# ANKRD23

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**Ankyrin repeat domain-containing protein 23** is a [protein](/source/Protein) that in humans is encoded by the *ANKRD23* [gene](/source/Gene).[1][2]

This gene is a member of the muscle ankyrin repeat protein (MARP) family and encodes a protein with four tandem ankyrin-like repeats. The protein is localized to the nucleus, functioning as a transcriptional regulator. Expression of this protein is induced during recovery following starvation.[2]

## Interactions

ANKRD23 has been shown to [interact](/source/Protein-protein_interaction) with [Titin](/source/Titin)[3] and [MYPN](/source/MYPN).[3]

## References

1. Ikeda K, Emoto N, Matsuo M, Yokoyama M (Feb 2003). "Molecular identification and characterization of a novel nuclear protein whose expression is up-regulated in insulin-resistant animals". *J Biol Chem*. **278** (6): 3514–20. [doi:10.1074/jbc.M204563200](https://doi.org/10.1074/jbc.M204563200). [PMID 12456686](https://pubmed.ncbi.nlm.nih.gov/12456686)

1. ["Entrez Gene: ANKRD23 ankyrin repeat domain 23"](https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=200539)

1. Miller, Melanie K; Bang Marie-Louise; Witt Christian C; Labeit Dietmar; Trombitas Charles; Watanabe Kaori; Granzier Henk; McElhinny Abigail S; Gregorio Carol C; Labeit Siegfried (Nov 2003). "The muscle ankyrin repeat proteins: CARP, ankrd2/Arpp and DARP as a family of titin filament-based stress response molecules". *J. Mol. Biol.*. **333** (5): 951–64. [doi:10.1016/j.jmb.2003.09.012](https://doi.org/10.1016/j.jmb.2003.09.012). [ISSN 0022-2836](https://www.worldcat.org/issn/0022-2836). [PMID 14583192](https://pubmed.ncbi.nlm.nih.gov/14583192)

## Further reading

- Hillier LW; Graves TA; Fulton RS et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". *Nature*. **434** (7034): 724–31. [Bibcode:2005Natur.434..724H](https://ui.adsabs.harvard.edu/abs/2005Natur.434..724H). [doi:10.1038/nature03466](https://doi.org/10.1038/nature03466). [PMID 15815621](https://pubmed.ncbi.nlm.nih.gov/15815621)
- Gerhard DS; Wagner L; Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". *Genome Res.*. **14** (10B): 2121–7. [doi:10.1101/gr.2596504](https://doi.org/10.1101/gr.2596504). [PMC 528928](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928). [PMID 15489334](https://pubmed.ncbi.nlm.nih.gov/15489334)
- Nagueh SF; Shah G; Wu Y et al. (2005). "Altered titin expression, myocardial stiffness, and left ventricular function in patients with dilated cardiomyopathy". *Circulation*. **110** (2): 155–62. [doi:10.1161/01.CIR.0000135591.37759.AF](https://doi.org/10.1161/01.CIR.0000135591.37759.AF). [PMID 15238456](https://pubmed.ncbi.nlm.nih.gov/15238456)
- Ota T; Suzuki Y; Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". *Nat. Genet.*. **36** (1): 40–5. [doi:10.1038/ng1285](https://doi.org/10.1038/ng1285). [PMID 14702039](https://pubmed.ncbi.nlm.nih.gov/14702039)
- Miller MK; Bang ML; Witt CC et al. (2003). "The muscle ankyrin repeat proteins: CARP, ankrd2/Arpp and DARP as a family of titin filament-based stress response molecules". *J. Mol. Biol.*. **333** (5): 951–64. [doi:10.1016/j.jmb.2003.09.012](https://doi.org/10.1016/j.jmb.2003.09.012). [PMID 14583192](https://pubmed.ncbi.nlm.nih.gov/14583192)
- Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". *Proc. Natl. Acad. Sci. U.S.A.*. **99** (26): 16899–903. [Bibcode:2002PNAS...9916899M](https://ui.adsabs.harvard.edu/abs/2002PNAS...9916899M). [doi:10.1073/pnas.242603899](https://doi.org/10.1073/pnas.242603899). [PMC 139241](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241). [PMID 12477932](https://pubmed.ncbi.nlm.nih.gov/12477932)
- Dias Neto E; Correa RG; Verjovski-Almeida S et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". *Proc. Natl. Acad. Sci. U.S.A.*. **97** (7): 3491–6. [Bibcode:2000PNAS...97.3491D](https://ui.adsabs.harvard.edu/abs/2000PNAS...97.3491D). [doi:10.1073/pnas.97.7.3491](https://doi.org/10.1073/pnas.97.7.3491). [PMC 16267](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC16267). [PMID 10737800](https://pubmed.ncbi.nlm.nih.gov/10737800)

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Adapted from the Wikipedia article [ANKRD23](https://en.wikipedia.org/wiki/ANKRD23) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/ANKRD23?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.