# Ampelopsin > Mediated Wiki article. Canonical URL: https://mediated.wiki/source/Ampelopsin > Markdown URL: https://mediated.wiki/source/Ampelopsin.md > Source: https://en.wikipedia.org/wiki/Ampelopsin > Source revision: 1353645362 > License: Creative Commons Attribution-ShareAlike 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/) For other uses, see [Ampelopsin (compound) (disambiguation)](/source/Ampelopsin_(compound)_(disambiguation)). **Ampelopsin**, also known as **dihydromyricetin** and **DHM**, when used as an herbal medicine, is a [flavanonol](/source/Flavanonol), a type of flavonoid. It is extracted from the Japanese raisin tree and found in *[Ampelopsis](/source/Ampelopsis)* species *japonica*, *megalophylla*, and *grossedentata*; *[Cercidiphyllum japonicum](/source/Cercidiphyllum_japonicum)*; *[Hovenia dulcis](/source/Hovenia_dulcis)*; *[Rhododendron cinnabarinum](/source/Rhododendron_cinnabarinum)*; some *[Pinus](/source/Pinus)* species; and some *[Cedrus](/source/Cedrus)* species,[1] as well as in *[Salix sachalinensis](/source/Salix_sachalinensis)*.[2] *[Hovenia dulcis](/source/Hovenia_dulcis)* has been used in traditional [Japanese](/source/Kampo), [Chinese](/source/Traditional_chinese_medicine), and [Korean](/source/Traditional_Korean_medicine) medicines to treat fever, parasitic infection, as a laxative, and a treatment of liver diseases, and as a [hangover](/source/Hangover) treatment.[3] Methods have been developed to extract ampelopsin on a larger scale, and laboratory research has been conducted with the compound to see if it might be useful as a drug in any of the conditions for which the parent plant has been traditionally used.[3] ## Research Research suggests that ampelopsin protects against [doxorubicin](/source/Doxorubicin)-induced [cardiotoxicity](/source/Cardiotoxicity) by inhibiting [NLRP3](/source/NLRP3) inflammasome activation via stimulation of the [SIRT1](/source/SIRT1) pathway.[4] In a study of 60 patients with [non-alcoholic fatty liver disease](/source/Non-alcoholic_fatty_liver_disease), ampelopsin improved glucose and lipid metabolism and yielded potentially beneficial anti-inflammatory effects.[5] A study of rats demonstrated pharmacological properties of ampelopsin which suggest it would be a therapeutic candidate to treat [alcohol use disorders](/source/Alcohol_use_disorders).[6] Additional research is required before claims of human efficacy and application, necessary dosage, and solutions to poor bioavailability, are met with scientific validation.[7] ## Purported benefits Ampelopsin has been claimed to possess various health, wellness, and [cosmetic](/source/Cosmetics) benefits, including: - Anti-alcohol intoxication: ampelopsin is widely used in hangover remedies due to its claimed ability to accelerate alcohol breakdown in the liver and mitigate alcohol-induced damage.[3] However, a pharmacokinetic study found no effect of DHM on alcohol metabolism.[8] - Cosmetic applications: ampelopsin is used in skincare products for its purported ability to protect skin from UV-induced damage and aging.[9] ## References 1. Zhou, Jiaju; Xie, Guirong; Yan, Xinjian (2011-02-21). [*Encyclopedia of Traditional Chinese Medicines – Molecular Structures, Pharmacological Activities, Natural Sources and Applications: Vol. 1: Isolated Compounds A-C*](https://books.google.com/books?id=PMsXJnUYTFkC). Springer Science & Business Media. p. 123. ISBN 978-3-642-16735-5. 1. Tahara S (June 2007). "A journey of twenty-five years through the ecological biochemistry of flavonoids". *Biosci Biotechnol Biochem*. **71** (6): 1387–404. [doi:10.1271/bbb.70028](https://doi.org/10.1271/bbb.70028). [PMID 17587669](https://pubmed.ncbi.nlm.nih.gov/17587669). [S2CID 35670587](https://api.semanticscholar.org/CorpusID:35670587) 1. Hyun TK, Eom SH, Yu CY, Roitsch T (July 2010). "Hovenia dulcis--an Asian traditional herb". *Planta Med*. **76** (10): 943–9. [doi:10.1055/s-0030-1249776](https://doi.org/10.1055/s-0030-1249776). [PMID 20379955](https://pubmed.ncbi.nlm.nih.gov/20379955) 1. Christidi E, Brunham LR (April 2021). "Regulated cell death pathways in doxorubicin-induced cardiotoxicity". *Cell Death Dis*. **12** (4). [doi:10.1038/s41419-021-03614-x](https://doi.org/10.1038/s41419-021-03614-x). [PMC 8017015](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8017015). [PMID 33795647](https://pubmed.ncbi.nlm.nih.gov/33795647) 1. Chen S, Zhao X, Wan J, Ran L, Qin Y, Wang X, Gao Y, Shu F, Zhang Y, Liu P, Zhang Q, Zhu J, Mi M (September 2015). "Dihydromyricetin improves glucose and lipid metabolism and exerts anti-inflammatory effects in nonalcoholic fatty liver disease: A randomized controlled trial". *Pharmacol Res*. **99**: 74–81. [doi:10.1016/j.phrs.2015.05.009](https://doi.org/10.1016/j.phrs.2015.05.009). [PMID 26032587](https://pubmed.ncbi.nlm.nih.gov/26032587) 1. Shen Y, Lindemeyer AK, Gonzalez C, Shao XM, Spigelman I, Olsen RW, Liang J (January 2012). "Dihydromyricetin as a novel anti-alcohol intoxication medication". *J Neurosci*. **32** (1): 390–401. [doi:10.1523/JNEUROSCI.4639-11.2012](https://doi.org/10.1523/JNEUROSCI.4639-11.2012). [PMC 3292407](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3292407). [PMID 22219299](https://pubmed.ncbi.nlm.nih.gov/22219299) 1. Li H, Li Q, Liu Z, Yang K, Chen Z, Cheng Q, Wu L (2017). "The Versatile Effects of Dihydromyricetin in Health". *Evid Based Complement Alternat Med*. **2017**. [doi:10.1155/2017/1053617](https://doi.org/10.1155/2017/1053617). [PMC 5602609](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5602609). [PMID 28947908](https://pubmed.ncbi.nlm.nih.gov/28947908) 1. Skotnicová, A.; Boubínová, G.; Boštíková, Z.; Dušková, Š; Šulc, M.; Kutinová-Canová, N.; Mráz, J.; Hodek, P. (2020-12-31). "Does dihydromyricetin impact on alcohol metabolism". *Physiological Research*. **69** (Suppl 4): S573–S581. [doi:10.33549/physiolres.934606](https://doi.org/10.33549/physiolres.934606). [ISSN 1802-9973](https://www.worldcat.org/issn/1802-9973). [PMC 8603706](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8603706). [PMID 33656905](https://pubmed.ncbi.nlm.nih.gov/33656905) 1. No. 2356980A2.[dead link] --- Adapted from the Wikipedia article [Ampelopsin](https://en.wikipedia.org/wiki/Ampelopsin) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/Ampelopsin?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.