# Butamifos

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**Butamifos** is an [herbicide](/source/Herbicide) that is used to control weeds.[1]

## Production

The production of butamifos is based on *N*-[chloro(ethoxy)phosphinothioyl]butan-2-amine and 5-methyl-2-nitrophenol and is described in the following reaction sequence:[2]

## Properties

Butamifos is a [chiral molecule](/source/Chiral_molecule). The technical product uses a mixture of the (*R*)- and (*S*)-isomers.[3]

In a study, the level of pesticide contamination in soil and water of an agriculturally intensive area in Nepal was investigated. [Endosulfan](/source/Endosulfan), Iprobefos, [monocrotophos](/source/Monocrotophos), [mevinphos](/source/Mevinphos), and *butamifos* were detected in water samples, while [cypermethrin](/source/Cypermethrin), [dichlorvos](/source/Dichlorvos), and [cyfluthrin](/source/Cyfluthrin) were detected in soil samples. The increased concentration of butamifos in water may be due to higher water solubility and lower affinity for adsorption in soil.[4]

## Use

### Application and mode of action

Butamifos is used on beans, turf and various vegetables.[2] The active ingredient is a non-systemic, selective herbicide. Its effect is based on inhibition of [microtubule](/source/Microtubule) formation. It also acts as an [acetylcholinesterase inhibitor](/source/Acetylcholinesterase_inhibitor), making it moderately toxic to [mammals](/source/Mammal).[3][5]

### Trade name

A crop protection product containing the active ingredient butamifos is marketed under the trade name Cremart.[2]

### Registration

No plant protection products containing butamifos are registered in the European Union or Switzerland.[6]

## References

1. Toshiyuki Katagi (March 1993), "Photochemistry of organophosphorus herbicide butamifos" (in German), *[Journal of Agricultural and Food Chemistry](/source/Journal_of_Agricultural_and_Food_Chemistry)*. Vol. 41, no. 3, pp. 496–501, [doi:10.1021/jf00027a028](https://doi.org/10.1021/jf00027a028). [ISSN 0021-8561](https://www.worldcat.org/issn/0021-8561)

1. Thomas A. Unger (1996), "Butamifos" (in German), *Pesticide Synthesis Handbook*, Elsevier, p. 376, [doi:10.1016/b978-081551401-5.50299-9](https://doi.org/10.1016/b978-081551401-5.50299-9). ISBN 978-0-8155-1401-5

1. Kafle, B. K., Pokhrel, B., Shrestha, S., Raut, R., Dahal, B. M. (2015), ["Determination of pesticide residues in water and soil samples from Ansikhola watershed, Kavre, Nepal"](https://www.researchgate.net/publication/281430111) (in German), *International Journal of Geology, Earth & Environmental Sciences*. Vol. 5, no. 2, pp. 119-127

1. Paranjape, Kalyani. (2014), *The pesticide encyclopedia* (in German), Wallingford, Oxfordshire UK: CABI, p. 74, ISBN 978-1-78064-014-3

1. ["European Commission Directorate-General for Health and Food Safety"](https://ec.europa.eu/food/plant/pesticides/eu-pesticides-database/active-substances/?event=as.details&as_id=682)

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Adapted from the Wikipedia article [Butamifos](https://en.wikipedia.org/wiki/Butamifos) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/Butamifos?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.