# CA10

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Protein-coding gene in humans

For the [U.S. federal circuit court of appeals](/source/United_States_courts_of_appeals), see [United States Court of Appeals for the Tenth Circuit](/source/United_States_Court_of_Appeals_for_the_Tenth_Circuit). For the highway, see [California State Route 10](/source/California_State_Route_10_(disambiguation)). For the congressional district, see [California's 10th congressional district](/source/California's_10th_congressional_district).

CA10 Identifiers Aliases CA10, CA-RPX, CARPX, HUCEP-15, carbonic anhydrase 10 External IDs OMIM: 604642; MGI: 1919855; HomoloGene: 23201; GeneCards: CA10; OMA:CA10 - orthologs Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.33-q22 Start 51,630,313 bp[1] End 52,160,017 bp[1] Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 D Start 92,988,854 bp[2] End 93,492,575 bp[2] RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cerebellar cortex cerebellar hemisphere right hemisphere of cerebellum cerebellar vermis middle temporal gyrus prefrontal cortex dorsolateral prefrontal cortex pons right frontal lobe Brodmann area 23 Top expressed in lobe of cerebellum cerebellar vermis primary motor cortex habenula ventromedial nucleus anterior amygdaloid area Epithelium of choroid plexus cingulate gyrus prefrontal cortex piriform cortex More reference expression data BioGPS More reference expression data Gene ontology Molecular function molecular function carbonate dehydratase activity zinc ion binding carbonic anhydrase Cellular component cellular component Biological process brain development Sources:Amigo / QuickGO Orthologs Species Human Mouse Entrez 56934 72605 Ensembl ENSG00000154975 ENSMUSG00000056158 UniProt Q9NS85 P61215 RefSeq (mRNA) NM_001082533 NM_001082534 NM_020178 NM_028296 NM_001361707 NM_001361708 RefSeq (protein) NP_001076002 NP_001076003 NP_064563 NP_082572 NP_001348636 NP_001348637 Location (UCSC) Chr 17: 51.63 – 52.16 Mb Chr 11: 92.99 – 93.49 Mb PubMed search [3] [4] Wikidata View/Edit Human View/Edit Mouse

**Carbonic anhydrase-related protein 10** is an [enzyme](/source/Enzyme) that in humans is encoded by the *CA10* [gene](/source/Gene).[5][6][7]

This gene encodes a [protein](/source/Protein) that belongs to the [carbonic anhydrase](/source/Carbonic_anhydrase) family of [zinc](/source/Zinc) [metalloenzymes](/source/Metalloenzymes), which catalyze the reversible hydration of [carbon dioxide](/source/Carbon_dioxide) in various biological processes. The protein encoded by this gene is an acatalytic member of the alpha-carbonic anhydrase subgroup, and it is thought to play a role in the [central nervous system](/source/Central_nervous_system), especially in [brain development](/source/Brain_development). Multiple [transcript variants](/source/Transcript_variants) encoding the same protein have been found for this gene.[7]

## References

1. ^ [***a***](#cite_ref-refGRCh38Ensembl_1-0) [***b***](#cite_ref-refGRCh38Ensembl_1-1) [***c***](#cite_ref-refGRCh38Ensembl_1-2) [GRCh38: Ensembl release 89: ENSG00000154975](http://May2017.archive.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000154975) – [Ensembl](/source/Ensembl_genome_database_project), May 2017

1. ^ [***a***](#cite_ref-refGRCm38Ensembl_2-0) [***b***](#cite_ref-refGRCm38Ensembl_2-1) [***c***](#cite_ref-refGRCm38Ensembl_2-2) [GRCm38: Ensembl release 89: ENSMUSG00000056158](http://May2017.archive.ensembl.org/Mus_musculus/Gene/Summary?db=core;g=ENSMUSG00000056158) – [Ensembl](/source/Ensembl_genome_database_project), May 2017

1. **[^](#cite_ref-3)** ["Human PubMed Reference:"](https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=56934). *National Center for Biotechnology Information, U.S. National Library of Medicine*.

1. **[^](#cite_ref-4)** ["Mouse PubMed Reference:"](https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=72605). *National Center for Biotechnology Information, U.S. National Library of Medicine*.

1. **[^](#cite_ref-pmid8673298_5-0)** Hewett-Emmett D, Tashian RE (Aug 1996). "Functional diversity, conservation, and convergence in the evolution of the alpha-, beta-, and gamma-carbonic anhydrase gene families". *Mol Phylogenet Evol*. **5** (1): 50–77. [doi](/source/Doi_(identifier)):[10.1006/mpev.1996.0006](https://doi.org/10.1006%2Fmpev.1996.0006). [PMID](/source/PMID_(identifier)) [8673298](https://pubmed.ncbi.nlm.nih.gov/8673298).

1. **[^](#cite_ref-pmid9921901_6-0)** Kleiderlein JJ, Nisson PE, Jessee J, Li WB, Becker KG, Derby ML, Ross CA, Margolis RL (Feb 1999). "CCG repeats in cDNAs from human brain". *Hum Genet*. **103** (6): 666–73. [doi](/source/Doi_(identifier)):[10.1007/s004390050889](https://doi.org/10.1007%2Fs004390050889). [PMID](/source/PMID_(identifier)) [9921901](https://pubmed.ncbi.nlm.nih.gov/9921901). [S2CID](/source/S2CID_(identifier)) [23696667](https://api.semanticscholar.org/CorpusID:23696667).

1. ^ [***a***](#cite_ref-entrez_7-0) [***b***](#cite_ref-entrez_7-1) ["Entrez Gene: CA10 carbonic anhydrase X"](https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=56934).

## External links

- Human [*CA10*](https://genome.ucsc.edu/cgi-bin/hgTracks?db=hg38&singleSearch=knownCanonical&position=CA10) genome location and [*CA10*](https://genome.ucsc.edu/cgi-bin/hgGene?db=hg38&hgg_type=knownGene&hgg_gene=CA10) gene details page in the [UCSC Genome Browser](/source/UCSC_Genome_Browser).

## Further reading

- Supuran CT, Scozzafava A, Casini A (2003). ["Carbonic anhydrase inhibitors"](https://doi.org/10.1002%2Fmed.10025). *Med Res Rev*. **23** (2): 146–89. [doi](/source/Doi_(identifier)):[10.1002/med.10025](https://doi.org/10.1002%2Fmed.10025). [PMID](/source/PMID_(identifier)) [12500287](https://pubmed.ncbi.nlm.nih.gov/12500287). [S2CID](/source/S2CID_(identifier)) [90349277](https://api.semanticscholar.org/CorpusID:90349277).

- Supuran CT, Vullo D, Manole G, et al. (2005). "Designing of novel carbonic anhydrase inhibitors and activators". *Curr Med Chem Cardiovasc Hematol Agents*. **2** (1): 49–68. [doi](/source/Doi_(identifier)):[10.2174/1568016043477305](https://doi.org/10.2174%2F1568016043477305). [PMID](/source/PMID_(identifier)) [15328829](https://pubmed.ncbi.nlm.nih.gov/15328829).

- Pastorekova S, Parkkila S, Pastorek J, Supuran CT (2004). "Carbonic anhydrases: current state of the art, therapeutic applications and future prospects". *J Enzyme Inhib Med Chem*. **19** (3): 199–229. [doi](/source/Doi_(identifier)):[10.1080/14756360410001689540](https://doi.org/10.1080%2F14756360410001689540). [PMID](/source/PMID_(identifier)) [15499993](https://pubmed.ncbi.nlm.nih.gov/15499993). [S2CID](/source/S2CID_(identifier)) [218868129](https://api.semanticscholar.org/CorpusID:218868129).

- Wiemann S, Weil B, Wellenreuther R, et al. (2001). ["Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC311072). *Genome Res*. **11** (3): 422–35. [doi](/source/Doi_(identifier)):[10.1101/gr.GR1547R](https://doi.org/10.1101%2Fgr.GR1547R). [PMC](/source/PMC_(identifier)) [311072](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC311072). [PMID](/source/PMID_(identifier)) [11230166](https://pubmed.ncbi.nlm.nih.gov/11230166).

- Okamoto N, Fujikawa-Adachi K, Nishimori I, et al. (2001). "cDNA sequence of human carbonic anhydrase-related protein, CA-RP X: mRNA expressions of CA-RP X and XI in human brain". *Biochim. Biophys. Acta*. **1518** (3): 311–6. [doi](/source/Doi_(identifier)):[10.1016/s0167-4781(01)00193-2](https://doi.org/10.1016%2Fs0167-4781%2801%2900193-2). [PMID](/source/PMID_(identifier)) [11311946](https://pubmed.ncbi.nlm.nih.gov/11311946).

- Taniuchi K, Nishimori I, Takeuchi T, et al. (2002). "Developmental expression of carbonic anhydrase-related proteins VIII, X, and XI in the human brain". *Neuroscience*. **112** (1): 93–9. [doi](/source/Doi_(identifier)):[10.1016/S0306-4522(02)00066-0](https://doi.org/10.1016%2FS0306-4522%2802%2900066-0). [PMID](/source/PMID_(identifier)) [12044474](https://pubmed.ncbi.nlm.nih.gov/12044474). [S2CID](/source/S2CID_(identifier)) [31186391](https://api.semanticscholar.org/CorpusID:31186391).

- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). ["Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241). *Proc. Natl. Acad. Sci. U.S.A*. **99** (26): 16899–903. [Bibcode](/source/Bibcode_(identifier)):[2002PNAS...9916899M](https://ui.adsabs.harvard.edu/abs/2002PNAS...9916899M). [doi](/source/Doi_(identifier)):[10.1073/pnas.242603899](https://doi.org/10.1073%2Fpnas.242603899). [PMC](/source/PMC_(identifier)) [139241](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241). [PMID](/source/PMID_(identifier)) [12477932](https://pubmed.ncbi.nlm.nih.gov/12477932).

- Clark HF, Gurney AL, Abaya E, et al. (2003). ["The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC403697). *Genome Res*. **13** (10): 2265–70. [doi](/source/Doi_(identifier)):[10.1101/gr.1293003](https://doi.org/10.1101%2Fgr.1293003). [PMC](/source/PMC_(identifier)) [403697](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC403697). [PMID](/source/PMID_(identifier)) [12975309](https://pubmed.ncbi.nlm.nih.gov/12975309).

- Gerhard DS, Wagner L, Feingold EA, et al. (2004). ["The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928). *Genome Res*. **14** (10B): 2121–7. [doi](/source/Doi_(identifier)):[10.1101/gr.2596504](https://doi.org/10.1101%2Fgr.2596504). [PMC](/source/PMC_(identifier)) [528928](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928). [PMID](/source/PMID_(identifier)) [15489334](https://pubmed.ncbi.nlm.nih.gov/15489334).

- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). ["Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1356129). *Genome Res*. **16** (1): 55–65. [doi](/source/Doi_(identifier)):[10.1101/gr.4039406](https://doi.org/10.1101%2Fgr.4039406). [PMC](/source/PMC_(identifier)) [1356129](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1356129). [PMID](/source/PMID_(identifier)) [16344560](https://pubmed.ncbi.nlm.nih.gov/16344560).

- Olsen JV, Blagoev B, Gnad F, et al. (2006). ["Global, in vivo, and site-specific phosphorylation dynamics in signaling networks"](https://doi.org/10.1016%2Fj.cell.2006.09.026). *Cell*. **127** (3): 635–48. [doi](/source/Doi_(identifier)):[10.1016/j.cell.2006.09.026](https://doi.org/10.1016%2Fj.cell.2006.09.026). [PMID](/source/PMID_(identifier)) [17081983](https://pubmed.ncbi.nlm.nih.gov/17081983). [S2CID](/source/S2CID_(identifier)) [7827573](https://api.semanticscholar.org/CorpusID:7827573).

v t e Carbonic anhydrases CA1 CA2 CA3 CA4 CA5A CA5B CA6 CA7 CA8 CA9 CA10 CA11 CA12 CA13 CA14

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