# 4-Fluoroamphetamine > Mediated Wiki article. Canonical URL: https://mediated.wiki/source/4-Fluoroamphetamine > Markdown URL: https://mediated.wiki/source/4-Fluoroamphetamine.md > Source: https://en.wikipedia.org/wiki/4-Fluoroamphetamine > Source revision: 1340551053 > License: Creative Commons Attribution-ShareAlike 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/) {{Short description|Psychoactive research chemical}} {{cs1 config|name-list-style=vanc|display-authors=6}} {{Use dmy dates|date=October 2020}} {{Drugbox | Verifiedfields = changed | verifiedrevid = 477221808 | image = 4-Fluoroamphetamine.svg | image_class = skin-invert-image | width = 225px | image2 = 4-Fluoroamphetamine molecule ball.png | image_class2 = bg-transparent | alt2 = Ball-and-stick model of the 4-fluoroamphetamine molecule | width2 = 225px | tradename = | pregnancy_category = N | routes_of_administration = [Oral](/source/Oral_administration){{cite journal | vauthors = Oeri HE | title = Beyond ecstasy: Alternative entactogens to 3,4-methylenedioxymethamphetamine with potential applications in psychotherapy | journal = J Psychopharmacol | volume = 35 | issue = 5 | pages = 512–536 | date = May 2021 | pmid = 32909493 | pmc = 8155739 | doi = 10.1177/0269881120920420 | url = }} | class = | legal_BR = F2 | legal_CA = Schedule I | legal_DE = Anlage I | legal_UK = Class A | legal_US = Schedule I | legal_UN = P II | legal_UN_comment = {{Cite web | title = Substance Details 4-Fluoroamphetamine | url = https://www.unodc.org/LSS/Substance/Details/35999356-e8a6-428b-a537-90e09d258e0c | access-date = 2024-01-22 }} | onset = | duration_of_action = 3–7 hours | CAS_number_Ref = {{cascite|correct|CAS}} | CAS_number = 459-02-9 | UNII_Ref = {{fdacite|correct|FDA}} | UNII = S5744XYR1Z | PubChem = 9986 | KEGG = C22767 | ChEMBL = 2009392 | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 9592 | synonyms = 4-FA; 4-FMP; ''para''-Fluoroamphetamine; PFA; PAL-303; PAL303; Flux | IUPAC_name = (''RS'')-1-(4-fluorophenyl)propan-2-amine | C = 9 | H = 12 | F = 1 | N = 1 | SMILES = Fc1ccc(cc1)CC(N)C | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C9H12FN/c1-7(11)6-8-2-4-9(10)5-3-8/h2-5,7H,6,11H2,1H3 | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = DGXWNDGLEOIEGT-UHFFFAOYSA-N }} '''4-Fluoroamphetamine''' ('''4-FA'''; '''4-FMP'''; '''PAL-303'''; "'''Flux'''"), also known as '''''para''-fluoroamphetamine''' ('''PFA'''), is a [psychoactive](/source/psychoactive_drug) [research chemical](/source/research_chemical) of the [phenethylamine](/source/phenethylamine) and [substituted amphetamine](/source/substituted_amphetamine) [chemical class](/source/chemical_class)es. It produces [stimulant](/source/stimulant) and [entactogen](/source/entactogen)ic effects. As a [recreational drug](/source/recreational_drug), 4-FA is sometimes sold along with related compounds such as [2-fluoroamphetamine](/source/2-fluoroamphetamine) and [4-fluoromethamphetamine](/source/4-fluoromethamphetamine).{{cite journal | vauthors = Rösner P, Quednow B, Girreser U, Junge T | title = Isomeric fluoro-methoxy-phenylalkylamines: a new series of controlled-substance analogues (designer drugs) | journal = Forensic Science International | volume = 148 | issue = 2–3 | pages = 143–156 | date = March 2005 | pmid = 15639609 | doi = 10.1016/j.forsciint.2004.05.003 | citeseerx = 10.1.1.670.7372 }}{{cite journal | vauthors = Nagai F, Nonaka R, Satoh Hisashi Kamimura K | title = The effects of non-medically used psychoactive drugs on monoamine neurotransmission in rat brain | journal = European Journal of Pharmacology | volume = 559 | issue = 2–3 | pages = 132–137 | date = March 2007 | pmid = 17223101 | doi = 10.1016/j.ejphar.2006.11.075 }} ==Usage== thumb|right|4-Fluoroamphetamine 4-FA was popular in the Netherlands where it was predominantly used for its specific effects (77% of users) rather than its legal status (18%). 4-FA has become illegal since May 2017.{{cite web | title = Het is nu officieel: de partydrug 4-FA is verboden | date = 25 May 2017 | url = https://nos.nl/op3/artikel/2174904-het-is-nu-officieel-de-partydrug-4-fa-is-verboden.html | website = nos.nl | url-status = live | archive-url = https://web.archive.org/web/20170824215837/https://nos.nl/op3/artikel/2174904-het-is-nu-officieel-de-partydrug-4-fa-is-verboden.html | archive-date = 24 August 2017 }} Since the ban usage has decreased a lot. Accurate statistics of usage are not available until 2020, but submitted samples to get tested were counted. In 2016 1.100 (10%) of samples tested for DIMS were 4-FA samples,{{cite web | vauthors = Croes E, de Ruiter N, Wijers L, Niesink R, Brunt T, van Goor M | title = Factsheet 4-FA | location = Netherlands | issue = 3 | date = October 2017 | url = https://www.trimbos.nl/wp-content/uploads/sites/31/2021/09/af1473-factsheet-4-fa.pdf | access-date = 15 December 2025 | publisher = Trimbos-Instituut | language = Dutch }} in 2024 less than 50 4-FA samples were submitted.{{cite web | vauthors = Hutten N, Smit Rigter L | title = Jaarbericht 2024 | location = Utrecht, Netherlands | pages = 6 | date = 2025 | url = https://www.trimbos.nl/wp-content/uploads/2025/10/Jaarbericht-DIMS-2024.pdf | access-date = 15 December 2025 | publisher = Trimbos-Instituut | language = Dutch | id = TRI-41-013 }} In 2020 0,3% of Dutch adults used 4-FA in the previous year, in 2024 this was just 0,1%.{{cite web | vauthors = Monitor ND | title = NPS 8.2.2 Veranderingen in NPS-gebruik onder volwassenen | location = Utrecht & Den Haag | date = 2025 | url = https://www.nationaledrugmonitor.nl/nps-demografische-kenmerken-algemene-bevolking/#4fa | website = Nationale Drug Monitor | publisher = Trimbos-instituut & WODC | access-date = 15 December 2025 | language = Dutch | trans-title = NPS-usage by adults }} ===Effects=== The subjective effects of 4-fluoroamphetamine include [euphoria](/source/euphoria) which some find similar to the effects of [MDMA](/source/MDMA) and amphetamine,{{cite journal | vauthors = Linsen F, Koning RP, van Laar M, Niesink RJ, Koeter MW, Brunt TM | title = 4-Fluoroamphetamine in the Netherlands: more than a one-night stand | journal = Addiction | volume = 110 | issue = 7 | pages = 1138–1143 | date = July 2015 | pmid = 25808511 | doi = 10.1111/add.12932 }} increased energy (stimulation), mood elevation, feelings of warmth and empathy, excessive talking, [bruxism](/source/bruxism), and suppressed appetite (anorexic). The general course of effects involves primarily empathogenic effects for the first few hours, which fades out as increased stimulation develops over the next several hours. {{medcn|date=August 2014}} The [dopamine reuptake inhibition](/source/Dopamine_reuptake_inhibitor) produced by 4-FA is stronger than that of either [4-CA](/source/para-Chloroamphetamine) or [4-IA](/source/para-Iodoamphetamine).{{cite journal | vauthors = Marona-Lewicka D, Rhee GS, Sprague JE, Nichols DE | title = Psychostimulant-like effects of p-fluoroamphetamine in the rat | journal = European Journal of Pharmacology | volume = 287 | issue = 2 | pages = 105–113 | date = December 1995 | pmid = 8749023 | doi = 10.1016/0014-2999(95)00478-5 }} 4-FA also produces less [hyperthermia](/source/hyperthermia) than similar compounds such as [PMA](/source/para-Methoxyamphetamine), [4-MTA](/source/4-Methylthioamphetamine) and [4-methylamphetamine](/source/4-methylamphetamine).{{medcn|date=August 2014}} 4-FA has been described as producing a very mild "[psychedelic](/source/psychedelic_drug)" state, intermediate between that of [amphetamine](/source/amphetamine) and [MDMA](/source/MDMA).{{cite journal | vauthors = Kuypers KP, De Sousa Fernandes Perna EB, Theunissen EL, Toennes SW, Mason NL, Hutten NR, Ramaekers JG | title = A First-in-Man Study with 4-Fluoroamphetamine Demonstrates it Produces a Mild Psychedelic State | journal = J Psychoactive Drugs | volume = 51 | issue = 3 | pages = 225–235 | date = 2019 | pmid = 30676284 | doi = 10.1080/02791072.2019.1569286 | doi-access = free }} It is unclear whether this is related to [induction of monoamine release](/source/monoamine_releasing_agent) or [serotonin](/source/serotonin) [5-HT2A receptor](/source/5-HT2A_receptor) [agonism](/source/agonism). Common acute side effects are nausea, headaches, increased heart rate and insomnia.{{medcn|date=January 2013}} ==Chemistry== 4-FA reacts with [reagent testing](/source/reagent_testing) to give a semi-unique array of colors which can be used to aid its identification. {| class="wikitable" |+ Final colors produced by reagent tests |- !Reagent !Reaction color |- | [Marquis](/source/Marquis_reagent) | No reaction{{cite web | title = 4-FA reaction colour results with liebermann and froehde reagent test kits | date = 3 January 2016 | url = https://www.reagent-tests.uk/blog/4-fa-reaction-colour-results-with-liebermann-and-froehde-reagent-test-kits/ | publisher = Reagent Tests UK | access-date = 14 February 2016 | url-status = live | archive-url = https://web.archive.org/web/20160214131923/https://www.reagent-tests.uk/blog/4-fa-reaction-colour-results-with-liebermann-and-froehde-reagent-test-kits/ | archive-date = 14 February 2016 }} |- | [Mandelin](/source/Mandelin_reagent) | Pale Blue{{cite journal | vauthors = Uchiyama N, Kawamura M, Kamakura H, Kikura-Hanajiri R, Goda Y | title = [Analytical data of designated substances (Shitei-Yakubutsu) controlled by the Pharmaceutical Affairs Law in Japan, part II: Color test and TLC] | journal = Yakugaku Zasshi | volume = 128 | issue = 6 | pages = 981–987 | date = June 2008 | pmid = 18520145 | doi = 10.1248/yakushi.128.981 | url = https://www.jstage.jst.go.jp/article/yakushi/128/6/128_6_981/_pdf | url-status = live | doi-access = free | archive-url = https://web.archive.org/web/20160305020825/https://www.jstage.jst.go.jp/article/yakushi/128/6/128_6_981/_pdf | archive-date = 5 March 2016 }} |- | [Liebermann](/source/Liebermann_reagent) | Orange |- | [Froehde](/source/Froehde_reagent) | Faint purple/brown or no reaction. |} ==Pharmacology== 4-Fluoroamphetamine is a [releasing agent](/source/releasing_agent) and [reuptake inhibitor](/source/reuptake_inhibitor) of [dopamine](/source/dopamine), [serotonin](/source/serotonin), and [norepinephrine](/source/norepinephrine).{{cite journal | vauthors = Toennes SW, Schneider D, Pogoda W, Paulke A, Wunder C, Theunissen EL, Kuypers KP, de Sousa Fernandes Perna E, Ramaekers JG | title = Pharmacokinetic properties of 4-fluoroamphetamine in serum and oral fluid after oral ingestion | journal = Drug Testing and Analysis | volume = 11 | issue = 7 | pages = 1028–1034 | date = July 2019 | pmid = 30912312 | doi = 10.1002/dta.2595 | s2cid = 85518011 }} The respective [EC50](/source/EC50) values are 200 nM, 730 nM, and 37 nM, while the [IC50](/source/IC50) values are 770 nM, 6800 nM, and 420 nM. The drug shows some [affinity](/source/affinity_(pharmacology)) for the [serotonin](/source/serotonin) [5-HT2A receptor](/source/5-HT2A_receptor) (Ki = 11,300{{nbsp}}nM) and serotonin [5-HT2C receptor](/source/5-HT2C_receptor) (Ki = 7,800{{nbsp}}nM), similar to that of [MDMA](/source/MDMA) in the case of the serotonin 5-HT2A receptor (Ki = 5,900{{nbsp}}nM), but far below the affinity of structurally related classical [serotonergic psychedelic](/source/serotonergic_psychedelic)s like [2C-B](/source/2C-B).{{cite journal | vauthors = Rickli A, Hoener MC, Liechti ME | title = Monoamine transporter and receptor interaction profiles of novel psychoactive substances: para-halogenated amphetamines and pyrovalerone cathinones | journal = Eur Neuropsychopharmacol | volume = 25 | issue = 3 | pages = 365–376 | date = March 2015 | pmid = 25624004 | doi = 10.1016/j.euroneuro.2014.12.012 }} It has also been shown to act as a very low-[potency](/source/potency_(pharmacology)) serotonin [5-HT2B receptor](/source/5-HT2B_receptor) [partial agonist](/source/partial_agonist) ({{Abbrlink|EC50|half-maximal effective concentration}} = 14,400{{nbsp}}nM; {{Abbrlink|Emax|maximal efficacy}} = 58%). 4-Fluoroamphetamine has been found to be a weak [monoamine oxidase A](/source/monoamine_oxidase_A) (MAO-A) [inhibitor](/source/monoamine_oxidase_inhibitor), with an {{Abbrlink|IC50|half-maximal inhibitory concentration}} of 16,000{{nbsp}}nM.{{cite journal | vauthors = Reyes-Parada M, Iturriaga-Vasquez P, Cassels BK | title = Amphetamine Derivatives as Monoamine Oxidase Inhibitors | journal = Front Pharmacol | volume = 10 | date = 2019 | pmid = 32038257 | pmc = 6989591 | doi = 10.3389/fphar.2019.01590 | article-number = 1590 | doi-access = free }} For comparison, the {{Abbrlink|IC50|half-maximal inhibitory concentration}} of [amphetamine](/source/amphetamine) for MAO-A inhibition was 11,000{{nbsp}}nM. Regarding the metabolic fate of 4-FA, the C-F bond at the 4-position on the phenyl ring likely resists deactivation in the liver by [cytochrome P450 oxidase](/source/cytochrome_P450_oxidase).{{cite journal | vauthors = Fisher MB, Henne KR, Boer J | title = The complexities inherent in attempts to decrease drug clearance by blocking sites of CYP-mediated metabolism | journal = Current Opinion in Drug Discovery & Development | volume = 9 | issue = 1 | pages = 101–109 | date = January 2006 | pmid = 16445122 }}{{cite journal | vauthors = Toennes SW, Schneider D, Pogoda W, Paulke A, Wunder C, Theunissen EL, Kuypers KP, de Sousa Fernandes Perna E, Ramaekers JG | title = Pharmacokinetic properties of 4-fluoroamphetamine in serum and oral fluid after oral ingestion | journal = Drug Testing and Analysis | volume = 11 | issue = 7 | pages = 1028–1034 | date = July 2019 | pmid = 30912312 | doi = 10.1002/dta.2595 | s2cid = 85518011 }} ===Neurotoxicity=== 4-FA does not cause long-lasting depletion of brain serotonin, unlike its [analogs](/source/structural_analog) [4-CA](/source/para-Chloroamphetamine) and [4-BA](/source/para-Bromoamphetamine).{{cite journal | vauthors = Harvey JA | title = Neurotoxic action of halogenated amphetamines | journal = Annals of the New York Academy of Sciences | volume = 305 | issue = 1 | pages = 289–304 | date = June 1978 | pmid = 81648 | doi = 10.1111/j.1749-6632.1978.tb31530.x | s2cid = 38386908 | bibcode = 1978NYASA.305..289H }} This is thought to "reflect the inability of the fluoro-compound to be metabolized in the same way as the other haloamphetamines."{{cite journal | vauthors = Fuller RW, Baker JC, Perry KW, Molloy BB | title = Comparison of 4-chloro-, 4-bromo- and 4-fluoroamphetamine in rats: drug levels in brain and effects on brain serotonin metabolism | journal = Neuropharmacology | volume = 14 | issue = 10 | pages = 739–746 | date = October 1975 | pmid = 1196472 | doi = 10.1016/0028-3908(75)90099-4 | s2cid = 9620299 }} [Neurotoxicity](/source/Neurotoxicity) does not increase down the series of ''para''-halogenated amphetamine derivatives, even though serotonin releasing potency does follow this trend. For example, [4-iodoamphetamine](/source/4-iodoamphetamine) is less toxic than is [4-chloroamphetamine](/source/4-chloroamphetamine).{{cite journal | vauthors = Nichols DE, Johnson MP, Oberlender R | title = 5-Iodo-2-aminoindan, a nonneurotoxic analogue of p-iodoamphetamine | journal = Pharmacology, Biochemistry, and Behavior | volume = 38 | issue = 1 | pages = 135–139 | date = January 1991 | pmid = 1826785 | doi = 10.1016/0091-3057(91)90601-W | s2cid = 20485505 | citeseerx = 10.1.1.670.504 }} Hence, this property is not related to serotonin releasing potency as such, since [PAL-287](/source/PAL-287) was reported to be not at all neurotoxic even though it is a powerful 5-HT releasing agent.{{cite journal | vauthors = Rothman RB, Blough BE, Woolverton WL, Anderson KG, Negus SS, Mello NK, Roth BL, Baumann MH | title = Development of a rationally designed, low abuse potential, biogenic amine releaser that suppresses cocaine self-administration | journal = The Journal of Pharmacology and Experimental Therapeutics | volume = 313 | issue = 3 | pages = 1361–1369 | date = June 2005 | pmid = 15761112 | doi = 10.1124/jpet.104.082503 | s2cid = 19802702 | author7-link = Bryan Roth }} It is unclear where [4-methylamphetamine](/source/4-methylamphetamine) fits in on the neurotoxicity scale. The extensive serotonergic neurotoxicity of 4-chloroamphetamine (and its brominated derivative), and the increased serotonergic toxicity of 4-methylamphetamine{{cite journal | vauthors = Blanckaert P, van Amsterdam J, Brunt T, van den Berg J, Van Durme F, Maudens K, van Bussel J | title = 4-Methyl-amphetamine: a health threat for recreational amphetamine users | journal = Journal of Psychopharmacology | volume = 27 | issue = 9 | pages = 817–822 | date = September 2013 | pmid = 23784740 | doi = 10.1177/0269881113487950 | s2cid = 35436194 }} suggest that para-substitution seems to increase overall serotonergic (neuro)toxicity, compared to amphetamine. Exceptions include [4-MTA](/source/4-MTA), a ''para''-substituted, non-neurotoxic amphetamine.{{cite journal | vauthors = Huang X, Marona-Lewicka D, Nichols DE | title = p-methylthioamphetamine is a potent new non-neurotoxic serotonin-releasing agent | journal = European Journal of Pharmacology | volume = 229 | issue = 1 | pages = 31–38 | date = December 1992 | pmid = 1473561 | doi = 10.1016/0014-2999(92)90282-9 }}{{cite journal | vauthors = Li Q, Murakami I, Stall S, Levy AD, Brownfield MS, Nichols DE, Van de Kar LD | title = Neuroendocrine pharmacology of three serotonin releasers: 1-(1,3-benzodioxol-5-yl)-2-(methylamino)butane (MBDB), 5-methoxy-6-methyl-2-aminoindan (MMAi) and p-methylthioamphetamine (MTA) | journal = The Journal of Pharmacology and Experimental Therapeutics | volume = 279 | issue = 3 | pages = 1261–1267 | date = December 1996 | pmid = 8968349 | doi = 10.1016/S0022-3565(25)21285-X }}{{cite journal | vauthors = Murphy J, Flynn JJ, Cannon DM, Guiry PJ, McCormack P, Baird AW, McBean GJ, Keenan AK | title = In vitro neuronal and vascular responses to 5-hydroxytryptamine: modulation by 4-methylthioamphetamine, 4-methylthiomethamphetamine and 3,4-methylenedioxymethamphetamine | journal = European Journal of Pharmacology | volume = 444 | issue = 1–2 | pages = 61–67 | date = May 2002 | pmid = 12191583 | doi = 10.1016/S0014-2999(02)01586-8 }} ===Toxicology=== The [LD50](/source/LD50) (mouse; i.p.) of 4-FA is 46 mg/kg.{{cite book | vauthors = Costa E, Garattini S | title = Amphetamines and Related Compounds | location = New York | pages = 28 | date = 1970 | publisher = Raven Press }} Fluoroamphetamine (isomer not determined) in a capsule mixed with [25C-NBOMe](/source/25C-NBOMe) was associated with three deaths in Melbourne in 2017.{{Cite web | title = News: March 2017 – Australia: "Ecstasy" capsules containing NPS are related to several deaths and severe intoxications in Melbourne | url = https://www.unodc.org/LSS/announcement/Details/48940b13-df58-4da2-a66b-d54a8f7362f7 | access-date = 2022-02-27 | website = www.unodc.org }} ==Legal status== As of October 2015, 4-FA is a controlled substance in China.{{cite web | title = 关于印发《非药用类麻醉药品和精神药品列管办法》的通知 | date = 27 September 2015 | url = http://www.sfda.gov.cn/WS01/CL0056/130753.html | publisher = China Food and Drug Administration | language = zh | access-date = 1 October 2015 | archive-url = https://web.archive.org/web/20151001222554/http://www.sfda.gov.cn/WS01/CL0056/130753.html | archive-date = 1 October 2015 | url-status = dead }} 4-FA is banned in the Czech Republic.{{cite web | title = Látky, o které byl doplněn seznam č. 4 psychotropních látek (příloha č. 4 k nařízení vlády č. 463/2013 Sb.) | url = http://www.mzcr.cz/Admin/_upload/files/3/Nov%C3%A9%20PL.pdf | publisher = Ministerstvo zdravotnictví | language = cs | url-status = live | archive-url = https://web.archive.org/web/20160309174659/http://www.mzcr.cz/Admin/_upload/files/3/Nov%C3%A9%20PL.pdf | archive-date = 9 March 2016 }} As of 25 May 2017 4-FA is a controlled substance in the Netherlands.{{cite web | vauthors = Van der Velden L | title = Vanaf vandaag is partydrug 4-FA officieel verboden - maar of dat helpt? | date = 25 May 2017 | url = http://www.volkskrant.nl/binnenland/vanaf-vandaag-is-partydrug-4-fa-officieel-verboden-maar-of-dat-helpt~a4496813/ | publisher = de Volkskrant | access-date = 25 May 2017 | language = nl | url-status = live | archive-url = https://web.archive.org/web/20170525093455/http://www.volkskrant.nl/binnenland/vanaf-vandaag-is-partydrug-4-fa-officieel-verboden-maar-of-dat-helpt~a4496813/ | archive-date = 25 May 2017 }} 4-FA is also controlled in Australia, Belgium, UK, Germany, Israel, Slovakia, Bulgaria, Chile, Brazil, Canada, Croatia, Sweden, New Zealand and France.{{citation needed|date=March 2017}} 4-FA is a controlled substance as of 27 August 2014 in South Korea.{{Cite web | title = 식약처,'4-플로오로암페타민'등 4개 물질 마약류로 지정 - 보도자료 {{!}} 브리핑룸 {{!}} 대한민국 정책브리핑|url=https://m.korea.kr/briefing/pressReleaseView.do?newsId=155989200#pressRelease|access-date=2025-09-07|website=m.korea.kr}} ===Finland=== Scheduled in the "government decree on narcotic substances, preparations and plants" and is therefore illegal.{{cite web | title = FINLEX ® - Ajantasainen lainsäädäntö: Valtioneuvoston asetus huumausaineina… 543/2008 | url = https://finlex.fi/fi/lainsaadanto/2008/543 }} ===United States=== In the United States, on June 3, 2025 the DEA announced by federal register its intent to place 4-Fluoroamphetamine into Schedule I status with public comments closing on July 3, 2025.{{cite web |date=3 June 2025 |title=Schedules of Controlled Substances: Placement of 4-Fluoroamphetamine in Schedule I |url=https://www.federalregister.gov/documents/2025/06/03/2025-09988/schedules-of-controlled-substances-placement-of-4-fluoroamphetamine-in-schedule-i}} On January 15, 2026 the DEA placed 4-FA in Schedule 1 of the Controlled Substances Act effective February 17, 2026.{{Cite web |date=2026-01-15 |title=Schedules of Controlled Substances: Placement of 4-Fluoroamphetamine in Schedule I |url=https://www.federalregister.gov/documents/2026/01/15/2026-00633/schedules-of-controlled-substances-placement-of-4-fluoroamphetamine-in-schedule-i |access-date=2026-01-20 |website=Federal Register |language=en}} == See also == * [2-Fluoroamphetamine](/source/2-Fluoroamphetamine) (2-FA) * [3-Fluoroamphetamine](/source/3-Fluoroamphetamine) (3-FA) * [3,4-Difluoroamphetamine](/source/3%2C4-Difluoroamphetamine) * [4-Fluoromethamphetamine](/source/4-Fluoromethamphetamine) (4-FMA) * [4-Fluoromethcathinone](/source/4-Fluoromethcathinone) (4-FMC) * [4'-Fluoro-4-methylaminorex](/source/4'-Fluoro-4-methylaminorex) * [''para''-Bromoamphetamine](/source/Para-Bromoamphetamine) (PBA) * [''para''-Bromomethamphetamine](/source/para-Bromomethamphetamine) (PBMA) == References == {{reflist}} == External links == * [https://www.erowid.org/chemicals/4_fluoroamphetamine/ Erowid: 4-Fluoroamphetamine] {{Stimulants}} {{Entactogens}} {{Monoamine releasing agents}} {{Phenethylamines}} {{DEFAULTSORT:Fluoroamphetamine, 4-}} Category:4-Fluorophenyl compounds Category:5-HT2B agonists Category:Designer drugs Category:Entactogens Category:Serotonin-norepinephrine-dopamine releasing agents Category:Substituted amphetamines --- Adapted from the Wikipedia article [4-Fluoroamphetamine](https://en.wikipedia.org/wiki/4-Fluoroamphetamine) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/4-Fluoroamphetamine?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.