17181162](https://api.semanticscholar.org/CorpusID:17181162).

1. **[^](#cite_ref-pmid14561775_14-0)** D'Angiolella V, Mari C, Nocera D, Rametti L, Grieco D (Oct 2003). ["The spindle checkpoint requires cyclin-dependent kinase activity"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC218146). *Genes & Development*. **17** (20): 2520–5. [doi](/source/Doi_(identifier)):[10.1101/gad.267603](https://doi.org/10.1101%2Fgad.267603). [PMC](/source/PMC_(identifier)) [218146](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC218146). [PMID](/source/PMID_(identifier)) [14561775](https://pubmed.ncbi.nlm.nih.gov/14561775).

1. **[^](#cite_ref-pmid12196507_15-0)** Kallio MJ, Beardmore VA, Weinstein J, Gorbsky GJ (Sep 2002). ["Rapid microtubule-independent dynamics of Cdc20 at kinetochores and centrosomes in mammalian cells"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173153). *The Journal of Cell Biology*. **158** (5): 841–7. [doi](/source/Doi_(identifier)):[10.1083/jcb.200201135](https://doi.org/10.1083%2Fjcb.200201135). [PMC](/source/PMC_(identifier)) [2173153](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173153). [PMID](/source/PMID_(identifier)) [12196507](https://pubmed.ncbi.nlm.nih.gov/12196507).

1. ^ [***a***](#cite_ref-pmid9736712_16-0) [***b***](#cite_ref-pmid9736712_16-1) Wassmann K, Benezra R (Sep 1998). ["Mad2 transiently associates with an APC/p55Cdc complex during mitosis"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC21618). *Proceedings of the National Academy of Sciences of the United States of America*. **95** (19): 11193–8. [Bibcode](/source/Bibcode_(identifier)):[1998PNAS...9511193W](https://ui.adsabs.harvard.edu/abs/1998PNAS...9511193W). [doi](/source/Doi_(identifier)):[10.1073/pnas.95.19.11193](https://doi.org/10.1073%2Fpnas.95.19.11193). [PMC](/source/PMC_(identifier)) [21618](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC21618). [PMID](/source/PMID_(identifier)) [9736712](https://pubmed.ncbi.nlm.nih.gov/9736712).

1. **[^](#cite_ref-pmid18997788_17-0)** Nilsson J, Yekezare M, Minshull J, Pines J (Dec 2008). ["The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2635557). *Nature Cell Biology*. **10** (12): 1411–20. [doi](/source/Doi_(identifier)):[10.1038/ncb1799](https://doi.org/10.1038%2Fncb1799). [PMC](/source/PMC_(identifier)) [2635557](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2635557). [PMID](/source/PMID_(identifier)) [18997788](https://pubmed.ncbi.nlm.nih.gov/18997788).

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1. **[^](#cite_ref-pmid9499405_19-0)** Shen M, Stukenberg PT, Kirschner MW, Lu KP (Mar 1998). ["The essential mitotic peptidyl-prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteins"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC316589). *Genes & Development*. **12** (5): 706–20. [doi](/source/Doi_(identifier)):[10.1101/gad.12.5.706](https://doi.org/10.1101%2Fgad.12.5.706). [PMC](/source/PMC_(identifier)) [316589](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC316589). [PMID](/source/PMID_(identifier)) [9499405](https://pubmed.ncbi.nlm.nih.gov/9499405).

1. **[^](#cite_ref-pmid10037602_20-0)** Lu PJ, Zhou XZ, Shen M, Lu KP (Feb 1999). "Function of WW domains as phosphoserine- or phosphothreonine-binding modules". *Science*. **283** (5406): 1325–8. [Bibcode](/source/Bibcode_(identifier)):[1999Sci...283.1325L](https://ui.adsabs.harvard.edu/abs/1999Sci...283.1325L). [doi](/source/Doi_(identifier)):[10.1126/science.283.5406.1325](https://doi.org/10.1126%2Fscience.283.5406.1325). [PMID](/source/PMID_(identifier)) [10037602](https://pubmed.ncbi.nlm.nih.gov/10037602).

## Further reading

- Tugendreich S, Tomkiel J, Earnshaw W, Hieter P (Apr 1995). ["CDC27Hs colocalizes with CDC16Hs to the centrosome and mitotic spindle and is essential for the metaphase to anaphase transition"](https://doi.org/10.1016%2F0092-8674%2895%2990336-4). *Cell*. **81** (2): 261–8. [doi](/source/Doi_(identifier)):[10.1016/0092-8674(95)90336-4](https://doi.org/10.1016%2F0092-8674%2895%2990336-4). [PMID](/source/PMID_(identifier)) [7736578](https://pubmed.ncbi.nlm.nih.gov/7736578). [S2CID](/source/S2CID_(identifier)) [17907584](https://api.semanticscholar.org/CorpusID:17907584).

- Chen PL, Ueng YC, Durfee T, Chen KC, Yang-Feng T, Lee WH (Feb 1995). "Identification of a human homologue of yeast nuc2 which interacts with the retinoblastoma protein in a specific manner". *Cell Growth & Differentiation*. **6** (2): 199–210. [PMID](/source/PMID_(identifier)) [7756179](https://pubmed.ncbi.nlm.nih.gov/7756179).

- Ho PP, Couch FJ, Brody LC, Abel KJ, Boehnke M, Shearon TH, Chandrasekharappa SC, Collins FS, Weber BL (Sep 1995). "Localization of the human homolog of the yeast cell division control 27 gene (CDC27) proximal to ITGB3 on human chromosome 17q21.3". *Somatic Cell and Molecular Genetics*. **21** (5): 351–5. [doi](/source/Doi_(identifier)):[10.1007/BF02257470](https://doi.org/10.1007%2FBF02257470). [hdl](/source/Hdl_(identifier)):[2027.42/45546](https://hdl.handle.net/2027.42%2F45546). [PMID](/source/PMID_(identifier)) [8619132](https://pubmed.ncbi.nlm.nih.gov/8619132). [S2CID](/source/S2CID_(identifier)) [9614052](https://api.semanticscholar.org/CorpusID:9614052).

- Ollendorff V, Donoghue DJ (Dec 1997). ["The serine/threonine phosphatase PP5 interacts with CDC16 and CDC27, two tetratricopeptide repeat-containing subunits of the anaphase-promoting complex"](https://doi.org/10.1074%2Fjbc.272.51.32011). *The Journal of Biological Chemistry*. **272** (51): 32011–8. [doi](/source/Doi_(identifier)):[10.1074/jbc.272.51.32011](https://doi.org/10.1074%2Fjbc.272.51.32011). [PMID](/source/PMID_(identifier)) [9405394](https://pubmed.ncbi.nlm.nih.gov/9405394).

- Yu H, Peters JM, King RW, Page AM, Hieter P, Kirschner MW (Feb 1998). "Identification of a cullin homology region in a subunit of the anaphase-promoting complex". *Science*. **279** (5354): 1219–22. [Bibcode](/source/Bibcode_(identifier)):[1998Sci...279.1219Y](https://ui.adsabs.harvard.edu/abs/1998Sci...279.1219Y). [doi](/source/Doi_(identifier)):[10.1126/science.279.5354.1219](https://doi.org/10.1126%2Fscience.279.5354.1219). [PMID](/source/PMID_(identifier)) [9469815](https://pubmed.ncbi.nlm.nih.gov/9469815).

- Shen M, Stukenberg PT, Kirschner MW, Lu KP (Mar 1998). ["The essential mitotic peptidyl-prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteins"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC316589). *Genes & Development*. **12** (5): 706–20. [doi](/source/Doi_(identifier)):[10.1101/gad.12.5.706](https://doi.org/10.1101%2Fgad.12.5.706). [PMC](/source/PMC_(identifier)) [316589](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC316589). [PMID](/source/PMID_(identifier)) [9499405](https://pubmed.ncbi.nlm.nih.gov/9499405).

- Zhou BB, Li H, Yuan J, Kirschner MW (Jun 1998). ["Caspase-dependent activation of cyclin-dependent kinases during Fas-induced apoptosis in Jurkat cells"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC22635). *Proceedings of the National Academy of Sciences of the United States of America*. **95** (12): 6785–90. [Bibcode](/source/Bibcode_(identifier)):[1998PNAS...95.6785Z](https://ui.adsabs.harvard.edu/abs/1998PNAS...95.6785Z). [doi](/source/Doi_(identifier)):[10.1073/pnas.95.12.6785](https://doi.org/10.1073%2Fpnas.95.12.6785). [PMC](/source/PMC_(identifier)) [22635](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC22635). [PMID](/source/PMID_(identifier)) [9618490](https://pubmed.ncbi.nlm.nih.gov/9618490).

- Wassmann K, Benezra R (Sep 1998). ["Mad2 transiently associates with an APC/p55Cdc complex during mitosis"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC21618). *Proceedings of the National Academy of Sciences of the United States of America*. **95** (19): 11193–8. [Bibcode](/source/Bibcode_(identifier)):[1998PNAS...9511193W](https://ui.adsabs.harvard.edu/abs/1998PNAS...9511193W). [doi](/source/Doi_(identifier)):[10.1073/pnas.95.19.11193](https://doi.org/10.1073%2Fpnas.95.19.11193). [PMC](/source/PMC_(identifier)) [21618](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC21618). [PMID](/source/PMID_(identifier)) [9736712](https://pubmed.ncbi.nlm.nih.gov/9736712).

- Lu PJ, Zhou XZ, Shen M, Lu KP (Feb 1999). "Function of WW domains as phosphoserine- or phosphothreonine-binding modules". *Science*. **283** (5406): 1325–8. [Bibcode](/source/Bibcode_(identifier)):[1999Sci...283.1325L](https://ui.adsabs.harvard.edu/abs/1999Sci...283.1325L). [doi](/source/Doi_(identifier)):[10.1126/science.283.5406.1325](https://doi.org/10.1126%2Fscience.283.5406.1325). [PMID](/source/PMID_(identifier)) [10037602](https://pubmed.ncbi.nlm.nih.gov/10037602).

- Grossberger R, Gieffers C, Zachariae W, Podtelejnikov AV, Schleiffer A, Nasmyth K, Mann M, Peters JM (May 1999). ["Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complex"](https://doi.org/10.1074%2Fjbc.274.20.14500). *The Journal of Biological Chemistry*. **274** (20): 14500–7. [doi](/source/Doi_(identifier)):[10.1074/jbc.274.20.14500](https://doi.org/10.1074%2Fjbc.274.20.14500). [PMID](/source/PMID_(identifier)) [10318877](https://pubmed.ncbi.nlm.nih.gov/10318877).

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## External links

- Human [*CDC27*](https://genome.ucsc.edu/cgi-bin/hgTracks?db=hg38&singleSearch=knownCanonical&position=CDC27) genome location and [*CDC27*](https://genome.ucsc.edu/cgi-bin/hgGene?db=hg38&hgg_type=knownGene&hgg_gene=CDC27) gene details page in the [UCSC Genome Browser](/source/UCSC_Genome_Browser).

- Overview of all the structural information available in the [PDB](/source/Protein_Data_Bank) for [UniProt](/source/UniProt): *[P30260](https://www.ebi.ac.uk/pdbe/pdbe-kb/proteins/P30260)* (Cell division cycle protein 27 homolog) at the [PDBe-KB](/source/PDBe-KB).

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Adapted from the Wikipedia article [CDC27](https://en.wikipedia.org/wiki/CDC27) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/CDC27?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.