# Bodybuilding supplement

> Mediated Wiki article. Canonical URL: https://mediated.wiki/source/Bodybuilding_supplement
> Markdown URL: https://mediated.wiki/source/Bodybuilding_supplement.md
> Source: https://en.wikipedia.org/wiki/Bodybuilding_supplement
> Source revision: 1345467836
> License: Creative Commons Attribution-ShareAlike 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/)

Dietary supplement used for bodybuilding

This article needs more reliable medical references for verification or relies too heavily on primary sources. Please review the contents of the article and add the appropriate references if you can. Unsourced or poorly sourced material may be challenged and removed. Find sources: "Bodybuilding supplement" – news · newspapers · books · scholar · JSTOR (November 2016)

**Bodybuilding supplements** are [dietary supplements](/source/Dietary_supplement) commonly used by those involved in [bodybuilding](/source/Bodybuilding), weightlifting, mixed martial arts, and [athletics](/source/Athletics_(physical_culture)) for the purpose of facilitating an increase in [lean body mass](/source/Lean_body_mass). Bodybuilding supplements may contain ingredients that are advertised to increase a person's muscle, body weight, athletic performance, and decrease a person's percent body fat for desired muscle definition. Among the most widely used are [high protein drinks](/source/Protein_supplement), [pre-workout](/source/Pre-workout) blends and [caffeinated](/source/Caffeine) [energy drinks](/source/Energy_drinks), [branched-chain amino acids (BCAA)](/source/Branched-chain_amino_acids), [glutamine](/source/Glutamine), [arginine](/source/Arginine), [essential fatty acids](/source/Essential_fatty_acids), [creatine](/source/Creatine), [HMB](/source/Beta-Hydroxy_beta-methylbutyric_acid), [whey protein](/source/Whey_protein), [ZMA](/source/ZMA_(supplement)), and [weight loss](/source/Weight_loss) products.[1][2] Supplements are sold either as single ingredient preparations or in the form of "stacks" – proprietary blends of various supplements marketed as offering synergistic advantages.

## History

[Athletes in ancient Greece](/source/Athletes_in_ancient_Greece) were advised to consume large quantities of meat and wine. A number of herbal concoctions and tonics have been used by strong men and athletes since ancient times across cultures to try to increase their strength and stamina.[3]

In the 1910s, [Eugen Sandow](/source/Eugen_Sandow), widely considered to be the first modern bodybuilder in the West, advocated the use of dietary control to enhance muscle growth. Later, bodybuilder Earle Liederman advocated the use of "beef juice" or "beef extract" (basically, [consommé](/source/Consomm%C3%A9)) as a way to enhance muscle recovery. In the 1950s, with recreational and competitive bodybuilding becoming increasingly popular, Irvin P. Johnson began to popularize and market [egg](/source/Egg)-based protein powders marketed specifically at bodybuilders and physical athletes. The 1970s and 1980s marked a dramatic increase in the growth of the bodybuilding supplement industry, fueled by the widespread use of modern marketing techniques and a marked increase in recreational bodybuilding.

In October 1994, the [Dietary Supplement Health and Education Act](/source/Dietary_Supplement_Health_and_Education_Act) (DSHEA) was signed into law in the USA. Under DSHEA, responsibility for determining the safety of the [dietary supplements](/source/Dietary_supplement) changed from the government to the manufacturer, and supplements no longer required approval from the U.S. [Food and Drug Administration](/source/Food_and_Drug_Administration) (FDA) before distributing the products. Since that time, manufacturers did not have to provide FDA with the evidence to substantiate safety or effectiveness unless a new dietary ingredient was added. It is widely believed that the 1994 DSHEA further consolidated the position of the supplement industry and lead to additional product sales.[4]

## Protein

Further information: [Protein quality](/source/Protein_quality) and [Protein supplement](/source/Protein_supplement)

Protein shakes, made from protein powder (center) and milk (left), are a common bodybuilding supplement.

[Bodybuilders](/source/Bodybuilder) may supplement their diets with [protein](/source/Protein_in_nutrition) for reasons of convenience, lower cost (relative to meat and fish products), ease of preparation, and to avoid the concurrent consumption of carbohydrates and fats. Additionally, some argue that bodybuilders, by virtue of their unique training and goals, require higher-than-average quantities of protein to support maximal muscle growth.[5][6][7][8][9][10][11][12] While the recommended dietary allowance is much less,[13] Harvard Medical School points out in Health Health Publishing that this RDA (recommended daily allowance) is “the minimum amount you need to keep from getting sick — not the specific amount you are supposed to eat every day.”[14] Protein supplements are sold in ready-to-drink [health shakes](/source/Health_shake), bars, meal replacement products (see below), bites, oats, gels and powders. Protein powders are the most popular and may have flavoring added for palatability. The powder is usually mixed with water, milk or fruit juice and is generally consumed immediately before and after exercising or in place of a meal. The sources of protein are as follows and differ in [protein quality](/source/Protein_quality) depending on their amino acid profile and digestibility:

- [Whey protein](/source/Whey_protein) contains high levels of all the [essential amino acids](/source/Essential_amino_acids) and [branched-chain amino acids](/source/Branched-chain_amino_acids). It also has the highest content of the amino acid [cysteine](/source/Cysteine), which aids in the biosynthesis of [glutathione](/source/Glutathione). For bodybuilders, whey protein provides amino acids used to aid in muscle recovery.[15] Whey protein is derived from the process of making [cheese](/source/Cheese) from [milk](/source/Milk). There are three types of whey protein: whey concentrate, whey isolate, and whey hydrolysate. Whey concentrate is 29–89% protein by weight whereas whey isolate is 90%+ protein by weight. Whey hydrolysate is enzymatically predigested and therefore has the highest rate of digestion of all protein types.[15]

- [Casein protein](/source/Casein_protein) (or milk protein) has [glutamine](/source/Glutamine), and [casomorphin](/source/Casomorphin).[15]

Shaker Bottle commonly used to mix supplements. Often has mesh or a metal whisk inside to breakdown lumps in the mixture.

Some nutritionists have suggested that higher calcium excretion may be due to a corresponding increase in protein-induced calcium absorption in the intestines.[16][17][18]

### Amino acids

Some bodybuilders believe that amino acid supplements may benefit muscle development, but consumption of such supplements is unnecessary in a diet that already includes adequate protein intake.[19]

## Prohormones

Main article: [Androgen prohormone](/source/Androgen_prohormone)

An androgen prohormone, or proandrogen, is a [prohormone](/source/Prohormone) (or [prodrug](/source/Prodrug)) of an [anabolic-androgenic steroid](/source/Anabolic-androgenic_steroid) (AAS). They can be prohormones of [testosterone](/source/Testosterone) or of [synthetic](/source/Synthetic_compound) AAS, for example, [nandrolone](/source/Nandrolone) (19-nortestosterone). [Dehydroepiandrosterone](/source/Dehydroepiandrosterone) (DHEA), [DHEA sulfate](/source/DHEA_sulfate) (DHEA-S), and [androstenedione](/source/Androstenedione) may all be considered proandrogens of testosterone.[20]

Since 2005, the use of steroid precursors (prohormones) has been illegal in the U.S.[21]

## Creatine

Main article: [Creatine supplements](/source/Creatine_supplements)

[Creatine](/source/Creatine) is an [organic acid](/source/Organic_acid) naturally occurring in the body (and in red meats)[22] that supplies energy to muscle cells for short bursts of energy (as required in lifting weights) via [creatine phosphate](/source/Creatine_phosphate) replenishment of [ATP](/source/Adenosine_triphosphate). Scientific studies have shown that creatine supplementation can increase the consumer's strength,[23] energy during performance,[24] muscle mass, and recovery times after exercise. In addition, recent studies have also shown that creatine improves brain function[25] and reduces mental fatigue.[26]

Some studies have suggested that consumption of creatine with protein and carbohydrates can have a greater effect than creatine combined with either protein or carbohydrates alone.[27]

While generally considered safe, long-term or excessive consumption of creatine may have an adverse effect on the [kidneys](/source/Kidneys), liver, or heart and should be avoided if any pre-existing conditions affecting these organs exist.[28]

## β-Hydroxy β-methylbutyrate

Main article: [Beta-Hydroxy beta-methylbutyric acid](/source/Beta-Hydroxy_beta-methylbutyric_acid)

When combined with an appropriate exercise program, dietary supplementation with [β-hydroxy β-methylbutyrate](/source/%CE%92-hydroxy_%CE%B2-methylbutyrate) (HMB) has been shown to [dose-dependently](/source/Dose-dependent) augment gains in [muscle hypertrophy](/source/Muscle_hypertrophy) (i.e., the size of a muscle),[29][30] [muscle strength](/source/Physical_strength),[29][31][32] and [lean body mass](/source/Lean_body_mass),[29][31][32] reduce exercise-induced skeletal muscle damage,[note 1][29][30][32] and expedite recovery from high-intensity exercise.[29][33] HMB is believed to produce these effects by increasing muscle protein synthesis and decreasing muscle protein breakdown by various mechanisms, including activation of the [mechanistic target of rapamycin](/source/Mechanistic_target_of_rapamycin) (mTOR) and inhibition of the [proteasome](/source/Proteasome) in skeletal muscles.[31][34]

The inhibition of exercise-induced skeletal muscle damage by HMB is affected by the time that it is used relative to exercise.[29][33] The greatest reduction in skeletal muscle damage from a single bout of exercise appears to occur when calcium HMB is ingested 1–2 hours prior to exercise.[33]

## Protein Intake and Muscle Hypertrophy

Research on resistance training shows that increasing daily protein intake supports gains in muscle mass, but the benefit have diminishing returns. A large meta-analysis by Morton et al. (2018) found that muscle growth increases as protein intake rises up to about 1.6 g/kg/day, after which additional protein offers little added effect.[35] A similar dose response analysis by Tagawa et al. (2020) reported that while higher protein intakes are generally associated with greater lean mass gains, the effect plateaus once basic requirements for resistance trained individuals are met.[36] Together, these findings suggest that moderate but adequate protein intake is sufficient for maximizing hypertrophy in most healthy adults.

## Controversy

This article reads like a press release or a news article and may be largely based on routine coverage. Please help improve it by adding independent secondary sources. (February 2020) (Learn how and when to remove this message)

### Mislabeling and adulteration

While many of the claims are based on scientifically based physiological or biochemical processes, their use in bodybuilding parlance is often heavily colored by bodybuilding lore and industry marketing and, as such, may deviate considerably from traditional scientific usages of the terms. In addition, ingredients listed have been found at times to be different from the contents. In 2015, [Consumer Reports](/source/Consumer_Reports) reported unsafe levels of [arsenic](/source/Arsenic), [cadmium](/source/Cadmium), [lead](/source/Lead), and [mercury](/source/Mercury_(element)) in several of the protein powders that were tested.[37]

In the United States, the manufacturers of dietary supplements do not need to provide the Food and Drug Administration with evidence of product safety prior to marketing.[38] As a result, the incidence of products adulterated with illegal ingredients has continued to rise.[38] In 2013, one-third of the supplements linked to liver damage in one study were adulterated with unlisted steroids.[39] More recently, the prevalence of [designer steroids](/source/Designer_steroid) with unknown safety and pharmacological effects has increased.[40][41]

In 2015, a [CBC](/source/Canadian_Broadcasting_Corporation) investigative report found that protein spiking (i.e., the addition of amino-acid filler to manipulate analysis) was not uncommon;[42] however, many of the companies involved challenged these claims.[42]

### Health problems

This section's tone or style may not reflect the encyclopedic tone used on Wikipedia. See Wikipedia's guide to writing better articles for suggestions. (September 2020) (Learn how and when to remove this message)

The US FDA reports 50,000 health problems a year due to dietary supplements[43] and these often involve bodybuilding supplements.[44] For example, the "natural" best-seller Craze, 2012's "New Supplement of the Year" by bodybuilding.com, widely sold in stores such as [Walmart](/source/Walmart) and [Amazon](/source/Amazon_(company)), was found to contain [N,alpha-Diethylphenylethylamine](/source/N%2Calpha-Diethylphenylethylamine), a [methamphetamine](/source/Methamphetamine) analog.[45]

[Liver damage](/source/Hepatotoxicity) from herbal and dietary supplements (HDS) accounted for about 16–20% of all drug-induced liver injury, with the proportion growing globally between 2004 and 2014. The total incidence of liver injury caused by HDS throughout the general population was estimated to be 3 per 100,000.[2][46] The most common liver injuries from weight loss and bodybuilding supplements involve [hepatocellular](/source/Hepatocyte) damage and [jaundice](/source/Jaundice). The most common supplement ingredients attributed to these injuries are [catechins](/source/Catechin) from [green tea](/source/Green_tea), [anabolic steroids](/source/Anabolic_steroid), and the herbal [extract](/source/Extract), [aegeline](/source/Aegle_marmelos).[2] Other products by supplement designer and CEO of Driven Sports, Matt Cahill, have contained dangerous substances causing blindness or liver damage, and his pre-workout supplement *Craze* was found to contain illegal stimulants[47] that resulted in several athletes failing drug tests.[48]

### Protein effectiveness

Some have argued that there is little evidence to indicate any benefit to using bodybuilding protein or [amino acid](/source/Amino_acid) supplements. A 2005 overview concluded that "[i]n view of the lack of compelling evidence to the contrary, no additional dietary protein is suggested for healthy adults undertaking resistance or endurance exercise".[13]

In contrast, a 2018 systematic review, meta-analysis and meta-regression concluded that, “Dietary protein supplementation significantly enhanced changes in muscle strength and size during prolonged RET in healthy adults.“ (RET is an abbreviation for resistance exercise training.)[49]

## See also

- [Instant breakfast](/source/Instant_breakfast)

- [Protein bar](/source/Protein_bar)

## Notes

1. **[^](#cite_ref-34)** The effect of HMB on skeletal muscle damage has been assessed in studies using four different [biomarkers](/source/Biomarker_(medicine)) of muscle damage or protein breakdown: [serum](/source/Blood_serum) [creatine kinase](/source/Creatine_kinase), serum [lactate dehydrogenase](/source/Lactate_dehydrogenase), urinary [urea nitrogen](/source/Urea_nitrogen), and urinary [3-methylhistidine](/source/3-methylhistidine).[29][32][33] When exercise intensity and volume are sufficient to cause skeletal muscle damage, such as during [long-distance running](/source/Long-distance_running) or [progressive overload](/source/Progressive_overload), HMB supplementation has been demonstrated to attenuate the rise in these biomarkers by 20–60%.[29][33]

## References

1. **[^](#cite_ref-1)** Cruz-Jentoft, Alfonso J. (2018). ["Beta-Hydroxy-Beta-Methyl Butyrate (HMB): From Experimental Data to Clinical Evidence in Sarcopenia"](https://doi.org/10.2174%2F1389203718666170529105026). *Current Protein & Peptide Science*. **19** (7): 668–672. [doi](/source/Doi_(identifier)):[10.2174/1389203718666170529105026](https://doi.org/10.2174%2F1389203718666170529105026). [ISSN](/source/ISSN_(identifier)) [1875-5550](https://search.worldcat.org/issn/1875-5550). [PMID](/source/PMID_(identifier)) [28554316](https://pubmed.ncbi.nlm.nih.gov/28554316).

1. ^ [***a***](#cite_ref-navarro_2-0) [***b***](#cite_ref-navarro_2-1) [***c***](#cite_ref-navarro_2-2) Navarro VJ, Khan I, Björnsson E, Seeff LB, Serrano J, Hoofnagle JH (January 2017). ["Liver injury from herbal and dietary supplements"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5502701). *Hepatology*. **65** (1): 363–373. [doi](/source/Doi_(identifier)):[10.1002/hep.28813](https://doi.org/10.1002%2Fhep.28813). [PMC](/source/PMC_(identifier)) [5502701](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5502701). [PMID](/source/PMID_(identifier)) [27677775](https://pubmed.ncbi.nlm.nih.gov/27677775).

1. **[^](#cite_ref-3)** Dalby A (2008). *Food in the ancient world, from A to Z*. London: Routledge. p. 203. [ISBN](/source/ISBN_(identifier)) [978-0-415-86279-0](https://en.wikipedia.org/wiki/Special:BookSources/978-0-415-86279-0).

1. **[^](#cite_ref-4)** Higgins M (June 1999). "Hard to Swallow: While federal law shut the door on regulation of dietary supplements, marketing hype may be leading the popular aids up courthouse steps". *ABA Journal*. **85** (6): 60–63.[JSTOR](/source/JSTOR_(identifier)) [27840828](https://www.jstor.org/stable/27840828)

1. **[^](#cite_ref-pmid14971434_5-0)** Tipton KD, Wolfe RR (January 2004). ["Protein and amino acids for athletes"](http://www.uni.edu/dolgener/Advanced_Sport_Nutrition/protein_intake.pdf) (PDF). *Journal of Sports Sciences*. **22** (1): 65–79. [doi](/source/Doi_(identifier)):[10.1080/0264041031000140554](https://doi.org/10.1080%2F0264041031000140554). [PMID](/source/PMID_(identifier)) [14971434](https://pubmed.ncbi.nlm.nih.gov/14971434). [S2CID](/source/S2CID_(identifier)) [16708689](https://api.semanticscholar.org/CorpusID:16708689). [Archived](https://web.archive.org/web/20160304201037/http://www.uni.edu/dolgener/Advanced_Sport_Nutrition/protein_intake.pdf) (PDF) from the original on 2016-03-04. Retrieved 2012-01-10.

1. **[^](#cite_ref-6)** Lemon PW (October 2000). "Beyond the zone: protein needs of active individuals". *Journal of the American College of Nutrition*. **19** (5 Suppl): 513S–521S. [doi](/source/Doi_(identifier)):[10.1080/07315724.2000.10718974](https://doi.org/10.1080%2F07315724.2000.10718974). [PMID](/source/PMID_(identifier)) [11023001](https://pubmed.ncbi.nlm.nih.gov/11023001). [S2CID](/source/S2CID_(identifier)) [14586881](https://api.semanticscholar.org/CorpusID:14586881).

1. **[^](#cite_ref-7)** Phillips SM (December 2006). "Dietary protein for athletes: from requirements to metabolic advantage". *Applied Physiology, Nutrition, and Metabolism*. **31** (6): 647–54. [doi](/source/Doi_(identifier)):[10.1139/h06-035](https://doi.org/10.1139%2Fh06-035). [PMID](/source/PMID_(identifier)) [17213878](https://pubmed.ncbi.nlm.nih.gov/17213878).

1. **[^](#cite_ref-8)** Phillips SM, Moore DR, Tang JE (August 2007). "A critical examination of dietary protein requirements, benefits, and excesses in athletes". *International Journal of Sport Nutrition and Exercise Metabolism*. 17 Suppl: S58-76. [doi](/source/Doi_(identifier)):[10.1123/ijsnem.17.s1.s58](https://doi.org/10.1123%2Fijsnem.17.s1.s58). [PMID](/source/PMID_(identifier)) [18577776](https://pubmed.ncbi.nlm.nih.gov/18577776).

1. **[^](#cite_ref-9)** Slater G, Phillips SM (2011). "Nutrition guidelines for strength sports: sprinting, weightlifting, throwing events, and bodybuilding". *Journal of Sports Sciences*. **29** (Suppl 1): S67-77. [doi](/source/Doi_(identifier)):[10.1080/02640414.2011.574722](https://doi.org/10.1080%2F02640414.2011.574722). [PMID](/source/PMID_(identifier)) [21660839](https://pubmed.ncbi.nlm.nih.gov/21660839). [S2CID](/source/S2CID_(identifier)) [8141005](https://api.semanticscholar.org/CorpusID:8141005).

1. **[^](#cite_ref-10)** Tipton KD, Wolfe RR (January 2004). "Protein and amino acids for athletes". *Journal of Sports Sciences*. **22** (1): 65–79. [doi](/source/Doi_(identifier)):[10.1080/0264041031000140554](https://doi.org/10.1080%2F0264041031000140554). [PMID](/source/PMID_(identifier)) [14971434](https://pubmed.ncbi.nlm.nih.gov/14971434). [S2CID](/source/S2CID_(identifier)) [16708689](https://api.semanticscholar.org/CorpusID:16708689).

1. **[^](#cite_ref-11)** Phillips SM, Van Loon LJ (2011). "Dietary protein for athletes: from requirements to optimum adaptation". *Journal of Sports Sciences*. **29** (Suppl 1): S29-38. [doi](/source/Doi_(identifier)):[10.1080/02640414.2011.619204](https://doi.org/10.1080%2F02640414.2011.619204). [PMID](/source/PMID_(identifier)) [22150425](https://pubmed.ncbi.nlm.nih.gov/22150425). [S2CID](/source/S2CID_(identifier)) [33218998](https://api.semanticscholar.org/CorpusID:33218998).

1. **[^](#cite_ref-lemon_12-0)** Lemon PW (June 1995). "Do athletes need more dietary protein and amino acids?". *International Journal of Sport Nutrition*. 5 Suppl: S39-61. [doi](/source/Doi_(identifier)):[10.1123/ijsn.5.s1.s39](https://doi.org/10.1123%2Fijsn.5.s1.s39). [PMID](/source/PMID_(identifier)) [7550257](https://pubmed.ncbi.nlm.nih.gov/7550257). [S2CID](/source/S2CID_(identifier)) [27679614](https://api.semanticscholar.org/CorpusID:27679614).

1. ^ [***a***](#cite_ref-fnic.nal.usda.gov_13-0) [***b***](#cite_ref-fnic.nal.usda.gov_13-1) ["Macronutrients"](https://www.nap.edu/read/10490/chapter/12#661). *Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids*. Washington, D.C.: National Academies Press. 2005. [doi](/source/Doi_(identifier)):[10.17226/10490](https://doi.org/10.17226%2F10490). [ISBN](/source/ISBN_(identifier)) [978-0-309-08525-0](https://en.wikipedia.org/wiki/Special:BookSources/978-0-309-08525-0). [Archived](https://web.archive.org/web/20190814213856/https://www.nap.edu/read/10490/chapter/12#661) from the original on 2019-08-14. Retrieved 2017-01-01.

1. **[^](#cite_ref-14)** [https://www.health.harvard.edu/blog/how-much-protein-do-you-need-every-day-201506188096#:~:text=The%20Recommended%20Dietary%20Allowance%20(RDA,meet%20your%20basic%20nutritional%20requirements](https://www.health.harvard.edu/blog/how-much-protein-do-you-need-every-day-201506188096#:~:text=The%20Recommended%20Dietary%20Allowance%20(RDA,meet%20your%20basic%20nutritional%20requirements). Harvard Medical School , Harvard Health Publishing. “How much protein do you need every day?” Reviewed by Howard E. LeWine, MD, Chief Medical Editor, Harvard Health Publishing. June 22, 2023.

1. ^ [***a***](#cite_ref-wolfe_15-0) [***b***](#cite_ref-wolfe_15-1) [***c***](#cite_ref-wolfe_15-2) Wolfe RR (August 2000). ["Protein supplements and exercise"](https://doi.org/10.1093%2Fajcn%2F72.2.551S). *The American Journal of Clinical Nutrition*. **72** (2 Suppl): 551S–7S. [doi](/source/Doi_(identifier)):[10.1093/ajcn/72.2.551S](https://doi.org/10.1093%2Fajcn%2F72.2.551S). [PMID](/source/PMID_(identifier)) [10919959](https://pubmed.ncbi.nlm.nih.gov/10919959).

1. **[^](#cite_ref-16)** Kerstetter JE, O'Brien KO, Insogna KL (September 2003). ["Dietary protein, calcium metabolism, and skeletal homeostasis revisited"](https://doi.org/10.1093%2Fajcn%2F78.3.584S). *The American Journal of Clinical Nutrition*. **78** (3 Suppl): 584S–592S. [doi](/source/Doi_(identifier)):[10.1093/ajcn/78.3.584S](https://doi.org/10.1093%2Fajcn%2F78.3.584S). [PMID](/source/PMID_(identifier)) [12936953](https://pubmed.ncbi.nlm.nih.gov/12936953).

1. **[^](#cite_ref-17)** Kerstetter JE, O'Brien KO, Insogna KL (March 2003). ["Low protein intake: the impact on calcium and bone homeostasis in humans"](https://doi.org/10.1093%2Fjn%2F133.3.855S). *The Journal of Nutrition*. **133** (3): 855S–861S. [doi](/source/Doi_(identifier)):[10.1093/jn/133.3.855S](https://doi.org/10.1093%2Fjn%2F133.3.855S). [PMID](/source/PMID_(identifier)) [12612169](https://pubmed.ncbi.nlm.nih.gov/12612169).

1. **[^](#cite_ref-18)** Dawson-Hughes B, Harris SS, Rasmussen H, Song L, Dallal GE (March 2004). ["Effect of dietary protein supplements on calcium excretion in healthy older men and women"](https://doi.org/10.1210%2Fjc.2003-031466). *The Journal of Clinical Endocrinology and Metabolism*. **89** (3): 1169–73. [doi](/source/Doi_(identifier)):[10.1210/jc.2003-031466](https://doi.org/10.1210%2Fjc.2003-031466). [PMID](/source/PMID_(identifier)) [15001604](https://pubmed.ncbi.nlm.nih.gov/15001604).

1. **[^](#cite_ref-sizer_19-0)** Sizer FS, Piché LA, Whitney EN (2012). [*Nutrition: Concepts and Controversies*](https://books.google.com/books?id=Q7VRgwLhGKgC&pg=PA407). Cengage Learning. p. 407. [ISBN](/source/ISBN_(identifier)) [978-0-17-650258-4](https://en.wikipedia.org/wiki/Special:BookSources/978-0-17-650258-4).

1. **[^](#cite_ref-Erkkola2006_20-0)** Risto Erkkola (2006). [*The Menopause*](https://books.google.com/books?id=1AU_NI__fpUC&pg=PA5). Elsevier. pp. 5–. [ISBN](/source/ISBN_(identifier)) [978-0-444-51830-9](https://en.wikipedia.org/wiki/Special:BookSources/978-0-444-51830-9).

1. **[^](#cite_ref-21)** Friedel, Angelika, et al. "17β-hydroxy-5alpha-androst-1-en-3-one (1-testosterone) is a potent androgen with anabolic properties." Toxicology letters 165.2 (2006): 149-155.

1. **[^](#cite_ref-22)** Williams, Melvin H.; Branch, J. David (June 1998). ["Creatine Supplementation and Exercise Performance: An Update"](http://www.tandfonline.com/doi/abs/10.1080/07315724.1998.10718751). *Journal of the American College of Nutrition*. **17** (3): 216–234. [doi](/source/Doi_(identifier)):[10.1080/07315724.1998.10718751](https://doi.org/10.1080%2F07315724.1998.10718751). [ISSN](/source/ISSN_(identifier)) [0731-5724](https://search.worldcat.org/issn/0731-5724). [PMID](/source/PMID_(identifier)) [9627907](https://pubmed.ncbi.nlm.nih.gov/9627907).

1. **[^](#cite_ref-23)** Becque MD, Lochmann JD, Melrose DR (March 2000). ["Effects of oral creatine supplementation on muscular strength and body composition"](https://doi.org/10.1097%2F00005768-200003000-00016). *Medicine and Science in Sports and Exercise*. **32** (3): 654–8. [doi](/source/Doi_(identifier)):[10.1097/00005768-200003000-00016](https://doi.org/10.1097%2F00005768-200003000-00016). [PMID](/source/PMID_(identifier)) [10731009](https://pubmed.ncbi.nlm.nih.gov/10731009).

1. **[^](#cite_ref-24)** Birch R, Noble D, Greenhaff PL (1994). "The influence of dietary creatine supplementation on performance during repeated bouts of maximal isokinetic cycling in man". *European Journal of Applied Physiology and Occupational Physiology*. **69** (3): 268–76. [doi](/source/Doi_(identifier)):[10.1007/BF01094800](https://doi.org/10.1007%2FBF01094800). [PMID](/source/PMID_(identifier)) [8001541](https://pubmed.ncbi.nlm.nih.gov/8001541). [S2CID](/source/S2CID_(identifier)) [8455503](https://api.semanticscholar.org/CorpusID:8455503).

1. **[^](#cite_ref-25)** Rae C, Digney AL, McEwan SR, Bates TC (October 2003). ["Oral creatine monohydrate supplementation improves brain performance: a double-blind, placebo-controlled, cross-over trial"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1691485). *Proceedings. Biological Sciences*. **270** (1529): 2147–50. [doi](/source/Doi_(identifier)):[10.1098/rspb.2003.2492](https://doi.org/10.1098%2Frspb.2003.2492). [PMC](/source/PMC_(identifier)) [1691485](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1691485). [PMID](/source/PMID_(identifier)) [14561278](https://pubmed.ncbi.nlm.nih.gov/14561278).

1. **[^](#cite_ref-26)** Watanabe A, Kato N, Kato T (April 2002). "Effects of creatine on mental fatigue and cerebral hemoglobin oxygenation". *Neuroscience Research*. **42** (4): 279–85. [doi](/source/Doi_(identifier)):[10.1016/S0168-0102(02)00007-X](https://doi.org/10.1016%2FS0168-0102%2802%2900007-X). [PMID](/source/PMID_(identifier)) [11985880](https://pubmed.ncbi.nlm.nih.gov/11985880). [S2CID](/source/S2CID_(identifier)) [6304255](https://api.semanticscholar.org/CorpusID:6304255).

1. **[^](#cite_ref-27)** Green AL, Hultman E, Macdonald IA, Sewell DA, Greenhaff PL (November 1996). "Carbohydrate ingestion augments skeletal muscle creatine accumulation during creatine supplementation in humans". *The American Journal of Physiology*. **271** (5 Pt 1): E821-6. [doi](/source/Doi_(identifier)):[10.1152/ajpendo.1996.271.5.E821](https://doi.org/10.1152%2Fajpendo.1996.271.5.E821). [PMID](/source/PMID_(identifier)) [8944667](https://pubmed.ncbi.nlm.nih.gov/8944667).

1. **[^](#cite_ref-28)** ["Creatine"](https://www.mayoclinic.org/drugs-supplements-creatine/art-20347591). *Mayo Clinic*. [Archived](https://web.archive.org/web/20201209180918/https://www.mayoclinic.org/drugs-supplements-creatine/art-20347591) from the original on 2020-12-09. Retrieved 2020-12-16.

1. ^ [***a***](#cite_ref-PEDs_in_sports_2015_review_29-0) [***b***](#cite_ref-PEDs_in_sports_2015_review_29-1) [***c***](#cite_ref-PEDs_in_sports_2015_review_29-2) [***d***](#cite_ref-PEDs_in_sports_2015_review_29-3) [***e***](#cite_ref-PEDs_in_sports_2015_review_29-4) [***f***](#cite_ref-PEDs_in_sports_2015_review_29-5) [***g***](#cite_ref-PEDs_in_sports_2015_review_29-6) [***h***](#cite_ref-PEDs_in_sports_2015_review_29-7) Momaya A, Fawal M, Estes R (April 2015). "Performance-enhancing substances in sports: a review of the literature". *Sports Medicine*. **45** (4): 517–31. [doi](/source/Doi_(identifier)):[10.1007/s40279-015-0308-9](https://doi.org/10.1007%2Fs40279-015-0308-9). [PMID](/source/PMID_(identifier)) [25663250](https://pubmed.ncbi.nlm.nih.gov/25663250). [S2CID](/source/S2CID_(identifier)) [45124293](https://api.semanticscholar.org/CorpusID:45124293). Wilson et al. [91] demonstrated that when non-resistance trained males received HMB pre-exercise, the rise of lactate dehydrogenase (LDH) levels reduced, and HMB tended to decrease soreness. Knitter et al. [92] showed a decrease in LDH and creatine phosphokinase (CPK), a byproduct of muscle breakdown, by HMB after a prolonged run. ... The utility of HMB does seem to be affected by timing of intake prior to workouts and dosage [97].

1. ^ [***a***](#cite_ref-Meta-analytic_systematic_review_September_2015_30-0) [***b***](#cite_ref-Meta-analytic_systematic_review_September_2015_30-1) Wu H, Xia Y, Jiang J, Du H, Guo X, Liu X, et al. (September 2015). "Effect of beta-hydroxy-beta-methylbutyrate supplementation on muscle loss in older adults: a systematic review and meta-analysis". *Archives of Gerontology and Geriatrics*. **61** (2): 168–75. [doi](/source/Doi_(identifier)):[10.1016/j.archger.2015.06.020](https://doi.org/10.1016%2Fj.archger.2015.06.020). [PMID](/source/PMID_(identifier)) [26169182](https://pubmed.ncbi.nlm.nih.gov/26169182).

1. ^ [***a***](#cite_ref-Molecular_Aspects_of_Medicine_2016_review_31-0) [***b***](#cite_ref-Molecular_Aspects_of_Medicine_2016_review_31-1) [***c***](#cite_ref-Molecular_Aspects_of_Medicine_2016_review_31-2) Brioche T, Pagano AF, Py G, Chopard A (August 2016). ["Muscle wasting and aging: Experimental models, fatty infiltrations, and prevention"](https://hal.archives-ouvertes.fr/hal-01837630/file/2016_Brioche_MAM_1.pdf) (PDF). *Molecular Aspects of Medicine*. **50**: 56–87. [doi](/source/Doi_(identifier)):[10.1016/j.mam.2016.04.006](https://doi.org/10.1016%2Fj.mam.2016.04.006). [PMID](/source/PMID_(identifier)) [27106402](https://pubmed.ncbi.nlm.nih.gov/27106402). [S2CID](/source/S2CID_(identifier)) [29717535](https://api.semanticscholar.org/CorpusID:29717535). [Archived](https://web.archive.org/web/20211124021646/https://hal.archives-ouvertes.fr/hal-01837630/file/2016_Brioche_MAM_1.pdf) (PDF) from the original on 2021-11-24. Retrieved 2020-09-01. In conclusion, HMB treatment clearly appears to be a safe potent strategy against sarcopenia, and more generally against muscle wasting, because HMB improves muscle mass, muscle strength, and physical performance. It seems that HMB is able to act on three of the four major mechanisms involved in muscle deconditioning (protein turnover, apoptosis, and the regenerative process), whereas it is hypothesized to strongly affect the fourth (mitochondrial dynamics and functions). Moreover, HMB is cheap (~30– 50 US dollars per month at 3 g per day) and may prevent osteopenia (Bruckbauer and Zemel, 2013; Tatara, 2009; Tatara et al., 2007, 2008, 2012) and decrease cardiovascular risks (Nissen et al., 2000). For all these reasons, HMB should be routinely used in muscle-wasting conditions especially in aged people. ... 3 g of CaHMB taken three times a day (1 g each time) is the optimal posology, which allows for continual bioavailability of HMB in the body (Wilson et al., 2013).

1. ^ [***a***](#cite_ref-Effects_of_amino_acid_derivatives_2015_review_32-0) [***b***](#cite_ref-Effects_of_amino_acid_derivatives_2015_review_32-1) [***c***](#cite_ref-Effects_of_amino_acid_derivatives_2015_review_32-2) [***d***](#cite_ref-Effects_of_amino_acid_derivatives_2015_review_32-3) Luckose F, Pandey MC, Radhakrishna K (2015). "Effects of amino acid derivatives on physical, mental, and physiological activities". *Critical Reviews in Food Science and Nutrition*. **55** (13): 1793–807. [doi](/source/Doi_(identifier)):[10.1080/10408398.2012.708368](https://doi.org/10.1080%2F10408398.2012.708368). [PMID](/source/PMID_(identifier)) [24279396](https://pubmed.ncbi.nlm.nih.gov/24279396). [S2CID](/source/S2CID_(identifier)) [22657268](https://api.semanticscholar.org/CorpusID:22657268). HMB, a derivative of leucine, prevents muscle damage and increases muscle strength by reducing exercise-induced proteolysis in muscles and also helps in increasing lean body mass. ... The meta analysis studies and the individual studies conducted support the use of HMB as an effective aid to increase body strength, body composition, and to prevent muscle damage during resistance training.

1. ^ [***a***](#cite_ref-ISSN_position_stand_2013_33-0) [***b***](#cite_ref-ISSN_position_stand_2013_33-1) [***c***](#cite_ref-ISSN_position_stand_2013_33-2) [***d***](#cite_ref-ISSN_position_stand_2013_33-3) [***e***](#cite_ref-ISSN_position_stand_2013_33-4) Wilson JM, Fitschen PJ, Campbell B, Wilson GJ, Zanchi N, Taylor L, et al. (February 2013). ["International Society of Sports Nutrition Position Stand: beta-hydroxy-beta-methylbutyrate (HMB)"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3568064). *Journal of the International Society of Sports Nutrition*. **10** (1): 6. [doi](/source/Doi_(identifier)):[10.1186/1550-2783-10-6](https://doi.org/10.1186%2F1550-2783-10-6). [PMC](/source/PMC_(identifier)) [3568064](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3568064). [PMID](/source/PMID_(identifier)) [23374455](https://pubmed.ncbi.nlm.nih.gov/23374455).

1. **[^](#cite_ref-Skeletal_muscle_homeostasis_2016_review_35-0)** Brook MS, Wilkinson DJ, Phillips BE, Perez-Schindler J, Philp A, Smith K, Atherton PJ (January 2016). ["Skeletal muscle homeostasis and plasticity in youth and ageing: impact of nutrition and exercise"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4843955). *Acta Physiologica*. **216** (1): 15–41. [doi](/source/Doi_(identifier)):[10.1111/apha.12532](https://doi.org/10.1111%2Fapha.12532). [PMC](/source/PMC_(identifier)) [4843955](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4843955). [PMID](/source/PMID_(identifier)) [26010896](https://pubmed.ncbi.nlm.nih.gov/26010896).

1. **[^](#cite_ref-36)** Morton, Robert W; Murphy, Kevin T; McKellar, Sean R; Schoenfeld, Brad J; Henselmans, Menno; Helms, Eric; Aragon, Alan A; Devries, Michaela C; Banfield, Laura; Krieger, James W; Phillips, Stuart M (March 2018). ["A systematic review, meta-analysis and meta-regression of the effect of protein supplementation on resistance training-induced gains in muscle mass and strength in healthy adults"](https://bjsm.bmj.com/lookup/doi/10.1136/bjsports-2017-097608). *British Journal of Sports Medicine*. **52** (6): 376–384. [doi](/source/Doi_(identifier)):[10.1136/bjsports-2017-097608](https://doi.org/10.1136%2Fbjsports-2017-097608). [ISSN](/source/ISSN_(identifier)) [0306-3674](https://search.worldcat.org/issn/0306-3674). [PMC](/source/PMC_(identifier)) [5867436](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867436). [PMID](/source/PMID_(identifier)) [28698222](https://pubmed.ncbi.nlm.nih.gov/28698222).

1. **[^](#cite_ref-37)** Tagawa, Ryoichi; Watanabe, Daiki; Ito, Kyoko; Ueda, Keisuke; Nakayama, Kyosuke; Sanbongi, Chiaki; Miyachi, Motohiko (2021-01-01). ["Dose–response relationship between protein intake and muscle mass increase: a systematic review and meta-analysis of randomized controlled trials"](https://academic.oup.com/nutritionreviews/article/79/1/66/5936522). *Nutrition Reviews*. **79** (1): 66–75. [doi](/source/Doi_(identifier)):[10.1093/nutrit/nuaa104](https://doi.org/10.1093%2Fnutrit%2Fnuaa104). [ISSN](/source/ISSN_(identifier)) [0029-6643](https://search.worldcat.org/issn/0029-6643). [PMC](/source/PMC_(identifier)) [7727026](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7727026). [PMID](/source/PMID_(identifier)) [33300582](https://pubmed.ncbi.nlm.nih.gov/33300582).

1. **[^](#cite_ref-MyUser_Theglobeandmail.com_December_11_2015c_38-0)** McGinn D (7 November 2010). ["Are protein shakes the weight-loss magic bullet? - The Globe and Mail"](https://www.theglobeandmail.com/life/health-and-fitness/health/conditions/are-protein-shakes-the-weight-loss-magic-bullet/article596648/). *Theglobeandmail.com*. [Archived](https://web.archive.org/web/20160602013106/http://www.theglobeandmail.com/life/health-and-fitness/health/conditions/are-protein-shakes-the-weight-loss-magic-bullet/article596648/) from the original on 2 June 2016. Retrieved December 11, 2015.

1. ^ [***a***](#cite_ref-FDAtestimony_39-0) [***b***](#cite_ref-FDAtestimony_39-1) ["Body-building Products and Hidden Steroids: Enforcement Barriers"](https://web.archive.org/web/20150314235825/https://www.fda.gov/NewsEvents/Testimony/ucm184497.htm). Food and Drug Administration. Archived from [the original](https://www.fda.gov/NewsEvents/Testimony/ucm184497.htm) on 2015-03-14.

1. **[^](#cite_ref-spike_40-0)** O'Connor A (21 December 2013). ["Spike in Harm to Liver Is Tied to Dietary Aids"](https://www.nytimes.com/2013/12/22/us/spike-in-harm-to-liver-is-tied-to-dietary-aids.html?_r=0). *[The New York Times](/source/The_New_York_Times)*. [Archived](https://web.archive.org/web/20190410210623/https://www.nytimes.com/2013/12/22/us/spike-in-harm-to-liver-is-tied-to-dietary-aids.html?_r=0) from the original on 10 April 2019. Retrieved 26 February 2017.

1. **[^](#cite_ref-41)** Joseph JF, Parr MK (January 2015). ["Synthetic androgens as designer supplements"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4462045). *Current Neuropharmacology*. **13** (1): 89–100. [doi](/source/Doi_(identifier)):[10.2174/1570159X13666141210224756](https://doi.org/10.2174%2F1570159X13666141210224756). [PMC](/source/PMC_(identifier)) [4462045](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4462045). [PMID](/source/PMID_(identifier)) [26074745](https://pubmed.ncbi.nlm.nih.gov/26074745).

1. **[^](#cite_ref-42)** Rocha T, Amaral JS, Oliveira MB (January 2016). ["Adulteration of Dietary Supplements by the Illegal Addition of Synthetic Drugs: A Review"](https://doi.org/10.1111%2F1541-4337.12173). *Comprehensive Reviews in Food Science and Food Safety*. **15** (1): 43–62. [doi](/source/Doi_(identifier)):[10.1111/1541-4337.12173](https://doi.org/10.1111%2F1541-4337.12173). [hdl](/source/Hdl_(identifier)):[10198/15401](https://hdl.handle.net/10198%2F15401). [PMID](/source/PMID_(identifier)) [33371574](https://pubmed.ncbi.nlm.nih.gov/33371574).

1. ^ [***a***](#cite_ref-Griffith-Greene_2015_43-0) [***b***](#cite_ref-Griffith-Greene_2015_43-1) Griffith-Greene M (13 November 2015). ["M Some protein powders fail fitness test"](http://www.cbc.ca/news/health/marketplace-protein-powders-1.3313084). *Marketplace*. CBC News. [Archived](https://web.archive.org/web/20170908232102/http://www.cbc.ca/news/health/marketplace-protein-powders-1.3313084) from the original on 8 September 2017. Retrieved 11 December 2015.

1. **[^](#cite_ref-skip_44-0)** Offit PA, Erush S (14 December 2013). ["Skip the Supplements"](https://www.nytimes.com/2013/12/15/opinion/sunday/skip-the-supplements.html?_r=0). *[The New York Times](/source/The_New_York_Times)*. [Archived](https://web.archive.org/web/20190717115958/https://www.nytimes.com/2013/12/15/opinion/sunday/skip-the-supplements.html?_r=0) from the original on 17 July 2019. Retrieved 26 February 2017.

1. **[^](#cite_ref-45)** ["Tainted Body Building Products"](https://web.archive.org/web/20190423022416/https://www.fda.gov/Drugs/ResourcesForYou/Consumers/BuyingUsingMedicineSafely/MedicationHealthFraud/ucm234523.htm). *U.S. Food and Drug Administration*. 17 December 2010. Archived from [the original](https://www.fda.gov/Drugs/ResourcesForYou/Consumers/BuyingUsingMedicineSafely/MedicationHealthFraud/ucm234523.htm) on 23 April 2019. Retrieved 16 December 2019.

1. **[^](#cite_ref-46)** Young A (25 October 2013). ["Popular sports supplements contain meth-like compound"](https://www.usatoday.com/story/news/nation/2013/10/14/tests-of-supplements-craze-and-detonate-find-methamphetamine-like-compound/2968041/). USA Today. [Archived](https://web.archive.org/web/20191112103646/https://www.usatoday.com/story/news/nation/2013/10/14/tests-of-supplements-craze-and-detonate-find-methamphetamine-like-compound/2968041/) from the original on 12 November 2019. Retrieved 24 August 2017. Cohen said researchers informed the FDA in May about finding the new chemical compound in Craze. The team found the compound — N,alpha-diethylphenylethylamine — has a structure similar to methamphetamine, a powerful, highly addictive, illegal stimulant drug. They believe the new compound is likely less potent than methamphetamine but greater than ephedrine.

1. **[^](#cite_ref-47)** Björnsson, Einar S.; Bergmann, Ottar M.; Björnsson, Helgi K.; Kvaran, Runar B.; Olafsson, Sigurdur (June 2013). ["Incidence, Presentation, and Outcomes in Patients With Drug-Induced Liver Injury in the General Population of Iceland"](https://pubmed.ncbi.nlm.nih.gov/23419359/). *Gastroenterology*. **144** (7): 1419–1425.e3. [doi](/source/Doi_(identifier)):[10.1053/j.gastro.2013.02.006](https://doi.org/10.1053%2Fj.gastro.2013.02.006). Retrieved March 20, 2026.

1. **[^](#cite_ref-48)** ["Driven Sports Inc. - 04/04/2014"](https://web.archive.org/web/20210122105247/https://www.fda.gov/inspections-compliance-enforcement-and-criminal-investigations/warning-letters/driven-sports-inc-04042014). *U.S. Food and Drug Administration*. 2019-12-20. Archived from [the original](https://www.fda.gov/inspections-compliance-enforcement-and-criminal-investigations/warning-letters/driven-sports-inc-04042014) on 2021-01-22. Retrieved 2020-12-16.

1. **[^](#cite_ref-49)** Young A (27 September 2013). ["Sports supplement designer has history of risky products"](https://www.usatoday.com/story/news/nation/2013/07/25/bodybuilding-supplement-designer-matt-cahill-usa-today-investigation/2568815/). *[USA Today](/source/USA_Today)*. [Archived](https://web.archive.org/web/20190625203255/https://www.usatoday.com/story/news/nation/2013/07/25/bodybuilding-supplement-designer-matt-cahill-usa-today-investigation/2568815/) from the original on 25 June 2019. Retrieved 24 August 2017.

1. **[^](#cite_ref-50)** Morton, Robert W., et al. "A systematic review, meta-analysis and meta-regression of the effect of protein supplementation on resistance training-induced gains in muscle mass and strength in healthy adults." British journal of sports medicine 52.6 (2018): 376-384.

## External links

Wikimedia Commons has media related to [Bodybuilding supplements](https://commons.wikimedia.org/wiki/Category:Bodybuilding_supplements).

- ["Dietary Supplement Health and Education Act of 1994"](https://web.archive.org/web/20090602042403/http://www.fda.gov/Food/DietarySupplements/default.htm). *U.S. Food and Drug Administration*. 4 February 2020. Archived from [the original](https://www.fda.gov/food/dietarysupplements/default.htm) on June 2, 2009.

v t e Pharmacological body alteration Bodybuilding supplement Breast enlargement Clitoris enlargement Ergogenic use of anabolic steroids Growth hormone therapy Transgender hormone therapy Feminizing hormone therapy Masculinizing hormone therapy Penis enlargement Performance-enhancing substance

v t e Dietary supplements Types Bodybuilding supplement Energy drink Energy bar Fatty acids Herbal supplements Minerals Prebiotics Probiotics (Lactobacillus Bifidobacterium) Protein supplements Vitamins Vitamins and chemical elements ("minerals") Retinol (Vitamin A) B vitamins Thiamine (B1) Riboflavin (B2) Niacin (B3) Pantothenic acid (B5) Pyridoxine (B6) Biotin (B7) Folic acid (B9) Cobalamin (B12) Ascorbic acid (Vitamin C) Ergocalciferol and Cholecalciferol (Vitamin D) Tocopherol (Vitamin E) Naphthoquinone (Vitamin K) Calcium Choline Chromium Cobalt Copper Fluorine Iodine Iron Magnesium Manganese Molybdenum Phosphorus Potassium Selenium Sodium Sulfur Zinc Other common ingredients AAKG β-hydroxy β-methylbutyrate Carnitine Chondroitin sulfate Cod liver oil Copper gluconate Creatine Dietary fiber Echinacea Ephedra Fish oil Folic acid Ginseng Glucosamine Glutamine Grape seed extract Guarana Iron supplements Japanese honeysuckle Krill oil Lingzhi Linseed oil Lipoic acid Milk thistle Melatonin Red yeast rice Royal jelly Saw palmetto Spirulina St John's wort Taurine Wheatgrass Wolfberry Yohimbine Zinc gluconate Related articles Codex Alimentarius Enzyte Hadacol Herbal tea Nutraceutical Multivitamin Nutrition

v t e Human nutrition and healthy diets Main articles Diet Dieting Cuisine Dietitian Hunger Leptin Meal Nutrition Obesity Staple food Dieting Basic types Omnivore Plant-based Regional diets Western Mediterranean Atlantic Sustainable diets Low carbon Planetary health diet Religious diets Buddhist Christian Hindu Islamic Jain Jewish Rastafari Sikh Vegetarianism and veganism Fruitarianism Meat analogue Milk substitute Raw vegan Tofu Semi-vegetarianism Ovo-lacto vegetarianism Pescetarian Pollotarian Supplement diets Bodybuilding supplements Meal replacement Therapeutic food Non-solid diets Liquid diets Very-low-calorie diet Specific restrictions Calorie restriction Cardiac diet Diabetic diet Elimination diet Fluid restriction diet Gluten-free Gluten-free and casein-free Intermittent fasting Low-sodium Low-FODMAP Low-carbohydrate Low-fat Low-fiber/low-residue diet Low-protein Monotrophic diet NPO Renal diet Soft diet Specific carbohydrate Other diets Entomophagy Cotton ball Pica DASH Inuit MIND Time Restricted Eating Liquid diet Ninja diet Raw foodism U.S. military Junk food Fad diets Cambridge Macrobiotic Master Cleanse Superfood Slow-Carb List of diets Diet food Nutrition Amino acids Alanine Arginine Asparagine Aspartic acid Cysteine Glutamic acid Glutamine Glycine Histidine Isoleucine Leucine Lysine Methionine Phenylalanine Proline Selenocysteine Serine Threonine Tryptophan Tyrosine Valine Vitamins Vitamin A Vitamin B1 Vitamin B2 Vitamin B3 Vitamin B5 Vitamin B6 Vitamin B7 Vitamin B9 Vitamin B12 Vitamin C Vitamin D Vitamin E Vitamin K Minerals Calcium Chlorine Chromium Cobalt Copper Iodine Iron Magnesium Manganese Molybdenum Nickel Phosphorus Potassium Selenium Sodium Vanadium Zinc Nutritional advice 5 A Day Dairy Council Dairy Council of California Food pyramid Fruits & Veggies – More Matters Healthy eating pyramid Latin American Diet Pyramid French paradox Mediterranean Diet Pyramid MyPlate MyPyramid Vegetarian Diet Pyramid Weight Watchers Category Commons Cookbook Food portal, Health and fitness portal

---
Adapted from the Wikipedia article [Bodybuilding supplement](https://en.wikipedia.org/wiki/Bodybuilding_supplement) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/Bodybuilding_supplement?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.