# ABCC5

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Protein-coding gene in the species Homo sapiens

ABCC5 Identifiers Aliases ABCC5, ABC33, EST277145, MOAT-C, MOATC, MRP5, SMRP, pABC11, ATP binding cassette subfamily C member 5 External IDs OMIM: 605251; MGI: 1351644; HomoloGene: 21164; GeneCards: ABCC5; OMA:ABCC5 - orthologs Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q27.1 Start 183,919,934 bp[1] End 184,017,939 bp[1] Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16 A3|16 12.41 cM Start 20,150,053 bp[2] End 20,245,144 bp[2] RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum middle temporal gyrus gastrocnemius muscle retinal pigment epithelium tibialis anterior muscle apex of heart primary visual cortex muscle of thigh Brodmann area 23 right frontal lobe Top expressed in superior frontal gyrus yolk sac neural layer of retina granulocyte primary visual cortex dentate gyrus of hippocampal formation granule cell gastrula decidua muscle of thigh cerebellar cortex More reference expression data BioGPS More reference expression data Gene ontology Molecular function nucleotide binding organic anion transmembrane transporter activity ATPase activity ATP binding ATPase-coupled inorganic anion transmembrane transporter activity ATPase-coupled transmembrane transporter activity Cellular component integral component of membrane plasma membrane integral component of plasma membrane membrane Biological process hyaluronan biosynthetic process organic anion transport transmembrane transport Sources:Amigo / QuickGO Orthologs Species Human Mouse Entrez 10057 27416 Ensembl ENSG00000114770 ENSMUSG00000022822 UniProt O15440 Q9R1X5 RefSeq (mRNA) NM_001023587 NM_005688 NM_001320032 NM_013790 NM_176839 RefSeq (protein) NP_001018881 NP_001306961 NP_005679 NP_038818 NP_789809 Location (UCSC) Chr 3: 183.92 – 184.02 Mb Chr 16: 20.15 – 20.25 Mb PubMed search [3] [4] Wikidata View/Edit Human View/Edit Mouse

**Multidrug resistance-associated protein 5** is a [protein](/source/Protein) that in humans is encoded by the *ABCC5* [gene](/source/Gene).[5][6][7]

## Function

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance.

This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides.

Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercaptopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients.

Alternative splicing of this gene has been detected; however, the complete sequence and translation initiation site is unclear.[7]

## Interactive pathway map

*Click on genes, proteins and metabolites below to link to respective articles.*[§ 1]

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Fluorouracil (5-FU) Activity  [edit](http://www.wikipathways.org/index.php/Pathway:WP1601)

1. **[^](#cite_ref-WikiPathways_8-0)** The interactive pathway map can be edited at WikiPathways: ["FluoropyrimidineActivity_WP1601"](http://www.wikipathways.org/index.php/Pathway:WP1601).

## See also

- [ATP-binding cassette transporter](/source/ATP-binding_cassette_transporter)

## References

1. ^ [***a***](#cite_ref-refGRCh38Ensembl_1-0) [***b***](#cite_ref-refGRCh38Ensembl_1-1) [***c***](#cite_ref-refGRCh38Ensembl_1-2) [GRCh38: Ensembl release 89: ENSG00000114770](http://May2017.archive.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000114770) – [Ensembl](/source/Ensembl_genome_database_project), May 2017

1. ^ [***a***](#cite_ref-refGRCm38Ensembl_2-0) [***b***](#cite_ref-refGRCm38Ensembl_2-1) [***c***](#cite_ref-refGRCm38Ensembl_2-2) [GRCm38: Ensembl release 89: ENSMUSG00000022822](http://May2017.archive.ensembl.org/Mus_musculus/Gene/Summary?db=core;g=ENSMUSG00000022822) – [Ensembl](/source/Ensembl_genome_database_project), May 2017

1. **[^](#cite_ref-3)** ["Human PubMed Reference:"](https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=10057). *National Center for Biotechnology Information, U.S. National Library of Medicine*.

1. **[^](#cite_ref-4)** ["Mouse PubMed Reference:"](https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=27416). *National Center for Biotechnology Information, U.S. National Library of Medicine*.

1. **[^](#cite_ref-pmid8894702_5-0)** Allikmets R, Gerrard B, Hutchinson A, Dean M (Oct 1996). ["Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database"](https://doi.org/10.1093%2Fhmg%2F5.10.1649). *Human Molecular Genetics*. **5** (10): 1649–55. [doi](/source/Doi_(identifier)):[10.1093/hmg/5.10.1649](https://doi.org/10.1093%2Fhmg%2F5.10.1649). [PMID](/source/PMID_(identifier)) [8894702](https://pubmed.ncbi.nlm.nih.gov/8894702).

1. **[^](#cite_ref-pmid9827529_6-0)** Belinsky MG, Bain LJ, Balsara BB, Testa JR, Kruh GD (Nov 1998). ["Characterization of MOAT-C and MOAT-D, new members of the MRP/cMOAT subfamily of transporter proteins"](https://doi.org/10.1093%2Fjnci%2F90.22.1735). *Journal of the National Cancer Institute*. **90** (22): 1735–41. [doi](/source/Doi_(identifier)):[10.1093/jnci/90.22.1735](https://doi.org/10.1093%2Fjnci%2F90.22.1735). [PMID](/source/PMID_(identifier)) [9827529](https://pubmed.ncbi.nlm.nih.gov/9827529).

1. ^ [***a***](#cite_ref-entrez_7-0) [***b***](#cite_ref-entrez_7-1) ["Entrez Gene: ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5"](https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=10057).

## Further reading

- Kool M, de Haas M, Scheffer GL, Scheper RJ, van Eijk MJ, Juijn JA, Baas F, Borst P (Aug 1997). "Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines". *Cancer Research*. **57** (16): 3537–47. [PMID](/source/PMID_(identifier)) [9270026](https://pubmed.ncbi.nlm.nih.gov/9270026).

- Suzuki T, Nishio K, Sasaki H, Kurokawa H, Saito-Ohara F, Ikeuchi T, Tanabe S, Terada M, Saijo N (Sep 1997). "cDNA cloning of a short type of multidrug resistance protein homologue, SMRP, from a human lung cancer cell line". *Biochemical and Biophysical Research Communications*. **238** (3): 790–4. [doi](/source/Doi_(identifier)):[10.1006/bbrc.1997.7346](https://doi.org/10.1006%2Fbbrc.1997.7346). [PMID](/source/PMID_(identifier)) [9325169](https://pubmed.ncbi.nlm.nih.gov/9325169).

- Cole SP (May 1999). ["Re: Characterization of MOAT-C and MOAT-D, new members of the MRP/cMOAT subfamily of transporter proteins"](https://doi.org/10.1093%2Fjnci%2F91.10.888). *Journal of the National Cancer Institute*. **91** (10): 888–9. [doi](/source/Doi_(identifier)):[10.1093/jnci/91.10.888](https://doi.org/10.1093%2Fjnci%2F91.10.888). [PMID](/source/PMID_(identifier)) [10340910](https://pubmed.ncbi.nlm.nih.gov/10340910).

- McAleer MA, Breen MA, White NL, Matthews N (Aug 1999). ["pABC11 (also known as MOAT-C and MRP5), a member of the ABC family of proteins, has anion transporter activity but does not confer multidrug resistance when overexpressed in human embryonic kidney 293 cells"](https://doi.org/10.1074%2Fjbc.274.33.23541). *The Journal of Biological Chemistry*. **274** (33): 23541–8. [doi](/source/Doi_(identifier)):[10.1074/jbc.274.33.23541](https://doi.org/10.1074%2Fjbc.274.33.23541). [PMID](/source/PMID_(identifier)) [10438534](https://pubmed.ncbi.nlm.nih.gov/10438534).

- Suzuki T, Sasaki H, Kuh HJ, Agui M, Tatsumi Y, Tanabe S, Terada M, Saijo N, Nishio K (Jan 2000). "Detailed structural analysis on both human MRP5 and mouse mrp5 transcripts". *Gene*. **242** (1–2): 167–73. [doi](/source/Doi_(identifier)):[10.1016/S0378-1119(99)00529-6](https://doi.org/10.1016%2FS0378-1119%2899%2900529-6). [PMID](/source/PMID_(identifier)) [10721709](https://pubmed.ncbi.nlm.nih.gov/10721709).

- Oguri T, Isobe T, Suzuki T, Nishio K, Fujiwara Y, Katoh O, Yamakido M (Apr 2000). ["Increased expression of the MRP5 gene is associated with exposure to platinum drugs in lung cancer"](https://doi.org/10.1002%2F%28SICI%291097-0215%2820000401%2986%3A1%3C95%3A%3AAID-IJC15%3E3.0.CO%3B2-G). *International Journal of Cancer*. **86** (1): 95–100. [doi](/source/Doi_(identifier)):[10.1002/(SICI)1097-0215(20000401)86:1<95::AID-IJC15>3.0.CO;2-G](https://doi.org/10.1002%2F%28SICI%291097-0215%2820000401%2986%3A1%3C95%3A%3AAID-IJC15%3E3.0.CO%3B2-G). [PMID](/source/PMID_(identifier)) [10728601](https://pubmed.ncbi.nlm.nih.gov/10728601).

- Dias Neto E, Correa RG, Verjovski-Almeida S, Briones MR, Nagai MA, da Silva W, Zago MA, Bordin S, Costa FF, Goldman GH, Carvalho AF, Matsukuma A, Baia GS, Simpson DH, Brunstein A, de Oliveira PS, Bucher P, Jongeneel CV, O'Hare MJ, Soares F, Brentani RR, Reis LF, de Souza SJ, Simpson AJ (Mar 2000). ["Shotgun sequencing of the human transcriptome with ORF expressed sequence tags"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC16267). *Proceedings of the National Academy of Sciences of the United States of America*. **97** (7): 3491–6. [Bibcode](/source/Bibcode_(identifier)):[2000PNAS...97.3491D](https://ui.adsabs.harvard.edu/abs/2000PNAS...97.3491D). [doi](/source/Doi_(identifier)):[10.1073/pnas.97.7.3491](https://doi.org/10.1073%2Fpnas.97.7.3491). [PMC](/source/PMC_(identifier)) [16267](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC16267). [PMID](/source/PMID_(identifier)) [10737800](https://pubmed.ncbi.nlm.nih.gov/10737800).

- Wijnholds J, Mol CA, van Deemter L, de Haas M, Scheffer GL, Baas F, Beijnen JH, Scheper RJ, Hatse S, De Clercq E, Balzarini J, Borst P (Jun 2000). ["Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC16570). *Proceedings of the National Academy of Sciences of the United States of America*. **97** (13): 7476–81. [Bibcode](/source/Bibcode_(identifier)):[2000PNAS...97.7476W](https://ui.adsabs.harvard.edu/abs/2000PNAS...97.7476W). [doi](/source/Doi_(identifier)):[10.1073/pnas.120159197](https://doi.org/10.1073%2Fpnas.120159197). [PMC](/source/PMC_(identifier)) [16570](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC16570). [PMID](/source/PMID_(identifier)) [10840050](https://pubmed.ncbi.nlm.nih.gov/10840050).

- Jedlitschky G, Burchell B, Keppler D (Sep 2000). ["The multidrug resistance protein 5 functions as an ATP-dependent export pump for cyclic nucleotides"](https://doi.org/10.1074%2Fjbc.M005463200). *The Journal of Biological Chemistry*. **275** (39): 30069–74. [doi](/source/Doi_(identifier)):[10.1074/jbc.M005463200](https://doi.org/10.1074%2Fjbc.M005463200). [PMID](/source/PMID_(identifier)) [10893247](https://pubmed.ncbi.nlm.nih.gov/10893247).

- Alcorn J, Lu X, Moscow JA, McNamara PJ (Nov 2002). "Transporter gene expression in lactating and nonlactating human mammary epithelial cells using real-time reverse transcription-polymerase chain reaction". *The Journal of Pharmacology and Experimental Therapeutics*. **303** (2): 487–96. [doi](/source/Doi_(identifier)):[10.1124/jpet.102.038315](https://doi.org/10.1124%2Fjpet.102.038315). [PMID](/source/PMID_(identifier)) [12388627](https://pubmed.ncbi.nlm.nih.gov/12388627). [S2CID](/source/S2CID_(identifier)) [16195525](https://api.semanticscholar.org/CorpusID:16195525).

- Wielinga PR, van der Heijden I, Reid G, Beijnen JH, Wijnholds J, Borst P (May 2003). ["Characterization of the MRP4- and MRP5-mediated transport of cyclic nucleotides from intact cells"](https://doi.org/10.1074%2Fjbc.M212723200). *The Journal of Biological Chemistry*. **278** (20): 17664–71. [doi](/source/Doi_(identifier)):[10.1074/jbc.M212723200](https://doi.org/10.1074%2Fjbc.M212723200). [PMID](/source/PMID_(identifier)) [12637526](https://pubmed.ncbi.nlm.nih.gov/12637526).

- Pascolo L, Fernetti C, Pirulli D, Crovella S, Amoroso A, [Tiribelli C](/source/Claudio_Tiribelli) (Mar 2003). "Effects of maturation on RNA transcription and protein expression of four MRP genes in human placenta and in BeWo cells". *Biochemical and Biophysical Research Communications*. **303** (1): 259–65. [doi](/source/Doi_(identifier)):[10.1016/S0006-291X(03)00327-9](https://doi.org/10.1016%2FS0006-291X%2803%2900327-9). [PMID](/source/PMID_(identifier)) [12646196](https://pubmed.ncbi.nlm.nih.gov/12646196).

- Reid G, Wielinga P, Zelcer N, De Haas M, Van Deemter L, Wijnholds J, Balzarini J, Borst P (May 2003). "Characterization of the transport of nucleoside analog drugs by the human multidrug resistance proteins MRP4 and MRP5". *Molecular Pharmacology*. **63** (5): 1094–103. [doi](/source/Doi_(identifier)):[10.1124/mol.63.5.1094](https://doi.org/10.1124%2Fmol.63.5.1094). [PMID](/source/PMID_(identifier)) [12695538](https://pubmed.ncbi.nlm.nih.gov/12695538). [S2CID](/source/S2CID_(identifier)) [7444400](https://api.semanticscholar.org/CorpusID:7444400).

- Dazert P, Meissner K, Vogelgesang S, Heydrich B, Eckel L, Böhm M, Warzok R, Kerb R, Brinkmann U, Schaeffeler E, Schwab M, Cascorbi I, Jedlitschky G, Kroemer HK (Oct 2003). ["Expression and localization of the multidrug resistance protein 5 (MRP5/ABCC5), a cellular export pump for cyclic nucleotides, in human heart"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1868287). *The American Journal of Pathology*. **163** (4): 1567–77. [doi](/source/Doi_(identifier)):[10.1016/S0002-9440(10)63513-4](https://doi.org/10.1016%2FS0002-9440%2810%2963513-4). [PMC](/source/PMC_(identifier)) [1868287](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1868287). [PMID](/source/PMID_(identifier)) [14507663](https://pubmed.ncbi.nlm.nih.gov/14507663).

- Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (Jun 2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". *Nature Biotechnology*. **22** (6): 707–16. [doi](/source/Doi_(identifier)):[10.1038/nbt971](https://doi.org/10.1038%2Fnbt971). [PMID](/source/PMID_(identifier)) [15146197](https://pubmed.ncbi.nlm.nih.gov/15146197). [S2CID](/source/S2CID_(identifier)) [27764390](https://api.semanticscholar.org/CorpusID:27764390).

- Jedlitschky G, Tirschmann K, Lubenow LE, Nieuwenhuis HK, Akkerman JW, Greinacher A, Kroemer HK (Dec 2004). ["The nucleotide transporter MRP4 (ABCC4) is highly expressed in human platelets and present in dense granules, indicating a role in mediator storage"](https://doi.org/10.1182%2Fblood-2003-12-4330). *Blood*. **104** (12): 3603–10. [doi](/source/Doi_(identifier)):[10.1182/blood-2003-12-4330](https://doi.org/10.1182%2Fblood-2003-12-4330). [PMID](/source/PMID_(identifier)) [15297306](https://pubmed.ncbi.nlm.nih.gov/15297306).

- Meyer Zu Schwabedissen HE, Grube M, Heydrich B, Linnemann K, Fusch C, Kroemer HK, Jedlitschky G (Jan 2005). ["Expression, localization, and function of MRP5 (ABCC5), a transporter for cyclic nucleotides, in human placenta and cultured human trophoblasts: effects of gestational age and cellular differentiation"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1602292). *The American Journal of Pathology*. **166** (1): 39–48. [doi](/source/Doi_(identifier)):[10.1016/S0002-9440(10)62230-4](https://doi.org/10.1016%2FS0002-9440%2810%2962230-4). [PMC](/source/PMC_(identifier)) [1602292](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1602292). [PMID](/source/PMID_(identifier)) [15631998](https://pubmed.ncbi.nlm.nih.gov/15631998).

## External links

- [ABCC5+protein,+human](https://meshb.nlm.nih.gov/record/ui?name=ABCC5+protein%2C+human) at the U.S. National Library of Medicine [Medical Subject Headings](/source/Medical_Subject_Headings) (MeSH)

- [*ABCC5*](https://genome.ucsc.edu/cgi-bin/hgTracks?db=hg38&singleSearch=knownCanonical&position=ABCC5) human gene location in the [UCSC Genome Browser](/source/UCSC_Genome_Browser).

- [*ABCC5*](https://genome.ucsc.edu/cgi-bin/hgGene?db=hg38&hgg_type=knownGene&hgg_gene=ABCC5) human gene details in the [UCSC Genome Browser](/source/UCSC_Genome_Browser).

*This article incorporates text from the [United States National Library of Medicine](/source/United_States_National_Library_of_Medicine), which is in the [public domain](/source/Public_domain).*

v t e Membrane proteins, carrier proteins: membrane transport proteins ABC transporter (TC 3A1) A A1 A2 A3 A4 A7 A8 A12 A13 B B1 B2-3 (B2 B3) B4 B5 B6 B7 B9 B11 C C1 C2 C3 C4 C5 C6 C7 C8-9 (C8, C9) C10 C11 C13 D D1 D2 D3 D4 E E1 F F1 F2 G G1 G2 G4 Sterolin (G5, G8) see also ABC transporter disorders

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Adapted from the Wikipedia article [ABCC5](https://en.wikipedia.org/wiki/ABCC5) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/ABCC5?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.