# BCLAF1

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**Bcl-2-associated transcription factor 1** is a [Bcl-2 family](/source/Bcl-2_family) [protein](/source/Protein) in humans that is encoded by the *BCLAF1* [gene](/source/Gene).[1][2][3]

This gene encodes a transcriptional [repressor](/source/Repressor) that interacts with several members of the [BCL-2](/source/BCL-2) family of proteins. Overexpression of this [protein](/source/Protein) induces apoptosis, which can be suppressed by co-expression of BCL2 proteins. The protein localizes to dot-like structures throughout the nucleus and redistributes to a zone near the nuclear envelope in cells undergoing [apoptosis](/source/Apoptosis). Multiple transcript variants encoding different [protein isoforms](/source/Protein_isoform) have been found for this gene.[3]

## References

1. Nagase T, Seki N, Ishikawa K, Tanaka A, Nomura N (Nov 1996). "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1". *DNA Res*. **3** (1): 17–24. [doi:10.1093/dnares/3.1.17](https://doi.org/10.1093/dnares/3.1.17). [PMID 8724849](https://pubmed.ncbi.nlm.nih.gov/8724849)

1. Kasof GM, Goyal L, White E (Jun 1999). "Btf, a Novel Death-Promoting Transcriptional Repressor That Interacts with Bcl-2-Related Proteins". *Mol Cell Biol*. **19** (6): 4390–404. [doi:10.1128/mcb.19.6.4390](https://doi.org/10.1128/mcb.19.6.4390). [PMC 104398](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC104398). [PMID 10330179](https://pubmed.ncbi.nlm.nih.gov/10330179)

1. ["Entrez Gene: BCLAF1 BCL2-associated transcription factor 1"](https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=9774)

## Further reading

- Strausberg RL, Feingold EA, Grouse LH (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". *Proc. Natl. Acad. Sci. U.S.A.*. **99** (26): 16899–903. [Bibcode:2002PNAS...9916899M](https://ui.adsabs.harvard.edu/abs/2002PNAS...9916899M). [doi:10.1073/pnas.242603899](https://doi.org/10.1073/pnas.242603899). [PMC 139241](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241). [PMID 12477932](https://pubmed.ncbi.nlm.nih.gov/12477932)
- Mungall AJ, Palmer SA, Sims SK (2003). "The DNA sequence and analysis of human chromosome 6". *Nature*. **425** (6960): 805–11. [Bibcode:2003Natur.425..805M](https://ui.adsabs.harvard.edu/abs/2003Natur.425..805M). [doi:10.1038/nature02055](https://doi.org/10.1038/nature02055). [PMID 14574404](https://pubmed.ncbi.nlm.nih.gov/14574404)
- Haraguchi T, Holaska JM, Yamane M (2004). "Emerin binding to Btf, a death-promoting transcriptional repressor, is disrupted by a missense mutation that causes Emery–Dreifuss muscular dystrophy". *Eur. J. Biochem.*. **271** (5): 1035–45. [doi:10.1111/j.1432-1033.2004.04007.x](https://doi.org/10.1111/j.1432-1033.2004.04007.x). [PMID 15009215](https://pubmed.ncbi.nlm.nih.gov/15009215)
- Beausoleil SA, Jedrychowski M, Schwartz D (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". *Proc. Natl. Acad. Sci. U.S.A.*. **101** (33): 12130–5. [Bibcode:2004PNAS..10112130B](https://ui.adsabs.harvard.edu/abs/2004PNAS..10112130B). [doi:10.1073/pnas.0404720101](https://doi.org/10.1073/pnas.0404720101). [PMC 514446](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC514446). [PMID 15302935](https://pubmed.ncbi.nlm.nih.gov/15302935)
- Jin J, Smith FD, Stark C (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". *Curr. Biol.*. **14** (16): 1436–50. [Bibcode:2004CBio...14.1436J](https://ui.adsabs.harvard.edu/abs/2004CBio...14.1436J). [doi:10.1016/j.cub.2004.07.051](https://doi.org/10.1016/j.cub.2004.07.051). [PMID 15324660](https://pubmed.ncbi.nlm.nih.gov/15324660). [S2CID 2371325](https://api.semanticscholar.org/CorpusID:2371325)
- Gerhard DS, Wagner L, Feingold EA (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". *Genome Res.*. **14** (10B): 2121–7. [doi:10.1101/gr.2596504](https://doi.org/10.1101/gr.2596504). [PMC 528928](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928). [PMID 15489334](https://pubmed.ncbi.nlm.nih.gov/15489334)
- Zheng H, Hu P, Quinn DF, Wang YK (2005). "Phosphotyrosine proteomic study of interferon alpha signaling pathway using a combination of immunoprecipitation and immobilized metal affinity chromatography". *Mol. Cell. Proteomics*. **4** (6): 721–30. [doi:10.1074/mcp.M400077-MCP200](https://doi.org/10.1074/mcp.M400077-MCP200). [PMID 15659558](https://pubmed.ncbi.nlm.nih.gov/15659558)
- Mansharamani M, Wilson KL (2005). "Direct binding of nuclear membrane protein MAN1 to emerin in vitro and two modes of binding to barrier-to-autointegration factor". *J. Biol. Chem.*. **280** (14): 13863–70. [doi:10.1074/jbc.M413020200](https://doi.org/10.1074/jbc.M413020200). [PMID 15681850](https://pubmed.ncbi.nlm.nih.gov/15681850)
- Kim JE, Tannenbaum SR, White FM (2005). "Global phosphoproteome of HT-29 human colon adenocarcinoma cells". *J. Proteome Res.*. **4** (4): 1339–46. [doi:10.1021/pr050048h](https://doi.org/10.1021/pr050048h). [PMID 16083285](https://pubmed.ncbi.nlm.nih.gov/16083285)
- Nousiainen M, Silljé HH, Sauer G (2006). "Phosphoproteome analysis of the human mitotic spindle". *Proc. Natl. Acad. Sci. U.S.A.*. **103** (14): 5391–6. [Bibcode:2006PNAS..103.5391N](https://ui.adsabs.harvard.edu/abs/2006PNAS..103.5391N). [doi:10.1073/pnas.0507066103](https://doi.org/10.1073/pnas.0507066103). [PMC 1459365](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1459365). [PMID 16565220](https://pubmed.ncbi.nlm.nih.gov/16565220)
- Beausoleil SA, Villén J, Gerber SA (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". *Nat. Biotechnol.*. **24** (10): 1285–92. [doi:10.1038/nbt1240](https://doi.org/10.1038/nbt1240). [PMID 16964243](https://pubmed.ncbi.nlm.nih.gov/16964243). [S2CID 14294292](https://api.semanticscholar.org/CorpusID:14294292)
- Olsen JV, Blagoev B, Gnad F (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". *Cell*. **127** (3): 635–48. [doi:10.1016/j.cell.2006.09.026](https://doi.org/10.1016/j.cell.2006.09.026). [PMID 17081983](https://pubmed.ncbi.nlm.nih.gov/17081983). [S2CID 7827573](https://api.semanticscholar.org/CorpusID:7827573)
- Liu H, Lu ZG, Miki Y, Yoshida K (2007). "Protein Kinase C δ Induces Transcription of the TP53 Tumor Suppressor Gene by Controlling Death-Promoting Factor Btf in the Apoptotic Response to DNA Damage". *Mol. Cell. Biol.*. **27** (24): 8480–91. [doi:10.1128/MCB.01126-07](https://doi.org/10.1128/MCB.01126-07). [PMC 2169390](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2169390). [PMID 17938203](https://pubmed.ncbi.nlm.nih.gov/17938203)

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Adapted from the Wikipedia article [BCLAF1](https://en.wikipedia.org/wiki/BCLAF1) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/BCLAF1?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.