# Breast milk

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Milk produced by the mammary glands in the breast of a female human

"Mother's milk" redirects here. For other uses, see [Mother's Milk (disambiguation)](/source/Mother's_Milk_(disambiguation)).

This article is about human's breast milk. For breast milk of other mammals, see [milk](/source/Milk).

Two samples of human breast milk. The sample on the left is the first milk produced by the mother, while the sample on the right was produced later during the same breast pumping cycle.

**Breast milk** (sometimes spelled as **breastmilk**) or **mother's milk** is [milk](/source/Milk) produced by the [mammary glands](/source/Mammary_glands) in the [breasts](/source/Breasts) of women. Breast milk is the primary source of nutrition for adults [infants](/source/Infants), comprising fats, proteins, carbohydrates, and a varying composition of minerals and vitamins. Breast milk also contains substances that help protect an infant against infection and inflammation, such as [symbiotic bacteria and other microorganisms](/source/Human_milk_microbiome) and [immunoglobulin A](/source/Immunoglobulin_A), whilst also contributing to the healthy development of the infant's [immune system](/source/Immune_system) and [gut microbiome](/source/Gut_microbiome).[1]

## Use and methods of consumption

Pumped breast milk in bottles

Breast feeding latch

The [World Health Organization](/source/World_Health_Organization) (WHO) and [UNICEF](/source/UNICEF) recommend [exclusive breastfeeding](/source/Breastfeeding#Duration_and_exclusivity) with breast milk for the first six months of an infant's life. This period is followed by the incorporation of nutritionally adequate and safe complementary solid foods at six months, a stage when an infant's nutrient and energy requirements start to surpass what breast milk alone can provide. Continuation of breastfeeding is recommended up to two years of age. This guidance is due to the protective benefits of breast milk, which include fewer infections such as diarrhea—a protection not afforded by [formula milk](/source/Formula_milk).[2]

Breast milk constitutes the sole source of nutrition for exclusively breastfed newborns, supplying all necessary nutrients for infants up to six months. Beyond this age, breast milk continues to be a source of energy for children up to two years old, providing over half of a child's energy needs up to the age of one and a third of the needs between one and two years of age.[2]

Despite the capability of most newborns to latch onto the mother's breast within an hour of birth, globally, sixty percent of infants are not breastfed within this crucial first hour. Breastfeeding within the first hour of life protects the newborn from acquiring infections and reduces risk of death during the neonatal period.[3][4]

Alternatively, breast milk can be expressed using a [breast pump](/source/Breast_pump) and administered via [baby bottle](/source/Baby_bottle), cup, spoon, supplementation drip system, or [nasogastric tube](/source/Nasogastric_tube).[5] This method is especially beneficial for [preterm babies](/source/Preterm_babies) who may initially lack the ability to suck effectively. Using cups to feed expressed breast milk and other supplements results in improved breastfeeding outcomes in terms of both duration and extent, compared with traditional bottle and tube feeding.[5][6]

For mothers unable to produce an adequate supply of breast milk, the use of [pasteurized](/source/Pasteurized) donor human breast milk is a viable option. In the absence of pasteurized donor milk, commercial formula milk is recommended as a secondary alternative.[7] However, unpasteurized breast milk from a source other than the infant's mother, particularly when shared informally, carries the risk of [vertically transmitting](/source/Vertical_transmission) bacteria, viruses (such as [HIV](/source/HIV)), and other microorganisms from the donor to the infant, rendering it an unsafe alternative.[7][8]

## Benefits

Breastfeeding offers health benefits to mother and child even after infancy.[9] These benefits include proper heat production and adipose tissue development,[10] a 73% decreased risk of [sudden infant death syndrome](/source/Sudden_infant_death_syndrome),[11] increased [intelligence](/source/Intelligence),[12] decreased likelihood of contracting [middle ear infections](/source/Middle_ear_infections),[13] cold and [flu](/source/Flu) resistance,[14] a tiny decrease in the risk of [childhood leukemia](/source/Childhood_leukemia),[15] lower risk of childhood onset [diabetes](/source/Diabetes),[16] decreased risk of [asthma](/source/Asthma) and [eczema](/source/Eczema),[17] decreased [dental problems](/source/Dental_problems),[17] decreased risk of [obesity](/source/Obesity) later in life,[18] and a decreased risk of developing [psychological disorders](/source/Psychological_disorders), including in [adopted](/source/Adoption) children.[19] In addition, feeding an infant breast milk is associated with lower insulin levels and higher leptin levels compared feeding an infant via [powdered-formula](/source/Infant_formula).[20] Many of the infection-fighting and immune system related benefits are associated with [human milk oligosaccharides](/source/Human_milk_oligosaccharide).[21]

Breastfeeding also provides health benefits for the mother. It assists the uterus in returning to its pre-pregnancy size and reduces post-partum bleeding, through the production of oxytocin (see Production). Breastfeeding can also reduce the risk of [breast cancer](/source/Breast_cancer) later in life.[22][23] [Lactation](/source/Lactation) may also reduce the risk for both mother and infant from both types of diabetes.[24] Lactation may protect the infant from specifically developing Type 2 diabetes, as studies have shown that bioactive ingredients in human breast milk could prevent excess weight gain during childhood via contributing to a feeling of energy and satiety. The lower risk of child-onset diabetes may be more applicable to infants who were born from diabetic mothers.[20] The reason is that while breastfeeding for at least the first six months of life minimizes the risk of type 1 diabetes from occurring in the infant, inadequate breastfeeding in an infant prenatally exposed to diabetes was associated with a higher risk of the child developing diabetes later.[20] There are arguments that breastfeeding may contribute to protective effects against the development of type 1 diabetes because the alternative of bottle-feeding may expose infants to unhygienic feeding conditions.[25]

Though it is almost universally prescribed, in some countries during the 1950s, the practice of [breastfeeding](/source/Breastfeeding) went through a period where it was out of vogue and the use of [infant formula](/source/Infant_formula) was considered superior to breast milk.[26] However, it is since universally recognized that there is no commercial formula that can adequately substitute for breast milk. In addition to the appropriate amounts of [carbohydrate](/source/Carbohydrate), [protein](/source/Protein), and [fat](/source/Fat), breast milk provides [vitamins](/source/Vitamin), [minerals](/source/Mineral_(nutrient)), [digestive enzymes](/source/Digestive_enzyme),[27] and [hormones](/source/Hormones).[27] Breast milk also contains antibodies and lymphocytes from the mother that may help the baby resist infections.[28] The immune function of breast milk is individualized, as the mother, through her touching and taking care of the baby, comes into contact with pathogens that colonize the baby, and, as a consequence, her body makes the appropriate antibodies and immune cells.[29]

At around four months of age, the internal iron supplies of the infant, held in the hepatic cells of the liver, are exhausted. The [American Academy of Pediatrics](/source/American_Academy_of_Pediatrics) recommends that at this time that an iron supplement should be introduced.[30] Other health organisations such as the [NHS](/source/National_Health_Service) in the [UK](/source/United_Kingdom) have no such recommendation.[31] Breast milk contains less iron than formula, but the iron is more [bioavailable](/source/Bioavailability) as [lactoferrin](/source/Lactoferrin), which carries more safety for mothers and children than ferrous sulphate.[32]

Both the AAP[33] and the NHS recommend [vitamin D](/source/Vitamin_D) supplementation for breastfed infants.[31] Vitamin D can be synthesised by the infant via exposure to sunlight; however, many infants are deficient due to being kept indoors or living in areas with insufficient sunlight. Formula is supplemented with vitamin D for this reason.[31][33]

## Production

See also: [Low milk supply](/source/Low_milk_supply)

Under the influence of the hormones [prolactin](/source/Prolactin) and [oxytocin](/source/Oxytocin), women produce milk after [childbirth](/source/Childbirth) to feed the [baby](/source/Baby).[34] The initial milk produced is referred to as [colostrum](/source/Colostrum), which is high in the [immunoglobulin](/source/Immunoglobulin) [IgA](/source/IgA), which coats the [gastrointestinal tract](/source/Gastrointestinal_tract). This helps to protect the newborn until its own [immune system](/source/Immune_system) is functioning properly. It also creates a mild laxative effect, expelling [meconium](/source/Meconium) and helping to prevent the build-up of [bilirubin](/source/Bilirubin) (a contributory factor in [jaundice](/source/Jaundice)[35]). Male lactation can occur; the production or administration of the hormone prolactin is necessary to induce lactation (see [male lactation](/source/Male_lactation)).

Actual inability to produce enough milk is rare, with studies showing that mothers from malnourished regions still produce amounts of milk of similar quality to that of mothers in developed countries.[36] There are many reasons a mother may [not produce enough breast milk](/source/Low_milk_supply).[37] Some of the most common reasons are an improper latch (i.e., the baby does not connect efficiently with the nipple), not nursing or pumping enough to meet supply, certain medications (including estrogen-containing [hormonal contraceptives](/source/Hormonal_contraceptives)), illness, and dehydration. A rarer reason is [Sheehan's syndrome](/source/Sheehan's_syndrome), also known as postpartum [hypopituitarism](/source/Hypopituitarism), which is associated with prolactin deficiency and may require hormone replacement.

The amount of milk produced depends on how often the mother is nursing and/or [pumping](/source/Breast_pump): the more the mother nurses her baby or pumps, the more milk is produced.[38][39][40] It is beneficial to nurse when the baby wants to nurse rather than on a schedule. A [Cochrane review](/source/Cochrane_review) came to the conclusion that a greater volume of milk is expressed whilst listening to relaxing audio during breastfeeding, along with warming and massaging of the breast prior to and during feeding. A greater volume of milk expressed can also be attributed to instances where the mother starts pumping milk sooner, even if the infant is unable to breastfeed.[41]

[Sodium](/source/Sodium) concentration is higher in hand-expressed milk, when compared with the use of manual and electric pumps, and fat content is higher when the breast has been massaged, in conjunction with listening to relaxing audio. This may be important for [low birthweight](/source/Low_birthweight) infants.[41] If pumping, it is helpful to have an electric, high-grade pump so that all of the milk ducts are stimulated. [Galactagogues](/source/Galactagogue) increase milk supply, although even herbal variants carry risks. Non-pharmaceutical methods should be tried first, such as pumping out the mother's breast milk supply often, warming or massaging the breast, as well as starting milk pumping earlier after the child is born if they cannot drink milk at the breast.[41][42][43][44]

## Composition

Further information: [Anti inflammatory agents in breast milk](/source/Anti_inflammatory_agents_in_breast_milk), [Human milk immunity](/source/Human_milk_immunity), and [Human milk microbiome](/source/Human_milk_microbiome)

Human breast milk Nutritional value per 100 mL Energy 65–78 kcal (270–330 kJ) Carbohydrates 6.7-7.8 g Sugars lactose 6.7-7.8 g Fat 3.2-4.8 g Protein 0.8-1.4 g Vitamins and minerals Vitamins Quantity %DV† Vitamin A 220 IU Thiamine (B1) 2% 21 μg Riboflavin (B2) 3% 35 μg Niacin (B3) 1% 0.15 mg Vitamin B6 8% 9-21 μg Folate (B9) 1% 2-5 μg Vitamin B12 4% 0.1 μg Vitamin C 4% 4 mg Vitamin D 0% 2 IU Vitamin E 1% 0.2 mg Vitamin K 0% 0.2 μg Minerals Quantity %DV† Calcium 18% 20-25 mg Copper -0% 0.00001-0.00003 mg Iron -0% 0.03-0.07 mg Magnesium 2% 3-3.5 mg Manganese -0% 0.0003-0.0004 mg Phosphorus 11% 12-14 mg Potassium 38% 40-55 mg Selenium -4% 1-2.5 μg Sodium 14% 15-25 mg Zinc -0% 0.0001-0.0003 mg Other constituents Quantity Water 87-88 g †Percentages estimated using US recommendations for adults,[48] except for potassium, which is estimated based on expert recommendation from the National Academies.[49] Source: [45][46][47]

Breast milk contains fats, proteins, carbohydrates (including lactose and human milk oligosaccharides), and a varying composition of minerals and vitamins.[50][51] The composition changes over a single feed as well as over the period of lactation.[52] Changes are particularly pronounced in [marsupials](/source/Marsupial).[53]

[Colostrum](/source/Colostrum) vs breastmilk

During the first few days after delivery, the mother produces [colostrum](/source/Colostrum). This is a thin yellowish fluid that is the same fluid that sometimes leaks from the breasts during pregnancy. It is rich in protein and antibodies that provide passive immunity to the baby (the baby's immune system is not fully developed at birth). Colostrum also helps the newborn's digestive system to grow and function properly.[*[citation needed](https://en.wikipedia.org/wiki/Wikipedia:Citation_needed)*]

Colostrum will gradually change to become mature milk. In the first 3–4 days it will appear thin and watery and will taste very sweet; later, the milk will be thicker and creamier. Human milk quenches the baby's thirst and hunger and provides the proteins, sugar, minerals, and antibodies that the baby needs.

In the 1980s and 1990s, lactation professionals (De Cleats) used to make a differentiation between foremilk and hindmilk. But this differentiation causes confusion as there are not two types of milk. Instead, as a baby breastfeeds, the fat content very gradually increases, with the milk becoming fattier and fattier over time.[54]

The level of [Immunoglobulin A](/source/Immunoglobulin_A) (IgA) in breast milk remains high from day 10 until at least 7.5 months post-partum.[55]

Human milk contains 0.8–0.9% protein, 4.5% fat, 7.1% carbohydrates, and 0.2% ash (minerals).[56] Carbohydrates are mainly [lactose](/source/Lactose); several lactose-based oligosaccharides (also called [human milk oligosaccharides](/source/Human_milk_oligosaccharide)) have been identified as minor components.[57] The fat fraction contains specific [triglycerides](/source/Triglycerides) of [palmitic](/source/Palmitic_acid) and [oleic acid](/source/Oleic_acid) (O-P-O triglycerides), and also lipids with trans bonds (see: [trans fat](/source/Trans_fat)). The lipids are [vaccenic acid](/source/Vaccenic_acid), and [conjugated linoleic acid](/source/Conjugated_linoleic_acid) (CLA) accounting for up to 6% of the human milk fat.[58][59]

The principal proteins are alpha-[lactalbumin](/source/Lactalbumin), [lactoferrin](/source/Lactoferrin) (apo-lactoferrin), IgA, [lysozyme](/source/Lysozyme), and [serum albumin](/source/Serum_albumin). In an acidic environment such as the [stomach](/source/Stomach), alpha-lactalbumin [unfolds](/source/Protein_folding) into a different form and binds [oleic acid](/source/Oleic_acid) to form a complex called [HAMLET](/source/Experimental_cancer_treatment#HAMLET_(human_alpha-lactalbumin_made_lethal_to_tumor_cells)) that kills [tumor](/source/Tumor) cells.[*[citation needed](https://en.wikipedia.org/wiki/Wikipedia:Citation_needed)*] This is thought to contribute to the protection of breastfed babies against cancer.[60]

Non-protein nitrogen-containing compounds, making up 25% of the milk's nitrogen, include [urea](/source/Urea), [uric acid](/source/Uric_acid), [creatine](/source/Creatine), [creatinine](/source/Creatinine), [amino acids](/source/Amino_acid), and [nucleotides](/source/Nucleotide).[61][62] Breast milk has [circadian](/source/Circadian) variations; some of the nucleotides are more commonly produced during the night, others during the day.[63]

Mother's milk has been shown to supply [endocannabinoids](/source/Endocannabinoid) (the natural neurotransmitters that [cannabis](/source/Cannabis) simulates) [2-arachidonoylglycerol](/source/2-Arachidonoylglycerol),[64] [anandamide](/source/Anandamide),[65][66] [oleoylethanolamide](/source/Oleoylethanolamide),[67] [palmitoylethanolamide](/source/Palmitoylethanolamide),[67] [N-arachidonoyl glycine](/source/N-arachidonoyl_glycine),[67] eicosapentaenoyl ethanolamide,[67] docosahexaenoyl ethanolamide,[67] N-palmitoleoyl-ethanolamine,[67] dihomo-γ-linolenoylethanolamine,[67] N-stearoylethanolamine,[67] prostaglandin F2alpha ethanolamides[67] and prostaglandin F2 ethanolamides,[67] Palmitic acid esters of hydroxy-stearic acids (PAHSAs).[68] They may act as an appetite stimulant, but they also regulate appetite so infants do not eat too much. That may be why formula-fed babies have a higher caloric intake than breastfed babies.[69]

Breast milk is not [sterile](/source/Sterilization_(microbiology)) and has [its own microbiome](/source/Human_milk_microbiome), but contains as many as 600 different species of [various bacteria](/source/Human_milk_microbiome), including beneficial *[Bifidobacterium](/source/Bifidobacterium) breve*, *B. adolescentis*, *B. longum*, *B. bifidum*, and *B. dentium*, which contribute to colonization of the infant gut.[70] As a result, it can be defined as a probiotic food, depending on how one defines "[probiotic](/source/Probiotic)".[71] Breast milk also contains a variety of [somatic cells](/source/Somatic_cell) and [stem cells](/source/Stem_cell) and the proportion of each cell type differs from individual to individual.[72][73] The somatic cells are mainly [lactocytes](https://en.wiktionary.org/wiki/lactocyte) and [myoepithelial cells](/source/Myoepithelial_cell) derived from the mother's mammary glands.[74] The stem cells found in human breast milk have been shown to be able to differentiate into a variety of other cells involved in the production of bodily [tissues](/source/Tissue_(biology)) and a small proportion of these cross over the nursing infant's intestinal tract into the bloodstream to reach certain organs and transform into fully functional cells.[75] Because of its diverse population of cells and multifarious functions, researchers have argued that breast milk should be considered a living tissue.[72]

Breast milk contains a unique type of sugars, [human milk oligosaccharides](/source/Human_milk_oligosaccharide) (HMOs), which were not present in traditional infant formula, however they are increasingly added by many manufacturers. HMOs are not digested by the infant but help to make up the [intestinal flora](/source/Intestinal_flora).[76] They act as [decoy receptors](/source/Decoy_receptors) that block the attachment of disease causing [pathogens](/source/Pathogens), which may help to prevent infectious diseases.[77] They also alter [immune cell](/source/Immune_cell) responses, which may benefit the infant. As of 2015 more than a hundred different HMOs have been identified; both the number and composition vary between women and each HMO may have a distinct functionality.[78]

The breast milk of diabetic mothers has been shown to have a different composition from that of non-diabetic mothers. It may contain elevated levels of glucose and insulin and decreased polyunsaturated fatty acids. A dose-dependent effect of diabetic breast milk on increasing language delays in infants has also been noted, although doctors recommend that diabetic mothers breastfeed despite this potential risk.[79]

Women [breastfeeding](/source/Breastfeeding) should consult with their physician regarding substances that can be unwittingly passed to the infant via breast milk, such as [alcohol](/source/Alcohol_(drug)), viruses ([HIV](/source/HIV) or [HTLV-1](/source/HTLV-1)), or medications.[80] Even though most infants infected with HIV contract the disease from breastfeeding, most infants that are breastfed by their HIV positive mothers never contract the disease.[81] While this paradoxical phenomenon suggests that the risk of HIV transmission between an HIV positive mother and her child via breastfeeding is small, studies have also shown that feeding infants with breast milk of HIV-positive mothers can actually have a preventative effect against HIV transmission between the mother and child.[81] This inhibitory effect against the infant contracting HIV is likely due to unspecified factors exclusively present in breast milk of HIV-positive mothers.[81]

Most women that do not breastfeed use [infant formula](/source/Infant_formula), but breast milk donated by volunteers to human milk banks can be obtained by prescription in some countries.[82] In addition, research has shown that women who rely on infant formula could minimize the gap between the level of immunity protection and cognitive abilities a breastfed child benefits from versus the degree to which a bottle-fed child benefits from them.[83] This can be done by supplementing formula-fed infants with bovine [milk fat globule membranes](/source/Milk_fat_globule_membrane) (MFGM) meant to mimic the positive effects of the MFGMs which are present in human breast milk.[84]

## Storage of expressed breast milk

Bottle of [pumped](/source/Breast_pump) breast milk

Expressed breast milk can be [stored](/source/Breastmilk_storage_and_handling). [Lipase](/source/Lipase) may cause thawed milk to taste soapy or rancid due to milk fat breakdown. It is still safe to use, and most babies will drink it. Scalding it will prevent rancid taste at the expense of antibodies.[85] It should be stored with airtight seals. Some plastic bags are designed for storage periods of less than 72 hours. Others can be used for up to 12 months if frozen. This table describes safe storage time limits.[86]

Place of storage Temperature Maximum storage time In a room 25 °C 77 °F Six to eight hours Insulated thermal bag with ice packs Up to 24 hours In a refrigerator 4 °C 39 °F Up to five days Freezer compartment inside a refrigerator −15 °C 5 °F Two weeks A combined refrigerator and freezer with separate doors −18 °C 0 °F Three to six months Chest or upright manual defrost deep freezer −20 °C −4 °F Six to twelve months

## Comparison to other milks

All [mammalian](/source/Mammal) species produce milk, but the composition of milk for each species varies widely and other kinds of milk are often very different from human breast milk. As a rule, the milk of mammals that nurse frequently (including human babies) is less rich, or more watery, than the milk of mammals whose young nurse less often. Human milk is noticeably thinner and sweeter than cow's milk.

Whole cow's milk contains too little [iron](/source/Iron), [retinol](/source/Retinol), [vitamin E](/source/Vitamin_E), [vitamin C](/source/Vitamin_C), [vitamin D](/source/Vitamin_D), [unsaturated fats](/source/Unsaturated_fat) or essential [fatty acids](/source/Fatty_acid) for human babies.[87][88][89][90] Whole cow's milk also contains too much [protein](/source/Protein), [sodium](/source/Sodium), [potassium](/source/Potassium), [phosphorus](/source/Phosphorus) and [chloride](/source/Chloride) which may put a strain on an infant's immature [kidneys](/source/Kidneys). In addition, the proteins, fats and [calcium](/source/Calcium) in whole cow's milk are more difficult for an infant to digest and absorb than the ones in breast milk.[88][91][92]

The composition of marsupial and monotreme milk contains essential nutrients, growth factors and immunological properties to support the development of joeys and puggles.[53]

Comparing milks (per cup [1cup=246g] in SI units of measurement)[93][94] Nutrient Human milk Cow milk (3.25% fat) Goat milk Calories (Kcal) 172 146 168 Water (g) 215 215 212 Protein (g) 2.5 7.9 8.7 Fat (g) 10.8 7.9 10.1 Saturated fat (g) 4.9 4.6 6.5 Monounsaturated fat (g) 4.1 2.0 2.7 Polyunsaturated fat (g) 1.2 0.5 0.4 Omega-3 fatty acids (mg) 128 183 97.6 Omega-6 fatty acids (mg) 920 293 266 Cholesterol (mg) 34.4 24.4 26.8 Carbohydrate (g) 17.0 11.0 10.9 Sugars (g) 17.0 11.0 10.9 Vitamin A (IU) 522 249 483 Vitamin C (mg) 12.3 0 3.2 Vitamin D (IU) * 9.8 97.6 29.3 Vitamin E (mg) 0.2 0.1 0.2 Vitamin K (mcg) 0.7 0.5 0.7 Thiamin (mg) 0.0 0.1 0.1 Riboflavin (mg) 0.1 0.4 0.3 Niacin (mg) 0.4 0.3 0.7 Vitamin B6 (mg) 0.0 0.1 0.1 Folate (mcg) 12 12 2 Vitamin B12 (mcg) 0.1 1.1 0.2 Pantothenic acid (mg) 0.5 0.9 0.8 Choline (mg) 39.4 34.9 39.0 Calcium (mg) 79 276 327 Iron (mg) 0.07 0.07 0.12 Magnesium (mg) 7.4 24.4 34.2 Phosphorus (mg) 34.4 222 271 Potassium (mg) 125 349 498 Sodium (mg) 42 98 122 Zinc (mg) 0.4 1.0 0.7 Copper (mg) 0.1 0.0 0.1 Manganese (mg) 0.1 0.0 0.0 Selenium (mcg) 4.4 9.0 3.4

* Note: Milk is generally fortified with vitamin D in the U.S. and Canada. Non-fortified milk contains only 2 IU per 3.5 oz.

## Effects of medications and other substances on milk content

Main article: [Breastfeeding and medications](/source/Breastfeeding_and_medications)

Further information: [Breast milk-mediated drug delivery](/source/Breast_milk-mediated_drug_delivery)

Almost all medicines, or drugs, pass into breastmilk in small amounts by a [concentration gradient](/source/Concentration_gradient).[95] The amount of the drug bound by maternal [plasma proteins](/source/Plasma_proteins), the size of the drug molecule, the pH and/or [pKa](/source/PKa) of the drug, and the [lipophilicity](/source/Lipophilicity) of the drug all determine whether and how much of the drug will pass into breastmilk.[96] Medications that are mostly non-protein bound, low in [molecular weight](/source/Molecular_weight), and highly lipid-soluble are more likely to enter the breast milk in larger quantities.[97] Some drugs have no effect on the baby and can be used whilst breastfeeding, while other medications may be dangerous and harmful to the infant.[98][97]

Some medications considered generally safe for use by a breastfeeding mother, with a doctor's or pharmacist's advice, include simple analgesics or pain killers such as [paracetamol/acetaminophen](/source/Paracetamol),[99] anti-hypertensives such as the [ACE-inhibitors](/source/ACE_inhibitor) [enalapril](/source/Enalapril) and [captopril](/source/Captopril), anti-depressants of the [SSRI](/source/SSRI) and [SNRI](/source/SNRI) classes, and medications for gastroesophageal reflux such as [omeprazole](/source/Omeprazole) and [ranitidine](/source/Ranitidine).[100]

Conversely, there are medications that are known to be toxic to the baby and thus should not be used in breastfeeding mothers, such as [chemotherapeutic agents](/source/Chemotherapeutic_agents) which are [cytotoxic](/source/Cytotoxic) like [doxorubicin](/source/Doxorubicin),[101] [immunosuppressants](/source/Immunosuppressants) like [methotrexate](/source/Methotrexate),[101] [amiodarone](/source/Amiodarone), or [lithium](/source/Lithium_(medication)).[97][96]

Furthermore, [drugs of abuse](/source/Drugs_of_abuse), such as cocaine, amphetamines, heroin, and marijuana cause adverse effects on the infant during breastfeeding. Adverse effects include seizures, tremors, restlessness, and diarrhea.[101]

To reduce infant exposure to medications used by the mother, use topical therapy or avoid taking the medication during breastfeeding times when possible.[95]

Hormonal products and combined oral contraceptives should be avoided during the early postpartum period as they can interfere with lactation.[100]

There are some medications that may stimulate the production of breast milk. These medications may be beneficial in cases where women with [hypothyroidism](/source/Hypothyroidism) may be unable to produce milk.[102][103] A Cochrane review looked at the drug domperidone (10 mg three times per day) with results showing a significant increase in volume of milk produced over a period of one to two weeks.[104] However, another review concluded little evidence that use of domperidone and metoclopramide to enhance milk supply works. Instead, non-pharmacological approaches such as support and more frequent breastfeeding may be more efficacious.[96]

Finally, there are other substances besides medications that may appear in breast milk. [Alcohol](/source/Alcohol_(drug)) use during pregnancy carries a significant risk of serious birth defects, but consuming alcohol after the birth of the infant is considered safe.[105] High [caffeine](/source/Caffeine) intake by breastfeeding mothers may cause their infants to become irritable or have trouble sleeping.[96] A meta-analysis has shown that breastfeeding mothers who smoke expose their infants to nicotine, which may cause respiratory illnesses, including [otitis media](/source/Otitis_media) in the nursing infant.[101]

## Market

Main article: [human milk bank](/source/Human_milk_bank)

There is a commercial [market](/source/Market_(economics)) for human breast milk, both in the form of a [wet nurse](/source/Wet_nurse) service and as a milk product.

As a product, breast milk is exchanged by [human milk banks](/source/Human_milk_bank), as well as directly between milk donors and customers as mediated by websites on the internet. Human milk banks generally have standardized measures for screening donors and storing the milk, sometimes even offering [pasteurization](/source/Pasteurization), while milk donors on websites vary in regard to these measures. A study in 2013 came to the conclusion that 74% of breast milk samples from providers found from websites were colonized with [gram-negative bacteria](/source/Gram-negative_bacteria) or had more than 10,000 [colony-forming units](/source/Colony-forming_unit)/mL of [aerobic bacteria](/source/Aerobic_bacteria).[106] Bacterial growth happens during transit.[106] According to the FDA, bad bacteria in food *at room temperature* can double every 20 minutes.[107]

Human milk is considered to be healthier than cow's milk and infant formula when it comes to feeding an infant in the first six months of life, but only under extreme situations do international health organizations support feeding an infant breast milk from a healthy [wet nurse](/source/Wet_nurse) rather than that of its biological mother.[108] One reason is that the unregulated breast milk market is fraught with risks, such as drugs of abuse and prescription medications being present in donated breast milk.[108] The transmission of these substances through breast milk can do more harm than good when it comes to the health outcomes of the infant recipient.[108]

### Fraud

In the United States, the online marketplace for breast milk is largely unregulated and the high premium has encouraged [food fraud](/source/Food_fraud).[109][110] Human breast milk may be diluted with other liquids to increase volume including [cow's milk](/source/Cow's_milk), [soy milk](/source/Soy_milk), and [water](/source/Water), thus undermining its health benefits.[109][111]

A 2015 [CBS](/source/CBS) article cites an editorial led by Dr. Sarah Steele in the *[Journal of the Royal Society of Medicine](/source/Journal_of_the_Royal_Society_of_Medicine)*, in which they say that "health claims do not stand up clinically and that [raw human milk](/source/Raw_milk) purchased online poses many health risks." CBS found a study from the Center for Biobehavioral Health at [Nationwide Children's Hospital](/source/Nationwide_Children's_Hospital) in [Columbus](/source/Columbus%2C_Ohio) that "found that 11 out of 102 breast milk samples purchased online were actually blended with [cow's milk](/source/Cow's_milk)." The article also explains that milk purchased online may be improperly sanitized or stored, so it may contain food-borne illness and infectious diseases such as [hepatitis](/source/Hepatitis) and [HIV](/source/HIV).[112]

## Consumption by adults

### Restaurants and recipes

A minority of people, including restaurateurs Hans Lochen of [Switzerland](/source/Switzerland) and Daniel Angerer of [Austria](/source/Austria), who operate a restaurant in New York City, have used human breast milk, or at least advocated its use, as a substitute for cow's milk in [dairy](/source/Dairy) products and food [recipes](/source/Recipe).[113][114] An icecreamist in London's Covent Garden, [The Licktators](/source/The_Licktators), started selling an ice cream named Baby Gaga in February 2011. Each serving cost £14. All the milk was donated by a Mrs Hiley who earned £15 for every 10 ounces and called it a "great recession beater".[115] The ice cream sold out on its first day. Despite the success of the new flavour, the Westminster Council officers removed the product from the menu to make sure that it was, as they said, "fit for human consumption."[116] Tammy Frissell-Deppe, a family counsellor specialized in [attachment parenting](/source/Attachment_parenting), published a book, titled *A Breastfeeding Mother's Secret Recipes*, providing a lengthy compilation of detailed food and beverage recipes containing human breast milk.[117] Human breast milk is not produced or distributed industrially or commercially, because the use of human breast milk as an adult food is considered unusual to the majority of [cultures](/source/Culture) around the world, and most disapprove of such a practice.[118]

In Costa Rica, there have been trials to produce human [cheese](/source/Cheese), and [custard](/source/Custard) from human milk, as an alternative to [weaning](/source/Weaning).[119]

### Bodybuilders

While there is no scientific evidence that shows that breast milk is advantageous for adults, according to several 2015 news sources, breast milk is being used by [bodybuilders](/source/Bodybuilders) for its nutritional value. In a February 2015 [ABC News](/source/ABC_News_(United_States)) article, one former competitive bodybuilder said, "It isn't common, but I've known people who have done this. It's certainly talked about quite a bit on the bodybuilding forums on the Internet." Calling bodybuilders "a strange breed of individuals", he said, "Even if this type of thing is completely unsupported by research, they're prone to gym lore and willing to give it a shot if there is any potential effect." At the time the article was written, in the U.S., the price of breast milk procured from milk banks that pasteurize the milk, and have expensive quality and safety controls, was about $10 per US fluid ounce ($0.34/mL), and the price in the alternative market online, bought directly from mothers, ranges from $1–$4 per US fluid ounce ($0.03–$0.14/mL), compared to cow's milk at about $3.44 per US gallon ($0.0269/US fl oz; $0.0009/mL).[120][121]

### Erotic lactation

This section needs expansion. You can help by adding missing information. (October 2024)

Main article: [Erotic lactation](/source/Erotic_lactation)

For sexual purposes, some couples have decided to [induce lactation](/source/Lactation#Without_pregnancy,_induced_lactation,_relactation) outside a pregnancy through a practice called "Erotic lactation".

## Breast milk contamination

Breast milk is oftentimes used as an environmental bioindicator given its ability to accumulate certain chemicals, including organochlorine pesticides.[122] Research has found that certain organic contaminants such as [PCBs](/source/Polychlorinated_biphenyl), [organochlorine pesticides](/source/Organochlorine_pesticide), [PCDDs](/source/Polychlorinated_dibenzodioxins), [PBDEs](/source/Polybrominated_diphenyl_ethers), and [DDT](/source/DDT) can contaminate breastmilk.[123] According to research done in 2002, the levels of the organochlorine pesticides, PCBs, and dioxins have declined in breast milk in countries where these chemicals have been banned or otherwise regulated, while levels of PBDEs are rising.[123]

### Pesticide contamination in breastmilk

Pesticides and other toxic substances [bioaccumulate](/source/Bioaccumulate); i.e., creatures higher up the [food chain](/source/Food_chain) will store more of them in their [body fat](/source/Body_fat). This is an issue in particular for the [Inuit](/source/Inuit), whose [traditional diet](/source/Inuit_diet) is predominantly meat. Studies are looking at the effects of [polychlorinated biphenyls](/source/Polychlorinated_biphenyls) and [persistent organic pollutants](/source/Persistent_organic_pollutants) in the body; the breast milk of Inuit mothers is extraordinarily high in toxic compounds.[124]

The CDC has provided some resources for breastfeeding mothers to reference for safe medication use, including [LactMed](https://www.ncbi.nlm.nih.gov/books/NBK501922/), [Mother to Baby](https://mothertobaby.org/), and [The InfantRisk Center](http://www.infantrisk.com/categories/breastfeeding).[125]

### Contamination effects of organochlorine pesticides on infants

When a mother is exposed to organochlorine pesticides (OCP's), her infant can be exposed to these OCP's through breast milk intake. This result is supported by a study done in India, which revealed that in each lactation period there is a loss of OCPs from the mother's body involved in the nursing of their children. A longitudinal study was conducted to assess pesticide residues in human breast milk samples and evaluate the risk-exposure of infants to these pesticides from consumption of mother's milk in Ethiopia. The estimated daily intake (EDI) of infants in the present study was above provisional tolerable daily intake (PTDI) during the first month of breastfeeding which indicates that there is a health risk for infants consuming breast milk at an early stage of breastfeeding in the study areas. Based on these studies, the exposure of women during pregnancy to these OCPs may lead to various health problems for fetus such as low birth weight, disturbance of thyroid hormone, and neurodevelopmental delay.[126]

## See also

- [Breastmilk storage and handling](/source/Breastmilk_storage_and_handling)

- [Blocked milk duct](/source/Blocked_milk_duct)

- [Breastfeeding in public](/source/Breastfeeding_in_public)

- [Breast milk jewelry](/source/Breast_milk_jewelry)

- [Human milk banking in North America](/source/Human_milk_banking_in_North_America)

- [La Leche League International](/source/La_Leche_League_International)

- [Lactation room](/source/Lactation_room)

- [Lactivism](/source/Lactivism)

- [Mary Rose Tully](/source/Mary_Rose_Tully)

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1. **[^](#cite_ref-122)** Mekonen, Sablework; Ambelu, Argaw; Wondafrash, Mekitie; Kolsteren, Patrick; Spanoghe, Pieter (2021). ["Exposure of infants to organochlorine pesticides from breast milk consumption in southwestern Ethiopia"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8585979). *Scientific Reports*. **11** (1): 22053. [Bibcode](/source/Bibcode_(identifier)):[2021NatSR..1122053M](https://ui.adsabs.harvard.edu/abs/2021NatSR..1122053M). [doi](/source/Doi_(identifier)):[10.1038/s41598-021-01656-x](https://doi.org/10.1038%2Fs41598-021-01656-x). [PMC](/source/PMC_(identifier)) [8585979](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8585979). [PMID](/source/PMID_(identifier)) [34764390](https://pubmed.ncbi.nlm.nih.gov/34764390).

1. ^ [***a***](#cite_ref-Solomon_123-0) [***b***](#cite_ref-Solomon_123-1) Solomon, Gina M; Weiss, Pilar M (June 2002). ["Chemical contaminants in breast milk: time trends and regional variability"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1240888). *Environmental Health Perspectives*. **110** (6): A339-47. [doi](/source/Doi_(identifier)):[10.1289/ehp.021100339](https://doi.org/10.1289%2Fehp.021100339). [PMC](/source/PMC_(identifier)) [1240888](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1240888). [PMID](/source/PMID_(identifier)) [12055065](https://pubmed.ncbi.nlm.nih.gov/12055065).

1. **[^](#cite_ref-124)** Cone, Marla (2007). *Silent Snow: The Slow Poisoning of the Arctic*. Open Road + Grove/Atlantic. [ISBN](/source/ISBN_(identifier)) [978-1-55584-769-2](https://en.wikipedia.org/wiki/Special:BookSources/978-1-55584-769-2).[*[page needed](https://en.wikipedia.org/wiki/Wikipedia:Citing_sources)*]

1. **[^](#cite_ref-125)** CDC (2018). ["Prescription Medication Use"](https://www.cdc.gov/breastfeeding/breastfeeding-special-circumstances/vaccinations-medications-drugs/prescription-medication-use.html). *Centers for Disease Control and Prevention*. [Archived](https://web.archive.org/web/20190623114642/https://www.cdc.gov/breastfeeding/breastfeeding-special-circumstances/vaccinations-medications-drugs/prescription-medication-use.html) from the original on 2019-06-23. Retrieved 2019-08-02.

1. **[^](#cite_ref-126)** Mekonen, Seblework; Ambelu, Argaw; Wondafrash, Mekitie; Kolsteren, Patrick; Spanoghe, Pieter (November 11, 2021). ["Exposure of infants to organochlorine pesticides from breast milk consumption in southwestern Ethiopia"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8585979). *Scientific Reports*. **11** (1): 22053. [Bibcode](/source/Bibcode_(identifier)):[2021NatSR..1122053M](https://ui.adsabs.harvard.edu/abs/2021NatSR..1122053M). [doi](/source/Doi_(identifier)):[10.1038/s41598-021-01656-x](https://doi.org/10.1038%2Fs41598-021-01656-x). [PMC](/source/PMC_(identifier)) [8585979](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8585979). [PMID](/source/PMID_(identifier)) [34764390](https://pubmed.ncbi.nlm.nih.gov/34764390).

## Further reading

- Van Esterik, Penny (2019). "Breastfeeding as Foodwork". In Counihan, Carole; Van Esterik, Penny; Julier, Alice P (eds.). *Food and Culture: A Reader* (4th ed.). New York & Oxford: [Routledge](/source/Routledge). [ISBN](/source/ISBN_(identifier)) [978-1-138-93057-5](https://en.wikipedia.org/wiki/Special:BookSources/978-1-138-93057-5).

## External links

- [Drug Interactions with Human Milk](https://www.cdc.gov/breastfeeding/breastfeeding-special-circumstances/vaccinations-medications-drugs/prescription-medication-use.html)

- *[Human milk and lactation](https://emedicine.medscape.com/article/1835675-overview)* by Carol L. Wagner (Overview article, eMedicine, December 14, 2010)

- [United Nations University Centre – Constituents of human milk](https://web.archive.org/web/20101023071139/http://www.unu.edu/unupress/food/8F174e/8F174E04.htm) – including comparison of human and cow's milk ones

- [Children's Health Topics: Breastfeeding](https://web.archive.org/web/20070120085511/http://www.aap.org/healthtopics/breastfeeding.cfm)

- [A comparison between human milk and cow's milk](https://web.archive.org/web/20140821103225/http://www.vegetarian.org.uk/campaigns/whitelies/wlreport05.shtml) and [The composition of cow's milk](https://web.archive.org/web/20140811224245/http://www.vegetarian.org.uk/campaigns/whitelies/wlreport06.shtml)

- Meigs, EB (August 30, 1913) [The comparative composition of human milk and of cow's milk](http://www.jbc.org/content/16/2/147.full.pdf), J.Biol.Chem 147–168

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Adapted from the Wikipedia article [Breast milk](https://en.wikipedia.org/wiki/Breast_milk) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/Breast_milk?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.