# Attractin

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> Source revision: 1301002086
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{{Short description|Protein-coding gene in the species Homo sapiens}}
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'''Attractin''' is a [protein](/source/protein) that in humans is encoded by the ''ATRN'' [gene](/source/gene).<ref name="pmid9736737">{{cite journal | vauthors = Duke-Cohan JS, Gu J, McLaughlin DF, Xu Y, Freeman GJ, Schlossman SF | title = Attractin (DPPT-L), a member of the CUB family of cell adhesion and guidance proteins, is secreted by activated human T lymphocytes and modulates immune cell interactions | journal = Proc Natl Acad Sci U S A | volume = 95 | issue = 19 | pages = 11336–41 |date=Oct 1998 | pmid = 9736737 | pmc = 21643 | doi =10.1073/pnas.95.19.11336  | bibcode = 1998PNAS...9511336D | doi-access = free }}</ref><ref name="pmid8596018">{{cite journal | vauthors = Duke-Cohan JS, Morimoto C, Rocker JA, Schlossman SF | title = Serum high molecular weight dipeptidyl peptidase IV (CD26) is similar to a novel antigen DPPT-L released from activated T cells | journal = J Immunol | volume = 156 | issue = 5 | pages = 1714–21 |date=Apr 1996 | doi = 10.4049/jimmunol.156.5.1714 | pmid = 8596018 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ATRN attractin| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=8455}}</ref>

Attractin is a Group XI [C-type lectin](/source/C-type_lectin).

Multiple transcript variants encoding different isoforms exist for this gene. One of the isoforms is a membrane-bound protein with sequence similarity to the mouse mahogany protein, a receptor involved in controlling obesity. The other isoform is a secreted protein involved in the initial immune cell clustering during inflammatory responses that may regulate the chemotactic activity of chemokines.<ref name="entrez" />

==References==
{{reflist}}

==External links==
* {{UCSC gene info|ATRN}}

==Further reading==
{{refbegin | 2}}
*{{cite journal  | vauthors=Mori M, Sakurai M, Araie M |title=[Topical timolol and blood-aqueous barrier permeability to protein in human eyes] |journal=Nippon Ganka Gakkai Zasshi |volume=96 |issue= 11 |pages= 1418–22 |year= 1993 |pmid= 1476071 }}
*{{cite journal  | author=Nagase T |title=Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro |journal=DNA Res. |volume=5 |issue= 1 |pages= 31–9 |year= 1998 |pmid= 9628581 |doi=10.1093/dnares/5.1.31  | author2=Ishikawa K  | author3=Miyajima N  | display-authors=3  | last4=Tanaka  | first4=A  | last5=Kotani  | first5=H  | last6=Nomura  | first6=N  | last7=Ohara  | first7=O  | doi-access=free  }}
*{{cite journal  | author=Nagle DL |title=The mahogany protein is a receptor involved in suppression of obesity |journal=Nature |volume=398 |issue= 6723 |pages= 148–52 |year= 1999 |pmid= 10086355 |doi= 10.1038/18210  | author2=McGrail SH  | author3=Vitale J  | display-authors=3  | last4=Vitale  | first4=James  | last5=Woolf  | first5=Elizabeth A.  | last6=Dussault  | first6=Barry J.  | last7=Dirocco  | first7=Lisa  | last8=Holmgren  | first8=Lisa  | last9=Montagno  | first9=Jill |bibcode=1999Natur.398..148N |s2cid=4400267 }}
*{{cite journal  | author=Gunn TM |title=The mouse mahogany locus encodes a transmembrane form of human attractin |journal=Nature |volume=398 |issue= 6723 |pages= 152–6 |year= 1999 |pmid= 10086356 |doi= 10.1038/18217  | author2=Miller KA  | author3=He L  | display-authors=3  | last4=He  | first4=Lin  | last5=Hyman  | first5=Richard W.  | last6=Davis  | first6=Ronald W.  | last7=Azarani  | first7=Arezou  | last8=Schlossman  | first8=Stuart F.  | last9=Duke-Cohan  | first9=Jonathan S. |bibcode=1999Natur.398..152G |s2cid=4371433 }}
*{{cite journal  | author=Tang W |title=Secreted and membrane attractin result from alternative splicing of the human ATRN gene |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 11 |pages= 6025–30 |year= 2000 |pmid= 10811918 |doi= 10.1073/pnas.110139897  | pmc=18552  | author2=Gunn TM  | author3=McLaughlin DF  | display-authors=3  | last4=Barsh  | first4=GS  | last5=Schlossman  | first5=SF  | last6=Duke-Cohan  | first6=JS |bibcode=2000PNAS...97.6025T |doi-access=free }}
*{{cite journal  | author=Deloukas P |title=The DNA sequence and comparative analysis of human chromosome 20 |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a  | author2=Matthews LH  | author3=Ashurst J  | display-authors=3  | last4=Burton  | first4=J.  | last5=Gilbert  | first5=J. G. R.  | last6=Jones  | first6=M.  | last7=Stavrides  | first7=G.  | last8=Almeida  | first8=J. P.  | last9=Babbage  | first9=A. K. |bibcode=2001Natur.414..865D | doi-access=free  }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241  | author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD |bibcode=2002PNAS...9916899M |doi-access=free }}
*{{cite journal  | author=Gevaert K |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566–9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810  | author2=Goethals M  | author3=Martens L  | display-authors=3  | last4=Van Damme  | first4=Jozef  | last5=Staes  | first5=An  | last6=Thomas  | first6=Grégoire R.  | last7=Vandekerckhove  | first7=Joël |s2cid=23783563 }}
*{{cite book  | vauthors=Friedrich D, Kühn-Wache K, Hoffmann T, Demuth HU |chapter=Isolation and Characterization of Attractin-2 |title=Dipeptidyl Aminopeptidases in Health and Disease |volume=524 |pages= 109–13 |year= 2003 |pmid= 12675230 |doi=10.1007/0-306-47920-6_14  | series=Advances in Experimental Medicine and Biology  | isbn=0-306-47717-3  }}
*{{cite journal  | vauthors=Bunkenborg J, Pilch BJ, Podtelejnikov AV, Wiśniewski JR |title=Screening for N-glycosylated proteins by liquid chromatography mass spectrometry |journal=Proteomics |volume=4 |issue= 2 |pages= 454–65 |year= 2004 |pmid= 14760718 |doi= 10.1002/pmic.200300556 |s2cid=29261009 }}
*{{cite journal  | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928  | author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  | author=Liu T |title=Human Plasma N-Glycoproteome Analysis by Immunoaffinity Subtraction, Hydrazide Chemistry, and Mass Spectrometry |journal=J. Proteome Res. |volume=4 |issue= 6 |pages= 2070–80 |year= 2006 |pmid= 16335952 |doi= 10.1021/pr0502065  | pmc=1850943  | author2=Qian WJ  | author3=Gritsenko MA  | display-authors=3  | last4=Camp  | first4=David G.  | last5=Monroe  | first5=Matthew E.  | last6=Moore  | first6=Ronald J.  | last7=Smith  | first7=Richard D. }}
*{{cite journal  | author=Wrenger S |title=Attractin, a dipeptidyl peptidase IV/CD26-like enzyme, is expressed on human peripheral blood monocytes and potentially influences monocyte function |journal=J. Leukoc. Biol. |volume=80 |issue= 3 |pages= 621–9 |year= 2007 |pmid= 16835316 |doi= 10.1189/jlb.1105678  | author2=Faust J  | author3=Friedrich D  | display-authors=3  | last4=Hoffmann  | first4=T  | last5=Hartig  | first5=R  | last6=Lendeckel  | first6=U  | last7=Kähne  | first7=T  | last8=Thielitz  | first8=A  | last9=Neubert  | first9=K |s2cid=31858918 | doi-access=  }}
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Category:Kelch proteins
Category:C-type lectins

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