# CD3EAP

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> Source: https://en.wikipedia.org/wiki/CD3EAP
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{{Short description|Protein-coding gene in humans}}
{{Infobox_gene}}
'''DNA-directed RNA polymerase I subunit RPA34''' is an [enzyme](/source/enzyme) that in humans is encoded by the ''CD3EAP'' [gene](/source/gene).<ref name="pmid10373416">{{cite journal | vauthors = Yamazaki T, Hamano Y, Tashiro H, Itoh K, Nakano H, Miyatake S, Saito T | title = CAST, a novel CD3epsilon-binding protein transducing activation signal for interleukin-2 production in T cells | journal = J Biol Chem | volume = 274 | issue = 26 | pages = 18173–80 |date=Jul 1999 | pmid = 10373416 | doi =10.1074/jbc.274.26.18173  | doi-access = free }}</ref><ref name="pmid9426281">{{cite journal | vauthors = Whitehead CM, Winkfein RJ, Fritzler MJ, Rattner JB | title = ASE-1: a novel protein of the fibrillar centres of the nucleolus and nucleolus organizer region of mitotic chromosomes | journal = Chromosoma | volume = 106 | issue = 8 | pages = 493–502 |date=Mar 1998 | pmid = 9426281 | doi =10.1007/s004120050271  | s2cid = 10684078 }}</ref><ref name="pmid15226435">{{cite journal | vauthors = Yamamoto K, Yamamoto M, Hanada K, Nogi Y, Matsuyama T, Muramatsu M | title = Multiple protein-protein interactions by RNA polymerase I-associated factor PAF49 and role of PAF49 in rRNA transcription | journal = Mol Cell Biol | volume = 24 | issue = 14 | pages = 6338–49 |date=Jun 2004 | pmid = 15226435 | pmc = 434256 | doi = 10.1128/MCB.24.14.6338-6349.2004 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CD3EAP CD3e molecule, epsilon associated protein| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=10849}}</ref>

==Interactions==
CD3EAP has been shown to [interact](/source/Protein-protein_interaction) with [T-cell surface glycoprotein CD3 epsilon chain](/source/T-cell_surface_glycoprotein_CD3_epsilon_chain),<ref name=pmid10373416 /> [POLR1E](/source/POLR1E)<ref name=pmid15226435 /> and [POLR1C](/source/POLR1C).<ref name=pmid15226435/>

==References==
{{reflist}}

==Further reading==
{{refbegin | 2}}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
*{{cite journal  | vauthors=Bouwmeester T, Bauch A, Ruffner H |title=A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. |journal=Nat. Cell Biol. |volume=6 |issue= 2 |pages= 97–105 |year= 2004 |pmid= 14743216 |doi= 10.1038/ncb1086 |s2cid=11683986 |display-authors=etal}}
*{{cite journal  | vauthors=Beausoleil SA, Jedrychowski M, Schwartz D |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101  | pmc=514446 |bibcode=2004PNAS..10112130B |display-authors=etal|doi-access=free }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 |display-authors=etal}}
*{{cite journal  | vauthors=Ma J, Dempsey AA, Stamatiou D |title=Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects. |journal=Atherosclerosis |volume=191 |issue= 1 |pages= 63–72 |year= 2007 |pmid= 16806233 |doi= 10.1016/j.atherosclerosis.2006.05.032 |display-authors=etal}}
*{{cite journal  | vauthors=Panov KI, Panova TB, Gadal O |title=RNA polymerase I-specific subunit CAST/hPAF49 has a role in the activation of transcription by upstream binding factor. |journal=Mol. Cell. Biol. |volume=26 |issue= 14 |pages= 5436–48 |year= 2006 |pmid= 16809778 |doi= 10.1128/MCB.00230-06  | pmc=1592716 |display-authors=etal}}
*{{cite journal  | vauthors=Skjelbred CF, Saebø M, Nexø BA |title=Effects of polymorphisms in ERCC1, ASE-1 and RAI on the risk of colorectal carcinomas and adenomas: a case control study. |journal=BMC Cancer |volume=6|article-number= 175 |year= 2006 |pmid= 16817948 |doi= 10.1186/1471-2407-6-175  | pmc=1533843 |display-authors=etal |doi-access=free }}
*{{cite journal  | vauthors=Beausoleil SA, Villén J, Gerber SA |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285–92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 |s2cid=14294292 |display-authors=etal}}
{{refend}}

==External links==
* {{UCSC gene info|CAST}}
* {{UCSC gene info|CD3EAP}}

{{gene-19-stub}}

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Adapted from the Wikipedia article [CD3EAP](https://en.wikipedia.org/wiki/CD3EAP) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/CD3EAP?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.