# CAP1 > Mediated Wiki article. Canonical URL: https://mediated.wiki/source/CAP1 > Markdown URL: https://mediated.wiki/source/CAP1.md > Source: https://en.wikipedia.org/wiki/CAP1 > Source revision: 1301315799 > License: Creative Commons Attribution-ShareAlike 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/) {{Short description|Gene of the species Homo sapiens}} {{Infobox_gene}} '''Adenylyl cyclase-associated protein 1''' is an [enzyme](/source/enzyme) that in humans is encoded by the ''CAP1'' [gene](/source/gene).{{cite journal | vauthors = Matviw H, Yu G, Young D | title = Identification of a human cDNA encoding a protein that is structurally and functionally related to the yeast adenylyl cyclase-associated CAP proteins | journal = Mol Cell Biol | volume = 12 | issue = 11 | pages = 5033–40 |date=Nov 1992 | pmid = 1406678 | pmc = 360436 | doi = 10.1128/mcb.12.11.5033}}{{cite journal | vauthors = Hubberstey A, Yu G, Loewith R, Lakusta C, Young D | title = Mammalian CAP interacts with CAP, CAP2, and actin | journal = J Cell Biochem | volume = 61 | issue = 3 | pages = 459–66 |date=Apr 1997 | pmid = 8761950 | doi =10.1002/(SICI)1097-4644(19960601)61:3<459::AID-JCB13>3.0.CO;2-E | s2cid = 46076387 }}{{cite web | title = Entrez Gene: CAP1 CAP, adenylate cyclase-associated protein 1 (yeast)| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=10487}} The protein encoded by this gene is related to the ''[Saccharomyces cerevisiae](/source/Saccharomyces_cerevisiae)'' CAP protein, which is involved in the [cyclic AMP](/source/cyclic_AMP) pathway. The human protein is able to interact with other molecules of the same protein, as well as with CAP2 and [actin](/source/actin). ==Interactions== CAP1 has been shown to [interact](/source/Protein-protein_interaction) with [ACTG1](/source/ACTG1){{cite journal |last=Hubberstey |first=A |author2=Yu G |author3=Loewith R |author4=Lakusta C |author5=Young D |date=Jun 1996 |title=Mammalian CAP interacts with CAP, CAP2, and actin |journal=J. Cell. Biochem. |volume=61 |issue=3 |pages=459–66 |location = UNITED STATES| issn = 0730-2312| pmid = 8761950 |doi = 10.1002/(SICI)1097-4644(19960601)61:3<459::AID-JCB13>3.0.CO;2-E |s2cid=46076387 }} and [CAP2](/source/CAP2). ==See also== * [Adenylyl cyclase](/source/Adenylyl_cyclase) ==References== {{reflist}} ==External links== * {{UCSC gene info|CAP1}} ==Further reading== {{refbegin | 2}} *{{cite journal | vauthors=Yu G, Swiston J, Young D |title=Comparison of human CAP and CAP2, homologs of the yeast adenylyl cyclase-associated proteins |journal=J. Cell Sci. |volume=107 |issue= 6|pages= 1671–8 |year= 1994 |doi=10.1242/jcs.107.6.1671 |pmid= 7962207 }} *{{cite journal | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }} *{{cite journal | vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 |display-authors=etal}} *{{cite journal | vauthors=Moriyama K, Yahara I |title=Human CAP1 is a key factor in the recycling of cofilin and actin for rapid actin turnover |journal=J. Cell Sci. |volume=115 |issue= Pt 8 |pages= 1591–601 |year= 2003 |doi=10.1242/jcs.115.8.1591 |pmid= 11950878 }} *{{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal|bibcode=2002PNAS...9916899M |doi-access=free }} *{{cite journal | vauthors=Gevaert K, Goethals M, Martens L |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566–9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810 |s2cid=23783563 |display-authors=etal}} *{{cite journal | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal|doi-access=free }} *{{cite journal | vauthors=Dodatko T, Fedorov AA, Grynberg M |title=Crystal structure of the actin binding domain of the cyclase-associated protein |journal=Biochemistry |volume=43 |issue= 33 |pages= 10628–41 |year= 2004 |pmid= 15311924 |doi= 10.1021/bi049071r |display-authors=etal}} *{{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}} *{{cite journal | vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |display-authors=etal|bibcode=2005Natur.437.1173R |s2cid=4427026 }} *{{cite journal | vauthors=Fautsch MP, Vrabel AM, Johnson DH |title=The identification of myocilin-associated proteins in the human trabecular meshwork |journal=Exp. Eye Res. |volume=82 |issue= 6 |pages= 1046–52 |year= 2006 |pmid= 16289162 |doi= 10.1016/j.exer.2005.09.016 }} *{{cite journal | vauthors=Oh JH, Yang JO, Hahn Y |title=Transcriptome analysis of human gastric cancer |journal=Mamm. Genome |volume=16 |issue= 12 |pages= 942–54 |year= 2006 |pmid= 16341674 |doi= 10.1007/s00335-005-0075-2 |s2cid=69278 |display-authors=etal}} *{{cite journal | vauthors=Gregory SG, Barlow KF, McLay KE |title=The DNA sequence and biological annotation of human chromosome 1 |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 |display-authors=etal|bibcode=2006Natur.441..315G |doi-access=free }} *{{cite journal | vauthors=Beranova-Giorgianni S, Zhao Y, Desiderio DM, Giorgianni F |title=Phosphoproteomic analysis of the human pituitary |journal=Pituitary |volume=9 |issue= 2 |pages= 109–20 |year= 2006|pmid= 16807684 |doi= 10.1007/s11102-006-8916-x |s2cid=10789246 }} *{{cite journal | vauthors=Garewal G, Das R, Awasthi A |title=The clinical significance of the spectrum of interactions of CAP+1 (A-->C), a silent beta-globin gene mutation, with other beta-thalassemia mutations and globin gene modifiers in north Indians |journal=Eur. J. Haematol. |volume=79 |issue= 5 |pages= 417–21 |year= 2007 |pmid= 17900295 |doi= 10.1111/j.1600-0609.2007.00958.x |s2cid=46630115 |display-authors=etal}} {{refend}} {{PDB Gallery|geneid=10487}} {{gene-1-stub}} --- Adapted from the Wikipedia article [CAP1](https://en.wikipedia.org/wiki/CAP1) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/CAP1?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.