# BAT1

> Mediated Wiki article. Canonical URL: https://mediated.wiki/source/BAT1
> Markdown URL: https://mediated.wiki/source/BAT1.md
> Source: https://en.wikipedia.org/wiki/BAT1
> Source revision: 1300829902
> License: Creative Commons Attribution-ShareAlike 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/)

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{cs1 config|name-list-style=vanc}}
{{Infobox_gene}}
'''Spliceosome RNA helicase BAT1''' is an [enzyme](/source/enzyme) that in humans is encoded by the ''BAT1'' [gene](/source/gene).<ref name="pmid7601445">{{cite journal | vauthors = Peelman LJ, Chardon P, Nunes M, Renard C, Geffrotin C, Vaiman M, Van Zeveren A, Coppieters W, van de Weghe A, Bouquet Y | title = The BAT1 gene in the MHC encodes an evolutionarily conserved putative nuclear RNA helicase of the DEAD family | journal = Genomics | volume = 26 | issue = 2 | pages = 210–8 |date=Aug 1995 | pmid = 7601445 | doi =10.1016/0888-7543(95)80203-X  |display-authors=etal}}</ref><ref name="pmid2813433">{{cite journal | vauthors = Spies T, Bresnahan M, Strominger JL | title = Human major histocompatibility complex contains a minimum of 19 genes between the complement cluster and HLA-B | journal = Proc Natl Acad Sci U S A | volume = 86 | issue = 22 | pages = 8955–8 |date=Dec 1989 | pmid = 2813433 | pmc = 298409 | doi =10.1073/pnas.86.22.8955  | bibcode = 1989PNAS...86.8955S | doi-access = free }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: BAT1 HLA-B associated transcript 1| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=7919}}</ref>

This gene encodes a member of the [DEAD box](/source/DEAD_box) family of RNA-dependent [ATPases](/source/ATPases) that mediate [ATP hydrolysis](/source/ATP_hydrolysis) during [pre-mRNA splicing](/source/RNA_splicing). The encoded protein is an essential [splicing factor](/source/splicing_factor) required for association of U2 small nuclear [ribonucleoprotein](/source/ribonucleoprotein) with [pre-mRNA](/source/pre-mRNA), and also plays an important role in [mRNA](/source/mRNA) export from the nucleus to the [cytoplasm](/source/cytoplasm). A cluster of genes, BAT1-BAT5, is localized in the vicinity of the genes for [TNF alpha](/source/TNF_alpha) and [TNF beta](/source/Lymphotoxin_alpha). These genes are all within the human [major histocompatibility complex class III](/source/Major_histocompatibility_complex) region. [Mutations](/source/Mutations) in this gene may be associated with [rheumatoid arthritis](/source/rheumatoid_arthritis). Alternatively spliced [transcript variants](/source/transcript_variants) encoding the same protein have been described.<ref name="entrez" />

==References==
{{reflist}}

==External links==
* {{UCSC gene info|DDX39B}}
* [https://www.ebi.ac.uk/pdbe/pdbe-kb/proteins/Q13838 PDBe-KB] provides an overview of all the structure information available in the PDB for Human Spliceosome RNA helicase DDX39B (BAT1)

==Further reading==
{{refbegin | 2}}
*{{cite journal  | vauthors=Spies T, Blanck G, Bresnahan M |title=A new cluster of genes within the human major histocompatibility complex. |journal=Science |volume=243 |issue= 4888 |pages= 214–7 |year= 1989 |pmid= 2911734 |doi=10.1126/science.2911734  |bibcode=1989Sci...243..214S |display-authors=etal}}
*{{cite journal  | vauthors=Cross SH, Charlton JA, Nan X, Bird AP |title=Purification of CpG islands using a methylated DNA binding column. |journal=Nat. Genet. |volume=6 |issue= 3 |pages= 236–44 |year= 1994 |pmid= 8012384 |doi= 10.1038/ng0394-236 |s2cid=12847618 }}
*{{cite journal  | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8  }}
*{{cite journal  | vauthors=Fleckner J, Zhang M, Valcárcel J, Green MR |title=U2AF65 recruits a novel human DEAD box protein required for the U2 snRNP-branchpoint interaction. |journal=Genes Dev. |volume=11 |issue= 14 |pages= 1864–72 |year= 1997 |pmid= 9242493 |doi=10.1101/gad.11.14.1864  |doi-access=free }}
*{{cite journal  | vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3  |display-authors=etal}}
*{{cite journal  | vauthors=Allcock RJ, Price P, Gaudieri S |title=Characterisation of the human central MHC gene, BAT1: genomic structure and expression. |journal=Exp. Clin. Immunogenet. |volume=16 |issue= 2 |pages= 98–106 |year= 1999 |pmid= 10343160 |doi=10.1159/000019100  |s2cid=22003689 |display-authors=etal}}
*{{cite journal  | vauthors=Ota M, Katsuyama Y, Kimura A |title=A second susceptibility gene for developing rheumatoid arthritis in the human MHC is localized within a 70-kb interval telomeric of the TNF genes in the HLA class III region. |journal=Genomics |volume=71 |issue= 3 |pages= 263–70 |year= 2001 |pmid= 11170743 |doi= 10.1006/geno.2000.6371 |display-authors=etal}}
*{{cite journal  | vauthors=Allcock RJ, Williams JH, Price P |title=The central MHC gene, BAT1, may encode a protein that down-regulates cytokine production. |journal=Genes Cells |volume=6 |issue= 5 |pages= 487–94 |year= 2001 |pmid= 11380625 |doi=10.1046/j.1365-2443.2001.00435.x  |s2cid=10605522 |doi-access= }}
*{{cite journal  | vauthors=Luo ML, Zhou Z, Magni K |title=Pre-mRNA splicing and mRNA export linked by direct interactions between UAP56 and Aly. |journal=Nature |volume=413 |issue= 6856 |pages= 644–7 |year= 2001 |pmid= 11675789 |doi= 10.1038/35098106 |bibcode=2001Natur.413..644L |s2cid=4395388 |display-authors=etal}}
*{{cite journal  | vauthors=Andersen JS, Lyon CE, Fox AH |title=Directed proteomic analysis of the human nucleolus. |journal=Curr. Biol. |volume=12 |issue= 1 |pages= 1–11 |year= 2002 |pmid= 11790298 |doi=10.1016/S0960-9822(01)00650-9  |s2cid=14132033 |display-authors=etal|doi-access=free |bibcode=2002CBio...12....1A }}
*{{cite journal  | vauthors=Strässer K, Masuda S, Mason P |title=TREX is a conserved complex coupling transcription with messenger RNA export. |journal=Nature |volume=417 |issue= 6886 |pages= 304–8 |year= 2002 |pmid= 11979277 |doi= 10.1038/nature746 |bibcode=2002Natur.417..304S |s2cid=1112194 |display-authors=etal}}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
*{{cite journal  | vauthors=McCracken S, Longman D, Johnstone IL |title=An evolutionarily conserved role for SRm160 in 3'-end processing that functions independently of exon junction complex formation. |journal=J. Biol. Chem. |volume=278 |issue= 45 |pages= 44153–60 |year= 2004 |pmid= 12944400 |doi= 10.1074/jbc.M306856200 |display-authors=etal|doi-access=free }}
*{{cite journal  | vauthors=Reuter TY, Medhurst AL, Waisfisz Q |title=Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport. |journal=Exp. Cell Res. |volume=289 |issue= 2 |pages= 211–21 |year= 2003 |pmid= 14499622 |doi=10.1016/S0014-4827(03)00261-1  |display-authors=etal}}
*{{cite journal  | vauthors=Li J, Hawkins IC, Harvey CD |title=Regulation of alternative splicing by SRrp86 and its interacting proteins. |journal=Mol. Cell. Biol. |volume=23 |issue= 21 |pages= 7437–47 |year= 2003 |pmid= 14559993 |doi=10.1128/MCB.23.21.7437-7447.2003  | pmc=207616  |display-authors=etal}}
*{{cite journal  | vauthors=Mungall AJ, Palmer SA, Sims SK |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 |bibcode=2003Natur.425..805M |display-authors=etal|doi-access=free }}
*{{cite journal  | vauthors=Lehner B, Semple JI, Brown SE |title=Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region. |journal=Genomics |volume=83 |issue= 1 |pages= 153–67 |year= 2004 |pmid= 14667819 |doi=10.1016/S0888-7543(03)00235-0  |display-authors=etal}}
*{{cite journal  | vauthors=Price P, Wong AM, Williamson D |title=Polymorphisms at positions -22 and -348 in the promoter of the BAT1 gene affect transcription and the binding of nuclear factors. |journal=Hum. Mol. Genet. |volume=13 |issue= 9 |pages= 967–74 |year= 2004 |pmid= 15028669 |doi= 10.1093/hmg/ddh113 |display-authors=etal|doi-access=free }}
{{refend}}
{{PDB Gallery|geneid=7919}}

{{Enzyme-stub}}

---
Adapted from the Wikipedia article [BAT1](https://en.wikipedia.org/wiki/BAT1) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/BAT1?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.