# Anavip

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**Anavip** is the brand name of a snake [antivenin](/source/Antivenin) indicated for the management of people with [North American rattlesnake](/source/Timber_rattlesnake) [envenomation](/source/Envenomation).[3][4][1] As defined by the US [Food and Drug Administration](/source/Food_and_Drug_Administration) (FDA), the proper name is [crotalidae](/source/Crotalidae) immune F(ab')2 (equine).[2] It is manufactured by Rare Disease Therapeutics.

Anavip is a divalent [fragment antigen-binding](/source/Fragment_antigen-binding) protein, F(ab')2, derived from the blood of [horses](/source/Horses) immunized with the [venom](/source/Venom) of the snakes *[Bothrops asper](/source/Bothrops_asper)* and *[Crotalus durissus](/source/Crotalus_durissus)*. The product is produced by [pepsin](/source/Pepsin) digestion of horse [blood plasma](/source/Blood_plasma) then purified resulting in a preparation containing >85% F(ab')2.[1]

## References

1. ["Anavip crotalidae immune F(ab’)2 (equine) Lyophilized Powder for Solution for Injection For Intravenous Use Only"](https://www.fda.gov/media/92139/download) (PDF). Rare Disease Therapeutics. Retrieved 18 August 2020.

1. ["Anavip"](https://www.fda.gov/vaccines-blood-biologics/approved-blood-products/anavip). *U.S. [Food and Drug Administration](/source/Food_and_Drug_Administration) (FDA)*. 1 April 2021. STN: 125488. Retrieved 3 October 2025.

1. Cocchio C, Johnson J, Clifton S (January 2020). "Review of North American pit viper antivenoms". *American Journal of Health-System Pharmacy*. **77** (3): 175–187. [doi:10.1093/ajhp/zxz278](https://doi.org/10.1093/ajhp/zxz278). [PMID 31974558](https://pubmed.ncbi.nlm.nih.gov/31974558)

1. ["Marketing authorization with orphan designation - USA"](https://www.orpha.net/consor/cgi-bin/Drugs_Search.php?lng=EN&data_id=116759&search=Drugs_Search_Simple&data_type=Status&Typ=Med). *orpha.net*. orphanet. Retrieved 19 August 2020.

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Adapted from the Wikipedia article [Anavip](https://en.wikipedia.org/wiki/Anavip) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/Anavip?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.