# CALY

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> Source: https://en.wikipedia.org/wiki/CALY
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**Neuron-specific vesicular protein calcyon** is a [protein](/source/Protein) that in humans is encoded by the *CALY* [gene](/source/Gene).[1][2] Its alternative name is **Calcyon**.

## Function

The protein encoded by this gene is a type II single [transmembrane protein](/source/Transmembrane_protein). It is required for maximal stimulated [calcium](/source/Calcium) release after stimulation of [purinergic](/source/Purinergic) or [muscarinic](/source/Muscarinic) but not [beta-adrenergic receptors](/source/Beta-adrenergic_receptor). The encoded protein interacts with [dopamine receptor D1](/source/Dopamine_receptor_D1) and may interact with other DA receptor subtypes and/or [GPCRs](/source/G-protein_coupled_receptor).[2]

## Interactions

- [SPARCL1](/source/SPARCL1) (hevin)[3]

## References

1. Heijtz RD, Alexeyenko A, Castellanos FX (July 2007). "Calcyon mRNA expression in the frontal-striatal circuitry and its relationship to vesicular processes and ADHD". *Behavioral and Brain Functions*. **3** (1): 33. [doi:10.1186/1744-9081-3-33](https://doi.org/10.1186/1744-9081-3-33). [PMC 1949817](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1949817). [PMID 17623072](https://pubmed.ncbi.nlm.nih.gov/17623072)

1. ["CALY calcyon neuron specific vesicular protein \[ Homo sapiens (human) \]"](https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=50632)

1. Kim JH, Jung HG, Kim A, Shim HS, Hyeon SJ, Lee YS, Han J, Jung JH, Lee J, Ryu H, Park JY, Hwang EM, Suk K (March 2021). "Hevin-calcyon interaction promotes synaptic reorganization after brain injury". *Cell Death and Differentiation*. **28** (9): 2571–2588. [doi:10.1038/s41418-021-00772-5](https://doi.org/10.1038/s41418-021-00772-5). [PMC 8408247](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8408247). [PMID 33753902](https://pubmed.ncbi.nlm.nih.gov/33753902)

## Further reading

- Milligan G, White JH (October 2001). "Protein-protein interactions at G-protein-coupled receptors". *Trends in Pharmacological Sciences*. **22** (10): 513–8. [doi:10.1016/S0165-6147(00)01801-0](https://doi.org/10.1016/S0165-6147(00)01801-0). [PMID 11583808](https://pubmed.ncbi.nlm.nih.gov/11583808)
- Ali MK, Bergson C (December 2003). "Elevated intracellular calcium triggers recruitment of the receptor cross-talk accessory protein calcyon to the plasma membrane". *The Journal of Biological Chemistry*. **278** (51): 51654–63. [doi:10.1074/jbc.M305803200](https://doi.org/10.1074/jbc.M305803200). [PMID 14534309](https://pubmed.ncbi.nlm.nih.gov/14534309)
- Luo X, Kranzler H, Lappalainen J, Rosenheck R, Charney D, Zuo L, Erdos J, van Kammen DP, Gelernter J (February 2004). "CALCYON gene variation, schizophrenia, and cocaine dependence". *American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics*. **125B** (1): 25–30. [doi:10.1002/ajmg.b.20092](https://doi.org/10.1002/ajmg.b.20092). [PMID 14755439](https://pubmed.ncbi.nlm.nih.gov/14755439). [S2CID 24881261](https://api.semanticscholar.org/CorpusID:24881261)
- Laurin N, Misener VL, Crosbie J, Ickowicz A, Pathare T, Roberts W, Malone M, Tannock R, Schachar R, Kennedy JL, Barr CL (December 2005). "Association of the calcyon gene (DRD1IP) with attention deficit/hyperactivity disorder". *Molecular Psychiatry*. **10** (12): 1117–25. [doi:10.1038/sj.mp.4001737](https://doi.org/10.1038/sj.mp.4001737). [PMID 16172615](https://pubmed.ncbi.nlm.nih.gov/16172615). [S2CID 25367235](https://api.semanticscholar.org/CorpusID:25367235)
- Xiao J, Dai R, Negyessy L, Bergson C (June 2006). "Calcyon, a novel partner of clathrin light chain, stimulates clathrin-mediated endocytosis". *The Journal of Biological Chemistry*. **281** (22): 15182–93. [doi:10.1074/jbc.M600265200](https://doi.org/10.1074/jbc.M600265200). [PMID 16595675](https://pubmed.ncbi.nlm.nih.gov/16595675)
- Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". *Cell*. **127** (3): 635–48. [doi:10.1016/j.cell.2006.09.026](https://doi.org/10.1016/j.cell.2006.09.026). [PMID 17081983](https://pubmed.ncbi.nlm.nih.gov/17081983). [S2CID 7827573](https://api.semanticscholar.org/CorpusID:7827573)
- Kruusmägi M, Zelenin S, Brismar H, Scott L (October 2007). "Intracellular dynamics of calcyon, a neuron-specific vesicular protein". *NeuroReport*. **18** (15): 1547–51. [doi:10.1097/WNR.0b013e3282f03f51](https://doi.org/10.1097/WNR.0b013e3282f03f51). [PMID 17885599](https://pubmed.ncbi.nlm.nih.gov/17885599). [S2CID 24544827](https://api.semanticscholar.org/CorpusID:24544827)

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Adapted from the Wikipedia article [CALY](https://en.wikipedia.org/wiki/CALY) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/CALY?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.