# ASAH2B

> Mediated Wiki article. Canonical URL: https://mediated.wiki/source/ASAH2B
> Markdown URL: https://mediated.wiki/source/ASAH2B.md
> Source: https://en.wikipedia.org/wiki/ASAH2B
> Source revision: 1116593417
> License: Creative Commons Attribution-ShareAlike 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/)

Protein-coding gene in the species Homo sapiens

ASAH2B Identifiers Aliases ASAH2B, ASAH2L, bA449O16.3, bA98I6.3, N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2B, ASAH2C, N-acylsphingosine amidohydrolase 2B External IDs GeneCards: ASAH2B; OMA:ASAH2B - orthologs Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q11.23 Start 50,739,318 bp[1] End 50,816,495 bp[1] RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in duodenum gonad islet of Langerhans ganglionic eminence testicle superior frontal gyrus liver primary visual cortex rectum ventricular zone n/a More reference expression data BioGPS n/a Gene ontology Molecular function N-acylsphingosine amidohydrolase activity Cellular component extracellular region Biological process long-chain fatty acid biosynthetic process sphingosine biosynthetic process ceramide catabolic process Sources:Amigo / QuickGO Orthologs Species Human Mouse Entrez 653308 n/a Ensembl ENSG00000204147 n/a UniProt P0C7U1 n/a RefSeq (mRNA) NM_001079516 NM_001321957 NM_001321958 NM_001321959 NM_001321960 n/a RefSeq (protein) NP_001072984 NP_001308886 NP_001308887 NP_001308888 NP_001308889 n/a Location (UCSC) Chr 10: 50.74 – 50.82 Mb n/a PubMed search [2] n/a Wikidata View/Edit Human

**Neutral ceramidase B** also known as **non-lysosomal ceramidase B** or **N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2B** or **ASAH2B** is a [ceramidase](/source/Ceramidase) [enzyme](/source/Enzyme) which in humans is encoded by the ASAH2B [gene](/source/Gene).[3][4]

## Clinical significance

ASAH2B shows reduced expression with increasing age and further reduction in late onset [Alzheimer's disease](/source/Alzheimer's_disease) patients.[3]

## References

1. ^ [***a***](#cite_ref-refGRCh38Ensembl_1-0) [***b***](#cite_ref-refGRCh38Ensembl_1-1) [***c***](#cite_ref-refGRCh38Ensembl_1-2) [GRCh38: Ensembl release 89: ENSG00000204147](http://May2017.archive.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000204147) – [Ensembl](/source/Ensembl_genome_database_project), May 2017

1. **[^](#cite_ref-2)** ["Human PubMed Reference:"](https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=653308). *National Center for Biotechnology Information, U.S. National Library of Medicine*.

1. ^ [***a***](#cite_ref-pmid17334805_3-0) [***b***](#cite_ref-pmid17334805_3-1) Avramopoulos D, Wang R, Valle D, Fallin MD, Bassett SS (April 2007). "A novel gene derived from a segmental duplication shows perturbed expression in Alzheimer's disease". *Neurogenetics*. **8** (2): 111–20. [doi](/source/Doi_(identifier)):[10.1007/s10048-007-0081-5](https://doi.org/10.1007%2Fs10048-007-0081-5). [PMID](/source/PMID_(identifier)) [17334805](https://pubmed.ncbi.nlm.nih.gov/17334805). [S2CID](/source/S2CID_(identifier)) [20156514](https://api.semanticscholar.org/CorpusID:20156514).

1. **[^](#cite_ref-pmid15164054_4-0)** Deloukas P, Earthrowl ME, Grafham DV, et al. (May 2004). ["The DNA sequence and comparative analysis of human chromosome 10"](https://doi.org/10.1038%2Fnature02462). *Nature*. **429** (6990): 375–81. [Bibcode](/source/Bibcode_(identifier)):[2004Natur.429..375D](https://ui.adsabs.harvard.edu/abs/2004Natur.429..375D). [doi](/source/Doi_(identifier)):[10.1038/nature02462](https://doi.org/10.1038%2Fnature02462). [PMID](/source/PMID_(identifier)) [15164054](https://pubmed.ncbi.nlm.nih.gov/15164054).

## External links

- Human [*ASAH2B*](https://genome.ucsc.edu/cgi-bin/hgTracks?db=hg38&singleSearch=knownCanonical&position=ASAH2B) genome location and [*ASAH2B*](https://genome.ucsc.edu/cgi-bin/hgGene?db=hg38&hgg_type=knownGene&hgg_gene=ASAH2B) gene details page in the [UCSC Genome Browser](/source/UCSC_Genome_Browser).

## Further reading

- Brandenberger R, Wei H, Zhang S, et al. (2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". *Nat. Biotechnol*. **22** (6): 707–16. [doi](/source/Doi_(identifier)):[10.1038/nbt971](https://doi.org/10.1038%2Fnbt971). [PMID](/source/PMID_(identifier)) [15146197](https://pubmed.ncbi.nlm.nih.gov/15146197). [S2CID](/source/S2CID_(identifier)) [27764390](https://api.semanticscholar.org/CorpusID:27764390).

v t e Metabolism, lipid metabolism, glycolipid enzymes Sphingolipid To glycosphingolipid Glycosyltransferase Sulfotransferase To ceramide From ganglioside β-Galactosidase Hexosaminidase A Neuraminidase Glucocerebrosidase From globoside Hexosaminidase B α-Galactosidase β-Galactosidase Glucocerebrosidase From sphingomyelin Sphingomyelin phosphodiesterase Sphingomyelin phosphodiesterase 1 From sulfatide Arylsulfatase A Galactosylceramidase To sphingosine Ceramidase ACER1 ACER2 ACER3 ASAH1 ASAH2 ASAH2B ASAH2C Other Sphingosine kinase NCL Palmitoyl protein thioesterase Tripeptidyl peptidase I CLN3 CLN5 CLN6 CLN8 Ceramide synthesis Serine C-palmitoyltransferase (SPTLC1) Ceramide glucosyltransferase (UGCG)

This article on a gene on human chromosome 10 is a stub. You can help Wikipedia by adding missing information.

- [v](https://en.wikipedia.org/wiki/Template:Gene-10-stub)
- [t](/source/Template_talk%3AGene-10-stub)
- [e](https://en.wikipedia.org/wiki/Special:EditPage/Template:Gene-10-stub)

---
Adapted from the Wikipedia article [ASAH2B](https://en.wikipedia.org/wiki/ASAH2B) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/ASAH2B?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.