# ACER3

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Protein-coding gene in the species Homo sapiens

ACER3 Identifiers Aliases ACER3, APHC, PHCA, alkaline ceramidase 3, PLDECO External IDs OMIM: 617036; MGI: 1913440; HomoloGene: 5410; GeneCards: ACER3; OMA:ACER3 - orthologs Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q13.5 Start 76,860,859 bp[1] End 77,026,797 bp[1] Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 E1 Start 98,206,389 bp[2] End 98,321,208 bp[2] RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell inferior ganglion of vagus nerve mucosa of ileum corpus callosum pancreatic epithelial cell pars reticulata pars compacta Brodmann area 46 subthalamic nucleus buccal mucosa cell Top expressed in conjunctival fornix cornea interventricular septum hair follicle skin of external ear sciatic nerve decidua skin of back lobe of prostate skin of abdomen More reference expression data BioGPS n/a Gene ontology Molecular function hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides hydrolase activity phytoceramidase activity N-acylsphingosine amidohydrolase activity dihydroceramidase activity ceramidase activity calcium ion binding zinc ion binding metal ion binding Cellular component integral component of membrane integral component of Golgi membrane integral component of endoplasmic reticulum membrane Golgi membrane Golgi apparatus endoplasmic reticulum membrane endoplasmic reticulum membrane Biological process sphingosine biosynthetic process sphingolipid biosynthetic process phytosphingosine biosynthetic process ceramide metabolic process positive regulation of cell population proliferation inflammatory response myelination regulation of programmed cell death ceramide catabolic process lipid metabolism sphingolipid metabolic process Sources:Amigo / QuickGO Orthologs Species Human Mouse Entrez 55331 66190 Ensembl ENSG00000078124 ENSMUSG00000030760 UniProt Q9NUN7 Q9D099 RefSeq (mRNA) NM_001300953 NM_001300954 NM_001300955 NM_018367 NM_025408 RefSeq (protein) NP_001287882 NP_001287883 NP_001287884 NP_060837 NP_079684 NP_001347544 NP_001347545 NP_001347546 Location (UCSC) Chr 11: 76.86 – 77.03 Mb Chr 7: 98.21 – 98.32 Mb PubMed search [3] [4] Wikidata View/Edit Human View/Edit Mouse

**Alkaline ceramidase 3** also known as **ACER3** is a [ceramidase](/source/Ceramidase) [enzyme](/source/Enzyme) which in [humans](/source/Human) is encoded by the *ACER3* [gene](/source/Gene).[5][6]

## References

1. ^ [***a***](#cite_ref-refGRCh38Ensembl_1-0) [***b***](#cite_ref-refGRCh38Ensembl_1-1) [***c***](#cite_ref-refGRCh38Ensembl_1-2) [GRCh38: Ensembl release 89: ENSG00000078124](http://May2017.archive.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000078124) – [Ensembl](/source/Ensembl_genome_database_project), May 2017

1. ^ [***a***](#cite_ref-refGRCm38Ensembl_2-0) [***b***](#cite_ref-refGRCm38Ensembl_2-1) [***c***](#cite_ref-refGRCm38Ensembl_2-2) [GRCm38: Ensembl release 89: ENSMUSG00000030760](http://May2017.archive.ensembl.org/Mus_musculus/Gene/Summary?db=core;g=ENSMUSG00000030760) – [Ensembl](/source/Ensembl_genome_database_project), May 2017

1. **[^](#cite_ref-3)** ["Human PubMed Reference:"](https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=55331). *National Center for Biotechnology Information, U.S. National Library of Medicine*.

1. **[^](#cite_ref-4)** ["Mouse PubMed Reference:"](https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=66190). *National Center for Biotechnology Information, U.S. National Library of Medicine*.

1. **[^](#cite_ref-pmid11356846_5-0)** Mao C, Xu R, Szulc ZM, Bielawska A, Galadari SH, Obeid LM (July 2001). ["Cloning and characterization of a novel human alkaline ceramidase. A mammalian enzyme that hydrolyzes phytoceramide"](https://doi.org/10.1074%2Fjbc.M102818200). *J. Biol. Chem*. **276** (28): 26577–88. [doi](/source/Doi_(identifier)):[10.1074/jbc.M102818200](https://doi.org/10.1074%2Fjbc.M102818200). [PMID](/source/PMID_(identifier)) [11356846](https://pubmed.ncbi.nlm.nih.gov/11356846).

1. **[^](#cite_ref-pmid18619555_6-0)** Mao C, Obeid LM (September 2008). ["Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2614331). *Biochim. Biophys. Acta*. **1781** (9): 424–34. [doi](/source/Doi_(identifier)):[10.1016/j.bbalip.2008.06.002](https://doi.org/10.1016%2Fj.bbalip.2008.06.002). [PMC](/source/PMC_(identifier)) [2614331](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2614331). [PMID](/source/PMID_(identifier)) [18619555](https://pubmed.ncbi.nlm.nih.gov/18619555).

## External links

- Human [*ACER3*](https://genome.ucsc.edu/cgi-bin/hgTracks?db=hg38&singleSearch=knownCanonical&position=ACER3) genome location and [*ACER3*](https://genome.ucsc.edu/cgi-bin/hgGene?db=hg38&hgg_type=knownGene&hgg_gene=ACER3) gene details page in the [UCSC Genome Browser](/source/UCSC_Genome_Browser).

## Further reading

- Strausberg RL, Feingold EA, Grouse LH, et al. (2002). ["Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241). *Proc. Natl. Acad. Sci. U.S.A*. **99** (26): 16899–903. [Bibcode](/source/Bibcode_(identifier)):[2002PNAS...9916899M](https://ui.adsabs.harvard.edu/abs/2002PNAS...9916899M). [doi](/source/Doi_(identifier)):[10.1073/pnas.242603899](https://doi.org/10.1073%2Fpnas.242603899). [PMC](/source/PMC_(identifier)) [139241](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241). [PMID](/source/PMID_(identifier)) [12477932](https://pubmed.ncbi.nlm.nih.gov/12477932).

- Gerhard DS, Wagner L, Feingold EA, et al. (2004). ["The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928). *Genome Res*. **14** (10B): 2121–7. [doi](/source/Doi_(identifier)):[10.1101/gr.2596504](https://doi.org/10.1101%2Fgr.2596504). [PMC](/source/PMC_(identifier)) [528928](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928). [PMID](/source/PMID_(identifier)) [15489334](https://pubmed.ncbi.nlm.nih.gov/15489334).

- Ota T, Suzuki Y, Nishikawa T, et al. (2004). ["Complete sequencing and characterization of 21,243 full-length human cDNAs"](https://doi.org/10.1038%2Fng1285). *Nat. Genet*. **36** (1): 40–5. [doi](/source/Doi_(identifier)):[10.1038/ng1285](https://doi.org/10.1038%2Fng1285). [PMID](/source/PMID_(identifier)) [14702039](https://pubmed.ncbi.nlm.nih.gov/14702039).

- Wheeler HE, Metter EJ, Tanaka T, et al. (2009). Gibson G (ed.). ["Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752811). *PLOS Genet*. **5** (10) e1000685. [doi](/source/Doi_(identifier)):[10.1371/journal.pgen.1000685](https://doi.org/10.1371%2Fjournal.pgen.1000685). [PMC](/source/PMC_(identifier)) [2752811](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752811). [PMID](/source/PMID_(identifier)) [19834535](https://pubmed.ncbi.nlm.nih.gov/19834535).

v t e Metabolism, lipid metabolism, glycolipid enzymes Sphingolipid To glycosphingolipid Glycosyltransferase Sulfotransferase To ceramide From ganglioside β-Galactosidase Hexosaminidase A Neuraminidase Glucocerebrosidase From globoside Hexosaminidase B α-Galactosidase β-Galactosidase Glucocerebrosidase From sphingomyelin Sphingomyelin phosphodiesterase Sphingomyelin phosphodiesterase 1 From sulfatide Arylsulfatase A Galactosylceramidase To sphingosine Ceramidase ACER1 ACER2 ACER3 ASAH1 ASAH2 ASAH2B ASAH2C Other Sphingosine kinase NCL Palmitoyl protein thioesterase Tripeptidyl peptidase I CLN3 CLN5 CLN6 CLN8 Ceramide synthesis Serine C-palmitoyltransferase (SPTLC1) Ceramide glucosyltransferase (UGCG)

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