# ASH2L
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> Source: https://en.wikipedia.org/wiki/ASH2L
> Source revision: 1301001703
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{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
'''Set1/Ash2 histone methyltransferase complex subunit ASH2''' is an [enzyme](/source/enzyme) that in humans is encoded by the ''ASH2L'' [gene](/source/gene).[{{cite journal | vauthors = Ikegawa S, Isomura M, Koshizuka Y, Nakamura Y | title = Cloning and characterization of ASH2L and Ash2l, human and mouse homologs of the Drosophila ash2 gene | journal = Cytogenet. Cell Genet. | volume = 84 | issue = 3–4 | pages = 167–72 | date = Jul 1999 | pmid = 10393421 | doi = 10.1159/000015248 | s2cid = 19257499 }}][{{cite web | title = Entrez Gene: ASH2L ash2 (absent, small, or homeotic)-like (Drosophila)| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=9070}}]
== Interactions ==
ASH2L has been shown to [interact](/source/Protein-protein_interaction) with [MLL](/source/MLL_(gene)).[{{cite journal | vauthors = Yokoyama A, Wang Z, Wysocka J, Sanyal M, Aufiero DJ, Kitabayashi I, Herr W, Cleary ML | title = Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression | journal = Mol. Cell. Biol. | volume = 24 | issue = 13 | pages = 5639–49 | date = Jul 2004 | pmid = 15199122 | pmc = 480881 | doi = 10.1128/MCB.24.13.5639-5649.2004 }}]
== References ==
{{reflist}}
==External links==
* {{UCSC gene info|ASH2L}}
== Further reading ==
{{refbegin | 2}}
* {{cite journal | vauthors = Wang J, Zhou Y, Yin B, Du G, Huang X, Li G, Shen Y, Yuan J, Qiang B | title = ASH2L: alternative splicing and downregulation during induced megakaryocytic differentiation of multipotential leukemia cell lines | journal = J. Mol. Med. | volume = 79 | issue = 7 | pages = 399–405 | year = 2001 | pmid = 11466562 | doi = 10.1007/s001090100222 | s2cid = 6719550 }}
* {{cite journal | vauthors = Goo YH, Sohn YC, Kim DH, Kim SW, Kang MJ, Jung DJ, Kwak E, Barlev NA, Berger SL, Chow VT, Roeder RG, Azorsa DO, Meltzer PS, Suh PG, Song EJ, Lee KJ, Lee YC, Lee JW | title = Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins | journal = Mol. Cell. Biol. | volume = 23 | issue = 1 | pages = 140–9 | year = 2003 | pmid = 12482968 | pmc = 140670 | doi = 10.1128/MCB.23.1.140-149.2003 }}
* {{cite journal | vauthors = Wysocka J, Myers MP, Laherty CD, Eisenman RN, Herr W | title = Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1 | journal = Genes Dev. | volume = 17 | issue = 7 | pages = 896–911 | year = 2003 | pmid = 12670868 | pmc = 196026 | doi = 10.1101/gad.252103 }}
* {{cite journal | vauthors = Hughes CM, Rozenblatt-Rosen O, Milne TA, Copeland TD, Levine SS, Lee JC, Hayes DN, Shanmugam KS, Bhattacharjee A, Biondi CA, Kay GF, Hayward NK, Hess JL, Meyerson M | title = Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus | journal = Mol. Cell | volume = 13 | issue = 4 | pages = 587–97 | year = 2004 | pmid = 14992727 | doi = 10.1016/S1097-2765(04)00081-4 | doi-access = free }}
* {{cite journal | vauthors = Yokoyama A, Wang Z, Wysocka J, Sanyal M, Aufiero DJ, Kitabayashi I, Herr W, Cleary ML | title = Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression | journal = Mol. Cell. Biol. | volume = 24 | issue = 13 | pages = 5639–49 | year = 2004 | pmid = 15199122 | pmc = 480881 | doi = 10.1128/MCB.24.13.5639-5649.2004 }}
* {{cite journal | vauthors = Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM | title = Functional proteomics mapping of a human signaling pathway | journal = Genome Res. | volume = 14 | issue = 7 | pages = 1324–32 | year = 2004 | pmid = 15231748 | pmc = 442148 | doi = 10.1101/gr.2334104 }}
* {{cite journal | vauthors = Barrios-Rodiles M, Brown KR, Ozdamar B, Bose R, Liu Z, Donovan RS, Shinjo F, Liu Y, Dembowy J, Taylor IW, Luga V, Przulj N, Robinson M, Suzuki H, Hayashizaki Y, Jurisica I, Wrana JL | title = High-throughput mapping of a dynamic signaling network in mammalian cells | journal = Science | volume = 307 | issue = 5715 | pages = 1621–5 | year = 2005 | pmid = 15761153 | doi = 10.1126/science.1105776 | bibcode = 2005Sci...307.1621B | s2cid = 39457788 }}
* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | year = 2005 | pmid = 16189514 | doi = 10.1038/nature04209 | bibcode = 2005Natur.437.1173R | s2cid = 4427026 }}
* {{cite journal | vauthors = Steward MM, Lee JS, O'Donovan A, Wyatt M, Bernstein BE, Shilatifard A | title = Molecular regulation of H3K4 trimethylation by ASH2L, a shared subunit of MLL complexes | journal = Nat. Struct. Mol. Biol. | volume = 13 | issue = 9 | pages = 852–4 | year = 2006 | pmid = 16892064 | doi = 10.1038/nsmb1131 | s2cid = 19384238 }}
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Adapted from the Wikipedia article [ASH2L](https://en.wikipedia.org/wiki/ASH2L) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/ASH2L?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.