# BEX4

> Mediated Wiki article. Canonical URL: https://mediated.wiki/source/BEX4
> Markdown URL: https://mediated.wiki/source/BEX4.md
> Source: https://en.wikipedia.org/wiki/BEX4
> Source revision: 1318129282
> License: Creative Commons Attribution-ShareAlike 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/)

{{Short description|Mammalian protein found in humans}}{{Technical|date=March 2022}}{{Infobox_gene}}

'''Brain expressed, X-linked 4''' is a [protein](/source/protein) that in humans is encoded by the '''BEX4''' [gene](/source/gene).<ref name="entrez">
{{cite web | title = Entrez Gene: Brain expressed, X-linked 4 | url = https://www.ncbi.nlm.nih.gov/gene?db=gene&cmd=retrieve&list_uids=56271 | access-date = 2013-04-04 }}</ref>

This [gene](/source/gene) is a member of the [brain](/source/brain) [expressed](/source/Gene_expression) [X-linked](/source/X-linked) [gene family](/source/gene_family). Proteins encoded by other members of this family act as [transcription](/source/Transcription_(biology)) [elongation factors](/source/Elongation_factor) that allow [RNA polymerase II](/source/RNA_polymerase_II) to escape pausing during elongation. Multiple [alternatively spliced](/source/Alternative_splicing) [variants](/source/Variant_(biology)) encoding the same protein have been identified.<ref name="entrez" />

== References ==
{{reflist}}

== Further reading ==
{{refbegin | 2}}
* {{cite journal | vauthors = Chien J, Staub J, Avula R, Zhang H, Liu W, Hartmann LC, Kaufmann SH, Smith DI, Shridhar V | display-authors = 6 | title = Epigenetic silencing of TCEAL7 (Bex4) in ovarian cancer | journal = Oncogene | volume = 24 | issue = 32 | pages = 5089–5100 | date = July 2005 | pmid = 15870691 | doi = 10.1038/sj.onc.1208700 | s2cid = 34533769 }}
* {{cite journal | vauthors = Gao W, Li JZ, Chen SQ, Chu CY, Chan JY, Wong TS | title = Decreased brain-expressed X-linked 4 (BEX4) expression promotes growth of oral squamous cell carcinoma | journal = Journal of Experimental & Clinical Cancer Research | volume = 35 | issue = 1 | article-number = 92 | date = June 2016 | pmid = 27297407 | pmc = 4906687 | doi = 10.1186/s13046-016-0355-6 | doi-access = free }}
* {{cite journal | vauthors = Lee JK, Lee J, Go H, Lee CG, Kim S, Kim HS, Cho H, Choi KS, Ha GH, Lee CW | display-authors = 6 | title = Oncogenic microtubule hyperacetylation through BEX4-mediated sirtuin 2 inhibition | journal = Cell Death & Disease | volume = 7 | issue = 8 | pages = e2336 | date = August 2016 | pmid = 27512957 | pmc = 5108325 | doi = 10.1038/cddis.2016.240 }}
* {{cite journal | vauthors = Yu W, Yaping L, Mingjun W, Jie H, Xiaogang L, Gang L | title = BEX4 upregulation alters Sertoli cell growth properties and protein expression profiles: An explanation for cadmium-induced testicular Sertoli cell injury | journal = Journal of Biochemical and Molecular Toxicology | volume = 31 | issue = 7 | date = July 2017 | article-number = e21908 | pmid = 28295929 | doi = 10.1002/jbt.21908 | s2cid = 27130849 }}
* {{cite journal | vauthors = Zhao Z, Li J, Tan F, Gao S, He J | title = mTOR up-regulation of BEX4 promotes lung adenocarcinoma cell proliferation by potentiating OCT4 | journal = Biochemical and Biophysical Research Communications | volume = 500 | issue = 2 | pages = 302–309 | date = June 2018 | pmid = 29660335 | doi = 10.1016/j.bbrc.2018.04.064 | bibcode = 2018BBRC..500..302Z | s2cid = 5045928 }}
* {{cite journal | vauthors = Lee JK, Ha GH, Kim HS, Lee CW | title = Oncogenic potential of BEX4 is conferred by Polo-like kinase 1-mediated phosphorylation | journal = Experimental & Molecular Medicine | volume = 50 | issue = 10 | pages = 1–12 | date = October 2018 | pmid = 30367032 | pmc = 6203768 | doi = 10.1038/s12276-018-0168-0 }}
* {{cite journal | vauthors = Zhu C, Xiao D | title = Aberrant brain-expressed X-linked 4 (BEX4) expression is a novel prognostic biomarker in gastric cancer | journal = Medicine | volume = 99 | issue = 47 | article-number = e23133 | date = November 2020 | pmid = 33217815 | pmc = 7676604 | doi = 10.1097/MD.0000000000023133 }}
* {{cite journal | vauthors = Lee S, Kang H, Shin E, Jeon J, Youn H, Youn B | title = BEX1 and BEX4 Induce GBM Progression through Regulation of Actin Polymerization and Activation of YAP/TAZ Signaling | journal = International Journal of Molecular Sciences | volume = 22 | issue = 18 | date = September 2021 | page = 9845 | pmid = 34576008 | pmc = 8471324 | doi = 10.3390/ijms22189845 | doi-access = free }}
{{refend}}

Category:Genes on human chromosome X

{{gene-X-stub}}

---
Adapted from the Wikipedia article [BEX4](https://en.wikipedia.org/wiki/BEX4) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/BEX4?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.