# Arul Chinnaiyan
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{{Short description|Indian scientist, medical researcher}}
{{EngvarB|date=September 2014}}
{{Use dmy dates|date=July 2020}}
{{Infobox scientist
| name = Arul Chinnaiyan
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| workplaces = [University of Michigan Medical School](/source/University_of_Michigan_Medical_School), [Howard Hughes Medical Institute](/source/Howard_Hughes_Medical_Institute)
| alma_mater = [University of Michigan Medical School](/source/University_of_Michigan_Medical_School)
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| known_for = [Cancer Research](/source/Cancer_Research)
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'''Arul M. Chinnaiyan''' is the S.P. Hicks Endowed Professor of Pathology, a Professor of Urology, and the Director of the Michigan Center for Translational Pathology at the [University of Michigan Medical School](/source/University_of_Michigan_Medical_School).[[https://medschool.umich.edu/profile/2694/arul-m-chinnaiyan Arul M. Chinnaiyan – University of Michigan Medical School] {{webarchive |url=https://web.archive.org/web/20251013182442/https://medschool.umich.edu/profile/2694/arul-m-chinnaiyan |date=13 October 2025 }}] He is also a [Howard Hughes Medical Institute](/source/Howard_Hughes_Medical_Institute) Investigator and an [American Cancer Society](/source/American_Cancer_Society) Research Professor.[[https://www.hhmi.org/scientists/arul-m-chinnaiyan Arul M. Chinnaiyan – HHMI] {{webarchive |url=https://web.archive.org/web/20240819123940/https://www.hhmi.org/scientists/arul-m-chinnaiyan |date=19 August 2024 }}]
Arul Chinnaiyan received both PhD and MD degrees at the [University of Michigan Medical School](/source/University_of_Michigan_Medical_School) in 1999. He is a cancer researcher and the recipient of the 28th annual [American Association for Cancer Research](/source/American_Association_for_Cancer_Research) Award for Outstanding Achievement in Cancer Research at the annual meeting of the [AACR](/source/American_Association_for_Cancer_Research) in April 2008 in San Diego.[[http://www.aacr.org/home/scientists/scientific-achievement-awards/scientific-award-winners/outstanding-achievement-award.aspx List of AACR Award for Outstanding Achievement in Cancer Research Winners] {{webarchive |url=https://web.archive.org/web/20080505093316/http://www.aacr.org/home/scientists/scientific-achievement-awards/scientific-award-winners/outstanding-achievement-award.aspx |date=5 May 2008 }}] He was also the leader of a group of scientists who received the inaugural 2007 [American Association for Cancer Research](/source/American_Association_for_Cancer_Research) "Team Science" Award for their discovery of gene fusions in prostate cancer.[[http://www.aacr.org/home/scientists/scientific-achievement-awards/scientific-award-winners/team-science-award-.aspx AACR Team Science Award Recipients] {{Webarchive|url=https://web.archive.org/web/20140310065337/http://www.aacr.org/home/scientists/scientific-achievement-awards/scientific-award-winners/team-science-award-.aspx |date=10 March 2014 }}, [American Association for Cancer Research](/source/American_Association_for_Cancer_Research) Award citation:"In recognition of their landmark discovery of recurrent gene fusions in a majority of prostate cancers, which has profound clinical and biological implications for understanding prostate cancers, and their embodiment of team science through interdisciplinary and inter-institutional collaboration."]
Arul Chinnaiyan received a number of other awards and prizes, including the [Burroughs Wellcome Fund](/source/Burroughs_Wellcome_Fund) Clinical Scientist Award in Translational Research and of the [Ramzi Cotran](/source/Ramzi_Cotran) Young Investigator Award from the [United States and Canadian Academy of Pathology](/source/United_States_and_Canadian_Academy_of_Pathology). He is an elected member of the [American Society for Clinical Investigation](/source/American_Society_for_Clinical_Investigation)[[http://www.med.umich.edu/opm/newspage/2007/hhmi.htm 2 UMHS researchers selected as Howard Hughes Medical Institute investigators.] {{webarchive |url=https://web.archive.org/web/20080421194716/http://www.med.umich.edu/opm/newspage/2007/hhmi.htm |date=21 April 2008 }} University of Michigan Health System Press Release. 12 October 2007] and the [National Academy of Sciences](/source/National_Academy_of_Sciences).[[https://www.nasonline.org/directory-entry/arul-m-chinnaiyan-jzmgks/ Arul M. Chinnaiyan – National Academy of Sciences.] {{webarchive |url=https://web.archive.org/web/20251207235007/https://www.nasonline.org/directory-entry/arul-m-chinnaiyan-jzmgks/ |date=7 December 2025}} National Academy of Sciences] He received the 2022 [Sjöberg Prize](/source/Sj%C3%B6berg_Prize)[[https://www.kva.se/en/news/upptackt-om-orsaken-till-prostatacancer-belonas-med-sjobergpriset-2/ Discovery about a cause of prostate cancer rewarded with the Sjöberg Prize.] {{webarchive |url=https://web.archive.org/web/20251115031029/https://www.kva.se/en/news/upptackt-om-orsaken-till-prostatacancer-belonas-med-sjobergpriset-2/ |date=15 November 2025}} Royal Swedish Academy of Sciences. 14 February 2022] and was jointly awarded the Harrington Prize for Innovation in Medicine[[https://www.harringtondiscovery.org/news-media/2026/03/24/international-harrington-prize-jointly-awarded-to-drs-arul-chinnaiyan-and-charles-sawyers International Harrington Prize Jointly Awarded to Drs. Arul Chinnaiyan and Charles Sawyers.] {{webarchive |url=https://web.archive.org/web/20260410144301/https://www.harringtondiscovery.org/news-media/2026/03/24/international-harrington-prize-jointly-awarded-to-drs-arul-chinnaiyan-and-charles-sawyers |date=10 April 2026}} Harrington Discovery Institute. 24 March 2026] alongside [Charles L. Sawyers](/source/Charles_L._Sawyers).
He is a member of the editorial board for ''[Oncogene](/source/Oncogene_(journal))''.[{{Cite web | url=https://www.nature.com/onc/editors/editorial-board |title = Editorial Board | Oncogene}}]
== Research and discovery ==
The focus of his research is molecular profiling of cancer to discover novel diagnostic markers and therapeutic targets. It is generally believed that blood cancers are caused by chromosome translocation such as Bcr-Abl in chronic myelogenous leukaemia (CML), whereas solid tumors are caused by mutations in growth or tumour suppressor genes. In research which challenges the current dogma, Arul has discovered chromosome translocation in solid prostate tumours. Arul has discovered that this translocation occurs between a male hormone related gene TMPRSS2 and transcription factors of the Erythroblast transformation specific (ETS) family.[{{cite journal| pmid=17671502 | doi=10.1038/nature06024 | volume=448 | title=Distinct classes of chromosomal rearrangements create oncogenic ETS gene fusions in prostate cancer | year=2007 | journal=Nature | pages=595–9 | last1 = Tomlins | first1 = SA | last2 = Laxman | first2 = B | last3 = Dhanasekaran | first3 = SM | last4 = Helgeson | first4 = BE | last5 = Cao | first5 = X | last6 = Morris | first6 = DS | last7 = Menon | first7 = A | last8 = Jing | first8 = X | last9 = Cao | first9 = Q | last10 = Han | first10 = B | last11 = Yu | first11 = J | last12 = Wang | first12 = L | last13 = Montie | first13 = JE | last14 = Rubin | first14 = MA | last15 = Pienta | first15 = KJ | last16 = Roulston | first16 = D | last17 = Shah | first17 = RB | last18 = Varambally | first18 = S | last19 = Mehra | first19 = R | last20 = Chinnaiyan | first20 = AM| issue=7153 | bibcode=2007Natur.448..595T | hdl = 2027.42/62659 | s2cid=4361134 | hdl-access = free }}]
==Publications==
Partial list:
* {{cite journal | pmid = 20056654 | doi=10.1093/nar/gkp1180 | volume=38 | title=On the detection and refinement of transcription factor binding sites using ChIP-Seq data | pmc=2853110 | date=April 2010 | journal=Nucleic Acids Res. | pages=2154–67 | last1 = Hu | first1 = M | last2 = Yu | first2 = J | last3 = Taylor | first3 = JM | last4 = Chinnaiyan | first4 = AM | last5 = Qin | first5 = ZS| issue=7 }}
* {{cite journal | pmid = 18596922 | doi=10.1172/JCI34780 | volume=118 | title=KLF6-SV1 overexpression accelerates human and mouse prostate cancer progression and metastasis | pmc=2441856 | date=August 2008 | journal=J. Clin. Invest. | pages=2711–21 | last1 = Narla | first1 = G | last2 = DiFeo | first2 = A | last3 = Fernandez | first3 = Y | issue=8 | display-authors = etal}}
* {{cite journal | pmid = 20005836 | doi=10.1016/j.molcel.2009.11.019 | volume=36 | title=A FIRE-y PAGE in the computational analysis of cancer profiles | date=December 2009 | journal=Mol. Cell | pages=732–3 | last1 = Prensner | first1 = JR | last2 = Chinnaiyan | first2 = AM| issue=5 | doi-access=free }}
* {{cite journal | pmid = 19955085 | doi=10.1074/mcp.M900159-MCP200 | volume=9 | title=Quantitative proteomic profiling of prostate cancer reveals a role for miR-128 in prostate cancer | pmc=2830841 | date=February 2010 | journal=Mol. Cell. Proteomics | pages=298–312 | last1 = Khan | first1 = AP | last2 = Poisson | first2 = LM | last3 = Bhat | first3 = VB | issue=2 | doi-access=free | display-authors = etal}}
* {{cite journal | pmid = 17319736 | doi=10.1371/journal.pcbi.0030012 | volume=3 | title=From bytes to bedside: data integration and computational biology for translational cancer research | pmc=1808026 | date=February 2007 | journal=PLOS Comput. Biol. | article-number=e12 | last1 = Mathew | first1 = JP | last2 = Taylor | first2 = BS | last3 = Bader | first3 = GD | issue=2 | bibcode=2007PLSCB...3...12M | display-authors = etal | doi-access=free }}
*{{cite journal | last1 = Ateeq | first1 = B | last2 = Tomlins | first2 = SA | last3 = Chinnaiyan | first3 = AM | date = Dec 2009 | title = AGTR1 as a therapeutic target in ER-positive and ERBB2-negative breast cancer cases | journal = Cell Cycle | volume = 8 | issue = 23| pages = 3794–5 | pmid = 19934656 | pmc = 2940713 | doi = 10.4161/cc.8.23.9976 }}
* {{cite journal | pmid = 19933109 | doi=10.1126/science.1178124 | volume=326 | title=Induced chromosomal proximity and gene fusions in prostate cancer | pmc=2935583 | date=November 2009 | journal=Science | page=1230 | last1 = Mani | first1 = RS | last2 = Tomlins | first2 = SA | last3 = Callahan | first3 = K | issue=5957 | bibcode=2009Sci...326.1230M | display-authors = etal}}
* {{cite journal | pmid = 19881495 | doi=10.1038/nbt.1584 | volume=27 | title=An integrative approach to reveal driver gene fusions from paired-end sequencing data in cancer | pmc=3086882 | date=November 2009 | journal=Nat. Biotechnol. | pages=1005–11 | last1 = Wang | first1 = XS | last2 = Prensner | first2 = JR | last3 = Chen | first3 = G | issue=11 | display-authors = etal}}
* {{cite journal | pmid = 19763266 | doi=10.1371/journal.pone.0007075 | volume=4 | title=Proteomic interrogation of androgen action in prostate cancer cells reveals roles of aminoacyl tRNA synthetases | pmc=2740864 | year=2009 | journal=PLOS ONE | article-number=e7075 | last1 = Vellaichamy | first1 = A | last2 = Sreekumar | first2 = A | last3 = Strahler | first3 = JR | issue=9 | bibcode=2009PLoSO...4.7075V | display-authors = etal| doi-access=free }}
*{{cite journal | last1 = Gust | first1 = KM | last2 = Hofer | first2 = MD | last3 = Perner | first3 = SR | last4 = Kim | first4 = R | last5 = Chinnaiyan | first5 = AM | last6 = Varambally | first6 = S | last7 = Moller | first7 = P | last8 = Rinnab | first8 = L | last9 = Rubin | first9 = MA | last10 = Greiner | first10 = J | last11 = Schmitt | first11 = M | last12 = Kuefer | first12 = R | last13 = Ringhoffer | first13 = M | date = Sep 2009 | title = RHAMM (CD168) is overexpressed at the protein level and may constitute an immunogenic antigen in advanced prostate cancer disease | journal = Neoplasia | volume = 11 | issue = 9| pages = 956–63 | pmid = 19724689 | pmc = 2735808 | doi = 10.1593/neo.09694 }}
* {{cite journal | pmid = 19679545 | doi=10.1158/0008-5472.CAN-09-1063 | volume=69 | title=Melanoma proliferation and chemoresistance controlled by the DEK oncogene | pmc=2727675 | date=August 2009 | journal=Cancer Res. | pages=6405–13 | last1 = Khodadoust | first1 = MS | last2 = Verhaegen | first2 = M | last3 = Kappes | first3 = F | issue=16 | display-authors = etal}}
== References ==
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Category:Year of birth missing (living people)
Category:Living people
Category:American health professionals of Indian descent
Category:University of Michigan faculty
Category:University of Michigan Medical School alumni
Category:Place of birth missing (living people)
Category:Howard Hughes Medical Investigators
Category:Members of the National Academy of Medicine
Category:Members of the United States National Academy of Sciences
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Adapted from the Wikipedia article [Arul Chinnaiyan](https://en.wikipedia.org/wiki/Arul_Chinnaiyan) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/Arul_Chinnaiyan?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.