# Acroplaxome

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Structure found between the acrosomal membrane and the nuclear membrane

[Spermatozoa](/source/Spermatozoon) develop in the [seminiferous tubules](/source/Seminiferous_tubules) of the testes. During their development, the [spermatogonia](/source/Spermatogonium) proceed through [meiosis](/source/Meiosis) to become spermatozoa. Many changes occur during this process: the DNA in nuclei becomes condensed; the [acrosome](/source/Acrosome) develops as a structure close to the nucleus. The acrosome is derived from the [Golgi apparatus](/source/Golgi_apparatus) and contains hydrolytic enzymes important for fusion of the spermatozoon with an [egg cell](/source/Ovum). During spermiogenesis, the nucleus condenses and changes shape. Abnormal shape change is a feature of sperm in [male infertility](/source/Infertility). The **acroplaxome** is a structure found between the acrosomal membrane and the [nuclear membrane](/source/Nuclear_envelope).[1] The acroplaxome contains structural proteins including keratin 5, [F-actin](/source/Actin)[1] and profilin IV.[2]

## References

- Kierszenbaum AL, Tres LL (November 2004). ["The acrosome-acroplaxome-manchette complex and the shaping of the spermatid head"](https://doi.org/10.1679%2Faohc.67.271). *Arch. Histol. Cytol*. **67** (4): 271–84. [doi](/source/Doi_(identifier)):[10.1679/aohc.67.271](https://doi.org/10.1679%2Faohc.67.271). [PMID](/source/PMID_(identifier)) [15700535](https://pubmed.ncbi.nlm.nih.gov/15700535).

1. ^ [***a***](#cite_ref-Kiersz03_1-0) [***b***](#cite_ref-Kiersz03_1-1) Kierszenbaum AL, Rivkin E, Tres LL (November 2003). ["Acroplaxome, an F-actin-keratin-containing plate, anchors the acrosome to the nucleus during shaping of the spermatid head"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC266778). *Mol. Biol. Cell*. **14** (11): 4628–40. [doi](/source/Doi_(identifier)):[10.1091/mbc.E03-04-0226](https://doi.org/10.1091%2Fmbc.E03-04-0226). [PMC](/source/PMC_(identifier)) [266778](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC266778). [PMID](/source/PMID_(identifier)) [14551252](https://pubmed.ncbi.nlm.nih.gov/14551252).

1. **[^](#cite_ref-2)** Obermann H, Raabe I, Balvers M, Brunswig B, Schulze W, Kirchhoff C (January 2005). "Novel testis-expressed profilin IV associated with acrosome biogenesis and spermatid elongation". *Mol. Hum. Reprod*. **11** (1): 53–64. [doi](/source/Doi_(identifier)):[10.1093/molehr/gah132](https://doi.org/10.1093%2Fmolehr%2Fgah132). [PMID](/source/PMID_(identifier)) [15591451](https://pubmed.ncbi.nlm.nih.gov/15591451).

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Adapted from the Wikipedia article [Acroplaxome](https://en.wikipedia.org/wiki/Acroplaxome) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/Acroplaxome?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.