# BFAST

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{{Short description|Universal DNA sequence aligner tool}}
{{refimprove|date=November 2017}}

{{distinguish|B-FAST}}

'''BFAST''' is a universal DNA sequence aligner tool developed at [UCLA](/source/UCLA) by Nils Homer.<ref>{{cite journal|title=BFAST: An Alignment Tool for Large Scale Genome Resequencing|first1=Nils|last1=Homer|display-authors=etal|journal=PLOS ONE |date=2009|volume=4|issue=11|doi=10.1371/journal.pone.0007767|pmc=2770639|pmid=19907642|article-number=e7767|bibcode=2009PLoSO...4.7767H|doi-access=free}}</ref>

The BFAST Web Server can be used to align short reads to reference sequences in both nucleotide space as well as [ABI SOLiD](/source/ABI_SOLiD) color space.

Utilities include BFAST alignment, conversion between nucleotide and color space, calculating the a priori power of the alignments, as well as a utility to perform [Smith Waterman alignment](/source/Smith-Waterman).

== Characteristics ==
BFAST has explicit time and accuracy tradeoff with a prior accuracy estimation, supported by indexing the reference sequences. The tool can handle short reads, [DNA insertions](/source/Insertion_(genetics)), [deletions](/source/Deletion_(genetics)), [SNP](/source/Single-nucleotide_polymorphism)s, and color errors (ABI SOLiD color space reads).

== See also ==
*[POSIX](/source/POSIX)
*[GPL](/source/GPL)

==References==
{{reflist}}

==External links==
*[https://sourceforge.net/projects/bfast/ BFAST at Sourceforge]
*[https://geneyx.com/ Genetic Data Analysis & Research]
*[http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0007767#pone-0007767-g004 BFAST: An Alignment Tool for Large Scale Genome Resequencing]

Category:DNA sequencing

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