# Azalanstat

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Anti-obesity drug

Pharmaceutical compound

Azalanstat Clinical data ATC code None Identifiers IUPAC name 4-({[(2S,4S)-2-[2-(4-Chlorophenyl)ethyl]-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl}sulfanyl)aniline CAS Number 143393-27-5 N PubChem CID 60876 ChemSpider 54858 Y UNII 2NL79NI1WS KEGG D03025 Y ChEMBL ChEMBL70611 Y CompTox Dashboard (EPA) DTXSID401029427 Chemical and physical data Formula C22H24ClN3O2S Molar mass 429.96 g·mol−1 3D model (JSmol) Interactive image SMILES Clc1ccc(cc1)CC[C@@]2(OC[C@H](O2)CSc3ccc(N)cc3)Cn4ccnc4 InChI InChI=1S/C22H24ClN3O2S/c23-18-3-1-17(2-4-18)9-10-22(15-26-12-11-25-16-26)27-13-20(28-22)14-29-21-7-5-19(24)6-8-21/h1-8,11-12,16,20H,9-10,13-15,24H2/t20-,22-/m0/s1 Y Key:VYNIUBZKEWJOJP-UNMCSNQZSA-N Y NY (what is this?)

**Azalanstat** ([INN](/source/International_nonproprietary_name),[1] codenamed **RS-21607**) is an [anti-obesity drug](/source/Anorectic) acting as a [lanosterol 14α-demethylase](/source/Lanosterol_14_alpha-demethylase) inhibitor.[2][3]

## References

1. **[^](#cite_ref-INN_1-0)** ["International Nonproprietary Names for Pharmaceutical Substances (INN). Recommended International Nonproprietary Names (Rec. INN): List 36"](https://www.who.int/medicines/publications/druginformation/innlists/RL36.pdf) (PDF). World Health Organization. p. 141. Retrieved 3 January 2017.

1. **[^](#cite_ref-2)** Walker KA, Kertesz DJ, Rotstein DM, Swinney DC, Berry PW, So OY, et al. (July 1993). "Selective inhibition of mammalian lanosterol 14 alpha-demethylase: a possible strategy for cholesterol lowering". *Journal of Medicinal Chemistry*. **36** (15): 2235–7. [doi](/source/Doi_(identifier)):[10.1021/jm00067a022](https://doi.org/10.1021%2Fjm00067a022). [PMID](/source/PMID_(identifier)) [8340925](https://pubmed.ncbi.nlm.nih.gov/8340925).

1. **[^](#cite_ref-3)** Burton PM, Swinney DC, Heller R, Dunlap B, Chiou M, Malonzo E, et al. (August 1995). "Azalanstat (RS-21607), a lanosterol 14 alpha-demethylase inhibitor with cholesterol-lowering activity". *Biochemical Pharmacology*. **50** (4): 529–44. [doi](/source/Doi_(identifier)):[10.1016/0006-2952(95)00152-p](https://doi.org/10.1016%2F0006-2952%2895%2900152-p). [PMID](/source/PMID_(identifier)) [7646560](https://pubmed.ncbi.nlm.nih.gov/7646560).

v t e Antiobesity agents/Anorectics (A08) Stimulants Amphetamines and phenethylamines 4-Methylamphetamine‡ Amfecloral Amfepentorex Amfepramone Amphetamine Amphetaminil Benzphetamine Cathine Cathinone Chlorphentermine Clobenzorex Cloforex Clortermine Dextroamphetamine Dimethylcathinone Ephedrine Ephedra‡ Etilamfetamine Etolorex Fenethylline Fenproporex Fludorex Furfenorex‡ Khat Lisdexamfetamine Mefenorex Methamphetamine Norfenfluramine Pentorex Phentermine (+topiramate) Xylopropamine Zylofuramine Adrenergic agonists Albuterol Clenbuterol§ Ephedrine Ephedra‡ Levopropylhexedrine Synephrine Terbutaline Yohimbine (Yohimbe) Other Aminorex‡ Atomoxetine Benfluorex‡ Bupropion (+naltrexone) Dexfenfluramine‡ Dexmethylphenidate Difemetorex‡ Fenbutrazate Fenfluramine (+phentermine‡) Manifaxine Mazindol Methylphenidate Phendimetrazine Phenethylamine Phenmetrazine Phenylpropanolamine Pipradrol Propylhexedrine Pyrovalerone Sibutramine‡ Tesofensine Cannabinoid antagonists Drinabant§ Ibipinabant§ Otenabant§ Rimonabant‡ Rosonabant§ Surinabant§ Taranabant§ GLP-1, GIP, and / or glucagon agonists AMG 133 Cinchonine Cotadutide Danuglipron Ecnoglutide Exenatide† Liraglutide Orforglipron Oxyntomodulin§ Retatrutide Semaglutide (+cagrilintide†) Tirzepatide† DACRAs Cagrilintide (+semaglutide†) 5-HT2C receptor agonists 5-HTP Lorcaserin‡ Absorption inhibitors Cetilistat Dirlotapide Mitratapide Orlistat Simmondsin Uncouplers 2,4-Dinitrophenol‡ Others Beloranib§ Bimagrumab§ Desiccated thyroid‡ Metformin Metreleptin Naltrexone Setmelanotide Topiramate ZGN-1061 Zonisamide Water #WHO-EM ‡Withdrawn from market Clinical trials: †Phase III §Never to phase III

v t e Lipid-lowering agents (C10) GI tract Cholesterol absorption inhibitors, NPC1L1 Ezetimibe Hyzetimibe SCH-48461 Bile acid sequestrants/resins (LDL) Colesevelam Colestilan Colestipol Colestyramine Colextran Soluble fiber such as psyllium and glucomannan Liver Statins (HMG-CoA reductase, LDL) Atorvastatin Cerivastatin‡ Fluvastatin Lovastatin Mevastatin Pitavastatin Pravastatin Rosuvastatin Simvastatin# Niacin and derivatives (HDL and LDL) Acipimox Aluminium nicotinate Nicotinic acid Niceritrol Nicofuranose Nicotinyl alcohol MTTP inhibitors (VLDL) Dirlotapide Lomitapide Mitratapide ATP citrate synthase inhibitors (LDL) Bempedoic acid Thyromimetics (VLDL) Dextrothyroxine‡ Resmetirom Blood vessels PPAR agonists (LDL) Fibrates Aluminium clofibrate Bezafibrate Choline fenofibrate Ciprofibrate Clinofibrate Clofibrate‡ Clofibride Etofibrate Fenofibrate Gemfibrozil Nafenopin Pemafibrate Ronifibrate Simfibrate Others GW501516§ CETP inhibitors (HDL) Anacetrapib† Dalcetrapib§ Evacetrapib§ Obicetrapib† Torcetrapib§ PCSK9 inhibitors (LDL) Alirocumab Bococizumab Enlicitide† Evolocumab Inclisiran Lerodalcibep ANGPTL3 inhibitors (LDL/HDL) Evinacumab Combinations Amlodipine/atorvastatin Bempedoic acid/ezetimibe Ezetimibe/atorvastatin Ezetimibe/rosuvastatin Ezetimibe/simvastatin Fenofibrate/pravastatin Fenofibrate/simvastatin Niacin/laropiprant Niacin/lovastatin Niacin/simvastatin Other Alipogene tiparvovec Azacosterol Azalanstat Benfluorex‡ Darapladib§ Lapaquistat§ Magnesium pyridoxal 5-phosphate glutamate Meglutol Mipomersen Olezarsen Omega−3-acid ethyl esters Plozasiran Policosanol Probucol Tiadenol Triparanol‡ Volanesorsen #WHO-EM ‡Withdrawn from market Clinical trials: †Phase III §Never to phase III

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Adapted from the Wikipedia article [Azalanstat](https://en.wikipedia.org/wiki/Azalanstat) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/Azalanstat?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.