# CD64

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Integral membrane glycoprotein

Fc fragment of IgG, high affinity Ia, receptor (CD64) Identifiers Symbol FCGR1A NCBI gene 2209 HGNC 3613 OMIM 146760 RefSeq NM_000566 UniProt P12314 Other data Locus Chr. 1 q21.2-21.3 Search for Structures Swiss-model Domains InterPro

Fc fragment of IgG, high affinity Ib, receptor (CD64) Identifiers Symbol FCGR1B NCBI gene 2210 HGNC 3614 OMIM 601502 RefSeq NM_001004340 UniProt Q92637 Other data Locus Chr. 1 p11.2 Search for Structures Swiss-model Domains InterPro

Fc fragment of IgG, high affinity Ic, receptor (CD64) Identifiers Symbol FCGR1C NCBI gene 2211 HGNC 3615 OMIM 601503 RefSeq XM_001133198 Other data Locus Chr. 1 q21.1

**CD64** (**C**luster of **D**ifferentiation **64**) is a type of [integral membrane](/source/Integral_membrane_protein) [glycoprotein](/source/Glycoprotein) known as an [Fc receptor](/source/Fc_receptor) that binds [monomeric](/source/Monomer) IgG-type [antibodies](/source/Antibody) with high [affinity](/source/Affinity_(pharmacology)).[1] It is more commonly known as Fc-gamma receptor 1 (FcγRI). After binding [IgG](/source/Immunoglobulin_G), CD64 interacts with an accessory chain known as the common γ chain (γ chain), which possesses an [ITAM](/source/Immunoreceptor_tyrosine-based_activation_motif) motif that is necessary for triggering cellular activation.[2]

Structurally CD64 is composed of a [signal peptide](/source/Signal_peptide) that allows its transport to the surface of a cell, three [extracellular](/source/Extracellular) [immunoglobulin domains](/source/Immunoglobulin_domain) of the C2-type that it uses to bind antibody, a [hydrophobic](/source/Hydrophobic) transmembrane domain, and a short cytoplasmic tail.[3]

CD64 is [constitutively](https://en.wiktionary.org/wiki/constitutive) found on only macrophages and monocytes, but treatment of [polymorphonuclear leukocytes](/source/Polymorphonuclear_leukocyte) with cytokines like [IFNγ](/source/IFN%CE%B3) and [G-CSF](/source/G-CSF) can induce CD64 expression on these cells.[4][5]

There are three distinct (but highly similar) [genes](/source/Gene) in humans for CD64 called FcγRIA (CD64A), FcγRIB (CD64B), and FcγRIC (CD64C) that are located on [chromosome 1](/source/Chromosome_1).[6] These three genes produce six different [mRNA](/source/MRNA) transcripts; two from CD64A, three from CD64B, and one from CD64C; by alternate splicing.[3]

## References

1. **[^](#cite_ref-1)** Hulett M, Hogarth P (1998). "The second and third extracellular domains of FcgammaRI (CD64) confer the unique high affinity binding of IgG2a". *Mol Immunol*. **35** (14–15): 989–96. [doi](/source/Doi_(identifier)):[10.1016/S0161-5890(98)00069-8](https://doi.org/10.1016%2FS0161-5890%2898%2900069-8). [PMID](/source/PMID_(identifier)) [9881694](https://pubmed.ncbi.nlm.nih.gov/9881694).

1. **[^](#cite_ref-2)** Nimmerjahn F, Ravetch J (2006). ["Fcgamma receptors: old friends and new family members"](https://doi.org/10.1016%2Fj.immuni.2005.11.010). *Immunity*. **24** (1): 19–28. [doi](/source/Doi_(identifier)):[10.1016/j.immuni.2005.11.010](https://doi.org/10.1016%2Fj.immuni.2005.11.010). [PMID](/source/PMID_(identifier)) [16413920](https://pubmed.ncbi.nlm.nih.gov/16413920).

1. ^ [***a***](#cite_ref-Ernst_L,_Duchemin_A,_Miller_K,_Anderson_C_1998_943–54_3-0) [***b***](#cite_ref-Ernst_L,_Duchemin_A,_Miller_K,_Anderson_C_1998_943–54_3-1) Ernst L, Duchemin A, Miller K, Anderson C (1998). "Molecular characterization of six variant Fcgamma receptor class I (CD64) transcripts". *Mol Immunol*. **35** (14–15): 943–54. [doi](/source/Doi_(identifier)):[10.1016/s0161-5890(98)00079-0](https://doi.org/10.1016%2Fs0161-5890%2898%2900079-0). [PMID](/source/PMID_(identifier)) [9881690](https://pubmed.ncbi.nlm.nih.gov/9881690).

1. **[^](#cite_ref-4)** Perussia B, Dayton E, Lazarus R, Fanning V, Trinchieri G (1983). ["Immune interferon induces the receptor for monomeric IgG1 on human monocytic and myeloid cells"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187379). *J Exp Med*. **158** (4): 1092–113. [doi](/source/Doi_(identifier)):[10.1084/jem.158.4.1092](https://doi.org/10.1084%2Fjem.158.4.1092). [PMC](/source/PMC_(identifier)) [2187379](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187379). [PMID](/source/PMID_(identifier)) [6225822](https://pubmed.ncbi.nlm.nih.gov/6225822).

1. **[^](#cite_ref-5)** Repp R, Valerius T, Sendler A, Gramatzki M, Iro H, Kalden J, Platzer E (1991). ["Neutrophils express the high affinity receptor for IgG (Fc gamma RI, CD64) after in vivo application of recombinant human granulocyte colony-stimulating factor"](https://doi.org/10.1182%2Fblood.V78.4.885.885). *Blood*. **78** (4): 885–9. [doi](/source/Doi_(identifier)):[10.1182/blood.V78.4.885.885](https://doi.org/10.1182%2Fblood.V78.4.885.885). [PMID](/source/PMID_(identifier)) [1714327](https://pubmed.ncbi.nlm.nih.gov/1714327).

1. **[^](#cite_ref-6)** Ernst L, van de Winkel J, Chiu I, Anderson C (1992). ["Three genes for the human high affinity Fc receptor for IgG (Fc gamma RI) encode four distinct transcription products"](https://doi.org/10.1016%2FS0021-9258%2819%2949591-4). *J Biol Chem*. **267** (22): 15692–700. [doi](/source/Doi_(identifier)):[10.1016/S0021-9258(19)49591-4](https://doi.org/10.1016%2FS0021-9258%2819%2949591-4). [PMID](/source/PMID_(identifier)) [1379234](https://pubmed.ncbi.nlm.nih.gov/1379234).

## External links

- [CD64+Antigens](https://meshb.nlm.nih.gov/record/ui?name=CD64+Antigens) at the U.S. National Library of Medicine [Medical Subject Headings](/source/Medical_Subject_Headings) (MeSH)

v t e Proteins: clusters of differentiation (see also list of human clusters of differentiation) 1–50 CD1 a-c 1A 1B 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50 51–100 CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100 101–150 CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150 151–200 CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200 201–250 CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 CD248 CD249 251–300 CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299 301–350 CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD327 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350 351–371 CD351 CD352 CD353 CD354 CD355 CD357 CD358 CD360 CD361 CD362 CD363 CD364 CD365 CD366 CD367 CD368 CD369 CD370 CD371 Category Commons

v t e Cluster of differentiation by lineage Lymphoid B cell Pre-B cell: CD10/CALLA CD79A mature: CD19 CD20 CD21/CR2 CD23/FcεRII CD127 CD40 plasma cell: CD38 CD138 T/NK T cell Pan-T antigens: CD3 CD7 CD1 CD4 CD8 CD13 CD18 CD26 CD27 CD28 NK cell CD16 CD56/NCAM CD57 All CD2 All CD5 Myeloid CFU-GM/ Myelomonocyte CD11c CD14 CD15 CD31 CD64 CD68 MEP CFU-Meg CD34/CD36 CD42 CD41/CD61 CFU-E CD36 CD71 All (pan-myeloid) CD13 CD33 Stem cell CD34

v t e Transmembrane receptors: immunoglobulin superfamily immune receptors Antibody receptor: Fc receptor Epsilon (ε) FcεRI (FcεRII is C-type lectin) Gamma (γ) FcγRI FcγRII FcγRIII Neonatal Alpha (α)/mu (μ) FcαRI Fcα/μR Secretory Polymeric immunoglobulin receptor Antigen receptor B cells Antigen receptor BCR Co-receptor stimulate: CD21/CD19/CD81 inhibit: CD22 Accessory molecules Ig-α/Ig-β (CD79) T cells Ligands MHC MHC class I MHC class II Antigen receptor TCR: TRA@ TRB@ TRD@ TRG@ Co-receptors CD8 (with two glycoprotein chains CD8α and CD8β) CD4 Accessory molecules CD3 CD3γ CD3δ CD3ε CD3ζ Cytokine receptor see cytokine receptors Killer-cell IG-like receptors KIR2DL1 KIR2DL2 KIR2DL3 KIR2DL4 KIR2DL5A KIR2DL5B KIR2DS1 KIR2DS2 KIR2DS3 KIR2DS4 KIR2DS5 KIR3DL1 KIR3DL2 KIR3DL3 KIR3DS1 Leukocyte IG-like receptors LILRA1 LILRA2 LILRA3 LILRA4 LILRA5 LILRA6 LILRB1 LILRB2 LILRB3 LILRB4 LILRB5

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Adapted from the Wikipedia article [CD64](https://en.wikipedia.org/wiki/CD64) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/CD64?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.