# 5-phytase

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The enzyme **5-phytase**[1] (EC 3.1.3.72) [catalyzes](/source/Catalysis) the reaction

- *myo*-inositol hexakisphosphate + H2O = 1L-*myo*-inositol 1,2,3,4,6-pentakisphosphate + phosphate

*myo*-Inositol hexakisphosphate is also known as [phytic acid](/source/Phytic_acid).

These enzymes belongs to the family of [hydrolases](/source/Hydrolase), specifically those acting on phosphoric [monoester](/source/Ester) bonds. The [systematic name](/source/List_of_enzymes) of this enzyme class is ***myo*-inositol-hexakisphosphate 5-phosphohydrolase**.

## Prevalence

Of the hundreds of phytase enzymes that have been characterized in the literature, only two have been characterized as 5-phytases.[2][needs update] A histidine acid phosphatases purified from lily pollen[1] and a protein tyrosine phosphatase-like phytase from *Selenomonas ruminantium* subsp. *lactilytica*[2] were both found to have specificity for the 5-phosphate position of *myo*-inositol hexakisphosphate.

## Structural studies

As of late 2007, only the phytase purified from lily pollen had its [structure](/source/Tertiary_structure) solved, with [PDB](/source/Protein_Data_Bank) accession codes , , , , , and .

## See also

- [3-phytase](/source/3-phytase) (1-phytase)
- [4-phytase](/source/4-phytase) (6-phytase)
- [Protein tyrosine phosphatase](/source/Protein_tyrosine_phosphatase)

## References

1. Barrientos L, Scott JJ, Murthy PP (1994). "Specificity of hydrolysis of phytic acid by alkaline phytase from lily pollen". *Plant Physiology*. **106** (4): 1489–1495. [doi:10.1104/pp.106.4.1489](https://doi.org/10.1104/pp.106.4.1489). [PMC 159689](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC159689). [PMID 7846160](https://pubmed.ncbi.nlm.nih.gov/7846160)

1. Puhl A, Greiner R, Selinger LB (2008). "A protein tyrosine phosphatase-like inositol polyphosphatase from *Selenomonas ruminantium* subsp. *lactilytica* has specificity for the 5-phosphate of *myo*-inositol hexakisphosphate". *The International Journal of Biochemistry & Cell Biology*. **40** (10): 2053–2064. [doi:10.1016/j.biocel.2008.02.003](https://doi.org/10.1016/j.biocel.2008.02.003). [PMID 18358762](https://pubmed.ncbi.nlm.nih.gov/18358762)

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