# 3-Fluoroethamphetamine

> Mediated Wiki article. Canonical URL: https://mediated.wiki/source/3-Fluoroethamphetamine
> Markdown URL: https://mediated.wiki/source/3-Fluoroethamphetamine.md
> Source: https://en.wikipedia.org/wiki/3-Fluoroethamphetamine
> Source revision: 1310627270
> License: Creative Commons Attribution-ShareAlike 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/)

{{Short description|Stimulant drug of the amphetamine class}}
{{Drugbox
| Verifiedfields = changed
| Watchedfields = changed
| verifiedrevid = 451560211
| IUPAC_name = ''N''-ethyl-1-(3-fluorophenyl)propan-2-amine
| image = 3-Fluoroethamphetamine.svg
| image_class = skin-invert-image

<!--Clinical data-->
| tradename =  
| pregnancy_category =  
| legal_CA = Schedule I
| legal_DE = NpSG
| legal_UK = Class A
| legal_status =  
| routes_of_administration =

<!--Pharmacokinetic data-->
| bioavailability =  
| metabolism =  
| elimination_half-life =  
| excretion =

<!--Identifiers-->
| CAS_number_Ref = {{cascite|correct|CAS}}
| CAS_number = 54982-43-3
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = 7ZY9F4B6GT
| ATC_prefix = none
| ATC_suffix =  
| PubChem = 57458869
| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}}
| ChemSpiderID      = 27050449

<!--Chemical data-->
| C=11 | H=16 | F=1 | N=1 
| smiles = CC(CC1=CC(F)=CC=C1)NCC
| StdInChI_Ref = {{stdinchicite|changed|chemspider}}
| StdInChI = 1S/C11H16FN/c1-3-13-9(2)7-10-5-4-6-11(12)8-10/h4-6,8-9,13H,3,7H2,1-2H3
| StdInChIKey_Ref = {{stdinchicite|changed|chemspider}}
| StdInChIKey = CKPWHLGHHXSVJI-UHFFFAOYSA-N
}}

'''3-Fluoroethamphetamine''' ('''3-FEA''') is a [stimulant](/source/stimulant) [drug](/source/drug) of the [amphetamine](/source/substituted_amphetamine) class which acts as a releasing agent of the monoamine neurotransmitters [norepinephrine](/source/norepinephrine), [dopamine](/source/dopamine) and [serotonin](/source/serotonin).

Compared to the unsubstituted [ethylamphetamine](/source/etilamphetamine), 3-fluoroethamphetamine is a weaker releaser of noradrenaline, but a stronger releaser of both dopamine and serotonin, and produced the strongest reinforcing effects in animal studies out of a range of 3-substituted ethamphetamine derivatives tested, despite not being the most potent dopamine releaser.<ref>{{cite journal | vauthors = Tessel RE, Woods JH | title = Structural relationship between meta-substituted N-ethylamphetamines and self-administration in rhesus monkeys. | journal = Pharmacologist | date = 1974 | volume = 16 | pages = 142 }}</ref><ref name="pmid1117418">{{cite journal | vauthors = Tessel RE, Woods JH, Counsell RE, Lu M | title = Structure-activity relationships between meta-substituted N-ethylamphetamines and locomotor activity in mice | journal = The Journal of Pharmacology and Experimental Therapeutics | volume = 192 | issue = 2 | pages = 310–8 | date = February 1975 | doi = 10.1016/S0022-3565(25)30065-0 | pmid = 1117418 }}</ref><ref name="pmid1271279">{{cite journal | vauthors = Tessel RE, Rutledge CO | title = Specificity of release of biogenic amines from isolated rat brain tissue as a function of the meta substituent of N-ethylamphetamine derivatives | journal = The Journal of Pharmacology and Experimental Therapeutics | volume = 197 | issue = 2 | pages = 253–62 | date = May 1976 | doi = 10.1016/S0022-3565(25)30504-5 | pmid = 1271279 }}</ref><ref name="pmid417172">{{cite journal | vauthors = Tessel RE, Woods JH | title = meta Substituted N-ethylamphetamine self injection responding in the rhesus monkey: structure-activity relationships | journal = The Journal of Pharmacology and Experimental Therapeutics | volume = 205 | issue = 2 | pages = 274–81 | date = May 1978 | doi = 10.1016/S0022-3565(25)31228-0 | pmid = 417172 }}</ref>

== See also ==
{{Colbegin}}
* [2-Fluoroamphetamine](/source/2-Fluoroamphetamine)
* [2-Fluoromethamphetamine](/source/2-Fluoromethamphetamine)
* [3-Fluoroamphetamine](/source/3-Fluoroamphetamine)
* [3-Fluoromethamphetamine](/source/3-Fluoromethamphetamine)
* [4-Fluoroamphetamine](/source/4-Fluoroamphetamine)
* [4-Fluoromethamphetamine](/source/4-Fluoromethamphetamine)
* [Fenfluramine](/source/Fenfluramine)
{{Colend}}

== References ==
{{Reflist}}

{{Stimulants}}
{{Phenethylamines}}

{{DEFAULTSORT:Fluoroethamphetamine, 3-}}
Category:Designer drugs
Category:3-Fluorophenyl compounds
Category:Serotonin-norepinephrine-dopamine releasing agents
Category:Stimulants
Category:Substituted amphetamines

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Adapted from the Wikipedia article [3-Fluoroethamphetamine](https://en.wikipedia.org/wiki/3-Fluoroethamphetamine) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/3-Fluoroethamphetamine?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.