# ADAM18

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Protein-coding gene in humans

ADAM18 Identifiers Aliases ADAM18, ADAM27, tMDCIII, ADAM metallopeptidase domain 18 External IDs MGI: 105986; HomoloGene: 74941; GeneCards: ADAM18; OMA:ADAM18 - orthologs Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8p11.22 Start 39,584,489 bp[1] End 39,730,065 bp[1] Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 A2 Start 25,092,262 bp[2] End 25,164,771 bp[2] RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle left testis right testis testicle gonad monocyte right coronary artery apex of heart left ventricle urinary bladder Top expressed in spermatocyte spermatid seminiferous tubule visual cortex primary visual cortex superior frontal gyrus islet of Langerhans somite More reference expression data BioGPS More reference expression data Gene ontology Molecular function metalloendopeptidase activity metallopeptidase activity Cellular component integral component of membrane membrane Biological process multicellular organism development cell differentiation spermatogenesis proteolysis Sources:Amigo / QuickGO Orthologs Species Human Mouse Entrez 8749 13524 Ensembl ENSG00000168619 ENSG00000278548 ENSMUSG00000031552 UniProt Q9Y3Q7 Q9R157 RefSeq (mRNA) NM_001190956 NM_014237 NM_001320313 NM_010084 RefSeq (protein) NP_001177885 NP_001307242 NP_055052 NP_034214 Location (UCSC) Chr 8: 39.58 – 39.73 Mb Chr 8: 25.09 – 25.16 Mb PubMed search [3] [4] Wikidata View/Edit Human View/Edit Mouse

**Disintegrin and metalloproteinase domain-containing protein 18** is an [enzyme](/source/Enzyme) that in humans is encoded by the *ADAM18* [gene](/source/Gene).[5][6]

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene is a sperm surface protein.[6]

## References

1. ^ [***a***](#cite_ref-refGRCh38Ensembl_1-0) [***b***](#cite_ref-refGRCh38Ensembl_1-1) [***c***](#cite_ref-refGRCh38Ensembl_1-2) [ENSG00000278548 GRCh38: Ensembl release 89: ENSG00000168619, ENSG00000278548](http://May2017.archive.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000168619,) – [Ensembl](/source/Ensembl_genome_database_project), May 2017

1. ^ [***a***](#cite_ref-refGRCm38Ensembl_2-0) [***b***](#cite_ref-refGRCm38Ensembl_2-1) [***c***](#cite_ref-refGRCm38Ensembl_2-2) [GRCm38: Ensembl release 89: ENSMUSG00000031552](http://May2017.archive.ensembl.org/Mus_musculus/Gene/Summary?db=core;g=ENSMUSG00000031552) – [Ensembl](/source/Ensembl_genome_database_project), May 2017

1. **[^](#cite_ref-3)** ["Human PubMed Reference:"](https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=8749). *National Center for Biotechnology Information, U.S. National Library of Medicine*.

1. **[^](#cite_ref-4)** ["Mouse PubMed Reference:"](https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=13524). *National Center for Biotechnology Information, U.S. National Library of Medicine*.

1. **[^](#cite_ref-pmid12200459_5-0)** Frayne J, Hurd EA, Hall L (Aug 2002). ["Human tMDC III: a sperm protein with a potential role in oocyte recognition"](https://doi.org/10.1093%2Fmolehr%2F8.9.817). *Mol Hum Reprod*. **8** (9): 817–22. [doi](/source/Doi_(identifier)):[10.1093/molehr/8.9.817](https://doi.org/10.1093%2Fmolehr%2F8.9.817). [PMID](/source/PMID_(identifier)) [12200459](https://pubmed.ncbi.nlm.nih.gov/12200459).

1. ^ [***a***](#cite_ref-entrez_6-0) [***b***](#cite_ref-entrez_6-1) ["Entrez Gene: ADAM18 ADAM metallopeptidase domain 18"](https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=8749).

## Further reading

- Gerhard DS, Wagner L, Feingold EA, et al. (2004). ["The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928). *Genome Res*. **14** (10B): 2121–7. [doi](/source/Doi_(identifier)):[10.1101/gr.2596504](https://doi.org/10.1101%2Fgr.2596504). [PMC](/source/PMC_(identifier)) [528928](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928). [PMID](/source/PMID_(identifier)) [15489334](https://pubmed.ncbi.nlm.nih.gov/15489334).

- Clark HF, Gurney AL, Abaya E, et al. (2003). ["The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC403697). *Genome Res*. **13** (10): 2265–70. [doi](/source/Doi_(identifier)):[10.1101/gr.1293003](https://doi.org/10.1101%2Fgr.1293003). [PMC](/source/PMC_(identifier)) [403697](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC403697). [PMID](/source/PMID_(identifier)) [12975309](https://pubmed.ncbi.nlm.nih.gov/12975309).

- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). ["Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241). *Proc. Natl. Acad. Sci. U.S.A*. **99** (26): 16899–903. [Bibcode](/source/Bibcode_(identifier)):[2002PNAS...9916899M](https://ui.adsabs.harvard.edu/abs/2002PNAS...9916899M). [doi](/source/Doi_(identifier)):[10.1073/pnas.242603899](https://doi.org/10.1073%2Fpnas.242603899). [PMC](/source/PMC_(identifier)) [139241](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241). [PMID](/source/PMID_(identifier)) [12477932](https://pubmed.ncbi.nlm.nih.gov/12477932).

- Zhu GZ, Lin Y, Myles DG, Primakoff P (1999). "Identification of four novel ADAMs with potential roles in spermatogenesis and fertilization". *Gene*. **234** (2): 227–37. [doi](/source/Doi_(identifier)):[10.1016/S0378-1119(99)00208-5](https://doi.org/10.1016%2FS0378-1119%2899%2900208-5). [PMID](/source/PMID_(identifier)) [10395895](https://pubmed.ncbi.nlm.nih.gov/10395895).

- Frayne J, Jury JA, Barker HL, et al. (1998). ["Macaque MDC family of proteins: sequence analysis, tissue distribution and processing in the male reproductive tract"](https://doi.org/10.1093%2Fmolehr%2F4.5.429). *Mol. Hum. Reprod*. **4** (5): 429–37. [doi](/source/Doi_(identifier)):[10.1093/molehr/4.5.429](https://doi.org/10.1093%2Fmolehr%2F4.5.429). [PMID](/source/PMID_(identifier)) [9665629](https://pubmed.ncbi.nlm.nih.gov/9665629).

- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". *Gene*. **200** (1–2): 149–56. [doi](/source/Doi_(identifier)):[10.1016/S0378-1119(97)00411-3](https://doi.org/10.1016%2FS0378-1119%2897%2900411-3). [PMID](/source/PMID_(identifier)) [9373149](https://pubmed.ncbi.nlm.nih.gov/9373149).

- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". *Gene*. **138** (1–2): 171–4. [doi](/source/Doi_(identifier)):[10.1016/0378-1119(94)90802-8](https://doi.org/10.1016%2F0378-1119%2894%2990802-8). [PMID](/source/PMID_(identifier)) [8125298](https://pubmed.ncbi.nlm.nih.gov/8125298).

## External links

- The [MEROPS](/source/MEROPS) online database for peptidases and their inhibitors: [M12.957](http://merops.sanger.ac.uk/cgi-bin/merops.cgi?id=M12.957)[*[dead link](https://en.wikipedia.org/wiki/Wikipedia:Link_rot)*]

- Human [*ADAM18*](https://genome.ucsc.edu/cgi-bin/hgTracks?db=hg38&singleSearch=knownCanonical&position=ADAM18) genome location and [*ADAM18*](https://genome.ucsc.edu/cgi-bin/hgGene?db=hg38&hgg_type=knownGene&hgg_gene=ADAM18) gene details page in the [UCSC Genome Browser](/source/UCSC_Genome_Browser).

v t e Proteases: metalloendopeptidases (EC 3.4.24) ADAM proteins Alpha secretases ADAM9 ADAM10 ADAM17 ADAM19 ADAM2 ADAM7 ADAM8 ADAM11 ADAM12 ADAM15 ADAM18 ADAM22 ADAM23 ADAM28 ADAM33 ADAMTS1 ADAMTS2 ADAMTS3 ADAMTS4 ADAMTS5 ADAMTS8 ADAMTS9 ADAMTS10 ADAMTS12 ADAMTS13 Matrix metalloproteinases Collagenases MMP1 MMP8 Gelatinases MMP2 MMP9 MMP3 MMP7 MMP10 MMP11 MMP12 MMP13 MMP14 MMP15 MMP16 MMP17 MMP19 MMP20 MMP21 MMP23A MMP23B MMP24 MMP25 MMP26 MMP27 MMP28 Other Neprilysin Procollagen peptidase Thermolysin Pregnancy-associated plasma protein A Bone morphogenetic protein 1 Lysostaphin Insulin-degrading enzyme ZMPSTE24

v t e Enzymes Activity Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis Regulation Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator Classification EC number Enzyme superfamily Enzyme family List of enzymes Kinetics Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics Types EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

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