# CDC23

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Protein-coding gene in humans

CDC23 Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4UI9, 5A31, 5G05, 5G04 Identifiers Aliases CDC23, ANAPC8, APC8, CUT23, cell division cycle 23 External IDs OMIM: 603462; MGI: 1098815; HomoloGene: 3426; GeneCards: CDC23; OMA:CDC23 - orthologs Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q31.2 Start 138,187,650 bp[1] End 138,213,343 bp[1] Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18 B1|18 18.69 cM Start 34,764,004 bp[2] End 34,784,788 bp[2] RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad ventricular zone tibia endothelial cell rectum cerebellar hemisphere right hemisphere of cerebellum ovary islet of Langerhans left ovary Top expressed in genital tubercle tail of embryo ventricular zone mandibular prominence medullary collecting duct superior cervical ganglion maxillary prominence abdominal wall ganglionic eminence renal corpuscle More reference expression data BioGPS More reference expression data Gene ontology Molecular function ubiquitin-protein transferase activity protein binding Cellular component nucleoplasm cytosol intracellular anatomical structure anaphase-promoting complex Biological process ubiquitin-dependent protein catabolic process regulation of exit from mitosis regulation of mitotic metaphase/anaphase transition cell cycle cell division protein K11-linked ubiquitination metaphase anaphase-promoting complex-dependent catabolic process protein ubiquitination mitotic metaphase plate congression mitotic cell cycle regulation of mitotic cell cycle phase transition Sources:Amigo / QuickGO Orthologs Species Human Mouse Entrez 8697 52563 Ensembl ENSG00000094880 ENSMUSG00000024370 UniProt Q9UJX2 Q8BGZ4 RefSeq (mRNA) NM_004661 NM_178347 RefSeq (protein) NP_004652 NP_848124 Location (UCSC) Chr 5: 138.19 – 138.21 Mb Chr 18: 34.76 – 34.78 Mb PubMed search [3] [4] Wikidata View/Edit Human View/Edit Mouse

**Cell division cycle 23 homolog (S. cerevisiae)**, also known as **CDC23**, is a [protein](/source/Protein) that is encoded by the *CDC23* [gene](/source/Gene) in humans.[5]

## Function

The CDC23 protein shares strong similarity with Saccharomyces cerevisiae Cdc23, a protein essential for [cell cycle](/source/Cell_cycle) progression through the G2/M transition. This protein is a component of [anaphase-promoting complex](/source/Anaphase-promoting_complex) (APC), which is composed of eight protein subunits and highly conserved in eukaryotic cells. APC catalyzes the formation of [cyclin B](/source/Cyclin_B)-[ubiquitin](/source/Ubiquitin) conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the [TPR](/source/Tetratricopeptide) (tetratricopeptide repeat), a protein domain important for protein-protein interaction.[5]

## Interactions

CDC23 has been shown to [interact](/source/Protein-protein_interaction) with [CDC27](/source/CDC27).[6][7]

## References

1. ^ [***a***](#cite_ref-refGRCh38Ensembl_1-0) [***b***](#cite_ref-refGRCh38Ensembl_1-1) [***c***](#cite_ref-refGRCh38Ensembl_1-2) [GRCh38: Ensembl release 89: ENSG00000094880](http://May2017.archive.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000094880) – [Ensembl](/source/Ensembl_genome_database_project), May 2017

1. ^ [***a***](#cite_ref-refGRCm38Ensembl_2-0) [***b***](#cite_ref-refGRCm38Ensembl_2-1) [***c***](#cite_ref-refGRCm38Ensembl_2-2) [GRCm38: Ensembl release 89: ENSMUSG00000024370](http://May2017.archive.ensembl.org/Mus_musculus/Gene/Summary?db=core;g=ENSMUSG00000024370) – [Ensembl](/source/Ensembl_genome_database_project), May 2017

1. **[^](#cite_ref-3)** ["Human PubMed Reference:"](https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=8697). *National Center for Biotechnology Information, U.S. National Library of Medicine*.

1. **[^](#cite_ref-4)** ["Mouse PubMed Reference:"](https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=52563). *National Center for Biotechnology Information, U.S. National Library of Medicine*.

1. ^ [***a***](#cite_ref-entrez_5-0) [***b***](#cite_ref-entrez_5-1) ["Entrez Gene: CDC23 cell division cycle 23 homolog (S. cerevisiae)"](https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=8697).

1. **[^](#cite_ref-pmid12956947_6-0)** Vodermaier HC, Gieffers C, Maurer-Stroh S, Eisenhaber F, Peters JM (Sep 2003). ["TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1"](https://doi.org/10.1016%2FS0960-9822%2803%2900581-5). *Current Biology*. **13** (17): 1459–68. [Bibcode](/source/Bibcode_(identifier)):[2003CBio...13.1459V](https://ui.adsabs.harvard.edu/abs/2003CBio...13.1459V). [doi](/source/Doi_(identifier)):[10.1016/S0960-9822(03)00581-5](https://doi.org/10.1016%2FS0960-9822%2803%2900581-5). [PMID](/source/PMID_(identifier)) [12956947](https://pubmed.ncbi.nlm.nih.gov/12956947).

1. **[^](#cite_ref-pmid10922056_7-0)** Gmachl M, Gieffers C, Podtelejnikov AV, Mann M, Peters JM (Aug 2000). ["The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC16806). *Proceedings of the National Academy of Sciences of the United States of America*. **97** (16): 8973–8. [Bibcode](/source/Bibcode_(identifier)):[2000PNAS...97.8973G](https://ui.adsabs.harvard.edu/abs/2000PNAS...97.8973G). [doi](/source/Doi_(identifier)):[10.1073/pnas.97.16.8973](https://doi.org/10.1073%2Fpnas.97.16.8973). [PMC](/source/PMC_(identifier)) [16806](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC16806). [PMID](/source/PMID_(identifier)) [10922056](https://pubmed.ncbi.nlm.nih.gov/10922056).

## External links

- Human [*CDC23*](https://genome.ucsc.edu/cgi-bin/hgTracks?db=hg38&singleSearch=knownCanonical&position=CDC23) genome location and [*CDC23*](https://genome.ucsc.edu/cgi-bin/hgGene?db=hg38&hgg_type=knownGene&hgg_gene=CDC23) gene details page in the [UCSC Genome Browser](/source/UCSC_Genome_Browser).

## Further reading

- Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". *Gene*. **138** (1–2): 171–4. [doi](/source/Doi_(identifier)):[10.1016/0378-1119(94)90802-8](https://doi.org/10.1016%2F0378-1119%2894%2990802-8). [PMID](/source/PMID_(identifier)) [8125298](https://pubmed.ncbi.nlm.nih.gov/8125298).

- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". *Gene*. **200** (1–2): 149–56. [doi](/source/Doi_(identifier)):[10.1016/S0378-1119(97)00411-3](https://doi.org/10.1016%2FS0378-1119%2897%2900411-3). [PMID](/source/PMID_(identifier)) [9373149](https://pubmed.ncbi.nlm.nih.gov/9373149).

- Yu H, Peters JM, King RW, Page AM, Hieter P, Kirschner MW (Feb 1998). "Identification of a cullin homology region in a subunit of the anaphase-promoting complex". *Science*. **279** (5354): 1219–22. [Bibcode](/source/Bibcode_(identifier)):[1998Sci...279.1219Y](https://ui.adsabs.harvard.edu/abs/1998Sci...279.1219Y). [doi](/source/Doi_(identifier)):[10.1126/science.279.5354.1219](https://doi.org/10.1126%2Fscience.279.5354.1219). [PMID](/source/PMID_(identifier)) [9469815](https://pubmed.ncbi.nlm.nih.gov/9469815).

- Zhao N, Lai F, Fernald AA, Eisenbart JD, Espinosa R, Wang PW, Le Beau MM (Oct 1998). "Human CDC23: cDNA cloning, mapping to 5q31, genomic structure, and evaluation as a candidate tumor suppressor gene in myeloid leukemias". *Genomics*. **53** (2): 184–90. [doi](/source/Doi_(identifier)):[10.1006/geno.1998.5473](https://doi.org/10.1006%2Fgeno.1998.5473). [PMID](/source/PMID_(identifier)) [9790767](https://pubmed.ncbi.nlm.nih.gov/9790767).

- Grossberger R, Gieffers C, Zachariae W, Podtelejnikov AV, Schleiffer A, Nasmyth K, Mann M, Peters JM (May 1999). ["Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complex"](https://doi.org/10.1074%2Fjbc.274.20.14500). *The Journal of Biological Chemistry*. **274** (20): 14500–7. [doi](/source/Doi_(identifier)):[10.1074/jbc.274.20.14500](https://doi.org/10.1074%2Fjbc.274.20.14500). [PMID](/source/PMID_(identifier)) [10318877](https://pubmed.ncbi.nlm.nih.gov/10318877).

- Gieffers C, Peters BH, Kramer ER, Dotti CG, Peters JM (Sep 1999). ["Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC18031). *Proceedings of the National Academy of Sciences of the United States of America*. **96** (20): 11317–22. [Bibcode](/source/Bibcode_(identifier)):[1999PNAS...9611317G](https://ui.adsabs.harvard.edu/abs/1999PNAS...9611317G). [doi](/source/Doi_(identifier)):[10.1073/pnas.96.20.11317](https://doi.org/10.1073%2Fpnas.96.20.11317). [PMC](/source/PMC_(identifier)) [18031](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC18031). [PMID](/source/PMID_(identifier)) [10500174](https://pubmed.ncbi.nlm.nih.gov/10500174).

- Gmachl M, Gieffers C, Podtelejnikov AV, Mann M, Peters JM (Aug 2000). ["The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC16806). *Proceedings of the National Academy of Sciences of the United States of America*. **97** (16): 8973–8. [Bibcode](/source/Bibcode_(identifier)):[2000PNAS...97.8973G](https://ui.adsabs.harvard.edu/abs/2000PNAS...97.8973G). [doi](/source/Doi_(identifier)):[10.1073/pnas.97.16.8973](https://doi.org/10.1073%2Fpnas.97.16.8973). [PMC](/source/PMC_(identifier)) [16806](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC16806). [PMID](/source/PMID_(identifier)) [10922056](https://pubmed.ncbi.nlm.nih.gov/10922056).

- Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (Sep 2000). ["Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1083732). *EMBO Reports*. **1** (3): 287–92. [doi](/source/Doi_(identifier)):[10.1093/embo-reports/kvd058](https://doi.org/10.1093%2Fembo-reports%2Fkvd058). [PMC](/source/PMC_(identifier)) [1083732](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1083732). [PMID](/source/PMID_(identifier)) [11256614](https://pubmed.ncbi.nlm.nih.gov/11256614).

- Walker MG (May 2001). "Drug target discovery by gene expression analysis: cell cycle genes". *[Current Cancer Drug Targets](/source/Current_Cancer_Drug_Targets)*. **1** (1): 73–83. [doi](/source/Doi_(identifier)):[10.2174/1568009013334241](https://doi.org/10.2174%2F1568009013334241). [PMID](/source/PMID_(identifier)) [12188893](https://pubmed.ncbi.nlm.nih.gov/12188893).

- Wang Q, Moyret-Lalle C, Couzon F, Surbiguet-Clippe C, Saurin JC, Lorca T, Navarro C, Puisieux A (Mar 2003). ["Alterations of anaphase-promoting complex genes in human colon cancer cells"](https://doi.org/10.1038%2Fsj.onc.1206224). *Oncogene*. **22** (10): 1486–90. [doi](/source/Doi_(identifier)):[10.1038/sj.onc.1206224](https://doi.org/10.1038%2Fsj.onc.1206224). [PMID](/source/PMID_(identifier)) [12629511](https://pubmed.ncbi.nlm.nih.gov/12629511).

- Vodermaier HC, Gieffers C, Maurer-Stroh S, Eisenhaber F, Peters JM (Sep 2003). ["TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1"](https://doi.org/10.1016%2FS0960-9822%2803%2900581-5). *Current Biology*. **13** (17): 1459–68. [Bibcode](/source/Bibcode_(identifier)):[2003CBio...13.1459V](https://ui.adsabs.harvard.edu/abs/2003CBio...13.1459V). [doi](/source/Doi_(identifier)):[10.1016/S0960-9822(03)00581-5](https://doi.org/10.1016%2FS0960-9822%2803%2900581-5). [PMID](/source/PMID_(identifier)) [12956947](https://pubmed.ncbi.nlm.nih.gov/12956947).

- Kraft C, Herzog F, Gieffers C, Mechtler K, Hagting A, Pines J, Peters JM (Dec 2003). ["Mitotic regulation of the human anaphase-promoting complex by phosphorylation"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC291822). *The EMBO Journal*. **22** (24): 6598–609. [doi](/source/Doi_(identifier)):[10.1093/emboj/cdg627](https://doi.org/10.1093%2Femboj%2Fcdg627). [PMC](/source/PMC_(identifier)) [291822](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC291822). [PMID](/source/PMID_(identifier)) [14657031](https://pubmed.ncbi.nlm.nih.gov/14657031).

- Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (Aug 2004). ["Large-scale characterization of HeLa cell nuclear phosphoproteins"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC514446). *Proceedings of the National Academy of Sciences of the United States of America*. **101** (33): 12130–5. [Bibcode](/source/Bibcode_(identifier)):[2004PNAS..10112130B](https://ui.adsabs.harvard.edu/abs/2004PNAS..10112130B). [doi](/source/Doi_(identifier)):[10.1073/pnas.0404720101](https://doi.org/10.1073%2Fpnas.0404720101). [PMC](/source/PMC_(identifier)) [514446](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC514446). [PMID](/source/PMID_(identifier)) [15302935](https://pubmed.ncbi.nlm.nih.gov/15302935).

- Ballif BA, Villén J, Beausoleil SA, Schwartz D, Gygi SP (Nov 2004). ["Phosphoproteomic analysis of the developing mouse brain"](https://doi.org/10.1074%2Fmcp.M400085-MCP200). *Molecular & Cellular Proteomics*. **3** (11): 1093–101. [doi](/source/Doi_(identifier)):[10.1074/mcp.M400085-MCP200](https://doi.org/10.1074%2Fmcp.M400085-MCP200). [PMID](/source/PMID_(identifier)) [15345747](https://pubmed.ncbi.nlm.nih.gov/15345747).

- Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". *Nature*. **437** (7062): 1173–8. [Bibcode](/source/Bibcode_(identifier)):[2005Natur.437.1173R](https://ui.adsabs.harvard.edu/abs/2005Natur.437.1173R). [doi](/source/Doi_(identifier)):[10.1038/nature04209](https://doi.org/10.1038%2Fnature04209). [PMID](/source/PMID_(identifier)) [16189514](https://pubmed.ncbi.nlm.nih.gov/16189514). [S2CID](/source/S2CID_(identifier)) [4427026](https://api.semanticscholar.org/CorpusID:4427026).

- Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (Apr 2006). ["Phosphoproteome analysis of the human mitotic spindle"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1459365). *Proceedings of the National Academy of Sciences of the United States of America*. **103** (14): 5391–6. [Bibcode](/source/Bibcode_(identifier)):[2006PNAS..103.5391N](https://ui.adsabs.harvard.edu/abs/2006PNAS..103.5391N). [doi](/source/Doi_(identifier)):[10.1073/pnas.0507066103](https://doi.org/10.1073%2Fpnas.0507066103). [PMC](/source/PMC_(identifier)) [1459365](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1459365). [PMID](/source/PMID_(identifier)) [16565220](https://pubmed.ncbi.nlm.nih.gov/16565220).

- Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (Oct 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". *Nature Biotechnology*. **24** (10): 1285–92. [doi](/source/Doi_(identifier)):[10.1038/nbt1240](https://doi.org/10.1038%2Fnbt1240). [PMID](/source/PMID_(identifier)) [16964243](https://pubmed.ncbi.nlm.nih.gov/16964243). [S2CID](/source/S2CID_(identifier)) [14294292](https://api.semanticscholar.org/CorpusID:14294292).

- Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). ["Global, in vivo, and site-specific phosphorylation dynamics in signaling networks"](https://doi.org/10.1016%2Fj.cell.2006.09.026). *Cell*. **127** (3): 635–48. [doi](/source/Doi_(identifier)):[10.1016/j.cell.2006.09.026](https://doi.org/10.1016%2Fj.cell.2006.09.026). [PMID](/source/PMID_(identifier)) [17081983](https://pubmed.ncbi.nlm.nih.gov/17081983).

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Adapted from the Wikipedia article [CDC23](https://en.wikipedia.org/wiki/CDC23) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/CDC23?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.