# ARDB

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> Source: https://en.wikipedia.org/wiki/ARDB
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{{Short description|Biological database}}
{{Infobox biodatabase|title=Antibiotic Resistance Genes Database|logo=|description=A database that tracks antibiotic resistance genes.|scope=Antibiotic resistance genes|organism=[Bacteria](/source/Bacteria)|center=|laboratory=|author=|pmid=18832362|released=|standard=|format=|url={{URL|http://ardb.cbcb.umd.edu}}|download=|webservice=|sql=|sparql=|webapp=|standalone=|license=|versioning=|frequency=|curation=|bookmark=yes|version=}}'''ARDB''' also known as '''Antibiotic Resistance Genes Database''' is a [database](/source/Biological_database) that tracks [antibiotic resistance](/source/Antimicrobial_resistance) [gene](/source/gene)s with information such as [mechanism of action](/source/mechanism_of_action), resistance profile, [ontology](/source/Ontology_(information_science)), Clusters of Orthologous Genes (COG) and [Conserved Domain Database](/source/Conserved_Domain_Database) (CDD) annotations.<ref name=":0">{{Cite journal|last1=Liu|first1=B.|last2=Pop|first2=M.|date=2009-01-01|title=ARDB--Antibiotic Resistance Genes Database|journal=Nucleic Acids Research|volume=37|issue=Database|pages=D443–D447|doi=10.1093/nar/gkn656|pmid=18832362|issn=0305-1048|pmc=2686595}}</ref> It also contains links to external databases. The database is also for the identification of new [resistance genes](/source/Antimicrobial_resistance). During the creation of ARDB in 2009, there was no comprehensive annotation system available. Thus, [ontology](/source/Ontology_(information_science)) terms for resistance profiles and [mechanisms of actions](/source/Mechanism_of_action) were created for ARDB. Other things classified by [ontology](/source/Ontology_(information_science)) include drug target modification, drug enzymatic destruction and [drug transport](/source/Efflux_(microbiology)).<ref name=":0" /> Drug transporters are further subclassified by [MFS Efflux pumps](/source/Major_facilitator_superfamily), [SMR Efflux pumps](/source/Small_multidrug_resistance_protein), [ABC Efflux pumps](/source/ATP-binding_cassette_transporter), [RND Efflux pumps](/source/Resistance-nodulation-cell_division_superfamily) following conventions outlined in this paper.<ref>{{Cite journal|last=Higgins|first=Christopher F.|date=April 2007|title=Multiple molecular mechanisms for multidrug resistance transporters|journal=Nature|volume=446|issue=7137|pages=749–757|doi=10.1038/nature05630|pmid=17429392|issn=0028-0836|bibcode=2007Natur.446..749H|s2cid=4414214}}</ref> Currently, ARDB contains resistance information for 13,293 [gene](/source/gene)s, 377 types, 257 [antibiotic](/source/antibiotic)s, 632 [genome](/source/genome)s, 933 [species](/source/species) and 124 [genera](/source/genera).

ARDB is no longer maintained. All ARDB data are in [CARD](/source/The_Comprehensive_Antibiotic_Resistance_Database), which the developers now recommend instead. 

== See also ==

* [Antimicrobial Resistance databases](/source/List_of_biological_databases)

== References ==
{{Reflist}}

Category:Antimicrobial resistance organizations
Category:Biological databases

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Adapted from the Wikipedia article [ARDB](https://en.wikipedia.org/wiki/ARDB) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/ARDB?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.