# BNIP2

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Protein-coding gene in the species Homo sapiens

BNIP2 Identifiers Aliases BNIP2, BNIP-2, NIP2, BCL2/adenovirus E1B 19kDa interacting protein 2, BCL2 interacting protein 2 External IDs OMIM: 603292; MGI: 109327; HomoloGene: 3194; GeneCards: BNIP2; OMA:BNIP2 - orthologs Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q22.2 Start 59,659,146 bp[1] End 59,689,534 bp[1] Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 D Start 69,896,748 bp[2] End 69,915,599 bp[2] RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon monocyte epithelium of colon bone marrow cell rectum body of pancreas minor salivary glands right uterine tube right lung gallbladder Top expressed in ascending aorta aortic valve tunica media of zone of aorta genital tubercle tail of embryo iris ciliary body stroma of bone marrow fossa body of femur More reference expression data BioGPS More reference expression data Gene ontology Molecular function GTPase activator activity calcium ion binding identical protein binding protein binding exopolyphosphatase activity Cellular component perinuclear region of cytoplasm cytoplasm intracellular membrane-bounded organelle nuclear envelope cytosol membrane integral component of membrane Biological process positive regulation of muscle cell differentiation negative regulation of apoptotic process apoptotic process positive regulation of GTPase activity polyphosphate catabolic process Sources:Amigo / QuickGO Orthologs Species Human Mouse Entrez 663 12175 Ensembl ENSG00000140299 ENSMUSG00000011958 UniProt Q12982 O54940 RefSeq (mRNA) NM_004330 NM_001320674 NM_001320675 NM_001008238 NM_016787 NM_001374750 RefSeq (protein) NP_001307603 NP_001307604 NP_004321 NP_001354986 NP_001354987 NP_001354988 NP_001354989 NP_001354990 NP_001008239 NP_058067 NP_001361679 Location (UCSC) Chr 15: 59.66 – 59.69 Mb Chr 9: 69.9 – 69.92 Mb PubMed search [3] [4] Wikidata View/Edit Human View/Edit Mouse

**BCL2/adenovirus E1B 19 kDa protein-interacting protein 2** is a [protein](/source/Protein) that in humans is encoded by the *BNIP2* [gene](/source/Gene).[5][6]

## Function

This gene is a member of the [BCL2](/source/Bcl-2_family)/adenovirus E1B 19 kd-interacting protein (BNIP) family. Though the specific function is unknown, it interacts with the E1B 19 kDa protein which is responsible for the protection of virally induced cell death, as well as E1B 19 kDa-like sequences of [BCL-2](/source/BCL-2), also an [apoptotic](/source/Apoptotic) protector.[6]

## Interactions

BNIP2 has been shown to [interact](/source/Protein-protein_interaction) with:

- [ARHGAP1](/source/ARHGAP1),[7][8]

- [Bcl-2](/source/Bcl-2),[5][9] and

- [CDC42](/source/CDC42).[7][8][10]

## References

1. ^ [***a***](#cite_ref-refGRCh38Ensembl_1-0) [***b***](#cite_ref-refGRCh38Ensembl_1-1) [***c***](#cite_ref-refGRCh38Ensembl_1-2) [GRCh38: Ensembl release 89: ENSG00000140299](http://May2017.archive.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000140299) – [Ensembl](/source/Ensembl_genome_database_project), May 2017

1. ^ [***a***](#cite_ref-refGRCm38Ensembl_2-0) [***b***](#cite_ref-refGRCm38Ensembl_2-1) [***c***](#cite_ref-refGRCm38Ensembl_2-2) [GRCm38: Ensembl release 89: ENSMUSG00000011958](http://May2017.archive.ensembl.org/Mus_musculus/Gene/Summary?db=core;g=ENSMUSG00000011958) – [Ensembl](/source/Ensembl_genome_database_project), May 2017

1. **[^](#cite_ref-3)** ["Human PubMed Reference:"](https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=663). *National Center for Biotechnology Information, U.S. National Library of Medicine*.

1. **[^](#cite_ref-4)** ["Mouse PubMed Reference:"](https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=12175). *National Center for Biotechnology Information, U.S. National Library of Medicine*.

1. ^ [***a***](#cite_ref-pmid7954800_5-0) [***b***](#cite_ref-pmid7954800_5-1) Boyd JM, Malstrom S, Subramanian T, Venkatesh LK, Schaeper U, Elangovan B, D'Sa-Eipper C, Chinnadurai G (November 1994). "Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins". *Cell*. **79** (2): 341–51. [doi](/source/Doi_(identifier)):[10.1016/0092-8674(94)90202-X](https://doi.org/10.1016%2F0092-8674%2894%2990202-X). [PMID](/source/PMID_(identifier)) [7954800](https://pubmed.ncbi.nlm.nih.gov/7954800). [S2CID](/source/S2CID_(identifier)) [38609845](https://api.semanticscholar.org/CorpusID:38609845).

1. ^ [***a***](#cite_ref-entrez_6-0) [***b***](#cite_ref-entrez_6-1) ["Entrez Gene: BNIP2 BCL2/adenovirus E1B 19kDa interacting protein 2"](https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=663).

1. ^ [***a***](#cite_ref-pmid10954711_7-0) [***b***](#cite_ref-pmid10954711_7-1) Low BC, Seow KT, Guy GR (December 2000). ["The BNIP-2 and Cdc42GAP homology domain of BNIP-2 mediates its homophilic association and heterophilic interaction with Cdc42GAP"](https://doi.org/10.1074%2Fjbc.M004897200). *J. Biol. Chem*. **275** (48): 37742–51. [doi](/source/Doi_(identifier)):[10.1074/jbc.M004897200](https://doi.org/10.1074%2Fjbc.M004897200). [PMID](/source/PMID_(identifier)) [10954711](https://pubmed.ncbi.nlm.nih.gov/10954711).

1. ^ [***a***](#cite_ref-pmid10551883_8-0) [***b***](#cite_ref-pmid10551883_8-1) Low BC, Lim YP, Lim J, Wong ES, Guy GR (November 1999). ["Tyrosine phosphorylation of the Bcl-2-associated protein BNIP-2 by fibroblast growth factor receptor-1 prevents its binding to Cdc42GAP and Cdc42"](https://doi.org/10.1074%2Fjbc.274.46.33123). *J. Biol. Chem*. **274** (46): 33123–30. [doi](/source/Doi_(identifier)):[10.1074/jbc.274.46.33123](https://doi.org/10.1074%2Fjbc.274.46.33123). [PMID](/source/PMID_(identifier)) [10551883](https://pubmed.ncbi.nlm.nih.gov/10551883).

1. **[^](#cite_ref-pmid12901880_9-0)** Qin W, Hu J, Guo M, Xu J, Li J, Yao G, Zhou X, Jiang H, Zhang P, Shen L, Wan D, Gu J (August 2003). "BNIPL-2, a novel homologue of BNIP-2, interacts with Bcl-2 and Cdc42GAP in apoptosis". *Biochem. Biophys. Res. Commun*. **308** (2): 379–85. [Bibcode](/source/Bibcode_(identifier)):[2003BBRC..308..379Q](https://ui.adsabs.harvard.edu/abs/2003BBRC..308..379Q). [doi](/source/Doi_(identifier)):[10.1016/s0006-291x(03)01387-1](https://doi.org/10.1016%2Fs0006-291x%2803%2901387-1). [PMID](/source/PMID_(identifier)) [12901880](https://pubmed.ncbi.nlm.nih.gov/12901880).

1. **[^](#cite_ref-pmid10799524_10-0)** Low BC, Seow KT, Guy GR (May 2000). ["Evidence for a novel Cdc42GAP domain at the carboxyl terminus of BNIP-2"](https://doi.org/10.1074%2Fjbc.275.19.14415). *J. Biol. Chem*. **275** (19): 14415–22. [doi](/source/Doi_(identifier)):[10.1074/jbc.275.19.14415](https://doi.org/10.1074%2Fjbc.275.19.14415). [PMID](/source/PMID_(identifier)) [10799524](https://pubmed.ncbi.nlm.nih.gov/10799524).

## External links

- Human [*BNIP2*](https://genome.ucsc.edu/cgi-bin/hgTracks?db=hg38&singleSearch=knownCanonical&position=BNIP2) genome location and [*BNIP2*](https://genome.ucsc.edu/cgi-bin/hgGene?db=hg38&hgg_type=knownGene&hgg_gene=BNIP2) gene details page in the [UCSC Genome Browser](/source/UCSC_Genome_Browser).

## Further reading

- Belcredito S, Vegeto E, Brusadelli A, et al. (2002). "Estrogen neuroprotection: the involvement of the Bcl-2 binding protein BNIP2". *Brain Res. Brain Res. Rev*. **37** (1–3): 335–42. [doi](/source/Doi_(identifier)):[10.1016/S0165-0173(01)00138-2](https://doi.org/10.1016%2FS0165-0173%2801%2900138-2). [PMID](/source/PMID_(identifier)) [11744098](https://pubmed.ncbi.nlm.nih.gov/11744098). [S2CID](/source/S2CID_(identifier)) [22189937](https://api.semanticscholar.org/CorpusID:22189937).

- Ohi N, Tokunaga A, Tsunoda H, et al. (1999). ["A novel adenovirus E1B19K-binding protein B5 inhibits apoptosis induced by Nip3 by forming a heterodimer through the C-terminal hydrophobic region"](https://doi.org/10.1038%2Fsj.cdd.4400493). *Cell Death Differ*. **6** (4): 314–25. [doi](/source/Doi_(identifier)):[10.1038/sj.cdd.4400493](https://doi.org/10.1038%2Fsj.cdd.4400493). [PMID](/source/PMID_(identifier)) [10381623](https://pubmed.ncbi.nlm.nih.gov/10381623).

- Zhou YT, Soh UJ, Shang X, et al. (2002). ["The BNIP-2 and Cdc42GAP homology/Sec14p-like domain of BNIP-Salpha is a novel apoptosis-inducing sequence"](https://doi.org/10.1074%2Fjbc.M109459200). *J. Biol. Chem*. **277** (9): 7483–92. [doi](/source/Doi_(identifier)):[10.1074/jbc.M109459200](https://doi.org/10.1074%2Fjbc.M109459200). [PMID](/source/PMID_(identifier)) [11741952](https://pubmed.ncbi.nlm.nih.gov/11741952).

- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). ["Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241). *Proc. Natl. Acad. Sci. U.S.A*. **99** (26): 16899–903. [Bibcode](/source/Bibcode_(identifier)):[2002PNAS...9916899M](https://ui.adsabs.harvard.edu/abs/2002PNAS...9916899M). [doi](/source/Doi_(identifier)):[10.1073/pnas.242603899](https://doi.org/10.1073%2Fpnas.242603899). [PMC](/source/PMC_(identifier)) [139241](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241). [PMID](/source/PMID_(identifier)) [12477932](https://pubmed.ncbi.nlm.nih.gov/12477932).

- Shang X, Zhou YT, Low BC (2003). ["Concerted regulation of cell dynamics by BNIP-2 and Cdc42GAP homology/Sec14p-like, proline-rich, and GTPase-activating protein domains of a novel Rho GTPase-activating protein, BPGAP1"](https://doi.org/10.1074%2Fjbc.M304514200). *J. Biol. Chem*. **278** (46): 45903–14. [doi](/source/Doi_(identifier)):[10.1074/jbc.M304514200](https://doi.org/10.1074%2Fjbc.M304514200). [PMID](/source/PMID_(identifier)) [12944407](https://pubmed.ncbi.nlm.nih.gov/12944407).

- Gerhard DS, Wagner L, Feingold EA, et al. (2004). ["The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928). *Genome Res*. **14** (10B): 2121–7. [doi](/source/Doi_(identifier)):[10.1101/gr.2596504](https://doi.org/10.1101%2Fgr.2596504). [PMC](/source/PMC_(identifier)) [528928](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928). [PMID](/source/PMID_(identifier)) [15489334](https://pubmed.ncbi.nlm.nih.gov/15489334).

- Zhou YT, Guy GR, Low BC (2005). ["BNIP-2 induces cell elongation and membrane protrusions by interacting with Cdc42 via a unique Cdc42-binding motif within its BNIP-2 and Cdc42GAP homology domain"](http://scholarbank.nus.edu.sg/handle/10635/100184). *Exp. Cell Res*. **303** (2): 263–74. [doi](/source/Doi_(identifier)):[10.1016/j.yexcr.2004.08.044](https://doi.org/10.1016%2Fj.yexcr.2004.08.044). [PMID](/source/PMID_(identifier)) [15652341](https://pubmed.ncbi.nlm.nih.gov/15652341).

- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". *Nature*. **437** (7062): 1173–8. [Bibcode](/source/Bibcode_(identifier)):[2005Natur.437.1173R](https://ui.adsabs.harvard.edu/abs/2005Natur.437.1173R). [doi](/source/Doi_(identifier)):[10.1038/nature04209](https://doi.org/10.1038%2Fnature04209). [PMID](/source/PMID_(identifier)) [16189514](https://pubmed.ncbi.nlm.nih.gov/16189514). [S2CID](/source/S2CID_(identifier)) [4427026](https://api.semanticscholar.org/CorpusID:4427026).

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Adapted from the Wikipedia article [BNIP2](https://en.wikipedia.org/wiki/BNIP2) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/BNIP2?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.