# Androgen-dependent condition

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An '''androgen-dependent condition''', '''disease''', '''disorder''', or '''syndrome''', is a [medical condition](/source/medical_condition) that is, in part or full, dependent on, or is sensitive to, the presence of [androgen](/source/androgen)ic activity in the body.{{cn|date=May 2022}}

Known androgen-dependent conditions include [acne](/source/acne),<ref name="PizzornoMurray2013">{{cite book|author1=Joseph E. Pizzorno|author2=Michael T. Murray|title=Textbook of Natural Medicine|url=https://books.google.com/books?id=6cjgo1IixvEC&pg=PA1157|year=2013|publisher=Elsevier Health Sciences|isbn=978-1-4377-2333-5|pages=1157–}}</ref> [seborrhea](/source/seborrhea),<ref name="HoathMaibach2003">{{cite book|author1=Steven B. Hoath|author2=Howard I. Maibach|title=Neonatal Skin: Structure and Function|url=https://books.google.com/books?id=KNQ9mY7ZkwUC&pg=PA67|date=18 April 2003|publisher=CRC Press|isbn=978-0-8247-0887-0|pages=67–}}</ref><ref name="StracquadanioCiotta2015">{{cite book|author1=Mariagrazia Stracquadanio|author2=Lilliana Ciotta|title=Metabolic Aspects of PCOS: Treatment With Insulin Sensitizers|url=https://books.google.com/books?id=w5xwCAAAQBAJ&pg=PA25|date=20 April 2015|publisher=Springer International Publishing|isbn=978-3-319-16760-2|pages=25–}}</ref><ref name="KrishnaR.2000">{{cite book|author1=Krishna|author2=Usha R.|title=Adolescence|url=https://books.google.com/books?id=wPQ6LVIQaQQC&pg=PA124|date=1 March 2000|publisher=Orient Blackswan|isbn=978-81-250-1794-3|pages=124–}}</ref> [androgenic alopecia](/source/androgenic_alopecia),<ref name="LebwohlHeymann2013">{{cite book|author1=Mark G. Lebwohl|author2=Warren R. Heymann|author3=John Berth-Jones|author4=Ian Coulson|title=Treatment of Skin Disease: Comprehensive Therapeutic Strategies|url=https://books.google.com/books?id=hRryAAAAQBAJ&pg=PA36|date=19 September 2013|publisher=Elsevier Health Sciences UK|isbn=978-0-7020-5236-1|pages=36–}}</ref> [hirsutism](/source/hirsutism),<ref name="Bergfeld1996">{{cite book|author=Wilma F. Bergfeld|title=A Woman Doctor's Guide to Skin Care: Essential Facts and Information on Keeping Skin Healthy|url=https://books.google.com/books?id=zE9CjIgP7MYC|date=22 February 1996|publisher=Hyperion|isbn=978-0-7868-8100-0}}</ref> [hidradenitis suppurativa](/source/hidradenitis_suppurativa),<ref name="Bekaert2007">{{cite book|author=Sarah Bekaert|title=Women's Health: A Practical Guide for Healthcare Professionals|url=https://books.google.com/books?id=1tWoLXYw9wsC&pg=PA128|year=2007|publisher=Radcliffe Publishing|isbn=978-1-84619-029-2|pages=128–}}</ref> [precocious puberty](/source/precocious_puberty) in boys,<ref name="PescovitzEugster2004">{{cite book|author1=Ora Hirsch Pescovitz|author2=Erica A. Eugster|title=Pediatric Endocrinology: Mechanisms, Manifestations, and Management|url=https://books.google.com/books?id=9gvBlktAT6YC&pg=PA328|year=2004|publisher=Lippincott Williams & Wilkins|isbn=978-0-7817-4059-3|pages=328–}}</ref> [hypersexuality](/source/hypersexuality),<ref>{{cite book|title=Newsletter|url=https://books.google.com/books?id=HJtGAQAAIAAJ|year=1986|publisher=The Academy}}</ref> [paraphilia](/source/paraphilia)s,<ref name="Raine2006">{{cite book|author=Adrian Raine|title=Crime and Schizophrenia: Causes and Cures|url=https://books.google.com/books?id=3vy6kkygp9IC&pg=PA290|year=2006|publisher=Nova Publishers|isbn=978-1-59454-609-9|pages=290–}}</ref> [benign prostatic hyperplasia](/source/benign_prostatic_hyperplasia) (BPH),<ref name="ChappleSteers2011">{{cite book|author1=Christopher R. Chapple|author2=William D. Steers|title=Practical Urology: Essential Principles and Practice: Essential Principles and Practice|url=https://books.google.com/books?id=A9m8TkdCUqEC&pg=PA361|date=10 May 2011|publisher=Springer Science & Business Media|isbn=978-1-84882-034-0|pages=361–}}</ref> [prostate cancer](/source/prostate_cancer),<ref name="Bentley1980">{{cite book|author=P. J. Bentley|title=Endocrine Pharmacology: Physiological Basis and Therapeutic Applications|url=https://books.google.com/books?id=W6M9AAAAIAAJ&pg=PA321|year=1980|publisher=CUP Archive|isbn=978-0-521-22673-8|pages=321–}}</ref> and [hyperandrogenism](/source/hyperandrogenism) in women such as in [polyendocrine metabolic ovarian syndrome](/source/polyendocrine_metabolic_ovarian_syndrome) (PMOS, formerly known as PCOS), [congenital adrenal hyperplasia](/source/congenital_adrenal_hyperplasia) (CAH), and androgen-secreting [tumor](/source/tumor)s ([gonadal](/source/gonadal_tumor) or [adrenal tumor](/source/adrenal_tumor)).<ref name="RubinStrayer2008">{{cite book|author1=Raphael Rubin|author2=David S. Strayer|author3=Emanuel Rubin |author4=Jay M. McDonald |title=Rubin's Pathology: Clinicopathologic Foundations of Medicine|url=https://books.google.com/books?id=kD9VZ267wDEC&pg=PA816|year=2008|publisher=Lippincott Williams & Wilkins|isbn=978-0-7817-9516-6|pages=816–}}</ref><ref name="DunaifChang2008">{{cite book|author1=Andrea Dunaif|author2=R. Jeffrey Chang|author3=Stephen Franks|author4=Richard S. Legro|title=Polycystic Ovary Syndrome: Current Controversies, from the Ovary to the Pancreas|url=https://books.google.com/books?id=xdxqJuE7tSwC&pg=PA222|date=12 January 2008|publisher=Springer Science & Business Media|isbn=978-1-59745-108-6|pages=222–}}</ref>

Such conditions may be treated with [drug](/source/drug)s with [antiandrogen](/source/antiandrogen) actions, including [androgen receptor](/source/androgen_receptor) [antagonist](/source/receptor_antagonist)s such as [cyproterone acetate](/source/cyproterone_acetate), [spironolactone](/source/spironolactone), and [bicalutamide](/source/bicalutamide), [5α-reductase inhibitor](/source/5%CE%B1-reductase_inhibitor)s such as [finasteride](/source/finasteride) and [dutasteride](/source/dutasteride), [CYP17A1](/source/CYP17A1) inhibitors such as [abiraterone acetate](/source/abiraterone_acetate), [gonadotropin-releasing hormone](/source/gonadotropin-releasing_hormone) (GnRH) [analogue](/source/gonadotropin-releasing_hormone_analogue)s such as [leuprorelin](/source/leuprorelin) and [cetrorelix](/source/cetrorelix), and/or other [antigonadotropin](/source/antigonadotropin)s such as [megestrol acetate](/source/megestrol_acetate) and [medroxyprogesterone acetate](/source/medroxyprogesterone_acetate).<ref name="Becker2001">{{cite book|author=Kenneth L. Becker|title=Principles and Practice of Endocrinology and Metabolism|url=https://books.google.com/books?id=FVfzRvaucq8C&pg=PA1195|year=2001|publisher=Lippincott Williams & Wilkins|isbn=978-0-7817-1750-2|pages=1195–}}</ref><ref>{{cite book|title=Annual Reports in Medicinal Chemistry|url=https://books.google.com/books?id=e2koZ5uWeaYC&pg=PA1994|date=3 October 1994|publisher=Academic Press|isbn=978-0-08-058373-0|pages=1994–}}</ref>

==See also==
* [Androgen deprivation therapy](/source/Androgen_deprivation_therapy)
* [Androgen insensitivity syndrome](/source/Androgen_insensitivity_syndrome)
* [Estrogen-dependent condition](/source/Estrogen-dependent_condition)
* [Spinal bulbar muscular atrophy](/source/Spinal_bulbar_muscular_atrophy)

==References==
{{reflist|30em}}

==Further reading==
* {{cite journal|last1=Shukla|first1=G. C.|last2=Plaga|first2=A. R.|last3=Shankar|first3=E.|last4=Gupta|first4=S.|title=Androgen receptor-related diseases: what do we know?|journal=Andrology|year=2016|pages=366–381|issn=2047-2919|doi=10.1111/andr.12167|volume=4|issue=3|pmid=26991422|doi-access=free}}

{{Gonadal disorder}}

Category:Endocrine gonad disorders
Category:Male genital disorders
Category:Mammal reproductive system
Category:Androgens

{{endocrine-disease-stub}}

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Adapted from the Wikipedia article [Androgen-dependent condition](https://en.wikipedia.org/wiki/Androgen-dependent_condition) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/Androgen-dependent_condition?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.