# Atrimustine
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> Source: https://en.wikipedia.org/wiki/Atrimustine
> Source revision: 1329018021
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{{short description|Chemical compound}}
{{Drugbox
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| IUPAC_name = [(8''R'',9''S'',13''S'',14''S'',17''S'')-17-[2-[4-[4-[''bis''(2-chloroethyl)amino]phenyl]butanoyloxy]acetyl]oxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[''a'']phenanthren-3-yl] benzoate
| image = Atrimustine.svg
| image_class = skin-invert-image
| width = 250px
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| class = [Chemotherapeutic agent](/source/Chemotherapeutic_agent); [Estrogen](/source/Estrogen_(medication)); [Estrogen ester](/source/Estrogen_ester)
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| CAS_number_Ref =
| CAS_number = 75219-46-4
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| PubChem = 6917688
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| ChemSpiderID = 5292918
| UNII = XC0K09B7K4
| ChEMBL = 2106381
| synonyms = Bestrabucil; Busramustine; KM-2210; Kregan; Estradiol 3-benzoate 17β-((4-(4-(bis(2-chloroethyl)amino)phenyl)-1-oxobutoxy)acetate; 3-Benzoyl-17β-((4-(4-(bis(2-chloroethyl)amino)phenyl)-1-oxobutoxy)acetylestradiol[{{cite book |author=J. Elks |title=The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies |url=https://books.google.com/books?id=0vXTBwAAQBAJ&pg=PR2 |date=14 November 2014 |publisher=Springer |isbn=978-1-4757-2085-3 |pages=897–898}}][{{cite book |author=William Andrew Publishing |title=Pharmaceutical Manufacturing Encyclopedia, 3rd Edition |url=https://books.google.com/books?id=_J2ti4EkYpkC&pg=PA438 |date=22 October 2013 |publisher=Elsevier |isbn=978-0-8155-1856-3 |pages=438–}}][{{cite web |url=https://adisinsight.springer.com/drugs/800000756 |title=Atrimustine – AdisInsight}}] It is the [benzoate](/source/benzoate) [ester](/source/ester) of an [ester](/source/ester) [conjugate](/source/conjugated_system) of [estradiol](/source/estradiol_(medication)) and [chlorambucil](/source/chlorambucil),[{{cite book |title=The Cancer Bulletin |url=https://books.google.com/books?id=mZMVAQAAMAAJ |year=1987 |publisher=Medical Arts Publishing Foundation |page=245}}] which results in targeted/site-directed cytostatic activity toward [estrogen receptor](/source/estrogen_receptor)–positive tissues such as [breast](/source/breast) and [bone](/source/bone).[{{cite journal |vauthors=Ohsawa N, Yamazaki Z, Wagatsuma T, Isurugi K |title=[Bestrabacil: a possible target-oriented anticancer agent] |language=ja |journal=Gan to Kagaku Ryoho |volume=11 |issue=10 |pages=2115–2124 |year=1984 |pmid=6548354}}][{{cite book |author=Joji Ishigami |title=Recent Advances in Chemotherapy: Proceedings of the 14th Internat. Congress of Chemotherapy, Kyoto, 1985. Antimicrobial section; 1. 1 ,1 |url=https://books.google.com/books?id=AKQTAQAAMAAJ |year=1985 |publisher=University of Tokyo Press |isbn=978-0-86008-385-6 |page=52,54,471}}] It reached [preregistration](/source/marketing_authorization) for the treatment of [cancer](/source/cancer) but was ultimately discontinued.